• 한국자원식물학회지
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• 제32권6호
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• pp.714-722
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• 2019

Oxidative DNA damage negatively affects humans and the research is currently ongoing to find ways to reduce oxidative stress. Oxidative stress has been identified as a key factor in triggering various diseases. Thus, its alleviation is important for human health. Broussonetia kazinoki (B. kazinoki) has been used in traditional Korean medicine as a dermatological therapy to treat burns, pruritus, and acne. B. kazinoki is generally segregated into peeled root (PR), root bark (RB), peeled stem (PS), and stem bark (SB). To assess these components for their antioxidant activity and protection against DNA damage, their ethyl acetate fractions were examined by 1,1-diphenyl-2-picryl hydrazyl (DPPH) and 2,2'-Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radical scavenging assay. As a result of confirming the expression of factors involved in attenuating DNA damage, the protective effect of SB on oxidative stress suppressed the expression of p-p53 and γ-H2AX. Additionally, the levels of p53 and H2AX mRNA were significantly downregulated. In conclusion, these results indicated that the SB component of B. kazinoki had the potential to be used as an effective natural antioxidant compared to the other parts of the plant.

• 한국산업융합학회 논문집
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• 제20권4호
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• pp.345-350
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• 2017

Saponin is the most pharmaceutical active ingredients of the ginseng plant, it was called "Ginsenoside" which means the Glycoside of ginseng that composed glycosides and aglycones. The human body will absorb the saponin easily if these substrate was decomposed by active microorganism. Fermentation is the most convenient technique to decompose this active ingredients. The purpose of this research was to study the sugar content, pH and acidity development during the ginseng fermentation process. Fresh Korean ginseng and red ginseng extract was used as the main ingredient. The concentrated of pure ginseng extract was added to increase the saponin extract. Furthermore, the mix microbial powder was added as starter to increase the fermentation efficiency. The ginseng was fermented in fermentation chamber at temperature $37^{\circ}C$ during 70 days. In the end of experiment the sugar content was decreased from 24% to 7.65%, The pH was decreased from 6.5 to 3.4, and the acidity level was incresed from 0% to 1.2%.

• Journal of Plant Biotechnology
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• 제44권2호
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• pp.191-202
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• 2017

Chemical compounds from four different tissues of the kenaf plant (Hibiscus cannabinus), a valuable medicinal crop originating from Africa, were examined to determine its potential for use as a new drug material. Leaves, bark, flowers, and seeds were harvested to identify phytochemical compounds and measure antioxidant activities. Gas chromatography mass spectrometry analyses identified 22 different phytocompounds in hexane extracts of the different parts of the kenaf plant. The most abundant volatile compounds were E-phytol (32.4%), linolenic acid (47.3%), trisiloxane-1,1,1,5,5,5-hexamethyl-3,3-bis[(trimethylsilyl)oxy] (16.4%), and linoleic acid (46.4%) in leaves, bark, flowers, and seeds, respectively. Ultra-high performance liquid chromatography identified the major compounds in the different parts of the kenaf plant as kaemperitrin, caffeic acid, myricetin glycoside, and p-hydroxybenzoic acid in leaves, bark, flowers, and seeds, respectively. Water extracts of flowers, leaves, and seeds exhibited the greatest DPPH radical scavenging activity and SOD activity. Our analyses suggest that water is the optimal solvent, as it extracted the greatest quantity of functional compounds with the highest levels of antioxidant activity. These results provide valuable information for the development of environmentally friendly natural products for the pharmaceutical industry.

• 대한한의학방제학회지
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• 제20권2호
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• pp.187-197
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• 2012

Objectives : The purpose of this study is to find a reasonable solution to a current status of drug classification between the drugs of western conventional (allopathic) medicine and Korean medicine. A clear and distinct concept on the drugs of allopathic medicine and Korean medicine based on reasonable concepts and broad consensus is a pressing issue in Korea, and will facilitate the development of herbal medicinal products and pharmaceutical industry. Methods : Considering the issue of drug classification from domestic and international regulations, we reviewed the current Drug Law of Korea and China, Guidance for Industry, Botanical Drug Products of USA, Directive 2004/24/EC of the European parliament and of the council. Results : In Korea, the drug classification of allopathic medicine and Korean medicine is quite vague even though differential licensure system is enforced for the clinicians of allopathic medicine and Korean medicine field. According to the definition in the Drug Law, the scope of Korean medicine drug is so broad that even a drug made of single-compound material, as well as herbal extract of crude mixture, is regarded as a drug of Korean medicine, as long as the material may be separated from medicinal herbs, animal tissues, or mineral resources. Only new compound not found in natural resources are outside of the scope of Korean medicine drug. In USA and EU, medicinal products manufactured from herbs are approved by separate regulations for the herbs with special waivers. In China, the category of new medicine and the definition of allopathic medicine and traditional chinese medicine are clearly specified and classified. Conclusions : As medicines are validated therapeutic materials for efficacy and toxicity, we suggest that generally the concept of conventional medicines is based on a single compound that has been synthesized and individually validated and that of Korean medicines is based on a compound extracted from natural materials or a complex of compounds that has been validated as a whole in its totality.

