• Journal of Pharmaceutical Investigation
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• 제40권6호
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• pp.367-372
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• 2010

Rabeprazole sodium (RPN) is known to be very unstable at acidic condition or some acidic pharmaceutical excipients such as acrylic acid polymer (carbomer 934) with carboxylic acids. Thus, degradation mechanism of binary blends of rabeprazole with pharmaceutical excipients in a solid state without using solvents at three different ratios (3:1, 1:1 and 1:3) was investigated using Fourier transform infrad (FTIR) spectroscopy. Alkalizer (MgO), neutral hydroxypropymethylcellulose (HPMC 4000) were also tested for comparison. The binary blends were stored under accelerated conditions ($40^{\circ}C$/75% relative humidity) for two weeks. The concentration of thioether rabeprazole from the binary blends with acidic carbomer 934 increased as the rabeprazole concentration decreased. In addition, the degradation half-life of rabeprazole as well as the relative peak area ratios obtained from FTIR spectra of S=O stretching at $1094.1\;cm^{-1}$ decreased consistently as the fraction of carbomer 934 increased due to its sensitivity between the basic benzimidazole nitrogen and carboxylic acid group of carbomer 934. The physical appearance also turned into strong brown color in the presence of carbomer 934. In contrast, there were no significant changes in the degradation kinetics of rabeprazole with MgO and HPMC 4000 in a solid state. This present study demonstrated that the solid-state compatibility test with the aid of HPLC chromatographic and FTIR spectral analyses could offer a valuable methodology to select suitable pharmaceutical excipients and to elucidate the degradation mechanism of RPN for drug formulations at the early formulation stages.

• 한국측량학회지
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• 제38권3호
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• pp.197-209
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• 2020

간판은 점포의 특성에 따라 서로 다른 유형과 크기로 건물에 설치되어있다. 하지만, 지방자치단체에서는 잦은 점포의 개업·폐업과 부족한 관리 인원으로 간판을 관리하는데 어려움을 겪고 있다. 이에 본 연구에서는 간판의 정보를 효율적으로 관리할 수 있도록 표준화하여 관리하는 방안을 제안하였다. 이를 위해, 옥외광고물 관련 시행령의 간판 표시방법을 분석하여 간판 표준 데이터의 속성 요소를 정의하였다. 또한, 선행 연구인 간판 인식 기술을 통해 간판의 물리적 정보를 얻고, 맨눈으로 판독 가능한 정보, 행정안전부의 건물통합정보, 도로명 주소를 통해 간판 표준 데이터의 속성 요소를 정의하였다. 간판 표준 데이터는 호환성을 위해 XML 형식으로 설계하였고, XML의 무결성을 위해 XSD를 정의하여 데이터의 유효성이 검증될 수 있도록 하였다. 마지막으로, 간판의 정보를 공간적 특성에 의해 표준화하기 위하여 국가 공간정보 표준에 따라 데이터 제품 사양과 메타데이터를 정의하였다. 이를 통해 간판의 정보화를 위한 표준 데이터 모델을 설계하였다.

• 한국재료학회지
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• 제33권7호
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• pp.285-294
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• 2023

Porous ceramics are used in various industrial applications based on their physical properties, including isolation, storage, and thermal barrier properties. However, traditional manufacturing environments require additional steps to control artificial pores and limit deformities, because they rely on limited molding methods. To overcome this drawback, many studies have recently focused on fabricating porous structures using additive manufacturing techniques. In particular, the binder jet technology enables high porosity and various types of designs, and avoids the limitations of existing manufacturing processes. In this study, we investigated process optimization for manufacturing porous ceramic filters using the binder jet technology. In binder jet technology, the flowability of the powder used as the base material is an important factor, as well as compatibility with the binder in the process and for the final print. Flow agents and secondary binders were used to optimize the flowability and compatibility of the powders. In addition, the effects of the amount of added glass frit, and changes in sintering temperature on the microstructure, porosity and mechanical properties of the final printed product were investigated.

