• Textile Coloration and Finishing
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• v.13 no.3
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• pp.188-196
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• 2001

1, 1-diamino-3, 3, 5, 5-tetrachlorocyclotriphosphazene, 1, 1-diami-no3, 3, 5, 5-tetra-(p-bromophenoxy)cyclotriphosphazene, and 1, 1-diamino-3, 3, 5, 5-tetra-(p-chlorophenoxy) cyclotri-phosphazene(ACPP) was prepared from hexachlorocyclotriphosphazene and used for the curing agent of bisphenol A type epoxy resin and phenol novolak. The resistance to chemicals and water of the cured epoxy resins were examined by DMTA and compared with those of the epoxy rosins cured with phosphazene derivatives and 4, 4'-diaminodiphenylmethane. The effect of the curing agent on resistance to chemicals and water of the cured epoxy resins were investigated. The epoxy resins cured with 1, 1-diamino-3, 3, 5, 5-tetrachlorocyclotriphosphazene and 1, 1- diamino-3, 3, 5, 5-tetra- (p-bromophenoxy)cyclotriphosphazene showed superior resistance to chemicals and water to those of 1, 1-diamino-3, 3, 5, 5-tetra- (p-chlorophenoxy)cyclotriphosphazene and 4, 4'-diaminodiphenylmethane. It is an effective curing agent for epoxy resins to enhance the resistance to chemicals, water and tome proofing.

• Proceedings of the Korean Environmental Sciences Society Conference
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• 2003.11a
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• pp.135-138
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• 2003

Based on solid phase extraction, gas chromatography and mass spectrometry procedure for determining phenol and its derivatives in natural water was presented. In solid phase extraction, three types of techniques using solid phase adsorption material were treated with acid and salt, and converted second portion of acetyl derivatives. Under the these condition, extraction efficiency and detection ability dependent on extraction methods were discussed. Obtained results using optimized solid phase extraction techniques showed more convenience, simplifier and lower cost than the conventional analytical methods with holding wide dynamic range and lower detection limits.

• Bulletin of the Korean Chemical Society
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• v.34 no.10
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• pp.3027-3032
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• 2013

Various phenol derivatives were synthesized in a one-pot reaction from MBH acetates and sodium diethyl oxalacetate via a [4C+2C] cyclization protocol. In addition, some pyridine derivatives could also be synthesized using the same starting materials, by isolating the $S_N2^{\prime}$ reaction intermediate and performing the cyclization with $NH_4OAc$.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.181.4-182
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• 2003

Telomeres are DNA-protein complexes at the ends of chromosomes, which play an essential protective role against DNA degradation and aberrant recombination during cell divisions. Several telomerase inhibitors have been reported as candidates for new antitumor drugs. Among them, 2-thiobenzylpyridines, developed by Geron. Co Ltd. as a telomerase inhibitor, were chosen as lead compounds. Twenty-one pyridine-2- carboxylate derivatives were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. (omitted)

• Journal of Life Science
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• v.3 no.1
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• pp.9-17
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• 1993

식물 특히, 우리가 섭취하고 있는 식품에 널리 존재하고 있는 phenolic compounds는 simple phenols과 phenolic acids, hydroxycinnamic acid derivatives 그리고 flavonoids 등의 세가지 종류들로 나누고 있다. 이들 물질은 일정수준의 항산화성, 항돌연변이원성, 항암성을 지니고 있다. 본 총설에서는 식물성 phenolic compounds의 특성, 산화작용과 항산화작용, phenolic compounds의 항산화 메카니즘, 그리고 식물성 phenolic compounds들의 항산화능 등에 대하여 차례로 살핀다. 특히, 우리가 일상적으로 섭취하고 있는 식품에서의 이들 물질과 그들의 항산화성에 대한 최근 연구결과들을 중심으로 고찰한다.

• Microbiology and Biotechnology Letters
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• v.19 no.5
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• pp.470-476
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• 1991

The distribution of peroxidase activity in 9 kinds of cruciferous plants was investigated. Among the plants examined, peroxidase activity was found to be high levels in roots of Chinese cabbage. One kind of peroxidase was purified approximately 56-fold from crude extracts of Chinese cabbage roots. The molecular weight of the enzyme was 50, 000 and consisted oif a single polypeptide chain, as estimated by sodium dodecyl sulfate polyacrylamide gel electrophoresis and Sephadex G-150 gel column chromatography. The enzyme showed optimum activity at pH 7.0 and $50^{\circ}C$. Phenol and phenol derivatives serves as substrates of the enzyme and Km value for $H_2O_2$ was 1.6 mM toward pyrogallol. The enzyme showed a Soret band at 406 nm and this result indicate that the enzyme contained heme as a prosthetic group. The immunochemical and electrophoretic properties of purified peroxidase from Chinese cabbage were very similar to horseradish peroxidase.

