• BMB Reports
• /
• v.45 no.12
• /
• pp.713-718
• /
• 2012

Gangliosides play important roles in the control of several biological processes, including proliferation and transmembrane signaling. In this study, we demonstrate the effect of ganglioside GM1 on the proliferation of mouse induced pluripotent stem cells (miPSCs). The proliferation rate of miPSCs was lower than in mouse embryonic stem cells (mESCs). Fluorescence activated cell sorting analysis showed that the percentage of cells in the G2/M phase in miPSCs was lower than that in mESCs. GM1 was expressed in mESCs, but not miPSCs. To confirm the role of GM1 in miPSC proliferation, miPSCs were treated with GM1. GM1-treated miPSCs exhibited increased cell proliferation and a larger number of cells in the G2/M phase. Furthermore, phosphorylation of mitogen-activated protein kinases was increased in GM1-treated miPSCs.

• Archives of design research
• /
• v.14 no.2
• /
• pp.117-126
• /
• 2001

Dietary life is said to be consummated even to a phase of art from phase of survival, recognition, selection and preference. Dietary life, from a sheer earing, is now transforming itself into a joy, and therefore, function of foodstuff packaging demand diversification rather than a simple packaging. Recently, socio-economic environment is showing conspicuous changes in that there are increasing number of working couples nuclear family, old-age population, social activity and improvement of living standards. Such a change in the living environment has much impact on our dietary life. Particularly, an age when cake and cookies of western origin were all but strange is gradually phasing out, while it is deemed to be improper to overlook the fact that bread and cakes are solidifying their position as part of foodstuff meanies for on dietary life. Of cakes and cookies, cakes have come to enjoy a position whereby they are regarded as part of an imperative for family banquets, various get-together and birthday celebration, etc., with a significant improvement that caters to our taste vis-a-vis an stage of introduction of cakes. At the time when reined foreign bakeries, one after another , are contemplating to make an inroad into Korea, and when the distribution market is to be opened fully in July of 1993, Korea bakeries that have been building up their position within the domestic market are expected to face a considerable number of difficulties. Accordingly, under such circumstances of the time text we are in it is attempted in this study to map out measures that may contribute to the strengthening of the products of business enterprises and improvement of corporate image that may appeal to feeling and emotions of consumers packaging that could attain objectives, and package design planning that, as an important factor for playing its own share in the restoration of humanism that is being alienated, may appeal to consumer sensitivity, rather than packaging that is being utilized merely as tool designed for marketing

• Geophysics and Geophysical Exploration
• /
• v.12 no.1
• /
• pp.69-76
• /
• 2009

We report an implementation of the Ground Penetrating Radar (GPR) survey at a site that corresponds to a ruined castle. The objective of the survey was to characterise buried archaeological structures such as walls and tiles in Van Khan Tooril's Ruin, Mongolia, by 2D and 3D GPR techniques. GPR datasets were acquired in an area 10mby 9 m, with 10 cm line spacing. Two datasets were collected, using GPR with 500MHz and 800MHz frequency antennas. In this paper, we report the use of instantaneous parameters to detect archaeological targets such as tile, brick, and masonry by polarimetric GPR. Radar polarimetry is an advanced technology for extraction of target scattering characteristics. It gives us much more information about the size, shape, orientation, and surface condition of radar targets. We focused our interpretation on the strongest reflections. The image is enhanced by the use of instantaneous parameters. Judging by the shape and the width of the reflections, it is clear that moderate to high intensity response in instantaneous amplitude corresponds to brick and tiles. The instantaneous phase map gave information about the location of the targets, which appeared as discontinuities in the signal. In order to increase our ability to interpret these archaeological targets, we compared the GPR datasets acquired in two orthogonal survey directions. A good correlation is observed for the alignments of reflections when we compare the two datasets. However, more reflections appear in the north-south survey direction than in the west-east direction. This is due to the electric field orientation, which is in the horizontal plane for north-south survey directions and the horizontally polarised component of the backscattered high energy is recorded.

