• 제목/요약/키워드: Phase I study

검색결과 1,620건 처리시간 0.026초

Early Detection of the Acute Exacerbation of Interstitial Pneumonia after the Surgical Resection of Lung Cancer by Planned Chest Computed Tomography

  • Oyama, Kunihiro;Kanzaki, Masato;Kondo, Mitsuko;Maeda, Hideyuki;Sakamoto, Kei;Isaka, Tamami;Tamaoki, Jun;Onuki, Takamasa
    • Journal of Chest Surgery
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    • 제50권3호
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    • pp.177-183
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    • 2017
  • Background: To improve postoperative outcomes associated with interstitial pneumonia (IP) in patients with lung cancer, the management of the postoperative acute exacerbation of IP (PAEIP) was investigated. Methods: Patients with primary lung cancer were considered to be at risk for PAEIP (possible PAEIP) based on a preoperative evaluation. The early phase of this study was from January 2001 to December 2008, and the late phase was from January 2009 to December 2014. In the early phase, chest computed tomography (CT) was performed for patients for whom PAEIP was suspected based on their symptoms, whereas in the late phase, chest CT was routinely performed within a few days postoperatively. The numbers of possible PAEIP cases, actual PAEIP cases, and deaths within 90 days due to PAEIP were compared between both phases. Results: In the early and late phases, surgery was performed in 712 and 617 patients, 31 and 72 possible PAEIP cases were observed, nine and 12 actual PAEIP cases occurred, and the mean interval from the detection of PAEIP to starting treatment was $7.3{\pm}2.3$ and $5.0{\pm}1.8$ days, respectively. Five patients died in the early phase, and one patient died in the late phase. Significantly fewer PAEIP-related deaths were observed in the late phase (p<0.05). Conclusion: Identifying patients at risk for PAEIP by routine postoperative CT examinations led to the early diagnosis and treatment of PAEIP, resulting in the reduction of PAEIP-related mortality.

UHF RFID 수신기의 위상 다이버시티 및 최적 I/Q 신호 결합 방법에 관한 연구 (A Study on the Phase Diversity and Optimal I/Q Signal Combining Methods on a UHF RFID Receiver)

  • 장병준;송호준
    • 한국전자파학회논문지
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    • 제19권4호
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    • pp.442-450
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    • 2008
  • 본 논문에서는 직접 변환 방식의 UHF RFID 수신기에서 사용되는 위상 다이버시티의 특성을 분석하고, 태그 변조 방식에 따른 최적의 I/Q 신호 결합 방법을 제시한다. 먼저 위상 다이버시티를 사용하지 않고 단일 채널 수신기를 구성했을 때 송신 신호와 국부발진기 신호 사이의 거리에 따른 위상차에 의해 발생하는 페이딩 특성을 분석하여 위상 다이버시티의 필요성을 보였다. 다음으로 이러한 페이딩 특성에 따른 수신 신호의 감쇄 특성을 극복하기 위한 최적의 I와 Q 채널의 결합 방법을 제안하였다. ASK의 경우, AWGN 환경에서 I와 Q 채널의 전력 평균값이 최적 신호 결합 방법임을 확인하였고, PSK의 경우는 최적 신호 결합 방법으로 arctangent 방법 및 principal component 결합 방법을 제안하였다. 제시된 결합 방법의 성능 비교를 위해 시간 파형 및 심볼 에러확률 성능을 I와 Q 패널 중 최적의 SNR 값을 갖는 패널을 선택하는 선택 다이버시티와 비교하여 분석하였다. 이론 분석 및 시뮬레이션 결과, 제시된 방법이 선택 다이버시티에 비해 최대 3 dB의 SNR 개선 효과를 가짐을 확인하였다.

패션 명품(名品) 복제품(複製品) 소비자(消費者)의 위험지각(危險知覺)에 관(關)한 질적(質的) 연구(硏究) (I) - 지각(知覺)된 위험유형(危險類型)을 중심(中心)으로 - (A Qualitative Study on the Consumers' Risk Perception for the Counterfeit of Fashion luxury Brands (I) - Focused on Perceived Risk Types -)

