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http://dx.doi.org/10.5483/BMBRep.2015.48.1.252

Physiological functions of the TRPM4 channels via protein interactions  

Cho, Chang-Hoon (School of Biosystem and Biomedical Science, College of Health Science, Korea University)
Lee, Young-Sun (Center for Functional Connectomics, Korea Institute of Science and Technology (KIST))
Kim, Eunju (School of Biosystem and Biomedical Science, College of Health Science, Korea University)
Hwang, Eun Mi (Center for Functional Connectomics, Korea Institute of Science and Technology (KIST))
Park, Jae-Yong (School of Biosystem and Biomedical Science, College of Health Science, Korea University)
Publication Information
BMB Reports / v.48, no.1, 2015 , pp. 1-5 More about this Journal
Abstract
Transient Receptor Potential, Melastatin-related, member 4 (TRPM4) channels are $Ca^{2+}$-activated $Ca^{2+}$-impermeable cation channels. These channels are expressed in various types of mammalian tissues including the brain and are implicated in many diverse physiological and pathophysiological conditions. In the past several years, the trafficking processes and regulatory mechanism of these channels and their interacting proteins have been uncovered. Here in this minireview, we summarize the current understanding of the trafficking mechanism of TRPM4 channels on the plasma membrane as well as heteromeric complex formation via protein interactions. We also describe physiological implications of protein-TRPM4 interactions and suggest TRPM4 channels as therapeutic targets in many related diseases.
Keywords
Glycosylation; Heteromerization; Phosphorylation; SUMOylation; Trafficking; TRPM4; 14-3-${\gamma}$;
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