• Molecules and Cells
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• 제43권8호
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• pp.686-693
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• 2020

Autophagy is an intracellular degradation system that breaks down damaged organelles or damaged proteins using intracellular lysosomes. Recent studies have also revealed that various forms of selective autophagy play specific physiological roles under different cellular conditions. Lipid droplets, which are mainly found in adipocytes and hepatocytes, are dynamic organelles that store triglycerides and are critical to health. Lipophagy is a type of selective autophagy that targets lipid droplets and is an essential mechanism for maintaining homeostasis of lipid droplets. However, while processes that regulate lipid droplets such as lipolysis and lipogenesis are relatively well known, the major factors that control lipophagy remain largely unknown. This review introduces the underlying mechanism by which lipophagy is induced and regulated, and the current findings on the major roles of lipophagy in physiological and pathological status. These studies will provide basic insights into the function of lipophagy and may be useful for the development of new therapies for lipophagy dysfunction-related diseases.

• 한국환경생태학회:학술대회논문집
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• 한국환경생태학회 2000년도 정기총회 및 학술논문 발표회
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• pp.95-98
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• 2000

• 한방재활의학과학회지
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• 제19권1호
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• pp.103-112
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• 2009

Objectives : This study was aimed to find out the physiological mechanism of craniosacral therapy, especially in CV4 technique and cranial rhythmic impulses. Methods : Recent studies were reviewed for cranial rhythmic impulses, and the ancient and present text were reviewed for the therapy of sub-occiput and cranial-suture part. Results and Conclusions : 1. Suboccipital muscles releasing may have made CV4 technique to effect. 2. The mechanism of the meridians of acupuncture and craniosacral system can be cooperative together in many parts of the clinical treatments. 3. Arterial vasomotor waves have a frequency similar to reports of cranial rhythmic impulses. The methods which have relation to heart rate variability, will be useful for the study of craniosacral therapy.

• Journal of Ginseng Research
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• 제46권4호
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• pp.543-549
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• 2022

Background: In physical activity or labor, the human body is in a state of high intensity stress, and all parts or physiological functions of the body respond positively to maintain or balance the need for movement. The human body has many physiological changes in the process of movement, and fatigue is the external manifestation of various complex changes inside the human body. Fatigue is also a physiological mechanism of self-protection after the body reaches a certain level of activity, which can prevent the occurrence of life-threatening excessive functional failure. The generation of fatigue is a very complex process, and its mechanism has not been concluded yet. Therefore, it is an important work to search and screen the effective components of natural plants that have anti-fatigue effect and to explore their mechanism. Methods: This was a 8-week, randomized, double-blind, placebo-controlled clinical trial. A total of 110 subjects who passed physical examination were included according to the scheme design, and randomly divided into a test group which was given KRG and a placebo control group. The calculation is carried out according to the standard of sub-high-intensity exercise test. Results: There was no adverse effect on safety index of subjects after taking red ginseng capsule. After KRG treatment, subjective strength grade is significant lower than placebo treatment. Blood lactic acid content is significantly get lower after trial in KRG group, and significant lower than placebo group. Creatine phosphokinase(CK) content is significantly get lower after trial in KRG group, and significant lower than placebo group. Conclusion: According to the criterion in the test scheme, the result shows that KRG is helpful on relieving physical fatigue.

• International Journal of Advanced Culture Technology
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• 제4권4호
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• pp.45-50
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• 2016

This is a humanistic study to trace phenomena logically the comprehensive therapeutic mechanism of the human body which is coded by the smart emotion of the rated signal conveyed by the Rated Sijo. The Gestalt, which is structured in the form of therapeutic metastasis conveyed by sentences, is intended to embody the principle of human response. So, this researcher explored the metastatic structure toward Gestalt of original human being through the passage of foreground and background by ergonomic and chemical structure. In the meantime, this researcher focused on revealing the structure of the field of existence by the symbol system in which the therapeutic mechanism of the human body is embodied. As a result, the basic framework of Gestalt literary therapy, which contributes to the improvement of the Quality of Life metaphorized as a mechanism of the symbol system by the metastasis of literary therapy or the electrical operation of the human body. As a result, the human body as a conductor through literature has turned out to be an original Gestalt structure pursued by literature. In addition, it was analyzed that the human body would accept signals such as emotions and Rated Emotions planted in the sentence, and synapse them into the human physiological psycho analytical symbol system. Therefore, it has been confirmed possibility that human existent environment and trauma are separated from the whole universe can push fully implement therapeutic techniques toward totalization by a combination of literary devices, especially appropriate electric signal combination of the Rated Sijo.

