• 동의생리병리학회지
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• 제18권3호
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• pp.729-733
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• 2004

Jaeum-Dan was reported new anti-aging effect formula previously. We investigated the physiological effects on human skin with Jaeum-Dan essence (JED). We made a skin application product as essence form contained oriental herbs, and measured various physiological effects such as skin moisture contents, red blood cell flow rates, skin surface temperature, corneocyte exfoliation and skin intensity when volunteers(female, n=40) used the application product for 4 weeks. The results were as follows: The skin moisture contents were not only increased in human face skin through using the product, but also red blood cell flow :rates in face skin were increased. After using the essence, the face skin temperature rose and corneocyte exfoliation was decreased. Furthermore the upper dermis intensity of skin in female face was subsequently increased 4 weeks later. The results indicate that the application product containing JED was improved the physiological effects of human facial skin..

• Archives of Pharmacal Research
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• 제10권4호
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• pp.250-257
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• 1987

The development of physiologically based pharmacokinetic model for drug distribution and excretion is described. The physiological modeling procedure is useful in animal and clinical applications to obtain fundamental knowledge of the transport and metabolism of a substance in vivo. In this paper a review of physiologically based pharmacokinetics is presented in the hope of understanding and increasing the use of this modelling technique. The method of model development and the composition of equations based on the different models are explained. For the better understanding a physiological pharmacokinetic model of tenoxicam disposition in the rat is presented as an example of flow limited model.

• 상하수도학회지
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• 제20권3호
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• pp.431-441
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• 2006

This study investigated the physiological characteristics of biofilm microorganisms formed onto the different drinking water distribution pipe surfaces. The simulated drinking water distribution pipe system which had several PVC, STS 304, and GS coupons was operated at flow velocity of 0.08 m/sec (Re 1,950) and 0.28 m/sec (Re 7,300), respectively. At velocity of 0.08 m/sec, the number of viable heterotrophic bacteria in the biofilm over the 3 months of operation averaged $3.3{\times}10^4$, $8.7{\times}10^4$, and $7.2{\times}10^3CFU/cm^2$ for PVC, STS, and GS surfaces, respectively. The number of attached heterotrophic bacteria averaged $1.4{\times}10^3$, $5.6{\times}10^2$, and $6.5{\times}10^2CFU/cm^2$ on PVC, STS, and GS surfaces at the system with relatively high flow velocity of 0.28m/sec. The changes of physiological profile of biofilm-forming microorganisms were characterized by community-level assay that utilized the Biolog GN microplates. Biofilms that formed on different pipe surfaces displayed distinctive patterns of community-level physiological profile (CLPP), which reflected the metabolic preference for different carbon sources and/or the utilization of these carbon sources to varying degrees. The CLPP patterns have shown that the metabolic potential of a biofilm community was different depending on the pipe material. The effect of the pipe material was also characterized differently by operation condition such as flow rate. At flow velocity of 0.08 m/sec, the metabolic potential of biofilm microorganisms on GS surface showed lower levels than PVC and STS biofilms. For biofilms on pipe material surfaces exposed to water flowing at 0.28 m/sec, the metabolic potential was in order of PVC>GS>STS. Generally, the levels of the bacterial biofilm's metabolic potentials were shown to be notably higher on pipe surfaces exposed to water at 0.08 m/sec when compared to those on pipe surfaces exposed to water at 0.28 m/sec.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1996년도 추계학술대회
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• pp.258-262
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• 1996

The physiological systems have nonlinear complex phenomena. Expecially, the flow of capillary blood vessel has a nonlinear dynamic system. Thus, this study analyzes nonlinear characteristics of the flow of capillary blood vessel in physiological systems using chaotic tools(phase space reconstruction, correlation dimension, largest lyapunov exponent). Experimental data have been acquired from examining 10 rabbits. The results of chaotic analysis showed a decreasing largest lyapunov exponent and correlation dimension according to increasement glocose index. And we also know the chaotic behavior.