• Journal of International Society for Simulation Surgery
• /
• v.1 no.1
• /
• pp.37-40
• /
• 2014

Purpose For living donor liver transplantation, liver segmentation is difficult due to the variability of its shape across patients and similarity of the density of neighbor organs such as heart, stomach, kidney, and spleen. In this paper, we propose an automatic segmentation of the liver using multi-planar anatomy and deformable surface model in portal phase of abdominal contrast-enhanced CT images. Method Our method is composed of four main steps. First, the optimal liver volume is extracted by positional information of pelvis and rib and by separating lungs and heart from CT images. Second, anisotropic diffusing filtering and adaptive thresholding are used to segment the initial liver volume. Third, morphological opening and connected component labeling are applied to multiple planes for removing neighbor organs. Finally, deformable surface model and probability summation map are performed to refine a posterior liver surface and missing left robe in previous step. Results All experimental datasets were acquired on ten living donors using a SIEMENS CT system. Each image had a matrix size of $512{\times}512$ pixels with in-plane resolutions ranging from 0.54 to 0.70 mm. The slice spacing was 2.0 mm and the number of images per scan ranged from 136 to 229. For accuracy evaluation, the average symmetric surface distance (ASD) and the volume overlap error (VE) between automatic segmentation and manual segmentation by two radiologists are calculated. The ASD was $0.26{\pm}0.12mm$ for manual1 versus automatic and $0.24{\pm}0.09mm$ for manual2 versus automatic while that of inter-radiologists was $0.23{\pm}0.05mm$. The VE was $0.86{\pm}0.45%$ for manual1 versus automatic and $0.73{\pm}0.33%$ for manaual2 versus automatic while that of inter-radiologist was $0.76{\pm}0.21%$. Conclusion Our method can be used for the liver volumetry for the pre-surgery planning of living donor liver transplantation.

• Genomics & Informatics
• /
• v.14 no.4
• /
• pp.196-204
• /
• 2016

Many researchers have found that one of the most important characteristics of the structure of linkage disequilibrium is that the human genome can be divided into non-overlapping block partitions in which only a small number of haplotypes are observed. The location and distribution of haplotype blocks can be seen as a population property influenced by population genetic events such as selection, mutation, recombination and population structure. In this study, we investigate the effects of the density of markers relative to the full set of all polymorphisms in the region on the results of haplotype partitioning for five popular haplotype block partition methods: three methods in Haploview (confidence interval, four gamete test, and solid spine), MIG++ implemented in PLINK 1.9 and S-MIG++. We used several experimental datasets obtained by sampling subsets of single nucleotide polymorphism (SNP) markers of chromosome 22 region in the 1000 Genomes Project data and also the HapMap phase 3 data to compare the results of haplotype block partitions by five methods. With decreasing sampling ratio down to 20% of the original SNP markers, the total number of haplotype blocks decreases and the length of haplotype blocks increases for all algorithms. When we examined the marker-independence of the haplotype block locations constructed from the datasets of different density, the results using below 50% of the entire SNP markers were very different from the results using the entire SNP markers. We conclude that the haplotype block construction results should be used and interpreted carefully depending on the selection of markers and the purpose of the study.

• The Journal of Engineering Geology
• /
• v.28 no.1
• /
• pp.35-45
• /
• 2018

Imaging technologies are applied at various geological scales including pore scale, core scale and intermediate scale in order to characterize pore space of rocks as well as to map the fluid distribution in porous media. This technical report presents experimental results using core-flooding apparatus suited with imaging technology. Three different core samples, that are homogeneous, fractured and heterogeneous cores, were used to assess the two-phase fluid migration behavior as $CO_2$ displaces resident brine. We show that imaging technology can be effective in characterizing salt-precipitation, capillary pressure and spatio-temporal variation of trapping mechanisms.

• Journal of the Korean Society for Aeronautical & Space Sciences
• /
• v.41 no.7
• /
• pp.539-546
• /
• 2013

Surge phenomenon can be occurred in a compressor when compressor performance of turbofan engine for an aircraft is changed considerably in a short time on the cases like take-off phase and changing of RPM from idle to maximum, because performance of aircraft engine is changed suddenly. This study is aimed to avoid surge in a compressor. Dynamic simulation in a compressor is modeled by simulink in specific condition. Fuel flow is control input, rpm and air mass flow are expressed in terms of transfer function. Surge margin is obtained by using compressor performance map from NPSS. VIGV(Variable Inlet Guide Vane) is controlled by PD controller with difference between surge margin and reference. Finally this paper verifies IGV can prevent surge phenomenon in a compressor.

