• BMB Reports
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• v.53 no.4
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• pp.181-190
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• 2020

Protein phosphatase 4 (PP4), one of serine/threonine phosphatases, is involved in many critical cellular pathways, including DNA damage response (DNA repair, cell cycle regulation, and apoptosis), tumorigenesis, cell migration, immune response, stem cell development, glucose metabolism, and diabetes. PP4 has been steadily studied over the past decade about wide spectrum of physiological activities in cells. Given the many vital functions in cells, PP4 has great potential to develop into the finding of key working mechanisms and effective treatments for related diseases such as cancer and diabetes. In this review, we provide an overview of the cellular and molecular mechanisms by which PP4 impacts and also discuss the functional significance of it in cell health.

• Fisheries and Aquatic Sciences
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• v.10 no.3
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• pp.159-169
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• 2007

The complex 2-dimensional movements of fish during an annual migration circuit were generated and simulated by a chaotic model of fish movement, which was expanded from a small-scale movement model. Fish migration was modeled as a neural network including stimuli, central decision-making, and output responses as variables. The input stimuli included physical stimuli (temperature, salinity, turbidity, flow), biotic factors (prey, predators, life cycle) and landmarks or navigational aids (sun, moon, weather), values of which were all normalized as ratios. By varying the amplitude and period coefficients of the klinokinesis index using chaotic equations, model results (i.e., spatial orientation patterns of migration through time) were represented as fish feeding, spawning, overwintering, and sheltering. Simulations using this model generated 2-dimesional annual movements of sea bream migration in the southern and western seas of the Korean Peninsula. This model of object-oriented and large-scale fish migration produced complicated and sensitive migratory movements by varying both the klinokinesis coefficients (e.g., the amplitude and period of the physiological month) and the angular variables within chaotic equations.

• Proceedings of the KOSOMBE Conference
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• v.1992 no.11
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• pp.51-54
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• 1992

In this paper, we quantitatively evaluated the anxiety data from humans in an anxiety state. It has been reported that the electric signals of human can be correlated with their emotional state. We chose heart rate, respiration rate, temperature and skin conductance as the anxiety parameters. For experiment protocol, the subject was given exercising load to induce the anxiety state and the exercise was done using the FITRON Cycle Ergometer. We divided the data into three stages: rest period, exercise period, and recovery period. During evaluation, We counted the heart rate, slope of heart rate, temperature change, and the skin conductance.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.6
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• pp.1715-1719
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• 2005

Delirium is a set of symptoms that includes Disturbance of consciousness, attention, cognition, sleep-wake cycle. It usually appears as a disease progresses. Also it can be considered as one of byun-jo(煩躁)'s symptoms because it shows similar symptom and progress to byun-jo(煩躁). One patient was admitted who was suffering delirium, restlessness, chest discomfort, disorientation. The patient was diagnosed as delirium and byun-jo that was caused by heat in the heart and stomach, and was treated with Chungul-san(淸鬱散). In the course of treatment, symptoms improved gradually. Resu suggest that Chungul-san(淸鬱散) is effective on delirium, byun-jo caused by heat in stomach.

• Journal of Physiology & Pathology in Korean Medicine
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• v.29 no.6
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• pp.510-516
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• 2015

The purpose of this study is to present the two treatment case of patient with dysfunctional uterine bleeding. Each patient has received the Korean Medicinal treatment including acupuncture, moxibustion, and herbal medication twice a week for a month or six months. This efficacy of treatment was evaluated with the degree of bleeding by the number of pad used per day. After finishing treatment, two patients had stopped bleeding, and their menstrual cycle returned to the normal range. Moreover, additional clinical manifestations including leukorrhea, hot flush, bloating, feeling tired and irritability which refers to the premenstrual syndrome were also alleviated. This case report showed that the acupuncture, moxibustion, and the herbal medicinal treatment can be effective for the treatment of the dysfunctional uterine bleeding.