• 한국생활과학회지
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• 제21권3호
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• pp.567-576
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• 2012

The purpose of this study was to analyze and determine the relationship between physiological responses including blood flow rate and garment pressure, and the feeling of restrictive tightness associated with the wearing skinny pants as a popular clothing style. Evaluation was based on material type, posture and activity type, and body part location. Five female college students took part in this research. Five kinds of experimental clothes with waist measurements of 66cm were chosen. An analysis of the selected skinny pants demonstrated the degree of the whole looseness was higher in this order: clothing type A>B>D>C, and E with E being knitted cloth. Garment pressure was the highest in the front knee portions and was lowest in the outside thigh region. Garment pressure was highest in this sequence : clothing type C>=D>A>=B>E. In terms of posture and activity types, garment pressure was the highest when research participants were crouching, and was the lowest when standing. The blood flow rate was highest in this order: clothing type E>D>B>A>C. Type C skinny pants impeded blood flow and demonstrated the tightest and most restrictive relationship. Blood flow rate varied depending on the type of movement and was highest in this order: getting up, rowing, kicking, jumping and O-shaped leg posture. The results of subjective pressure evaluation demonstrated that pressure was highest in this order: E>=C>B>A>D. These results suggests the need to improve on the patterns and the material design in the area of the front knees. The degree of the looseness when wearing skinny pants did not always correspond to garment pressure or subjective sensation.

• The Korean Journal of Physiology
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• 제23권2호
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• pp.225-236
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• 1989

1) At the isolated perfused guinea-pig and rat heart heterometric autoregulation of the myocardium and myogenic autoregulation of the coronary vessels were induced by means of stepwise increases of perfusion pressure. 2) According to this loading test Frank-Starling function curves of the left ventricle and pressure-flow curves of the coronary vessels can be drawn. This graphic evaluation gives more information about the condition of the heart and the coronary vessels than simple evaluation under hemodynamic equilibrium. 3) There are significant differences in both curves between animal species and between different perfusate Mg concentration. 4) Myogenic autoregulation is not affected by the cyclooxygenase inhibitors indometacin and me- clofenamate. Thus it appears unlikely that prostanoides are involved in myogenic autoregulation. 5) Ca antagonists (Gallopamil, prenylamine) depress myogenic autoregulation dose-dependently. Enhanced myogenic autoregulation, induced by low extracellular magnesium, can be reduced effectively by Gallopamil. 6) Ginsenosides from Panax ginseng as well as the ginsenoside 'Rg' are effective inhibitors of myogenic autoregulation without major negative inotropic effects.

• 한국정밀공학회지
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• 제22권9호
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• pp.179-187
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• 2005

The characteristics of blood flow and the interaction between the blood vessel and blood flow play important roles in plaque cap rupture and the growth of atherosclerosis which may lead directly to a heart attack or a stroke. In this study, carotid arteries with different stenoses have been numerically simulated to investigate the wall shear stress(WSS) and the elastic motion of the vessel. Blood flow has been treated as physiological, laminar and incompressible flow. To model the shear thining behavior of the blood, the Carreau-Yasuda model has been employed but the viscoelasticity of blood has not been considered. The results show that the WSS of $severe(75\%)$ stenosis is much higher than those of $25\%\;and\;50\%$ stenosis in the region of stenosis. With the increase in the stenosis thickness, the expansion ratio of the center of the stenosis decreases while the expansion ratio of the upstream region of the stenosis increases.

