Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.05a
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- Pages.44-64
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- 2002
OXIDATIVE DAMAGE, DNA REPAIR AND SIGNAL TRANSDUCTION IN CHEMICAL TERATOGENESIS.
- Peter G Wells (Faculty of Pharmacy and Depts. of Pharmacology, University of Toronto) ;
- Yadvinder Bhuller (Faculty of Pharmacy, University of Toronto) ;
- Connie S Chen (Faculty of Pharmacy, University of Toronto) ;
- Jeffrey T Henderson (Faculty of Pharmacy, University of Toronto) ;
- Winnie Jeng (Faculty of Pharmacy, University of Toronto) ;
- Sonja Kasapinovic (Faculty of Pharmacy, University of Toronto) ;
- Julia C Kennedy (Faculty of Pharmacy, University of Toronto) ;
- Rebecca R Laposa (Faculty of Pharmacy, University of Toronto) ;
- Christopher J Nicol (Depts. of Pharmacology, University of Toronto) ;
- Toufan Parman (Faculty of Pharmacy, University of Toronto) ;
- Michael J Wiley (Dept. of Surgery, University of Toronto) ;
- Louise M Winn (Faculty of Pharmacy, University of Toronto) ;
- Andrea W Wong (Faculty of Pharmacy, University of Toronto)
- Published : 2002.05.01
Abstract
Embryonic prostaglandin H synthases (PHSs) and lipoxygenases bioactivate xenobiotics (phenytoin, thalidomide, benzo[a]pyrene) to free radical intermediates that initiate reactive oxygen species (ROS) formation, which oxidatively damage cellular macromolecules and/or alter signal transduction.(omitted)
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