• Molecules and Cells
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• v.39 no.9
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• pp.654-662
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• 2016

Almost all eukaryotic proteins are subject to post-translational modifications during mitosis and cell cycle, and in particular, reversible phosphorylation being a key event. The recent use of high-throughput experimental analyses has revealed that more than 70% of all eukaryotic proteins are regulated by phosphorylation; however, the mechanism of dephosphorylation, counteracting phosphorylation, is relatively unknown. Recent discoveries have shown that many of the protein phosphatases are involved in the temporal and spatial control of mitotic events, such as mitotic entry, mitotic spindle assembly, chromosome architecture changes and cohesion, and mitotic exit. This implies that certain phosphatases are tightly regulated for timely dephosphorylation of key mitotic phosphoproteins and are essential for control of various mitotic processes. This review describes the physiological and pathological roles of mitotic phosphatases, as well as the versatile role of various protein phosphatases in several mitotic events.

• Korean Journal of Animal Reproduction
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• v.16 no.3
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• pp.225-230
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• 1992

Many transgenic mice expressing human growth hormone gene were infertile. To investigate the infertility of these transfenic mice, it was looked into the estrus cycle and sexual behaviour and also tested through in vitro fertilization whether the germ cells of these mice normal or not. The infertile female transgenic mice were mated to the fertile males of ICR strain, but in almost all of them the vaginal plugs were not detected and their estrus cycles by vaginal smear were almost irregular which kept up estrus or diestrus stage. Many male transgenic mice did not have the ability of sexual behaviour. Therefore the viability of germ cells in infertile male transgenic mice was investigated by in vitro fertilization, but the sperm were normally fertilized with the eggs and the transgene of parent was passed on to the progeny. These results consequently suggest that the infertility of transgenic mice experssing human growth hormone gene may be due to the physiological activity of human growth hormone, not germ cells.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.1
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• pp.83-87
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• 2006

The oriental medicine is necessary to the development of oriental medicine diagnosis, to satisfy the Senior-Friendly. We experiment on the elderly women in 3-D mac, and carry into effect the comparative-study on the youth's pulsation. The elder pulsation's division factor are analyzed press power, w/t, h5/h1 , dispersion of period. In the press power, the elder pulsation is shallow compared with the youth's pulsation. In the w/t (pressurization time / pulsation cycle), the elder pulsation is longer compared with the youth's pulsation, In the h5/h1 (dicrotic / main peak), the elder pulsation is small compared with the youth's pulsation. In the range of dispersion of period, the elder pulsation is narrow-changed compared with the youth's pulsation. Therefore the elder pulsation is characterized by the deficiency of flexibility and injection power.

• Journal of the Korean Applied Science and Technology
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• v.15 no.1
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• pp.47-54
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• 1998

On contraction of the muscles, marked changes in X-ray reflections are observed, suggesting that conformational changes of contractile molecules and the movement of myosin heads during muscle contraction. The time needed to the peak tension after the onset of stimulation and the amount of peak tension depend on the number of twitch cycle. It was found that the successive twitches decreased not only the time needed to the peak tension after the onset of stimulation but also the time needed to the maximum change of the X-ray intensity. However, the difference of the time between the peak tension and the maximum intensity change($T_{i}-I_{i}$) is nearly the same at any twitch. Based on these results the causes of the decrease of $T_{i}$ and $I_{i}$, and physiological implication of $T_{i}-I_{i}$ are discussed.

• BMB Reports
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• v.52 no.1
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• pp.35-41
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• 2019

Cellular senescence, a permanent state of cell cycle arrest, is believed to have originally evolved to limit the proliferation of old or damaged cells. However, it has been recently shown that cellular senescence is a physiological and pathological program contributing to embryogenesis, immune response, and wound repair, as well as aging and age-related diseases. Unlike replicative senescence associated with telomere attrition, premature senescence rapidly occurs in response to various intrinsic and extrinsic insults. Thus, cellular senescence has also been considered suppressive mechanism of tumorigenesis. Current studies have revealed that therapy-induced senescence (TIS), a type of senescence caused by traditional cancer therapy, could play a critical role in cancer treatment. In this review, we outline the key features and the molecular pathways of cellular senescence. Better understanding of cellular senescence will provide insights into the development of powerful strategies to control cellular senescence for therapeutic benefit. Lastly, we discuss existing strategies for the induction of cancer cell senescence to improve efficacy of anticancer therapy.