• Korean Institute of Interior Design Journal
• /
• v.20 no.1
• /
• pp.182-189
• /
• 2011

This study is purposed on applying to certifying environmental-friendly buildings about remodeling schools as an issue recently, keeping up a worldwide resource conservation movement. Application standard is directed, comparing with systems certifying green-schools in domestic and foreign policies. The following is the primary result of this study. First, on developing systems for certifying environmental-friendly buildings about remodeling schools, characteristics like ‘the phase of certifying essential lists and the diversity of certifying lists’, ‘developing departmentally into new-building, reconstruction, remodeling, existing-building in basic data’, ‘development of certifying existing-buildings as well as new-building’ in foreign systems should be developed appropriately for Korea. Next, not only reuse of the existing facilities but better assessment through diversification of classified contents in domestic system are carried out in comparing remodeling lists. Especially the primary list that is found out commonly limited lists certifying remodeling should be developed appropriately. Impossible lists getting certification should be applied to map out a concrete standard. Lastly, the range of certification should be diversified and developed sustainable like other systems for better assessment. Adding various lists suiting for Korea and departmentalizing score of phases and items in particular, for avoiding a needless collision between certification lists, absence of them. Above of all, basic direction about certifying environmental-friendly buildings about remodeling schools should be developed the only individual instrument, not for gaining it simply as a part of the environmental policy in Korea. This study has significance on vitalization of certifying environmental-friendly buildings, which performing primary environmental-friendly education facilities, based on its advance.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.10 no.5
• /
• pp.565-570
• /
• 2015

Spread spectrum communications have increased interest due to their immunity to channel fading and low probability of intercept. One of the limitations of the traditional digital spread spectrum systems is the need for spreading code synchronization. Chaotic communication is the analogue alternative of digital spread spectrum systems beside some extra features like simple transceiver structures. In this paper, This paper was used instead of the digital modulation and demodulation carriers for use in the chaotic signal in a digital communication system among the chaotic modulation schemes, the Differential Chaos Shift Keying(DCSK) is the most efficient one because its demodulator detects the data without the need to chaotic signal phase recovery. Also Implementation of Differential Chaos Shift Keying Communication System Using Matlab/Simulink and the receiver con decode the binary information sent by the transmitter, performance curves of DCSK are given in terms of bit-error probability versus signal to noise ratio with spreading factor as a parameter and we compare it to BPSK modulation.

• Journal of the Korean Society for Aviation and Aeronautics
• /
• v.16 no.4
• /
• pp.54-62
• /
• 2008

International organizations related to air transport such as ICAO, IATA, ACI are forecasting that the number of passenger will grow about 4.4% annually up to 2015. Therefore, the innovation of given system technology and operation procedure is required in global scale to cope with the increase of air traffic demand. CNS/ATM infrastructure based on satellite is considered to play key role in order to solve the problems due to the dramatic increase of air traffic demand over the world. Free flight concept in the air transport operation has been proved with CNS/ATM infrastructure especially in USA and Europe. Therefore, it is necessary to develop key technologies to overcome technology gap and to secure international competitiveness in Korea. ADS-B is an important issue, and new element technologies should be considered as essential items which were shown in Capstone project. Nowadays, the free flight concept is combined to Air Transport Road Map such as NextGen project in USA, SESAR in Europe. In this process, free flight is included in the concepts such as ATM(Air Traffic Management), aviation security and safety, environmental protection and economy development, wide area weather variable reduction service, information integration and application between the related authorities (civil/military) etc. The purpose of research is to establish mid-term and long-term infrastructure plan and strategy for free flight realization in Korea. The analysis of action target and equipment construction status, phase construction plan of infrastructure has been performed by considering mid-term and long-term free flight plans of USA and Europe.