• 대한가정학회지
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• 제29권1호
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• pp.13-25
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• 1991

We measured change of peripheral skin temperature and mean skin temperature when the upper arm and thigh are pressured in order to know the effect of skin pressure applied by clothing on blood circulation. After release from pressure, we observed also recovery condition. At the same time, we examined relation between pressure and a feeling of thightness. Three physiques of healthy females, namely slender, standard and plump, served as subjects. We used continuous restraint method with skin pressure applied by experimental fabric for 10 min. As a result of this experiment, we obtained following findings. 1. The significant difference was marked at the pressure, measuring time and physique with change of skin temperature under upper arm restraint. The peripheral and mean skin temperature decreased with the lapse of restraint time. A remarkable tendency observed according to the increase of restraint pressure. Recovery condition after release from pressure not yet recovered to original state, for all after a lapse of 10 min. 2. The significant difference was marked at the pressure, measuring time and physique with change of skin temperature under thigh restraint, especially different physique was remarkable among them. The peripheral skin temperature decreased or decreased. Recovery condition after release from pressure was the same upper arm. 3. Main factor affecting the evaluation of a feeling of tightness was restraint pressure. The value of pressure sensation made remarkable declined after a lapse of 10 min restraint time. Individual differences, however, were shown in pressure sensation.

• International Journal of Internet, Broadcasting and Communication
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• 제9권4호
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• pp.8-13
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• 2017

Movement technique is comprised of the movement status of the circulation differentiation rate (CDR) and rotation differentiation rate (RDR) on the shiver movement form. Condition of the differentiation rate by the shiver movement form is to be modified the teetering movement system. As to fix the movement of signal on the material of body, we compared a shiver value of the circulation differentiation rate on the circulation state. The concept of rotation differentiation rate was identified the reference of rotation differentiation signal and rotation differentiation signal by the rotation state. For detecting a alteration of the CDR-RDR of the maximum and average in terms of the movement form, and shiver movement value that was a shiver value of the top alteration of the Top-ф$_{MAX-AVG}$ with $12.80{\pm}1.27units$, that was a shiver value of the peripheral alteration of the Per-ф$_{MAX-AVG}$ with $4.38{\pm}1.15units$, that was a shiver value of the limbus alteration of the Lim-ф$_{MAX-AVG}$ with $1.65{\pm}0.25units$, that was a shiver value of the center alteration of the Cen-ф$_{MAX-AVG}$ with $0.25{\pm}0.01units$. The teetering movement will be to assess at the ability of the movement form for the control degree of differentiation rate on the CDR-RDR that was shown the circulation and rotation form by the differentiation rate system. Teetering differentiation system was modified of a form by the special movement and was included a shiver data of teetering movement rate.

• 대한한의학회지
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• 제23권2호
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• pp.164-179
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• 2002

Object: Death rate due to hypertension, atherosclerosis, ischemic heart disease and cerebral infarction induced by Westernized diet and increased average life span is on the rise. Decrease in blood circulation, activation of thrombus generation and intravascular lipid accumulation, cited as the principal causes of the above mentioned diseases in recent studies, result in circulatory disturbance and blood vessel obstruction leading to ischemic cell death of heart, brain and peripheral vessels. Method: We investigated the biochemical changes in microvascular permeability, aggregation of platelet and the intravascular lipid accumulation in induced-diabetic rat using Streptozotocin. We also studied the effects of Woohwangcheongsirn-won after oral administration on blood circulation, platelet function and lipid metabolism. The results are as follows: I. Woohwangcheongsim-won increased blood circulation in microvessels. 2. Woohwangcheongsim-won increased the reduced erythrocyte deformability in diabetes. 3. Woohwangcheongsim-won induced the reduction of contents of 2, 3-DPG, but failed to affect the reduced contents of ATP in erythrocyte in diabetes. 4. Woohwangcheongsim-won reduced the activity of Ca/sup 2+/-ATPase in the membrane of erythrocyte. 5. Woohwangcheongsim-won reduced the platelet aggregation evoked by platelet agglutinin factor. 6. Woohwangcheongsim-won reduced the production of platelet-derived granules. 7. Woohwangcheongsim-won reduced the production of metabolites of arachidonic acid in diabetes, and also reduced the production of increased thromboxane B2. 8. Woohwangcheongsim-won reduced the synthesis of oxidized LDL-cholesterol. In conclusion, Woohwangcheongsim-won enhanced blood circulation in microvesseles, erythrocyte deformability and inhibited the increased platelet aggregation and the synthesis of oxidized LDL-cholesterol in diabetes. Therefore Woohwangcheongsim-won is believed to positively affect blood circulation (J Korean Oriental Med 2002;23(2):164-179)

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.282.2-283
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• 2002

In situ and circulating estrogen is the most important endocrine hormone that promotes the growth of hormone-dependent breast cancer. Consequently. decrease of estrogen on in situ and circulation can inhibit breast cancer. Estrogen is mainly produced by the ovary in premenopausal women and by peripheral tissues such as adipose tissues in postmenopausal women. The cytochrome p450 (CYP19), aromatase. is a key enzyme in the synthesis of estrogen hormones. (omitted)