• 한국염색가공학회지
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• 제35권3호
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• pp.159-168
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• 2023

Polyolefin elastomer (POE) is widely used in a variety of applications, particularly in the manufacture of composites, due to its excellent mechanical properties, chemical resistance, and flexibility. However, POE has a high processing temperature, which causes damage to the fiber during the manufacturing process when impregnating the fiber. Therefore, ethylene vinylacetate (EVA), which has a low melting point and excellent adhesion properties, is blended with POE to reduce the processing temperature, and POE-g-MAH (Polyolefin elastomer-grafted-maleic anhydride) is used as a compatibilizer to further improve the POE/EVA blend properties. The compatibility of POE/EVA blends is observed by SEM, and the interaction between each polymer is confirmed by DSC and FT-IR. In addition, the effect of adding the compatibilizer is analyzed through mechanical properties such as tensile strength and elongation. The optimal content of compatibilizer for POE/EVA blends considering physical properties and moldability is sought, and 20 phr is determined to be the most appropriate.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 1994년도 가을 학술발표회 논문집
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• pp.1-8
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• 1994

A variable-node-flat shell element designated as CLS which has variable mid-side nodes with drilling freedom has been presented in this paper. The shell element to be applied in finite element analysis has been developed by combining a membrane element named as CLM with drilling rotation d.o.f. and plate bending element. The combined shell element possess six degrees of freedom per node. By introducing the variable-node elements which have physical midside nodes, some difficulties associated with imposing displacement constraints on irregular nodes to enforce interelement compatibility in common adaptive h-refinement on quadrilateral mesh are easily overcome. Detailed numerical studies show the excellent performance of the new shell elements developed in this study.

• 세라미스트
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• 제21권3호
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• pp.216-232
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• 2018

The average life span is over 80 years of age, and various biomaterials have being studied. Many research institutes and companies around the world have been commercializing bioactive glass through R&D, however, there is not much research in Korea. Most bioactive glass is applied to bone regeneration in powder form due to its excellent bio-compatibility. Recently, new applications such as scaffolds for tissue engineering and nerve regeneration have been found in composite form. The global market size is not as large as US $ 556 million in 2019, but the growth rate is very high at a CAGR of 14.35 %. This field is waiting for the challenge of new researchers.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 1999년도 봄 학술발표회 논문집(I)
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• pp.585-590
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• 1999

There is still a lack of knowledge and modelling relating to shear behaviour in reinforced concrete beams. The reason is that shear loading leads to complicated physical mecanisms, such as interlock action, dowel action, etc. Therefore, It is difficult that we make the ideal model of shear behaviour, while Truss model theory has been made good use of shear design because of simplicity and reasonableness. In this study, 6 T-type reinforced concrete beams were designed and made based on the two truss models, i.e, the plasticity truss model and the compatibility truss model, to observe shear strength of concrete and stress distribution of stirrups. 6 beams test pieces were tested with the following testing parameters. 1) specified concrete strength ; 270kg/$\textrm{cm}^2$, 400kg/$\textrm{cm}^2$ 2) with and without the steel fiber.

• Spatial Information Research
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• 제5권1호
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• pp.61-75
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• 1997

National Geographic Information System(NGIS) should be designed on the assumption that geographic data collected by each national organization should be integrated into geographic database systemically. To achieve this object, NGIS database would be better connected to National Very High-Speed Communication Network. In the process of research, some problems related to Korean NGIS are found. These are standardization, compatibility, extension, issue of making and opening digital map, and issue related to land information. So, it is required that pilot project apply National Geographic Information System in terms of National Very High-Speed computer network project. This project is to contain two main theme building of physical network and special management of network which is related with NGIS.

• 한국섬유공학회:학술대회논문집
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• 한국섬유공학회 1998년도 가을 학술발표회논문집
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• pp.236-239
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• 1998

The in situ composites based on poly(ethylene 2,6-naphthalate) and thermotropic liquid crystalline polymer (LCP) have been an area of increasing interest and study, since LCP exhibits high chemical stabilities and excellent thermo mechanical properties such as high strength and modulus. In a binary, however, poor compatibility and interfacial adhesions between two phases frequently results in deteriorated mechanical properties. (omitted)

• 한국기계가공학회지
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• 제3권4호
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• pp.81-87
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• 2004

The titanium has many superior characteristics such as specific strength, heat resistance, corrosion resistance, organism compatibility, non-magnetic and etc. and their quantity are abundant. This study performed turning operation of Ti-6Al-4V alloy using the TiAlN coated tool which was treated with PVD. Experimental works were also executed to measure cutting force, chip figuration and surface roughness for different cutting conditions. As a result of study, tool wear was serious at the condition over 100m/min of cutting speed. The excellent cutting condition of cutting depth was at 1.0mm.