• Korean Journal of Acupuncture
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• 제25권2호
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• pp.33-41
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• 2008

Objectives : The aim of this study was to understand electro-physiological peculiarity in meridian and acupoints, and understand acupuncture therapy mechanism as an electro-physiological viewpoints. Methods : I reviewed the articles on the electro-physiological peculiarity of the meridian and acupoints Results and Conclusions : It has been reported that meridian and acupoints have high-electrical conductivity and row-electrical resistance. On this scientific basis, to understand the mechanism of acupuncture therapy, I made some hypotheses. At first, there is electro-property in meridian and acupoint. The second, energy flowing in meridian is related with electro-property. The third, there is electronic interaction between practitioner of acupuncture therapy and patient receiving acupuncture therapy. The forth, acupuncture effects which may be expressed by the electro-charge capacity is transfered between practitioner and patient via acupuncture. Electro-charge induced via acupuncture in practitioner may be an important factor that initiate the electro-charge changes in meridian and acupoint of patient.

• 대한의용생체공학회:의공학회지
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• 제22권4호
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• pp.331-338
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• 2001

In this paper, we have proposed a new computer retina model reflecting the mechanism of transient amacrine cell on the basis of a conventional computer retina model to understand mechanism of visual information processing. The conventional computer retina model contained most of mechanism for other retina models and it was verified with the physiological data. However, we found that a conventional computer retina model doesn't have the mechanism of amacrine cell that was likely to respond to moving stimulus. In proposed model, therefore, a conventional computer model that considered from photoreceptors to bipolar cells and a new computer model that considered for transient amacrine cell and ganglion cell was combined. As we compared the physiological data with the results of computer simulation of transient amacrine cell about fixed stimulus and moving stimulus, we confirmed that the proposed new computer retina model was normally operated.

• 대한인간공학회지
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• 제31권6호
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• pp.785-791
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• 2012

Objective: The aim of this study was to investigate the correlation between 3D visual fatigue and physiological measures by canonical correlation analysis enabling to categorical correlation. Background: Few studies have been conducted to investigate the physiological mechanism underlying the visual fatigue caused by processing 3D information which may make the cognitive mechanism overloaded. However, even the previous studies lack validation in terms of the correlation between physiological variables and the visual fatigue. Method: 9 Female and 6 male subjects with a mean age of $22.53{\pm}2.55$ voluntarily participated in this experiment. All participants were asked to report how they felt about their health sate at after viewing 3D. In addition, Low & Hybrid measurement test(Event Related Potential, Steady-state Visual Evoked Potential) and for evaluating cognitive fatigue before and after viewing 3D were performed. The physiological signal were measured with subjective fatigue evaluation before and after in watching the 3D content. For this study suggesting categorical correlation, all measures were categorized into three sets such as included Visual Fatigue set(response time, subjective evaluation), Autonomic Nervous System set(PPG frequency, PPG amplitude, HF/LF ratio), Central Nervous System set(ERP amplitude P4, O1, O2, ERP latency P4, O1, O2, SSVEP S/N ratio P4, O1, O2). Then the correlation of three variables sets, canonical correlation analysis was conducted. Results: The results showed a significant correlation between visual fatigue and physiological measures. However, different variables of visual fatigue were highly correlated to respective HF/LF ratio and to ERP latency(O2). Conclusion: Response time was highly correlated to ERP latency(O2) while the subjective evaluation was to HF/LF ratio. Application: This study may provide the most significant variables for the quantitative evaluation of visual fatigue using HF/LF ratio and ERP latency based human performance and subjective fatigue.

• 수면정신생리
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• 제16권1호
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• pp.5-9
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• 2009

Relatively little is known about the neurobiology of insomnia, despite its wide prevalence and broad medical impact. Although much is still to be learned about the pathophysiology of the disorder, identification, systematic assessment, and appropriate treatment are clearly beneficial to patients. Recent research, using quantitative EEG, polysomnography (PSG), multiple sleep latency test (MSLT) and neuroimaging techniques, suggests that some broad areas can be identified as possible pathophysiological models. Sleep-wake homeostat model hypothesizes a failure in homeostatic regulation of sleep, an attenuated increase in sleep drive with time awake, and/or defective sensing of sleep need. Circadian clock model hypothesizes a dysfunctional circadian clock, resulting in changes in the timing of sleep-wake propensity that are incompatible with normal sleep. Intrinsic sleep-wake state mechanism model suggests that abnormal function of insomnia comprises the systems responsible for expression of the sleep states themselves. Extrinsic over-ride mechanism (stress-response) model suggests that insomnia reflects the consequences of overactivity of one of the systems considered "extrinsic" to normal sleep-wake control. Many current therapies for insomnia are based on these physiological models. Several attempts have been made to create a physiological model that would explain this disorder and could be used as a foundation for treatment. However, it appeared that no model can fully explain and clarify all aspects of insomnia. Future research should be necessary to expand our knowledge on the biological dimensions of insomnia.

• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2006년도 학술대회 1부
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• pp.960-965
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• 2006

Privacy and security are latent problems in pervasive healthcare system. For the sake of protecting health monitoring information, it is necessary to classify and categorize the various contexts in terms of obfuscation. In this paper, we propose the physiological context categorization and specification methodology by exploiting data fusion network for automatic context alignment. In addition, we introduce the methodologies for making various level of physiological context on the context aware application model, which is wear-UCAM. This physiological context has several layers of context according to the level of abstraction such as user-friendly level or parametric level. This mechanism facilitates a user to restrict access to his/her monitoring results based on the level of details in context.

• Journal of Nutrition and Health
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• 제33권5호
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• pp.556-565
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• 2000

• 기본간호학회지
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• 제13권2호
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• pp.275-284
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• 2006

Purpose: The purpose of this study was to analyze tile trends in physiological variables in CAT research in nursing in Korea. Method: Of studies published in Korea between January, 2000 and December, 2005, 227 studies were analyzed according to the criteria of type, theme, and patterns in physiological variables related to CAT. Results: There were 72 articles on CAT research in which physiological variables were examined. The most frequently researched type of CAT was massage and in particular, foot massage. The most frequently used physiological variables in CAT research were blood pressure, pulse, and body temperature. Patients with high blood pressure were the most frequent subjects for CAT research. As to the effect of physiological variable by CAT type, foot massage showed a decline in blood pressure in all six research studies involving patients with high blood pressure. Conclusion: There is a need to describe accurately the mechanism by which CAT affects physiological variables. There is also a need for repetitive analysis to verify the effect, and meta-analysis for the effect on physiological variables according to type of CAT.

• Journal of Microbiology and Biotechnology
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• 제24권2호
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• pp.197-208
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• 2014

A novel protease gene from Bacillus gibsonii, aprBG, was cloned, expressed in B. subtilis, and characterized. High-level expression of aprBG was achieved in the recombinant strain when a junction was present between the promoter and the target gene. The purified recombinant enzyme exhibited similar N-terminal sequences and catalytic properties to the native enzyme, including high affinity and hydrolytic efficiency toward various substrates and a superior performance when exposed to various metal ions, surfactants, oxidants, and commercial detergents. AprBG was remarkably stable in 50% organic solvents and retained 100% activity and stability in 0-4 M NaCl, which is better than the characteristics of previously reported proteases. AprBG was most closely related to the high-alkaline proteases of the subtilisin family with a 57-68% identity. The secretion and maturation mechanism of AprBG was dependent on the enzyme activity, as analyzed by site-directed mutagenesis. Thus, when taken together, the results revealed that the halo-solvent-tolerant protease AprBG displays significant activity and stability under various extreme conditions, indicating its potential for use in many biotechnology applications.

• 농약과학회지
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• 제2권3호
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• pp.1-20
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• 1998

Chlorsulfuron, one of sulfonylurea herbicides acts through inhibition of acetolactate syuthase (EC 4.1.3.18; ALS, also known as acetohydroxyacid synthase) in the branched-chain amino acid biosynthesis process. After chlorsulfuron-ALS interaction, many physiological and metabolic disruptions occur in plants. However, it is not clear how this chlorsulfuron-ALS interaction affects those physiological and metabolic processes and how this interaction leads subsequently to plant death. Several researchers suggested that the death of chlorsulfuron-treated plants might be due to a shortage of the branched-chain amino acids, an accumulation of toxic metabolites, and/or a depletion of photoassimilates. It remains as a mystery presently, however, if such changes result in the plant death. In this review, we discussed how the chlorsulfuran-ALS interaction leads to physiological and metabolic disruptions in plants.

• BMB Reports
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• 제48권1호
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• pp.1-5
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• 2015

Transient Receptor Potential, Melastatin-related, member 4 (TRPM4) channels are $Ca^{2+}$-activated $Ca^{2+}$-impermeable cation channels. These channels are expressed in various types of mammalian tissues including the brain and are implicated in many diverse physiological and pathophysiological conditions. In the past several years, the trafficking processes and regulatory mechanism of these channels and their interacting proteins have been uncovered. Here in this minireview, we summarize the current understanding of the trafficking mechanism of TRPM4 channels on the plasma membrane as well as heteromeric complex formation via protein interactions. We also describe physiological implications of protein-TRPM4 interactions and suggest TRPM4 channels as therapeutic targets in many related diseases.