• Title/Summary/Keyword: Physiologic function

Search Result 112, Processing Time 0.027 seconds

Studies of the Thyroid Function Test Using Radioiodine by Intradermal Injection (방사성옥소(放射性沃素)의 피내주사(皮內注射)에 의(依)한 갑상선기능검사(甲狀腺機能檢査)에 관(關)한 연구(硏究))

  • Kim, Dong-Soo
    • The Korean Journal of Nuclear Medicine
    • /
    • v.3 no.2
    • /
    • pp.29-31
    • /
    • 1969
  • The author observed the uptake rate of $^{131}I$ by the thyroid gland, and disappearing rate of the $^{131}I$ at the site of the intradermal injection of 0.1ml of 5mCi of $^{131}I$ in normal physiologic saline on 20 patients with hyperthyroidism and on 15 patients with hypothyroidism who visited the Radioisotpe department of the Pusan National University Hospital during the period from January 1967 to Aug. 1968, and during the same period 15 normal persons were examined by the same methods and found. The results were as follows: (1) The disappearance rate of $^{131}I$ at the injected site was highest in the cases of hyperthyrodism. The next highest results were obtained in the normal cases. The lowest results were obtained in the cases of hypothyroidism. (2) The uptake rate of the thyroid gland after intradermal injection of the $^{131}I$ was highest in the cases of hyperthyroidism and the next highest results were obtained in the cases of nomal findings. The lowest results were obtained in the cases of hypothyroidism. (3) In conclusion, the intradermal method of injecting $^{131}I$ by the author is a useful way of testing the function of the thyroid gland.

  • PDF

Improvement of skin barrier function using lipid mixture

  • Park, Won-Seok;Son, Eui-Dong;Nam, Gae-Won;Park, Jong-Ho
    • Journal of the Society of Cosmetic Scientists of Korea
    • /
    • v.27 no.1
    • /
    • pp.53-72
    • /
    • 2001
  • Dry skin is caused mainly by the perturbation of stratum corneum lipids which affected by ageing, change of season, excess use of surfactant and the effect of disease like atopic dermatitis and psoriasis. Intercellular lipid structures in stratum corneum are responsible for the barrier function of mammalian skin. The major lipd classes that can be extracted from stratum corneum are ceramides, cholesterol and fatty acid, which make up approximately 50, 25, 10 percent of the stratum corneum lipid mass, respectively. Small amount of cholesterol sulfate, phospholipids, glycosylceramide and cholesterol esters are also present. Recent studies have shown that application of one or two these lipids to the perturbed skin delays barrier recovery; only equimolar mixtures allow normal recovery. We observed that barrier recovery rate was improved in hairless mouse by topical application of single neutral lipids (ceramide, free fatty acid, cholesterol) and lipid mixtures. Whereas the application of single lipid didn’t allows a significant enhancement comparing with normal barrier repair, the equimolar mixtures of 3 components(including synthetic pseudoceramide PC104) improved barrier repair, as assessed by the transepidermal water loss. At clinical study to the volunteers aged over sixty, skin dryness recuperated by the increase of moisture(capacitance) and the reduction of scaling. Utilization of physiologic lipid mixture containing natural ceramides or synthetic pseudoceramide could lead to new forms of topical therapy for the dryness and dermatoses(e.g., psoriasis, atopic dermatitis and irritant dermatitis).

  • PDF

Increased Association of ${\alpha}$-synuclein to Perturbed Cellular Membranes

  • Kim, Yoon-Suk;Lee, Seung-Jae
    • Biomedical Science Letters
    • /
    • v.17 no.2
    • /
    • pp.167-171
    • /
    • 2011
  • [ ${\alpha}$ ]synuclein (${\alpha}$-syn) is implicated in the pathogenesis of Parkinson's disease (PD) and other related diseases. We have previously reported that ${\alpha}$-syn binds to the cell membranes in a transient and reversible manner. However, little is known about the physiologic function and/or consequence of this association. Here, we examined whether chemically induced perturbations to the cellular membranes enhance the binding of ${\alpha}$-syn, based on hypothesis that ${\alpha}$-syn may play a role in maintenance of membrane integrity or repair. We induced membrane perturbations or alterations in ${\alpha}$-syn-overexpressing human neuroblastoma cells (SH-SY5Y) by treating the cells with hydrogen peroxide ($H_2O_2$) or oleic acid. In addition, membranes fractionated from these cells were perturbed by treating them with proteinase K or chloroform. Dynamic interaction of ${\alpha}$-syn to the membranes was analyzed by the chemical cross-linking assay that we developed in the previous study. We found that membrane interaction of ${\alpha}$-syn was increased upon treatment with membrane-perturbing reagents in a dose and time dependent manner. These results suggest that perturbations in the cellular membranes cause increased binding of ${\alpha}$-syn, and this may have significant implication in the physiological function of ${\alpha}$-syn in cells.