• 대한기계학회:학술대회논문집
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• 대한기계학회 2002년도 학술대회지
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• pp.9-10
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• 2002

Human circulatory system between heart and tissue is not directly connected in normal condition but mandatory to go through the capillary system in order to fulfill its physiologic aim to deliver oxygen and nutrients, etc. to the tissue and retrieve used blood together with waste products from the tissue properly. When abnormal connection between arterial and venous system (AV fistula), these two circulatory systems respond differently to the hemodynamic impact of this abnormal connection between high pressure (artery) and low pressure (vein) system. Depending upon the location and/or degree (e.g. size and flow) of fistulous condition, each circulatory system exerts different compensatory hemodynamic response to this newly developed abnormal inter-relationship between two systems in order to minimize its hemodynamic impact to own system of different hemodynamic characteristics. Pump action of the heart can assist the failing arterial system directly to maintain arterial circulation against newly established low peripheral resistance by the AV fistula during the compensation period, while it affects venous system in negative way with increased venous loading. However, the negative impact of increased heart action to the venous system is partly compensated by the lymphatic system which is the third circulatory system to assist venous system independently with different hemodynamics. The lymphatic system with own unique Iymphodynamics based on peristaltic circulation from low resistance to high resistance condition, also increases its circulation to assist the compensation of overloaded venous system. Once these compensation mechanisms should fail to fight to newly established hemodynamic condition due to this abnormal AV connection, each system start to show different physiologic ${\underline{de}compensation}$ including heart and lymphatic system. The vicious cycle of decompensation between arterial and vein, two circulatory system affecting each other by mutually negative way steadily progresses to show series of hemodynamic change throughout entire circulation system altogether including heart. Clinical outcome of AV fistula from the compensated status to decompensated status is closely affected by various biological and mechanical factors to make the hemodynmic status more complicated. Proper understanding of these crucial biomechanical factors iii particular on hemodyanmic point of view is mandatory for the advanced assessment of biomechanical impact of AV fistula, since this new advanced concept of AY fistula based on blomechanical information will be able to improve clinical control of the complicated AV fistula, either congenital or acquired.

• Journal of Chest Surgery
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• 제12권3호
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• pp.174-182
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• 1979

This is a report on four cases of successful surgical correction of coarctation of the aorta [COA] in Department of the Thoracic & Cardiovascular Surgery, Hanyang University Hospital. The first case was a postductal type of coarctation of the aorta associated with Patent ductus arteriosus [PDA], Persistent left superior vena cava [LSVC] and richly developed collateral circulation. Blood pressure was measured to be hypertensive at the arm, but hypotensive at the legs. The coarctation of the aorta was corrected with following procedure: Partial resection of the aortic wall with diaphragmatic structure lust above and below the coarctating line of the aorta, and then the defect of the aortic wall was closed by lateral aortographic suture. PDA was closed by ligation procedure. The second case a preductal type of coarctation of the aorta associated with PDA, LSVC, ventricular septal defect [VSD] and poorly developed collateral circulation. Normal blood pressure was measured at the arm, but hypotension was observed at the legs. Correction of coarctation of the aorta was performed under the establishment of tube bypass because of poor collateral circulation. After resection of coarctating short segment, end to end anastomosis was performed without any tension. PDA was closed by division procedure. Simple suture closure of VSD was performed by open heart surgery two weeks after correction of COA. The third case was a long segment COA without any other anomaly. Blood pressure was measured to be hypertensive at the arm, but hypotensive at the legs. Vascular prosthesis was performed using Teflon graft tube after resecting coarctating long segment [6.5 cm] of the aorta. The fourth case was a long segment COA associated with aortic insufficiency and richly developed collateral circulation. Normal blood pressure was measured at the arm, but hypotension was observed at the legs. Vascular prosthesis was performed using Teflon graft tube after resecting coarctating long segment [6.0 cm] of the aorta. Both blood pressure and peripheral pulse on the arm and the legs returned to normal postoperatively in all patients.

• Journal of Digestive Cancer Research
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• 제11권1호
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• pp.21-29
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• 2023

Despite recent advancements in the diagnosis and treatment of pancreatic cancer, clinical results remain dismal. Furthermore, there are no reliable biomarkers or alternatives beyond carbohydrate antigen 19-9. Circulating tumor cells (CTCs) may be a potential biomarker, but their therapeutic application is constrained by their rarity in peripheral venous blood. Theoretically, the portal vein can be a more appropriate location for the detection of CTCs, because the first venous drainage of pancreatic cancer is portal circulation. According to several studies, the number and detection rate of CTCs may be higher in the portal blood than in the peripheral blood. CTC counts in the portal blood are strongly correlated with several prognostic parameters such as hepatic metastasis, recurrence after surgery, and survival. The phenotypic and genotypic properties analyzed in the captured portal CTCs can assist us to comprehend tumor heterogeneity and predicting the prognosis of pancreatic cancer. The investigations to date are limited by small sample sizes and varied CTC detection techniques. Therefore, a large number of prospective studies are required to confirm portal CTCs as a valid biomarker in pancreatic cancer.