• Journal of Microbiology and Biotechnology
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• 제33권1호
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• pp.106-113
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• 2023

The supply of microbiological risk-free water is essential to keep food safety and public hygiene. And removal, inactivation, and destruction of microorganisms in drinking water are key for ensuring safety in the food industry. Ultraviolet-C (UV-C) irradiation is an attractive method for efficient disinfection of water without generating toxicity and adversely affecting human health. In this study, the disinfection efficiencies of UV-C irradiation on Shigella flexneri (Gram negative) and Listeria monocytogenes (Gram positive) at various concentrations in drinking water were evaluated using a water purifier. Their morphological and physiological characteristics after UV-C irradiation were observed using fluorescence microscopy and flow cytometry combined with live/dead staining. UV-C irradiation (254 nm wavelength, irradiation dose: 40 mJ/cm²) at a water flow velocity of 3.4 L/min showed disinfection ability on both bacteria up to 10⁸ CFU/4 L. And flow cytometric analysis showed different physiological shift between S. flexneri and L. monocytogenes after UV-C irradiation, but no significant shift of morphology in both bacteria. In addition, each bacterium revealed different characteristics with time-course observation after UV-C irradiation: L. monocytogenes dramatically changed its physiological feature and seemed to reach maximum damage at 4 h and then recovered, whereas S. flexneri seemed to gradually die over time. This study revealed that UV-C irradiation of water purifiers is effective in disinfecting microbial contaminants in drinking water and provides basic information on bacterial features/responses after UV-C irradiation.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1996년도 추계학술대회
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• pp.363-367
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• 1996

In general, the physiological systems have shown nonlinear complex phenomena. This study analyzes nonlinear characteristics of the flow of peripheral blood vessel dynamics in physiological systems using chaos theory. We performed this study by means of several quantity methods and power spectrum. The quantity methods are a phase space reconstruction and a poincare's map. And the power spectrum method is a conventional linear analysis. Experimental data have been acquired from examining 10 diabetic patients, and 10 control subjects in initial stable state. In acquisition experminetal data, we anlysized the differences of nonlinear characteristics between diabetic group and control group. The results of quality analysis methods showed the flow of peripheral blood vessel had the nonlinear and chaotic characteristics, screening a strange attractor on reconstructed phase space. In conclusion, the flow dynamics of peripheral blood vessel had a chaotic behavior of nonlinear dynamic systems, dynamic system, and differences of characteristic of nonlinear dynamic system.

• 대한한의학원전학회지
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• 제23권2호
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• pp.157-189
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• 2010

Many chapters of the Hwangjenaegyeong[HN] explain the process of transmission and transmutation of disease. The transmission and transmutation process in the HN can be categorized into one between the viscera and bowels, and another of the external pathogenic gi itself. The process between the viscera and bowels indicates the transport of the pathologic burden between each viscera and bowel. This again is categorized into three types. Interpromoting, intercontrolling and that by Saeng-yang(生陽), Sa-eum(死陰). Next, the transport of the pathogenic gi can be categorized into one moving inwards from the exterior according to personal traits, and that according to the three Eum and three Yang. Although there are numerous types of transmission and transmutation, there are two main criteria in understanding the process. First, whether the process is in accordance with the physiological or natural flow of the body. Interpromoting and three Eum three Yang processes are such examples. To follow the physiological flow of the body means to correspond to either the Heaven and Earth or the original physiology of the human body. Therefore, the disease progresses according to a certain date or season. This indicates a partial malfunction in the circulation of the vital energy, which is relatively easy to recover. In contrast, there are processes that go against the physiological flow, for example, intercontrolling transmission and transmutation. This process focuses on the movement of the pathogenic gi rather than the vital gi. The disease progresses regardless of the flow of the vital energy, and sequential functional damage occurs accordingly. Consequently, as the transmission and transmutation continue, formerly passed organs are left damaged, and the whole process is headed towards death. The second criteria for understanding the process is whether it is cyclic or not. To have a cyclic pattern means that the occurrence of a disease and the time of death is not fixed. Transmission and transmutation processes that have a cyclic pattern mostly follow the physiological flow of the body. As a result, they rarely end in deaths, and the process is centered on vital energy. On the other hand, those with acyclic patterns have a fixed occurrence and death point in the course of the disease. They are mostly unnatural processes, found in fatal acute diseases or consumption diseases.