• Journal of the Korean Institute of Landscape Architecture
• /
• v.44 no.1
• /
• pp.40-50
• /
• 2016

A BIM, which is being applied actively to the construction and civil construction industries, is a technology that can maximize efficiency of various sectors from initial planning and design, construction, and maintenance, to demolition; however, it is in the introductory phase in the field of domestic landscaping. In order to introduce and promote BIM in the field of landscape design, this study developed a prototype of a library and template and analyzed the performance of trial application. For the development of a prototype, annotations and types were analyzed from floor plans of existing small parks, and components of landscape template were deduced. Based on this, play facilities, pergola, and benches were madeintofamily and templates, making automatic design possible. In addition, annotations and tags that are often used in landscape design were made, and a 3D view was materialized through visibility/graphic reassignment. As for tables and quantities, boundary stone table, mounding table, summary sheet of quantities, table of contents, and summary sheet of packaging quantities were grouped and connected with floor plans; regarding landscaping trees, classification criteria and name of trees that are suitable for domestic situations were applied. A landscape template was created to enable the library file format(rfa) that can be mounted on a building with BIM programs. As for problems that arose after the trial application of the prepared template, some CAD files could not be imported; also, while writing tables, the basis of calculation could not be made automatically. Regarding this, it is thought that functions of a BIM program and template need improvement.

• Journal of Food Hygiene and Safety
• /
• v.31 no.5
• /
• pp.319-326
• /
• 2016

Colistin is a last resort antimicrobial agent against multi-drug resistant Gram-negative bacteria. This study was conducted to develop an analytical method to determine colistin in fish and shrimp. The analytes were confirmed and quantified via liquid chromatography-tandem mass spectrometry (LC-MS/MS) in the positive ion mode using multiple reaction monitoring (MRM). The sample was extracted with acidified 5% methanol (containing 0.5% formic acid). Then, solid phase extraction (SPE) was used for cleanup. Matrix-matched calibration curves were linear over the calibration ranges (0.05-1.2 mg/kg) for all the analytes into blank sample with $r^2$ > 0.99. All the values fulfilled the criteria requested by the Codex guidelines. Average recoveries ranged from 85.9% to 107.9%. The repeatability of measurements, expressed as the coefficient of variation (CV, %), was less than 15%. The limit of detection (LOD) was 0.02 mg/kg, and the limit of quantitation (LOQ) was 0.05 mg/kg. This improved method showed higher accuracy and acceptable sensitivity to meet the CAC guideline requirements and is applicable for the analysis of residual colistin (A+B) in fish and shrimp.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
• /
• v.8 no.1
• /
• pp.5-11
• /
• 1997

To set up an objective basis for the evaluation of the stroboscopic findings, video-strobolaryngoscopic images of vocal fold vibration in 5 female and 5 male normal speakers were analyzed using an image analysis computer program called KSIP(Kay Storoboscopy Image Processing, Kay Elemetrics Corp., NJ, USA). Four consecutive vibratory cycles were compared in comfortable, louder, high-pitched /ee/ phonation for every subject. findings mostly replicated earlier studies including glottal chinks which were observed in most female speakers throughout the cycles and clear distinction between female and male speakers in their vibratory patterns as well as intensity and frequency-re-lated differences. However, there were some findings incompatible with those from previous studies which may be attributable to technical problems. This study may provide an objective basis of the stroboscopic findings such as image shape, amplitude, area, and their changes according to frequency and intensity variations. We anticipate that funker study with larger samples ran provide an objective criteria for normal vibratory characteristics of the laryngostro-boscopic findings.

• Journal of Energy Engineering
• /
• v.13 no.1
• /
• pp.51-59
• /
• 2004

The NSSS (Nuclear Steam Supply System) thermal-hydraulic programs adopted in the domestic full-scope power plant simulators were provided in early 1980s by foreign vendors. Because of limited compulsational capability at that time, they usually used very simplified physical models for a real-time simulation of NSSS thermal-hydraulic transients, which entails inaccurate results and, thus, the possibility of so-called "negative training", especially for complicated two-phase flows in the reactor coolant system. In resolve the problem, KEPRI developed a realistic NSSS T/H program ARTS which was based on the RETRAN-3D code for the improvement of the Nuclear Power Plant full-scope simulator. The ARTS (based on the RETRAN-3D code) guarantees the real-time calculations of almost all transients and ensures the robustness of simulations. However, there is some possibility of failing to calculate in the case of large break loss of coolant accident (LBLOCA) and low-pressure low-flow transient. In this case, the backup calculation system cover automatically the ARTS. The backup calculation system was expected to provide substantially more accurate predictions in the analysis of the system transients involving LBLOCA. The results were reasonable in terms of accuracy, real-time simulation, robustness and education of operators, complying with FSAR and the AMSI/ANS-3.5-1998 simulator software performance criteria.