• Clinical and Experimental Pediatrics
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• 제59권sup1호
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• pp.49-52
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• 2016

X-linked agammaglobulinemia (XLA) is a hereditary humoral immunodeficiency that results from Bruton's tyrosine kinase (BTK ) gene mutations. These mutations cause defects in B-cell development, resulting in the virtual absence of these lymphocytes from the peripheral circulation. Consequently, this absence leads to a profound deficiency of lg all isotypes, and an increased susceptibility to encapsulated bacterial infections. A 15-month-old Korean boy presented with recurrent sinusitis and otitis media after 6 months of age, and had a family history of 2 maternal uncles with XLA. Laboratory tests revealed a profound deficiency of Ig isotypes, and a decreased count of $CD19^+$ B cells in the peripheral circulation. Based on his family history and our laboratory test results, he was diagnosed with XLA. We performed BTK gene analysis of peripheral blood samples obtained from family members to confirm the diagnosis. Mutational analysis revealed a novel hemizygous frameshift mutation (c.82delC, p.Arg28Alafs*5), in the BTK gene. His mother and maternal grandmother were heterozygous carriers of this mutation and his two maternal uncles were hemizygous at the same position. After XLA diagnosis, intravenous immunoglobulin (400 mg/kg, monthly) treatment was initiated; recurrent sinusitis and otitis media were subsequently brought under control. To our knowledge, this is the first reported case of a Korean pedigree with a novel mutation in the BTK gene.

• 복식
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• 제16권
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• pp.173-185
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• 1991

We measured change of peripheral skin temperature and mean skin temperature when the upper arm and thigh pressured in order to know the effect of skin pressure applied by clothing on blood circulation. After release from pressure, we observed also recovery condition. At the same time, we examined relation between pressure and a feeling of tightness. Three physiques of healthy females, namely slender, standard and plump, served as subjects. We used intermittent method with skin pressure applied by experimental fabric at l-minute intervals. Besides we made a comparative study with results according to different restraint method (continuous method and intermittent method). As a result of this experiment, we obtained following findings. 1. The significant difference was marked at the pressure, measuring time, physique and measuring region with change of skin temperature under upper arm and thigh restraint by intermittent method. The peripheral skin temperature decreased with the lapse of restraint time. A remarkable tendency observed according to the. increase of restraint pressure. Recovery condition after release from pressure not yet recovered to original state, for all after a lapse of 10 min. The mean skin temperature decreased with the lapse of restraint time in case of upper arm restraint, it was not an obvious tendency except 60mmHg under thigh restraint. 2. Main factor affecting the evaluation of a feeling of tightness was restraint pressure, when the upper arm and thigh restraint by intermittent method. The respondence rate of 'very tight' grew larger according to the increase of restraint pressure. The value of pressure sensation declined after restraint ten times as compared with one time, but there was difference according to restraint pressure. 3. We reexamined change of skin temperature and feeling of tightness by different restraint method(continuous method and intermittent method). The results were as follows. 1) The skin temperature decreased more greatly during skin pressure by continuous method than intermittent method, especially in the peripheral. Without different restraint method, the skin temperature of slender plysique decreased more greatly than that of plump physique. 2) The value of pressure sensation by intermittent method was highly on both sites of upper arm and thigh.

• The Korean Journal of Physiology and Pharmacology
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• 제16권1호
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• pp.25-30
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• 2012

Under some pathological conditions as bile flow obstruction or liver diseases with the enterohepatic circulation being disrupted, regurgitation of bile acids into the systemic circulation occurs and the plasma level of bile acids increases. Bile acids in circulation may affect the nervous system. We examined this possibility by studying the effects of bile acids on gating of neuronal (N)-type $Ca^{2+}$ channel that is essential for neurotransmitter release at synapses of the peripheral and central nervous system. N-type $Ca^{2+}$ channel currents were recorded from bullfrog sympathetic neuron under a cell-attached mode using 100 mM $Ba^{2+}$ as a charge carrier. Cholic acid (CA, $10^{-6}M$) that is relatively hydrophilic thus less cytotoxic was included in the pipette solution. CA suppressed the open probability of N-type $Ca^{2+}$ channel, which appeared to be due to an increase in (no activity) sweeps. For example, the proportion of sweep in the presence of CA was ~40% at +40 mV as compared with ~8% in the control recorded without CA. Other single channel properties including slope conductance, single channel current amplitude, open and shut times were not significantly affected by CA being present. The results suggest that CA could modulate N-type $Ca^{2+}$ channel gating at a concentration as low as $10^{-6}M$. Bile acids have been shown to activate nonselective cation conductance and depolarize the cell membrane. Under pathological conditions with increased circulating bile acids, CA suppression of N-type $Ca^{2+}$ channel function may be beneficial against overexcitation of the synapses.