• Journal of Pharmaceutical Investigation
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• 제2권1호
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• pp.5-13
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• 1972

There are some repels in which they studied on the change of acid-consuming capacity of aluminium hydroxide resulted from the passing of time. However, the relationship between grain sizes(particle sizes) and the acid-consuming capacity of dried aluminium hydroxide gel was not been studied. And studies on the grain sizes of aluminium hydroxide gel qualified by pharmacopoeia of Korea has not been reported. For the purpose of studying these two problems, the author prepared two-kinds of aluminium hydroxide gel as follows : $Na_2OAl_2O_3+CO_2------{\longrightarrow}Al(OH)_3{\cdots}{\cdots}{\cdots}$sample 1 $Al_2(SO_4)_318H_2O+6NaHCO_3{\longrightarrow}Al(OH)_3{\cdots}{\cdots}{\cdots}$sample 2 Both of sample 1 and 2 are found to be amorphous by X-ray diffraction methods, and their acid-consuming capacities were determined by the method of pharmacopeia of Korea. The grain size was measured by X-ray diffraction method, the particle sizes observed by electron microscopy, and the change of acid-consuming capacity with passing of time was determined by the method of pharmacopoeia of Korea. The results of these studies are summerized as follows: 1. The grain size was linearly enlarged as the time goes by. The aluminium hydroxide gel gradually crystallized in a certain period of time. 2. The acid-consuming capacity was in exponential function, decreased as the grain size of them enlarged. 3. One particle consists of tens of grains.4. Grinding the Sample obtained in any period of testing time in mortar did not change both their grain size and their acid-consuming capacity. 5. The grain size of dried aluminium hydroxide gel ought to be micronized less than $100{\AA}$ for maintaining the ability such as consumes 250m1 of 0. 1N-HC1 solution per Is of $Al(OH)_3$ described in pharmacopoeia of Korea.

• 대한본초학회지
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• 제32권1호
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• pp.55-62
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• 2017

Objectives : Crataegi Fructus has been used as traditional medicines for more digestion action, amenorrhea due to blood stasis, and hyperlipemia. The aim of this study was to compare of Crataegi Fructus in South Korea collected during three years according to the standards in monographs of the Korean Pharmacopoeia Eleventh edition (KP 11). Methods : Crataegi Fructus was carried out identification test (Qualitative reaction, Thin layer chromatography), heavy metal test, and total ash registered at KP. Add to we tested loss on dry, contents of ethanol-soluble extracts, and HPLC profiling. Results : Identification test (TLC) was on comparing with ursolic acid standard solution in $R_f$ value, all samples showed red purple spot ($R_f$ value 0.9). Ursolic acid spot in $R_f$ value 0.35 showed by changing mobile phase condition. Heavy metals showed contents for Pb, Cd, As, and Hg range of 0.0 ~ 0.5 ppm, 0.0 ~ 0.2 ppm, 0.0 ~ 0.3 ppm, and 0.0 ~ 0.1 ppm. Loss on drying was ranged from 5.5 to 11.9 %, total ash was between the range 2.7 ~ 4.0 %. Contents of ethanol-soluble extracts was ranged from 17.8 to 44.9 %. The content of chlorogenic acid was ranged from 0.0 to 0.1 % based on the chlorogenic acid standard curve. Conclusion : We have verified the current specification standard of Crataegi Fructus and standard that is not set. We hope that it will help the standardization of Crataegi Fructus.

• 대한본초학회지
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• 제28권1호
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• pp.51-58
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• 2013

Objectives : As Daily Dose of Zizyphi Fructus was designated by the numbers in Treatise on Cold Damage Disease, estimation of Daily Dose was all different among researchers. The purpose of this study was to estimate exact Daily Dose of Zizyphi Fructus. Methods : We fixed the errors in various copy of Treatise on Cold Damage Disease and considered the meaning of the Bee Zizyphi Fructus(肥大棗) and general rules of Daily Dose in Treatise on Cold Damage Disease. So we reduced Daily Dose of Zizyphi Fructus, and compared this with the standard of Zizyphy Fructus in Pharmacopoeia of several Nation and Korean Forest Service. Results : Daily Dose of Zizyphi Fructus was generally 12 pieces; less was for prescriptions which scaled down the amount of ingredients prescribed in the originals; 15, 25, and 30 pieces were used when more was required. The medicinal part was the pulp of fructus, and the dosage of 12 pieces was respectively equivalent to 3 Ryang(兩), and 19.5 g. As defined in the Korean Pharmacopoeia Ninth Edition and standards of forest products by Korea Forest Service, Zizyphi Fructus was medium-sized, and weighs about 1.625 g if properly dehydrated. Conclusions : In short, the proper Daily Dose of Zizyphi Fructus in Treatise on Cold damage Disease was 12 pieces of Zizyphi Fructus and 19.5 g of its pulp, weighing three Ryang(兩). The pulp was estimated to be 1.625 g; it was medium-sized according to the present standard.