• Preventive Nutrition and Food Science
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• 제12권4호
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• pp.209-216
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• 2007

To investigate the applicability as the functional food materials of germinated Glycine max Merr soybeans, its biochemical characteristics and its abilities to inhibit platelet aggregation and hydrolyze alcohol were examined. With the progression of germination time, crude protein content gradually increased, and on the 5th day of germination it was 30.19%. However, crude fat content tended to decrease, and on the 5th day of germination it was 14.30%. Total amino acid content was highest on the 3rd day of germination at 80,875 mg%. The free amino acid content doubled from day 0 of germination (1,273.35 mg%) until the 5th day of germination (2,742.99 mg%). Fatty acid analysis revealed that linoleic acid was highest among all the samples, ranging from $53.55{\sim}56.00%$. Linolenic acid content slightly increased as the germination period was prolonged. The ability to inhibit platelet aggregation increased according to the germination period and then decreased again on the 5th day of germination; it was somewhat higher in the ethanol fraction. In measuring ADH, we found that the activity of the ethanol fraction increased with increasing days of germination. In the case of the water fraction, the activity decreased as germination was prolonged, and the ADH activity of the water fraction was higher than that of the ethanol fraction. Based on the above results, we deemed that the Glycine max Merr soybeans germinated for $2{\sim}3$ days were most pertinent for use as functional food materials.

• 대한설비공학회:학술대회논문집
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• 대한설비공학회 2008년도 동계학술발표대회 논문집
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• pp.611-617
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• 2008

Nowadays Plate Heat Exchanger (PHE) is widely used in different industries such as chemical, food and pharmaceutical process and refrigeration due to the efficient heat transfer performance, extreme compact design and efficient use of the construction material. In present study, discussed main conception of plate heat exchanger and applied in vacuum. PHE and aimed apply in the fresh water generator which installed in ship to desalinate seawater to fresh water use heat from engines. The experiment is proceeded to investigate the heat transfer between cold and hot fluid stream at different flow rate and supply temperature of hot fluid. Generated fresh water as outcome of the system. PHE is an important part of a condensing or evaporating system. One of common assumptions in basic heat exchanger design theory is that fluid is to be distributed uniformly at the inlet of each fluid side and throughout the core. However, in practice, flow mal-distribution is more common and can significantly reduce the heat exchanger performance. The flow and heat transfer are simulated by the k-$\varepsilon$ standard turbulence model. Moreover, the simulation contacted flow maldistribution in a PHE with 6 channels.

• 한국재료학회지
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• 제34권7호
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• pp.341-354
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• 2024

Today, the principles of green chemistry are being fundamentally applied in the chemical industry, such as the nitrobenzene industry, which is an essential intermediate for various commercial products. Research on the application of response surface methodology (RSM) to optimize nitrobenzene synthesis was conducted using a sulfated silica (SO₄/SiO₂) catalyst and batch microwave reactor. The nitrobenzene synthesis process was carried out according to RSM using a central composite design (CCD) design for three independent variables, consisting of sulfuric acid concentration on the silica (%), stirring time (min), and reaction temperature (℃), and the response variable of nitrobenzene yield (%). The results showed that a three-factorial design using the response surface method could determine the optimum conditions for obtaining nitrobenzene products in a batch microwave reactor. The optimum condition for a nitrobenzene yield of 63.38 % can be obtained at a sulfuric acid concentration on the silica of 91.20 %, stirring time of 140.45 min, and reaction temperature of 58.14 ℃. From the 20 experiments conducted, the SO₄/SiO₂ catalyst showed a selectivity of 100 %, which means that this solid acid catalyst can potentially work well in converting benzene to nitrobenzene.

