The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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The Pathophysiologic Roles of TRPM7 Channel

  • Park, Hyun Soo (Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine) ;
  • Hong, Chansik (Department of Physiology, Seoul National University College of Medicine) ;
  • Kim, Byung Joo (Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine) ;
  • So, Insuk (Department of Physiology, Seoul National University College of Medicine)
  • Received : 2013.08.20
  • Accepted : 2013.11.18
  • Published : 2014.02.28
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Abstract

Transient receptor potential melastatin 7 (TRPM7) is a member of the melastatin-related subfamily and contains a channel and a kinase domain. TRPM7 is known to be associated with cell proliferation, survival, and development. It is ubiquitously expressed, highly permeable to $Mg^{2+}$ and $Ca^{2+}$, and its channel activity is negatively regulated by free $Mg^{2+}$ and Mg-complexed nucleotides. Recent studies have investigated the relationships between TRPM7 and a number of diseases. TRPM7 regulates cell proliferation in several cancers, and is associated with ischemic cell death and vascular smooth muscle cell (VSMC) function. This review discusses the physiologic and pathophysiologic functions and significance of TRPM7 in several diseases.

Keywords

References

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