• 대한본초학회지
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• 제32권2호
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• pp.97-105
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• 2017

Objectives : Gardeniae Fructus is a ripe fruit of Gardenia jasminoides Ellis, which has been used as traditional medicines for anti-inflammatory, diuretic, antipyretic, and antibacterial activity. The aim of this study was to compare of Gardeniae Fructus in South Korea collected during three years according to the standards in monographs of the Korean Pharmacopoeia Eleventh edition (KP11). Methods : 30 items of Gardeniae Fructus from two cultivation regions were classified into dried(n=15) & steamed (n=15) and tested according to the standards in monographs of the KP11. Gardeniae Fructus was carried out identification(comparison of colors, thin layer chromatography), heavy metals, residual pesticides, total ash, and assay registered at KP11. Add to we tested loss on dry, contents of ethanol-soluble extracts, and HPLC profiling. Results : In TLC chromatogram of identification test, the spot of gardenoside and geniposide were observed at $R_f$ value of about 0.3 and 0.5. Heavy metals and residual pesticides met the requirements of the standards for all samples. The results of total ash of each samples are measured maximum 4.87 %. According to HPLC for assay, the samples contain 4.80~6.10 % of geniposide and 0.45~1.83 % of gardenoside. Conclusion : We have verified the current specification standard of Gardeniae Fructus and standard that is not set. By the results, it is proposed a new draft of loss on drying and confirmed the content of gardenoside revised. HPLC standard chromatogram of Gardeniae Fructus is proposed. We hope that it will help the standardization of Gardeniae Fructus.

• 대한약학회:학술대회논문집
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• 대한약학회 2000년도 춘계총회 및 학술대회
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• pp.208.2-209
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• 2000

• 한국작물학회지
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• 제49권spc1호
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• pp.117-145
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• 2004

• 생약학회지
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• 제35권4호통권139호
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• pp.265-270
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• 2004

The phylogenetic relationship of Polygonatum species were examined by RAPD analysis. Polygonatum Rhizoma is called 'Whang-jung', and used Polygonatum sibiricum Redoute in defined as a source plant in Korean Pharmacopoeia. Polygonati Odorati Rhizoma is called 'Wui-yu', and P. odoratum Druce var. pluriflorum Ohiwi and related species are defined is source plants in Korean Herbal Pharmacopoeia. In UPGMA analysis, Polygonum was divided into two major groups. Polygonatum sibiricum and P. stenophyllum was placed in a cluster. On the other hand, P. falcatum A. Gray was included in the other cluster comprising. P. odoratum and related species, which are used as source plants for Polygonati Odorati Rhizome.

• 한국약용작물학회지
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• 제19권6호
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• pp.407-413
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• 2011

This study was analyzed and investigated to evaluate ecological distribution of medicinal plants in Miho Stream of Korea. Totality 463 taxa of vascular plants were appeared in lower part of Miho Stream. Medicinal plants were distributed 253 taxa, which were 54.6% of the total vascular plants appeared. Medicinal plants of official drug compendium(Korean pharmacopoeia) were 85 taxa. Medicinal plants were distributed most of the forest area, and followed field surrounding, stream surrounding and paddy surrounding respectively. The distribution of life form hemicryptophyte was the most frequent. Plant community of appearing area of medicinal plants was classified into Salix koreensis, Phragmites japonica, Echinochloa crusgalli, Artemisia selengensis, Miscanthus sacchariflorus, Setaria faberii, Panicum dichotomiflorum, Bidens frondosa, Humulus japonicus, Monochoria vaginalis var. plantaginea, Eleocharis kuroguwai, Erigeron acris, Pinus densiflora, Pinus rigida, Quercus acutissima, Quercus serrata, Robinia pseudoacacia and Castanea crenata community. Medicinal plants in plant communities that occur frequently were Humulus japonicus, Corylus heterophylla and Liriope spicata.

• 한국한의학연구원논문집
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• 제12권3호통권18호
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• pp.79-90
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• 2006

This study was investigated to determine the quality monitoring of distributed materials from Glycyrrhizae Radix (26 samples), Atractylodis Rhizoma Alba (24 samples) according to storage period after $1{\sim}3$ year. We have estimated by identification, purity, loss on drying, ash, acid insoluble ash, extract content, essential oil content, assay and microbial contamination. As a result, Glycyrrhizae Radix (26 samples) were satisfied with the standard of K.P. (Korean Pharmacopoeia) and WHO's microbial contamination limit standard. In the Atractylodis Rhizoma Alba (24 samples), 2 samples were not satisfied with the standard of K.P.(Korean Pharmacopoeia) and WHO's microbial contamination limit standard. The results make practical application of the basic data for the quality control of herbal medicine in storage.

• 대한한의학회지
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• 제37권1호
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• pp.53-61
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• 2016

Background: It has been some controversy about the interpretation of the sentence including 'Youngin Eunhyung' that was listed in the classic, Dongeui bogam (first published 1610). The purpose of this study is to demonstrate another assumption to interpretate the meaning of 'Youngin Eunhyung' in the sentence. Methods and Results: It was identified that the quotation of the original text of the sentence. The original text was Zhenglei bencao (Categorized Pharmacopoeia) (First edition in 1082) by Tang Shenwei and Shiliao bencao (Pharmacopoeia for Healing through Nutrition). (First edition in 721-739) by Meng Shen. It was found that there were the missing of five chinese characters in the sentence of Dongeui bogam, that it meant that 'to get rid of the watery pus in the anterior chamber of eyeball'. So, I understand that the meaning of the sentence is related with one of the ophthalmologic disease. All the evidence supports this assumption, including the mystery of another sentence of the 'blue dog'. Conclusions: It is concluded that the treatment using in Dongeui bogam that means to alleviate the symptom of obstruction or indistinction of the vision field was caused by hypopyon. However, further scientific research is warranted to provide to support this opinion.