• Membrane Journal
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• v.34 no.2
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• pp.114-123
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• 2024

Hydrogen isotopes can be categorized into light hydrogen, heavy hydrogen, and tritium based on the number of neutrons, each of which is used in specific fields. Specifically, deuterium is of interest in the electronics industry, nuclear energy industry, analytical technology industry, pharmaceutical industry, and telecommunications industry. Conventional methods such as cold distillation, thermal cycling absorption processes, Girdler sulfide processes, and water electrolysis have their own advantages and disadvantages, leading to the need for alternative technologies with high separation and energy efficiency. In this context, membrane-based hydrogen isotope separation is one of the promising solutions to reduce energy consumption. In this review, we will present the state-of-the-art in hydrogen isotope separation using membranes and their operating principles. The technology for separating hydrogen isotopes using membranes is just beginning to be conceptualized, and many challenges remain to be overcome. However, if achieved, the economic benefits are expected to be significant. We will discuss future research directions for this purpose.

• Molecules and Cells
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• v.20 no.1
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• pp.17-29
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• 2005

Therapeutic antibodies represent one of the fastest growing areas of the pharmaceutical industry. There are currently 19 monoclonal antibodies in the market that have been approved by the FDA and over 150 in clinical developments. Driven by innovation and technological developments, therapeutic antibodies are the second largest biopharmaceutical product category after vaccines. Antibodies have been engineered by a variety of methods to suit a particular therapeutic use. This review describes the structural and functional characteristics of antibody and the antibody engineering for the generation and optimization of therapeutic antibodies.

• Journal of Technology Innovation
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• v.26 no.3
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• pp.69-97
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• 2018

This study explored the influence of failure experience of Korean pharmaceutical industries on the innovative activities of corporations from the perspectives of R&D and knowledge search. Previous studies have defined the cause of the failure or studied the reasons for the decline. However, studies analyzing the influence of failure on the innovative activities of corporations are rare. This study set a research period of 10 years for the Korean pharmaceutical industry to conduct a longitudinal analysis of the influence of the influence of failure on innovation activities and the influence of innovation activities on radical innovation. A summary of the research results is as follows. Firstly, failure of corporations induce exploratory innovation activities, and the extent differs greatly from the size of financial slack resource. Secondly, experiences of corporations' failure were not significant from the perspective of knowledge search. Thirdly, the interaction between the corporation's exploratory innovation activities and knowledge search had a positive (+) relationship with radical innovation performance. This study is significant in that it suggested empirical evidence by verifying the positive influence of failure to learning and innovation unlike previous researches viewing failure negatively, and suggested the direction of future studies based on these research results.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2019.10a
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• pp.20-20
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• 2019

Sedge family is second largest family in the Korean flora with more than 240 taxa, following Aster family (about 300 taxa). Although high species diversity, a very limited number of taxa has been utilized for ethnobotanical usages. In the study, previous researches on Cyperaceae ethnobotanical information are documented and analyzed for future research directions on the taxa. A total number of seven taxa has been used for medicinal, food, and material purposes: Carex boottiana Hook. & Arn., Cyperus amuricus Maxim., Cyperus esculentus L., Cyperus exaltatus Retz., Cyperus rotundus L., Eleocharis kuroguwai Ohwi, and Bolboschoenus maritimus (L.) Palla. Underground parts such as tubers are used with medicinal purpose, and aboveground portions such as leaves and stems provide materials for various tools and foods for people and animals. They are all native to Korea, except C. esculentus, which is introduced from Mediterranean areas for anti-erosion materials. The ethnobotanical value of C. esculentus has been well recognized from ancient times, for example, starch grains in USA (excavations at the Mashantucket Pequot Reservation) and Tiger nut milk (Horchata de chufa in Spain). Among material sources, C. exaltatus has a long history in the Korean peninsula from Three Kingdoms of Korea (57 BC~668 AD). C. rotundus is distributed widely in Asia, Africa, Europe, and America, and utilized for medicines, food, and materials. In addition, Eleocharis kuroguwai is only one taxon utilized for ethnobotanical uses among fifteen Eleocharis Korean native species. The number of species with ethnobotanical uses is small in sedge family, but the family has long been utilized accompanying long human history. Cyperus papyrus L., the source of papyrus paper (Egypt in the Nile Delta), is also a member of sedge family. Sedge family has contributed to human societies in various aspects but, the cultural, botanical, ecological values of family members have been underestimated.

• YAKHAK HOEJI
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• v.55 no.4
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• pp.345-351
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• 2011

Gastritis is the most common disease among Korean. The demand for the development of gastritis drugs has been increasing. Currently, however, there is no guideline available for the clinical evaluation of gastritis drugs worldwide. As a consequence, domestic and international pharmaceutical companies make errors in the drug development processes, and it becomes difficult for them to establish the scientific validity and objectivity of newly developed drugs. The objective of this study was to develop the Guideline for Clinical Trials Evaluation of Gastritis which can be used in improving the quality and consistency of clinical trials. First, we collected and reviewed the clinical trials on gastritis drugs that were available from Japan Pharmaceuticals and Medical Devices Agency and Korea Food and Drug Administration (KFDA), and investigated the recent research trends on clinical trials of gastritis drugs. Reviewers from KFDA and National Institute of Food and Drug Safety Evaluation and scientific experts from the pharmaceutical industries developed the guidelines through regularly scheduled meetings. Opinions and consultation from academic fields and industry experts were also obtained. This project will provide the clinical trial practitioners, investigator and reviewers the scientific and rational guidelines for performance and evaluation of clinical trials for gastritis drugs. Furthermore, we hope this guideline contributes to establishing the national competitiveness, improving the quality of clinical trial, and encouraging researches on drug development for gastritis.