• Journal of Pharmaceutical Investigation
• /
• v.41 no.4
• /
• pp.255-262
• /
• 2011

Method using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) was developed and validated for the determination of pregabalin in plasma samples. Acquisition was performed by monitoring the transitions: m/z 160.1${\rightarrow}$142.2 for pregabalin and m/z 423.2${\rightarrow}$207.1 for losartan (as an internal standard). After cold acetonitrileinduced protein precipitation of the plasma samples, separation was performed with C18 column by isocratic mobile phase consisted of 10 mM ammonium acetate and acetonitrile (15:85, v/v). Results were linear over the concentration ranged from 0.1 to $10{\mu}g$/mL and the correlation coefficients (r) were $\geq0.99$. Intra- and inter-day precisions were $\leq6.02$ and $\leq11.04%$, respectively, and intra- and inter-day accuracies were 96.60-101.09 and 98.10-102.60%, respectively. This validated method was successfully applied to a bioequivalence study of two formulations of pregabalin, Daewoong pregabalin capsule (Daewoong Pharm. Co., Ltd.) and Lyrica$^{(R)}$ capsule (Pfizer Korea Ltd.) in twenty eight healthy Korean volunteers. The subjects received a single oral dose of each formulation (150 mg as pregabalin) in a randomized $2{\times}2$ crossover study and plasma samples were obtained from each subject at predetermined time intervals. Then, the pharmacokinetic parameters ($AUC_{0-t}$, $C_{max}$ and $T_{max}$) were calculated and statistically analyzed to assess the differences between two formulations. The 90% confidence intervals for the log-transformed data were acceptable range of log 0.8-log 1.25 (e.g., log 1.0048-log 1.0692 for AUC0-t, log 0.9142-log 1.0421 for $C_{max}$). Thus, $AUC_{0-t}$ and $C_{max}$ met the criteria of the Korea Food and Drug Administration (KFDA) for bioequivalence test indicating that Daewoong pregabalin capsule was bioequivalent to Lyrica$^{(R)}$ capsule.

• Journal of Pharmaceutical Investigation
• /
• v.39 no.1
• /
• pp.65-71
• /
• 2009

The aim of the present study was to evaluate the bioequivalence of two domperidone maleate tablets, Motilium-$M^{(R)}$ Tablet (Janssen Korea Ltd., reference product) and $Toriem^{(R)}$ Tablet (Daewon Pharm. Co., Ltd., test product). Domperidone was extracted by liquid-liquid extraction using tert-butyl methyl ether and separated in less than 3 min on $C_{18}$ reverse-phase column using an isocratic elution. A tandem mass spectrometer, as detector, was used for quantitative analysis in positive mode by a multiple reaction monitoring mode to monitor the m/z $426.1{\rightarrow}119.1$ and the m/z $837.4{\rightarrow}158.2$ transitions for domperidone and the internal standard (roxithromycin), respectively. Calibration curves, from $0.05{\sim}50$ ng/mL of domperidone, showed correlation coefficients (r) higher than 0.9941. Intra day and inter day precision (C.V. %) for quality control were ranged from 10.04 to 16.09% and from 10.87 to 18.69%, respectively. The lower limit of quantification (LLOQ) of domperidone was 0.05 ng/mL. The method described is precise and sensitive and has been successfully applied to the study of bioequivalence of domperidone in 24 healthy Korean volunteers. Twenty-four healthy male Korean volunteers received a single dose of each medicine ($2{\times}12.72\;mg$ domperidone maleate) in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of domperidone were monitored for over a period of 24 hr after the administration. $AUC_{0-t}$ (the area under the plasma concentration-time curve) was calculated by the linear trapezoidal rule. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. The 90% confidence intervals for the log transformed data were within acceptable range of log 0.8 to log 1.25 (e.g., $log\;0.92{\sim}log\;1.05$ for $AUC_{0-t}$, $log\;0.81{\sim}log\;1.05$ for $C_{max}$). The major parameters, $AUC_{0-t}$ and $C_{max}$ met the criteria of KFDA for bioequivalence indicating that $Toriem^{(R)}$ tablet is bioequivalent to Motilium-$M^{(R)}$ tablet.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.19 no.10
• /
• pp.640-647
• /
• 2018