• 한국작물학회지
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• 제35권6호
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• pp.548-558
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• 1990

Physiology and genetics of early maturity in cereals are the subject of practical as well as scientific interest for agronomist and plant breeders, Thorough understanding of the true nature of such a complex character requires physiological and genetical knowledge about the internal factors, which are closely bound up with and react to some particular external or environmental factors. From the practical point of view. experiments should be conducted under controlled conditions. especially the day length and temperature, so that the genotypic differences pertaining to these factors may be discerned. Takahashi and Yasuda (1958, 1970) maintained that at least three physiological factors were responsible for determining earliness in barley. namely. (1) spring and winter habit of growth or vernalization requirement, (2) ogitioeruiduc response or sensitivity to short-day, and (3) earliness factor in a narrow sense or minimal vegetative growth. The same situations were true in common wheat also (Yasuda and Shimoyama, 1965), In this report. physiology and genetics of internal factors and their relations to the time of heading in the field will be presented with some problems concerning differences in mechanism of early maturity between barley and wheat.

• Journal of Ginseng Research
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• 제20권4호
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• pp.431-471
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• 1996

Korean ginseng has been thought and used the most very important medicinal herb among the oriental medicinal drugs for thounds of years Korean ginseng had many ingredients such as tripenoid saponins. Nitrogen compounds, polysaccharides, polyacetylenic compounds and lipid compounds. Korean ginseng has wide effects in the various systems of human such as nervous system. Vascular system. Digestive system. endocrine system, immune system. etc. Many researchess who were interested in the biological effects of Korean ginseng have concerned the tripenoid saponins among the components of ginseng and carried out to find the effects of ginseng using the various experimental system. From their results, it was unveiled many effects of Korean ginseng gractually in the experimental systems and shown that Korean ginseng has various effects in the biological system. But recent studies has been carried out to the difference ginseng components, besides ginseng saponin thought to have various effects in biological systems. Also the functional mechanism of ginseng in the biological system is limited but the basic research to elucidate the mysterious effects of ginseng has been preferred. In this review, we focus on biological effects of Korean ginseng. Especially physiological and biochemical aspects in biological systems.

• Journal of Life Science
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• 제12권1호
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• pp.33-42
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• 2002

In several species, a short period of ischemic preconditioning protects the heart by reducing the size of infarcts resulting from subsequent prolonged bouts of ischemia. The mechanism by which activation of ATP-sensitive $K^+$($K_ATP$) channels could provide the memory associated with ischemic preconditioning is still under debate. Several signal transduction pathways have been implicated in the mechanisms of protection induced by ischemic preconditioning. The exact receptor-coupled pathways involved in preconditioning remain to be identified. Likely extracellular agonists are those whose circulating levels increase under conditions that activate $K_ATP$ channels; these conditions include ischemia and ischemic preconditioning. Potential physiological agonists include the following: (1) nitric oxide; (2) catecholamine; (3) adenosine; (4) acetylcholine; (5) bradykinin and (6) prostacycline. The purpose of this review was to understand the mechanism by which biological signal transduction mechanism acts as a link in one or more known receptor-mediated pathways to increase $K_ATP$ channel activity during ischemic preconditioning.

• Toxicological Research
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• 제26권4호
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• pp.237-243
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• 2010

Endocrine disrupting chemicals (EDCs) have been shown to interfere with physiological systems, i.e., adversely affecting hormone balance (endocrine system), or disrupting normal function, in the female and male reproductive organs. Although endocrine disruption is a global concern for human health, its impact and significance and the screening strategy for detecting these synthetic or man-made chemicals are not clearly understood in female and male reproductive functions. Thus, in this review, we summarize the interference of environmental EDCs on reproductive development and function, and toxicological mechanism(s) of EDCs in in vitro and in vivo models of male and female reproductive system. In addition, this review highlights the effect of exposure to multiple EDCs on reproductive functions, and brings attention to their toxicological mechanism(s) through estrogen receptors.

• The Korean Journal of Physiology
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• 제29권2호
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• pp.243-250
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• 1995

A possible potentiation between cholecystokinin (CCK) and secretin in amylase secretion from isolated rat pancreatic acini was investigated. Combined treatment of acini with secretin and CCK at low concentrations, which are known to be physiological, resulted in enzyme secretion larger than the arithmetic sum of their separate effects. Such a potentiating effect also occurred between secretin and A23187 (Ca ionophore), between forskolin (adenylate cyclase activator) and CCK, and between forskolin and A23187. Staurosporin (protein kinase C inhibitor) and W7 (calmodulin antagonist) inhibited markedly the potentiated amylase release induced by the agonists, but KT5720 (protein kinase A inhibitor) did not affect the potentiated amylase release. Therefore, we concluded that the action of CCK in a physiological concentration is potentiated by secretin in a physiological concentration range and vice versa, and that the intracellular mechanism necessary for the potentiation is associated with $Ca^{2+}$. However, it is uncertain what mechanisms are involved in potentiation of amylase release after CAMP and $Ca^{2+}$.