  • 김일
    • 패션비즈니스
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    • 제9권1호
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    • pp.120-136
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    • 2005
  • The purpose of this study is to analyze consumers' perceived risk which is shown in the process of purchase phase and consumption phase for the counterfeits of fashion luxury brands and to analyze the interrelationship of each type of perceived risk. The research method of the study used a qualitative approach. 6 informants were selected and then an in-depth interview was held with them. Through this process the data on the perceived risk for counterfeits were collected and analyzed. The results of the study are as follows; The perceived level of psychological risk including counterfeits exposure was extremely high; besides, economic risk and performance risk were also perceived. On the contrary, the perceived level of social risk and fashionability loss were relatively low. The risk perception for counterfeits appeared not only on the purchase phase but also on the consumption phase, and when perceived risk existed on the consumption phase, it had an influence on the level of perceived risk on the next purchase phase. However the psychological risk was continuously perceived on both purchase and consumption phase, even if it did not exist on the consumption phase. Psychological risk, economic risk and performance risk were not independent but interdependent. Moreover, the entire level of perceived risk could be controlled by reducing the level of other perceived risks when a certain type of risk was highly perceived.

비 최소위상 플랜트에 대한 LQG/LTR에 관한 연구(I) : 최적 근사 방법 (A Study on the LQG/LTR for Nonminimum Phase Plant (I) : Optimal Approximation Method)

  • 강진식;서병설
    • 한국통신학회논문지
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    • 제16권10호
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    • pp.972-980
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    • 1991
  • LQG/LTR method have a theoretical constraint that it cannot applied to nonminimum phase plant. In this paper we suggest two methods of approximation of minimum phase plant for a given nonminimum phase plant to solve this constraint. Error is described by additive form which can reduce its magnitude in broad frequency range. A optimal approximation method was suggested by using Hankel operator theory and Nehan theory it is shown by example that the methods suggested can resolve the frequency domain constraint arised in Stein and Athans approximation.

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스트립캐스팅한 구상흑연주철 박판의 흑연화 과정에 대한 phase-field 모델링 (I);고용도가 없는 상의 모델링 (Phase Field Modeling of Graphitization in Ductile Cast Iron by Strip Casting(I);Modeling of Phases with Negligible Solubility)

  • 김성균;나형용
    • 한국주조공학회지
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    • 제20권2호
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    • pp.129-140
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    • 2000
  • This study aims at the phase-field modeling of the phase transformation in graphitization of the cast iron. As the first step, we constructed a phase-field model including the phases with negligible solubility. Under the dilute regular solution approximation, a simplified version of the phase-field model was obtained, which can be used for the phase transformation related with the stoichiometric phases. The results from the numerical calculation of the phase-field model was in good agreement with the exact analytic solution. The compositional shift due to Gibbs-Thomson effect can be reproduced within 0.5% error in the numerical calculation. The interface velocity, whereas, in numerical calculation of phase-field model appeared to be 15% larger than that from the analytic solution. This error is due to the shift of the interface position in phase-field model from the position with ${\phi}=0.5$.

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제 1상 임상시험에서 멈춤 규칙과 SM3 디자인을 이용한 최대허용용량 추정법 (Maximum Tolerated Dose Estimation by Stopping Rule and SM3 Design in a Phase I Clinical Trial)

  • 김병찬;김동재
    • 응용통계연구
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    • 제27권1호
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    • pp.13-20
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    • 2014
  • 제 1상 임상시험의 목적은 피험자가 견딜 수 있는 최대의 용량인 최대허용용량(Maimum Tolerated Dose; MTD)을 추정하는 것이다. 최대허용용량을 추정하는 방법으로는 SM방법, ATD방법, CRM방법 등이 있다. 본 연구에서는 제 1상 임상시험에서 멈춤규칙을 이용한 최대허용용량 추정법을 제안하였다. 제안한 최대허용용량 추정법은 연속재평가방법(Continual Reassessment Method; CRM)과 모의실험을 통해 비교하였다.

제1상 임상시험에서 Stopping Rule을 이용한 두 단계 MTD 추정법 (Two-Stage Maximum Tolerated Dose Estimation by Stopping Rule in a Phase I Clinical Trial)

  • 이나미;김동재
    • Communications for Statistical Applications and Methods
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    • 제19권1호
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    • pp.57-64
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    • 2012
  • 제 1상 임상시험에서 주목표는 부작용이 발생하지 않고 피험자가 견딜 수 있는 한도 내에서 최대 용량인 최대허용용량(Maximum Tolerated Dose; MTD)을 결정하는 것이다. 최대허용용량을 결정하는 방법에는 SM방법, CRM방법 등이 있는데 본 논문에서는 기존의 Stopping rule을 변형한 두 단계 MTD 추정방법을 제안하였다. 기존의 방법들을 본 논문에서 제안한 방법과 모의실험을 통하여 비교하였다.