Biomechanical Analysis of the Rotator Cuff Function During Elevation Motion in Scapula Plane using a Skeletal Muscle Model

  • Tanaka, Hiroshi;Nobuhara, Katsuya
    • The Academic Congress of Korean Shoulder and Elbow Society
    • /
    • 2009.03a
    • /
    • pp.74-74
    • /
    • 2009
  • The purpose of this study was to estimate force of muscles that constituted the rotator cuff during elevation motion in scapula plane, using a skeletal muscle model and quantitatively evaluate rotator cuff function in vivo. A healthy volunteer was measured with an open MR and CT system at elevation positions in scapula plane (MR: $30^{\circ}$, $60^{\circ}$, $90^{\circ}$, $120^{\circ}$, $150^{\circ}$, CT: $0^{\circ}$). After reconstruction three-dimensional MRI-based and CT-based bone surface models, matched each models with registration technique. Then supraspinatus, infraspinatus, subscapularis, teres minor, deltoid (anterior, middle, posterior portions) represented as plural lines. These lines were proportional to physiologic cross-sectional area (PCSA) and defined straight line to bind origin and insertion. Force of supraspinatus became greatest at $59^{\circ}$ of elevation. Subsequently force of deltoid middle portion became greatest at $89^{\circ}$ of elevation. Infraspinatus and subscapularis were active at the meantime. In addition, supraspinatus was active during elevation. These results resembled clinical finding and were proved force couples that contribute to mobility and stability of shoulder complex.

  • PDF

Arthrokinetic Analysis of Knee Joint (슬관절의 운동학적 분석)

  • Kim, Jae-hun
    • PNF and Movement
    • /
    • v.6 no.1
    • /
    • pp.53-60
    • /
    • 2008
  • Purpose : To describes the important aspects of knee joint movement and function used when applying PNF technique to the lower limb. Method : The knee was a very important roles in the lower limb movement and ambulation. This study summarizes the physiologic movement of knee to the PNF lower extremity patterns. Result : The tibiofemoral joint is usually described as a modified hinge joint with flexion-extension and axial rotation by two degrees of freedom movement. These arthrokinematics are a result of the geometry of the joints and the tension produced in the ligamentous structures. The patellofemoral joint is a sellar joint between the patella and the femur. Stability of the patellofemoral joint is dependent on the passive and dynamic restraints around the knee. In a normal knee the ligaments are inelastic and maintain a constant length as the knee flexes and extends, helping to control rolling, gliding and translation of the joint motions. Conclusions : It is important to remember that small alterations in joint alignment can result in significant alterations in patellofemoral joint stresses and that changes in the mechanics of the patellofemoral joint can also result in changes in the tibiofemoral compartments. Successful treatment requires the physical therapist to understand and apply these arthrokinematic concepts. When applied to PNF low extremity patterns, understanding of these mechanical concepts can maximize patient function while minimizing the risk for further symptoms or injury.

  • PDF

Modulation of DNA methylation by one-carbon metabolism: a milestone for healthy aging

  • Sang-Woon Choi ;Simonetta Friso
    • Nutrition Research and Practice
    • /
    • v.17 no.4
    • /
    • pp.597-615
    • /
    • 2023
  • Healthy aging can be defined as an extended lifespan and health span. Nutrition has been regarded as an important factor in healthy aging, because nutrients, bioactive food components, and diets have demonstrated beneficial effects on aging hallmarks such as oxidative stress, mitochondrial function, apoptosis and autophagy, genomic stability, and immune function. Nutrition also plays a role in epigenetic regulation of gene expression, and DNA methylation is the most extensively investigated epigenetic phenomenon in aging. Interestingly, age-associated DNA methylation can be modulated by one-carbon metabolism or inhibition of DNA methyltransferases. One-carbon metabolism ultimately controls the balance between the universal methyl donor S-adenosylmethionine and the methyltransferase inhibitor S-adenosylhomocysteine. Water-soluble B-vitamins such as folate, vitamin B6, and vitamin B12 serve as coenzymes for multiple steps in one-carbon metabolism, whereas methionine, choline, betaine, and serine act as methyl donors. Thus, these one-carbon nutrients can modify age-associated DNA methylation and subsequently alter the age-associated physiologic and pathologic processes. We cannot elude aging per se but we may at least change age-associated DNA methylation, which could mitigate age-associated diseases and disorders.