• The Korean Journal of Pharmacology
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• v.2 no.2
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• pp.47-53
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• 1966

The bacteriostatic action of trichlorophenoxy alkylene ammonium derivatives, 2(2,4,5-trichlorophenoxy) ethylene N-triethyl ammonium bromide; (2,4,5-TETB), 2(2,4,6-trichlorophenoxy) ethylene N-triethyl ammonium bromide; (2,4,6-TETB), 2,4,5-triphenoxy ethylene pyridinium bromide; (2,4,5-TEPB), and 2,4,6-trichlorophenoxy ethylene pyridinium bromide:(2,4,6-TEPB) were observed by Jackson and Finland's and Finland's and Pak's on Staphylococcus aureus, E. coli, Salmonella typhi, Shigella flexneri, and Bacillus subtilis, comparing with those of phenol and trichlorophenol. The following results were obtained. 1) Phenol is bacteriostatic in a concentration of $10^{-3}$ for all above species. 2) Trichlorophenol is bacteriostatic in concentration of $10^{-4}$ to $5{\times}10^{-5}$ for all above species(Table 7), 3) 2,4,5-TETB and 2,4,6-TETB are bacteriostatic in a concentration of $10^{-4}$ and $5{\times}10^{-5}$ for Staphylococcus aureus, Salmonella typhi, and Shigella flexneri, but do not for E. coli and Bacillus subtilis(Table 8 and 9). 4) 2,4,5-TEPB and 2,4,6-TEPB are bacteriostatic in a concentrationof $10^{-4}$ and $5{\times}10^{-5}$ only for Staphylococcus aureus among four species(Table 10 and 11).

• Journal of the Korean Chemical Society
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• v.66 no.6
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• pp.442-450
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• 2022

Diverse pyrrolo[3,2-d]pyrimidines that are expected to exhibit bioactivity were synthesized through O-arylation and Suzuki coupling reactions. Microwave-assisted O-arylation was successfully performed using a Cu metal catalyst, so that 4 position of pyrrolo[3,2-d]pyrimidine could be substituted with phenol group. In addition, 4-aryl substituted pyrrolo[3,2-d]pyrimidines were synthesized with good to excellent yields by microwave-assisted Suzuki coupling reaction using a Pd metal catalyst. By using microwaves as reaction conditions for diversification of derivatives, it was possible to dramatically overcome the disadvantages of traditional heat reactions of long reaction times and heat transfer efficiency problems. The result of this study can be used to be diversify pyrrolo[3,2-d]pyrimidine derivatives, which are expected to play an important role in the drug discovery research.

• Journal of the Korean Society of Food Science and Nutrition
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• v.27 no.3
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• pp.537-542
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• 1998

The present study was performed to elucidate desmutagenic principles from Ecklonia stolonifera extracts against 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine(PhIP) and 2-amino-3,8-dime-thylimidazo[4,5-f]duinoxaline(MeIQx) with Salmonella/mammalian-microsome mutagenicity test. Alginate, phenols, chlorophyll and carotenoids from Ecklonia stolonifera were extracted and their desmutagenicities were assayed. Alginate hydroysates showed desmutagenic activities against PhIP and MeIQx at high level dose. Phenol fractions and bromophenol showed desmutagenic activity of about MeIQx at high level dose. Phenol fractions and bromophenol showed desmutagenic activity of about 90% per 0.5mg against PhIP and MeIQx. Chlorophyllin among chlorophyll derivatives exhibited remarkable desmutagenic activities of 92.9% and 82.7% at 20uM against PhIP and MeIQx, respectively. Carotenoids, such as lutein and $\alpha$-cryptoxanthin isolated from Ecklonia stolonifera exerted also high desmutagenic activity. Major desmutagenic substances from Ecklonia stolonifera are considered to be chlorophyllin, phenols, lutein, $\alpha$-cryptoxanthin and low molecular alginates.

• Archives of Pharmacal Research
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• v.26 no.9
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• pp.697-705
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• 2003

The alkylphenols, chlorophenols, and bisphenol A were determined by gas chromatography/mass spectrometry-selected ion monitoring (GC/MS-SIM) followed by two work-up methods for comparison: isobutoxycarbonyl (isoBOC) derivatization and tert-butyldimethylsilyl (TBDMS) derivatization. Eleven endocrine disrupting chemicals (EDCs) of phenols in biological samples were extracted with acetonitrile and then the acetonitrile layer underwent freezing filtration 6$0^{\circ}C$ for 2 hours. Solid-phase extraction (SPE) was used with XAD-4 and subsequent conversion to isoBOC or TBDMS derivatives for sensitivity analysis with the GC/MS-SIM mode. For isoBOC derivatization and TBDMS derivatization the recoveries were 92.3∼150.6% and 93.8∼108.3%, the method detection limits (MDLs) of bisphenol A for SIM were 0.062 $\mu$ g/kg and 0.010 $\mu$ g/kg, and the SIM responses were linear with the correlation coefficient varying by 0.9755∼0.9981 and 0.9908∼0.9996, respectively. When these methods were applied to mackerel samples, the concentrations of the 11 phenol EDCs were below the MDL.