Raman Frequencies Calculated at Various Pressures in Phase I of Benzene

  • Tari, Ozlem;Yurtseven, Hamit
    • 대한화학회지
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    • 제57권2호
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    • pp.204-209
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    • 2013
  • We calculate in this study the pressure dependence of the frequencies for the Raman modes of A ($A_g$), B ($A_g$, $B_{2g}$) and C ($B_{1g}$, $B_{3g}$) at constant temperatures of 274 and 294K (room temperature) for the solid phase I of benzene. Using the mode Gr$\ddot{u}$neisen parameter of each lattice mode, which correlates the pressure dependence of the crystal volume and the frequency, the Raman frequencies of those modes are computed for phase I of benzene. Our results show that the Raman frequencies of the three lattice modes (A, B and C) increase as the pressure increases, as expected. The temperature effect on the Raman frequencies is not significant, which can be explained by the experimental measurements.

12 스텝 PWM 2상 인버터를 이용한 콘덴서형 단상 유도전동기의 연속제어 방안에 대한 연구 (A Study on Continuous Control of $1{\Phi}$ Condenser Type Induction Motor using 12 Step PWM 2 Phase Inverter)

  • 오석문;이성룡;유철로
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 1995년도 하계학술대회 논문집 A
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    • pp.227-230
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    • 1995
  • This paper presents continuous control concept of unsymmetrical 2 phase induction machine(I.M.). For 2 phase driving of the unsymmetrical I.M., variable voltage and variable frequency inverter is needed. In this paper, a new 12 step PWM 2 phase inverter was proposed. And then, proposed inverter fed 2 phase driving of unsymmetrical I.M. was studied, expecially on average torque and pulsation torque. This system has merits like higher fundamental component and better harmonic characteristics. The simulation was done on this issue and experimental research is on the way.

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Removal study of As (V), Pb (II), and Cd (II) metal ions from aqueous solution by emulsion liquid membrane

  • Dohare, Rajeev K.;Agarwal, Vishal;Choudhary, Naresh K.;Imdad, Sameer;Singh, Kailash;Agarwal, Madhu
    • Membrane and Water Treatment
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    • 제13권4호
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    • pp.201-208
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    • 2022
  • Emulsion Liquid Membrane (ELM) is a prominent technique for the separation of heavy metal ions from wastewater due to the fast extraction and is a single-stage operation of stripping-extraction. The selection of the components (Surfactant and Carrier) of ELM is a very significant step for its preparation. In the ELM technique, the primary water- in-oil (W/O) emulsion is emulsified in water to produce water-in-oil-in-water (W/O/W) emulsion. The water in oil emulsion was prepared by mixing the membrane phase and internal phase. To prepare the membrane phase, the extractant D2EHPA (di-2-ethylhexylphosphoric acid) was used as a mobile carrier, Span-80 as a surfactant, and Paraffin as a diluent. Moreover, the internal (receiving) phase was prepared by dissolving sulphuric acid in water. Di-(2- ethylhexyl) phosphoric acid such as surfactant concentration, carrier concentration, sulphuric acid concentration in the receiving (internal) phase, agitation time (emulsion phase and feed phase), the volume ratio of the membrane phase to the receiving phase, the volume ratio of the external feed phase to the primary water-in-oil emulsion and pH of feed were studied on the percentage extraction of metal ions at 20℃. The results show that it is possible to remove 78% for As(V), 98% for Cd(II), and 99% for Pb(II). Emulsion Liquid Membrane (ELM) is a well-known technique for separating heavy metal ions from wastewater due to the fast extraction and is a single-stage operation of stripping-extraction. The selection of ELM components (Surfactant and Carrier) is a very significant step in its preparation. In the ELM technique, the primary water-in-oil (W/O) emulsion is emulsified to produce water-in-oil-in-water (W/O/W) emulsion. The water in the oil emulsion was prepared by mixing the membrane and internal phases. The extractant D2EHPA (di-2-ethylhexylphosphoric acid) was used as a mobile carrier, Span-80 as a surfactant, and Paraffin as a diluent. Moreover, the internal (receiving) phase was prepared by dissolving sulphuric acid in water. Di-(2-ethylhexyl) phosphoric acid such as surfactant concentration, carrier concentration, sulphuric acid concentration in the receiving (internal) phase, agitation time (emulsion phase and feed phase), the volume ratio of the membrane phase to the receiving phase, the volume ratio of the external feed phase to the primary water-in-oil emulsion and pH of feed were studied on the percentage extraction of metal ions at 20℃. The results show that it is possible to remove 78% for As(V), 98% for Cd(II), and 99% for Pb(II).