• Title/Summary/Keyword: Pharmacy Faculty

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OXIDATIVE DAMAGE, DNA REPAIR AND SIGNAL TRANSDUCTION IN CHEMICAL TERATOGENESIS.

  • Peter G Wells;Yadvinder Bhuller;Connie S Chen;Jeffrey T Henderson;Winnie Jeng;Sonja Kasapinovic;Julia C Kennedy;Rebecca R Laposa;Christopher J Nicol;Toufan Parman;Michael J Wiley;Louise M Winn;Andrea W Wong
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2002.05a
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    • pp.44-64
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    • 2002

  • Embryonic prostaglandin H synthases (PHSs) and lipoxygenases bioactivate xenobiotics (phenytoin, thalidomide, benzo[a]pyrene) to free radical intermediates that initiate reactive oxygen species (ROS) formation, which oxidatively damage cellular macromolecules and/or alter signal transduction.(omitted)

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Synthesis, Analgesic, and Anti-Inflammatory Activities of [6-(3,5-Dimethyl-4-Chloropyrazole-1-yl)-3(2H)-Pyridazinon-2-yl]Acetamides

  • Sukuroglu, Murat;Caliskanergun, Burcu;Unlu, Serdar;Sahin, M.Fethi;Kupeli, Esra;Yesilada, Erdem;Banoglu, Erden
    • Archives of Pharmacal Research
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    • v.28 no.5
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    • pp.509-517
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    • 2005

  • A series of structurally diverse amide derivatives of [6-(3,5-dimethyl-4- chloro-pyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acid were prepared and tested for their in vivo analgesic and anti-inflammatory activity by using p-benzoquinone-induced writhing test and carrageenan induced hind paw edema model, respectively. The analgesic and anti-inflammatory activity of the compounds, 7c, 7d and 7k were found to be equipotent to aspirin (as an analygesic) and indometacin (as an anti-inflammatory drug), respectively. The other amide derivatives generally resulted in lower activity on comparision with reference compounds.

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Anticancer Effects of the Hsp90 Inhibitor 17-Demethoxy-Reblastatin in Human Breast Cancer MDA-MB-231 Cells

  • Zhao, Qing;Wu, Cheng-Zhu;Lee, Jae Kyoung;Zhao, Su-Rong;Li, Hong-Mei;Huo, Qiang;Ma, Tao;Zhang, Jin;Hong, Young-Soo;Liu, Hao
    • Journal of Microbiology and Biotechnology
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    • v.24 no.7
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    • pp.914-920
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    • 2014

  • Triple-negative breast cancer (TNBC) possesses a higher rate of distant recurrence and a poorer prognosis than other breast cancer subtypes. Interestingly, most of the heat shock protein 90 (Hsp90) client proteins are oncoproteins, and some are closely related to unfavorable factors of TNBC patients. 17-Demethoxy-reblastatin (17-DR), a novel non-benzoquinone-type geldanamycin analog, exhibited potent Hsp90 ATPase inhibition activity. In this study, the anticancer effects of 17-DR on TNBC MDA-MB-231 cells were investigated. These results showed that 17-DR inhibited cell proliferation, induced apoptosis, and suppressed cell invasion and migration in the MDA-MB-231 cells. Down-regulation of the key Hsp90-dependent tumor-driving molecules, such as RIP1 and MMP-9, by 17-DR may be related to these effects. Taken together, our results suggest that 17-DR has potential as a therapeutic agent for the treatment of TNBC.

  • https://doi.org/10.4014/jmb.1311.11052 인용 PDF KSCI KPUBS