Histopathologic and Physiologic Features of the Aging Larynx (노인성 후두의 조직병리학적, 생리학적 특성)

  • Park, Il-Seok
    • Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
    • /
    • v.25 no.1
    • /
    • pp.20-23
    • /
    • 2014
  • Age-related changes in larynx can have a direct impact on voice quality and general comfort level. Observations of vocal aging have spanned perceptual, acoustic, aerodynamic, physical, electromyographic (EMG) and histological levels. Evidence of differential vocal aging in relation to gender and physical condition has been reported. Perceptual, acoustic, aerodynamic, kinematic, EMG and histological data document age-related changes in laryngeal structure and function with advancing age. These changes contribute to a functional age-related impact of vocal hypofunction or compensatory hyperfunction. This review will focus on the current understanding of the clinical and cellular changes in the larynx that lead to presbyphonia.

  • PDF

Full mouth rehabilitation of the patient with severely worn dentition: a case report

  • Song, Mi-Young;Park, Ji-Man;Park, Eun-Jin
    • The Journal of Advanced Prosthodontics
    • /
    • v.2 no.3
    • /
    • pp.106-110
    • /
    • 2010
  • The severe wear of anterior teeth facilitates the loss of anterior guidance, which protects the posterior teeth from wear during excursive movement. The collapse of posterior teeth also results in the loss of normal occlusal plane and the reduction of the vertical dimension. This case report describes 77-year-old female, who had the loss of anterior guidance, the severe wear of dentition, and the reduction of the vertical dimension. Occlusal overlay splint was used after the decision of increasing vertical dimension by anatomical landmark, facial and physiologic measurement. Once the compatibility of the new vertical dimension had been confirmed, interim fixed restoration and the permanent reconstruction was initiated. This case reports that a satisfactory clinical result was achieved by restoring the vertical dimension with an improvement in esthetics and function.

Scintigraphic Evaluation of Gastrointestinal Motility Disorders (기능성 위장관 질환에서 핵의학 검사의 역할)

  • Choe, Jae-Gol
    • The Korean Journal of Nuclear Medicine
    • /
    • v.35 no.1
    • /
    • pp.1-11
    • /
    • 2001
  • Current scintigraphic tests of gastrointestinal motor function provides relevant pathophysiologic information, but their clinical utility is controversial. Many scintigraphic methods are developed to investigate gastrointestinal motility from oral cavity to colon. These are esophageal transit scintigraphy, oropharyngeal transit study, gastric emptying test, small bowel transit time measurement, colon transit study and gastroesopahgeal reflux scintigraphy. Scintigraphy of gastrointestinal tract is the most physiologic and noninvasive method to evaluate gastrointestinal motility disorders. Stomach emptying test is regarded as a gold standard in motility study. Gastrointestinal transit scintigraphy also has a certain role in assessment of drug effect to GI motility and changes alter therapy of motility disorders. Scintigraphy provides noninvasive and quantitative assessment of physiological transit throughout the gastrointestinal tract, and it is extremely useful for diagnosing gastrointestinal motor dysfunction. This article reviews the current procedures, indications, significance and guidelines for gastrointestinal motility measurements by scintigraphy.

  • PDF

The Pathophysiologic Roles of TRPM7 Channel

  • Park, Hyun Soo;Hong, Chansik;Kim, Byung Joo;So, Insuk
    • The Korean Journal of Physiology and Pharmacology
    • /
    • v.18 no.1
    • /
    • pp.15-23
    • /
    • 2014
  • Transient receptor potential melastatin 7 (TRPM7) is a member of the melastatin-related subfamily and contains a channel and a kinase domain. TRPM7 is known to be associated with cell proliferation, survival, and development. It is ubiquitously expressed, highly permeable to $Mg^{2+}$ and $Ca^{2+}$, and its channel activity is negatively regulated by free $Mg^{2+}$ and Mg-complexed nucleotides. Recent studies have investigated the relationships between TRPM7 and a number of diseases. TRPM7 regulates cell proliferation in several cancers, and is associated with ischemic cell death and vascular smooth muscle cell (VSMC) function. This review discusses the physiologic and pathophysiologic functions and significance of TRPM7 in several diseases.