• 제목/요약/키워드: Physiology

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Overexpression of Ref-1 Inhibits Lead-induced Endothelial Cell Death via the Upregulation of Catalase

  • Lee, Kwon-Ho;Lee, Sang-Ki;Kim, Hyo-Shin;Cho, Eun-Jung;Joo, Hee-Kyoung;Lee, Eun-Ji;Lee, Ji-Young;Park, Myoung-Soo;Chang, Seok-Jong;Cho, Chung-Hyun;Park, Jin-Bong;Jeon, Byeong-Hwa
    • The Korean Journal of Physiology and Pharmacology
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    • 제13권6호
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    • pp.431-436
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    • 2009

  • The role of apurinic/apyrimidinic endonuclease1/redox factor-1 (Ref-1) on the lead (Pb)-induced cellular response was investigated in the cultured endothelial cells. Pb caused progressive cellular death in endothelial cells, which occurred in a concentration- and time-dependent manner. However, Ref-1 overexpression with AdRef-1 significantly inhibited Pb-induced cell death in the endothelial cells. Also the overexpression of Ref-1 significantly suppressed Pb-induced superoxide and hydrogen peroxide elevation in the endothelial cells. Pb exposure induced the downregulation of catalase, it was inhibited by the Ref-1 overexpression in the endothelial cells. Taken together, our data suggests that the overexpression of Ref-1 inhibited Pb-induced cell death via the upregulation of catalase in the cultured endothelial cells.

  • https://doi.org/10.4196/kjpp.2009.13.6.431 인용 PDF KSCI

팔미지황탕(八味地黃湯) 전탕액(煎湯液) 투여(投與)가 백서(白鼠)의 혈장(血漿) Renin 활성도(活性度), 혈장(血漿) Aldosterone 및 Atrial Natriuretic Peptide 농도(濃度)에 미치는 영향(影響) (Effects of Palmijihwangtang Water Extracts on the Plasma Renin Activity, Plasma Levels of Aldosterone and Artrial Natriuretic Peptide in Rats)

  • 정은경;조남수;이춘우;최민호;허진영;강성도;고정수;성은경;성기호;이관형;류도곤;이호섭
    • 동의생리학회지
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    • 제14권2호통권20호
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    • pp.209-214
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    • 1999

  • The aim of the present experiments was to investigate the effect of Palmijihwangtang water extracts on the plasma renin activity and plasma levels of atrial natriuretic peptide and aldosterone in rats. The results of this study were as follows 1. Plasma renin activity was not different after the administration of Palmijihwangtang water extracts 2. Plasma levels of aldosterone decreased significantly after the administration of Palmijihwangtang water extract 3.0 ml/kg. 3. Plasma levels of atrial natriuretic peptide (ANP) decreased significantly after the administration of Palmijihwangtang water extracts.

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