• 인삼문화
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• 제2권
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• pp.27-38
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• 2020

개성은 고려인삼의 메카다. 개성이 고려인삼의 대표 브랜드가 된 배경은 복합적이다. 인삼 재배에 적합한 천혜의 자연조건에 개성의 막강한 상업자본과 증포소 설치가 물적 토대라면 개성상인의 단합과 근검, 실리주의, 창의적인 상업제도 등 인적 토대가 결합하면서 개성은 한국 인삼의 본산지가 되었다. 개성 인삼의 부흥을 끌어온 개성상인으로 손봉상, 김원배(金元培), 공성학(孔聖學), 김정호(金正浩), 박우현(朴宇鉉) 등을 들 수 있다. 개성 삼업을 주도한 이들은 인삼경작법과 병충해 방제법을 보급하고 관립종삼회사를 설립, 종자보존을 하고 영농자금 선불제를 도입하는 등 현대적 경영기법을 선보였다. 그 중 인삼 대왕으로 칭송되는 손봉상(孫鳳祥)의 생애를 조명함으로써 개성 인삼 상인의 업적을 살펴본다. 1927년에 발간된 '조선인회사, 대상점사전(朝鮮人會社 大商店辭典)'에 "손봉상은 개성 인삼경작계의 원로이며 그의 손에 의하여 발명된 인삼 제품도 적지 않다. 이 인삼 경작업은 손씨가의 전래지업(傳來之業)이나 손봉상에 의하여 대성되었다"고 소개되어있다. 손봉상의 주요한 업적은 첫째, 인삼에 적부병(赤腐病)이 발생하여 인삼경작이 절망(絶望)에 빠졌을 때 종삼회사(種蔘會社)를 창립, 우량한 종삼(種蔘)을 재배하였고 둘째, 종삼 심사 제도를 도입하여 우량 종삼 확보 제도를 확립시켰고 셋째, 개성삼업조합(開城蔘業組合)을 창설해 경작자금 저리 융자, 종삼의 개량, 병충해 예방, 경작법 개량 등을 시행하였고 넷째 개성인삼동업조합(開城人蔘同業組合)을 창립해 인삼의 성가(聲價)를 회복시켰다. 그는 삼업에서 모은 자본을 바탕으로 각종 회사 설립에 참여하여 주도적 역할을 했다. 1912년 10월 합자회사 영신사(永信社)를 개성의 거상인 김원배(金元培), 공성학(孔聖學), 김정호(金正浩), 박우현(朴宇鉉)과 함께 설립하여 사장에 취임하였고, 상품의 도산매·위탁판매, 창고업과 금융업을 경영하였다. 또 개성의 전기 보급을 위하여 1917년 4월 개성상인들과 합작으로 전기주식회사를 설립하여 취체역을 맡는 등 다양한 기업 활동을 했다. 개성 인삼 상인들은 삼업의 발전뿐만 아니라 상업자본을 산업자본으로 연결하는 시대적 선구자 역할을 함으로써 한국의 근대화에 큰 역할을 했다.

• Journal of Plant Biotechnology
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• 제4권3호
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• pp.103-107
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• 2002

The Good Agriculture Practice (GAP) program, being established in China, is an optimal way for the sustainable utilization of the medicinal plant and animal resources. Most frequently used Chinese materia medica will be mainly produced from the GAP bases in the future. To assure the successful operation of GAP program, standard operating procedure (SOP) should be implemented for specific plants or animals. Both GAP and SOP include the requirements in many aspects from the ecological environment of cultivation place, germplasm and varieties, seedling and transplant, fertilization, irrigation, and field care, to harvest and process, package, transport and storage. As a complex system, GAP demands strong commitment from the pharmaceutical industry, local administrative involvement, long term R&D support, and years of time of development before a satisfactory result can be achieved.

• 제어로봇시스템학회논문지
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• 제11권9호
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• pp.810-815
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• 2005

As the pharmaceutical industry grows and becomes more competitive, the need of automation increases to establish effective mass production and to maintain consistent quality control. Accurate counting and packing of medicinal pills is one of the most essential processes that the automation can benefit. In conventional automated counting and packing processes, the performance of counting process varies with the size, the shape and the dispersion degree of pills. In this research, the authors developed a new pill-counting algorithm based on carefully analyzed characteristics of the pill-drop behavior. Also a new scheme for the packing of an exact number of pills has been implemented. A pill counting and packing machine with the new pill-counting algorithm and the new packing scheme has been constructed and put in an actual production line. To achieve precise and quick sensing of pills dropping at a high speed from the preceding processors, the machine uses non-contact photo sensors. Experimental results from the actual process using the machine are included to verify the effectiveness of the proposed algorithm and the machine.