Many harbor structures have been constructed, and some structures are now under construction in Korea, which is a peninsular state and a logistics hub in Northeast Asia. Expansions and extensions of existing harbors are also being planned to meet increasing natural disaster threats. Wave-dissipation concrete blocks are recycled or discarded based on the personal experience of engineers only, and there are no safety checks or criteria. To check the safety of used blocks, material evaluations were done by visual inspection of blocks on the ground and under water and from 20 non-destructive measurements of the rebound hardness test and 3 concrete core samples. Wave-dissipation blocks are sometimes fully or partially damaged in the process of transferring and mounting them or during construction. Therefore, a safety check is essential for recycling blocks with an evaluation of materials while considering the construction phases. To do this, a block was modeled with a 3D finite element method using ADINA, and impact analyses were done according to the transfer, mounting, and construction phases. From the results of the impact analyses and material evaluation, the safety checks and reasonable evaluation of used blocks were examined, and detailed construction methods are proposed. The methods are expected to maximize the reuse of used wave-dissipation blocks from an economical point of view.

• Journal of Korean Tunnelling and Underground Space Association
• /
• v.21 no.6
• /
• pp.795-810
• /
• 2019

In this paper, The study was conducted on the method to roughly determine the area and length of the multi-utility tunnel before the planning and design phase of the multi-utility tunnel construction. For this purpose, four feasibility indexes were used: traffic density, population density, disaster prevention index (number of workers), and urbanization rate, which reflect the regional characteristics. The installation criteria were set in consideration of the average value and minimum value of the feasibility indexes for the tunnel type among areas that can be installed in the multi-utility tunnel of Seoul. The analysis area included 200 areas based on 14 zones. The results of the analysis based on the minimum value of feasibility indexes indicated that the tunnel type of multi-utility tunnel is suitable for 39 areas with high traffic volume and population. On the other hand, the 'gun' area, etc., has a wider population than the 'si' and 'gu', suggesting that it is not suitable to install multi-utility tunnel. In addition, it can be seen that the larger the index value centered on the minimum value of each index, the smaller the tunnel type of multi-utility tunnel installation area.

• Journal of Pharmaceutical Investigation
• /
• v.35 no.5
• /
• pp.323-328
• /
• 2005

The purpose of the present study was to evaluate the bioequivalence of two torasemide tablets, Torem tablet (Roche Korea Co., Ltd., Korea, reference drug) and Boryung Torsemide tablet (Boryung Pharmaceutical Co., Ltd., Korea, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). After adding an internal standard (furosemide) to human serum, serum samples were extracted using 5 mL of ethyl acetate. Compounds were analyzed by reverse-phase HPLC method with UV detection. This method showed linear response over the concentration range of 0.05 ug/mL with correlation coefficient of 0.999. The lower limit of quantitation using 0.5 mL of serum was 0.05 ug/mL which was sensitive enough for pharmacokinetic studies. Twenty-eight healthy male Korean volunteers received each medicine at the torasemide dose of 20 mg in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Serum concentrations of torasemide were monitored by an HPLC-UV for over a period of 12 hr after the administration. $AUC_{t}$(the area under the serum concentration-time curve from time zero to 12 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum serum drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the serum concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_{t}$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_{t}$ ratio and the $C_{max}$ ratio for Boryung Torsemide/Torem were log 0.97-10g 1.03 and log 0.93log 1.12, respectively. These values were within the acceptable bioequivalence intervals of log 0.80-log 1.25. Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating Boryung Torsemide tablet and Torem tablet are bioequivalent.

• The Korean Journal of Pesticide Science
• /
• v.17 no.2
• /
• pp.107-116
• /
• 2013

Polar pesticides like pymetrozine (log $P_{ow}$: -0.18) are known to be difficult to analyze. The analytical method of pymetrozine using hydromatrix included in the official method of KFDA was uncommon and provided ambiguous evidence to confirm both the identity and the quantity. Therefore, precise single residue analytical method was developed in representative crops for using liquid-liquid extraction (LLE). The pymetrozine residue was extracted with methanol from 11 representative crops which comprised apple, blueberry, broccoli, cabbage, cherry, crown daisy, hulled rice, Korean cabbage, potato, rice and watermelon. The extract was purified serially by liquid-liquid extraction (LLE) and silica solid phase extraction (SPE). For rice and hulled rice samples, n-hexane partition was additionally adopted to remove nonpolar interferences, mainly lipids. The residue levels were analyzed by HPLC with DAD, using $C_8$ column. LOQ (limit of quantitation) of pymetroizinie was 1 ng (S/N > 10) and MQL (method quantitation limit) was 0.01 mg/kg. Mean recoveries from 11 crop samples fortified at three levels (MQL, 10 ${\times}$ MQL and 50 ${\times}$ MQL) in triplicate were in the range of 83.1~98.5% with coefficients of variation (CV) of less than 10%, regardless of sample type, which satisfies the criteria of KFDA. The method established in this study could be applied to most of crops as an official and general method for analysis of pymetrozine residue.