• STI Policy Review
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• v.8 no.1
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• pp.62-86
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• 2017

Intellectual Property Rights (IPR) system is one of the major institutions for incentivizing innovation. However, a strong IPR regime does not necessarily encourage innovation every time. This is because a variety of factors come into play in configuring the ways the IPR system interacts with the dynamics of innovation. In the present study, we examine whether different degrees of absorptive capacity at the industry level bring about heterogeneous effects of a strong IPR regime on the innovation capability of innovators across different industries in developing country. Using the case of the 1986 IPR reform in Korea, which permitted patenting pharmaceutical products and copyrighting computer programs, we analyze the quality of patents produced by Korean applicants between 1982 and 1991. Our analysis finds no evidence that the IPR reform improved the innovation capability of innovators in the two aforementioned sectors, but rather affected their patenting behavior differently.

• Journal of the Korean Chemical Society
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• v.60 no.4
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• pp.235-238
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• 2016

Mt. Jiri located in the southwestern part of Korea is a treasure trove of wild medicinal plants. More than 1200 species currently classified as herbs are grown or cultivated in the area. Recently, safflower has attracted interest because of its ability to control fine wrinkle formation on the neck. The objective of this study therefore was to determine whether the active ingredient of safflower could be used in the form of an extract to reduce wrinkle formation in individuals aged 30 to 59 years. In particular, this study was aimed at determining the extract’s elastase activity and anti-oxidant effect by using DPPH assay in vitro and evaluating the anti-wrinkle efficacy of different types of safflower extracts in improving fine wrinkles on the neck. This study will provide a basis for future studies to develop safflower extracts using advanced composition technology and contribute to the development of the herbal cosmetics industry.

• Journal of Microbiology and Biotechnology
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• v.33 no.3
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• pp.387-397
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• 2023

Cytochrome P450 (CYP) is a heme-containing enzyme that catalyzes hydroxylation reactions with various substrate molecules. Steroid hydroxylases are particularly useful for effectively introducing hydroxyl groups into a wide range of steroids in the pharmaceutical industry. This study reports a newly identified CYP steroid hydroxylase (BaCYP106A6) from the bacterium Bacillus sp. and characterizes it using an in vitro enzyme assay and structural investigation. Bioconversion assays indicated that BaCYP106A1 catalyzes the hydroxylation of progesterone and androstenedione, whereas no or low conversion was observed with 11β-hydroxysteroids such as cortisol, corticosterone, dexamethasone, and prednisolone. In addition, the crystal structure of BaCYP106A6 was determined at a resolution of 2.8 Å to investigate the configuration of the substrate-binding site and understand substrate preference. This structural characterization and comparison with other bacterial steroid hydroxylase CYPs allowed us to identify a unique Arg295 residue that may serve as the key residue for substrate specificity and regioselectivity in BaCYP106A6. This observation provides valuable background for further protein engineering to design commercially useful CYP steroid hydroxylases with different substrate specificities.

• Journal of Technology Innovation
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• v.9 no.1
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• pp.167-187
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• 2001

Bioindustry is rapidly changing. Many biologists redefine biotechnlolgy as 'reprogramming the genetic codes of living things to suit cultural and economic needs and desires.'We regarded this change as the 'paradigm shift'in bioindustry. The genome research is reorganizing agricultural and environmental industries as well as a pharmaceutical industry. By analysing patent data granted in the United States from 1997 to 1999, we tried to explore the international patterns and trends of technological innovation in bioindustry, especially in the genome research. As the result, we could find that the United States'monopolistic position in the bioindustry was consolidated by the genome research. Competitive positions in the countries such as Japan and Germany, however, have been aggravated continuously. Korean inventors weren't also active in many biotechnological areas as comparing to developed countries such as US and UK. Especially, the gaps between Korea and developed countries in genome research were greater than any other areas.

• Journal of Distribution Science
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• v.17 no.7
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• pp.99-109
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• 2019

Purpose - The purpose of this development the business model of the healthcare sector in order to promote patents satisfaction towards medical sector services improvement for the medical business model innovation to possess a competitive advantage in the medical and pharmaceutical industry. Research design, data, and methodology - Safety standard protocol from existing multidisciplinary literature is a process of theorization, which uses grounded theory methodology rather than a description of the data and the targeted phenomenon by using Jabareen (2009). The first task is to map the spectrum of food safety literature regarding the phenomenon in safety management. This process includes developing the implementation factors and other sources such as existing business models and practices into the protocol design. Results - The study suggests the conceptual framework to improve the safety management for patients' environmental sustainability performance. Conclusion - The business model may support the beneficial aspect to healthcare government's policymakers, hospital employees, and medical specialist who can apply the practical perspective of its value regarding an educational protocol. Originality/value - This study contributes to and extends our understanding of environmental sustainability performance, identifying the rationale for safety standards performance in the healthcare industry with suggested hybrid safety standards market consumer interconnector.