• 대한예방한의학회지
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• 제18권1호
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• pp.125-138
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• 2014

Objective : Polycan, exopolymers purified from Aureobasidium pullulans SM-2001 and calcium gluconate have been showed favorable inhibitory effects on the periodontitis and related alveolar bone losses through antioxidant and anti-inflammatory activities, respectively. In the present study, we intended to observe the possible synergic effects of mixed formula consisted of Polycan and calcium gluconate on ligation-induced experimental periodontitis and related alveolar bone losses in rats, and to select the fittest compositions for further developing as effective agents to ameliorate periodontal diseases. Method : Experiments were conducted as two separated two tests - first is synergic effects of Polycan and calcium gluconate 1:1, 1:9 and 9:1 mixtures, and second is 1:99, 2:98, 4:96, 8:92 and 1:9 mixtures. Experimental periodontal diseases were induced by ligature placed around the cervix of upper left incisior teeth of rats. One day after ligation placements, 200mg/kg of each single or mixed formulas of Polycan or/and calcium gluconate were orally administered for 10 days. The changes on the alveolar bone loss index and maxillary bone mineral density (BMD) were observed for detecting alveolar bone losses, and for anti-inflammatory effects, myeloperoxidase (MPO) activities and proinflammatory cytokine (tumor necrosis factor; TNF-${\alpha}$) contents were also evaluated in gingival tissues around ligature placed incisior teeth. The results of mixtures were compared with those of singe Polycan and calcium gluconate treated rat. Results : Each single or mixed formulas of Polycan or/and calcium gluconate favorably and significantly inhibited the inflammatory changes. The inhibitory effects of mixed formula consisted of Polycan and calcium gluconate 1:9 showed against periodontitis and related alveolar bone losses as compared with those of each Polycan and calcium gluconate single formula (p<0.05). In second experiment, Polycan and calcium gluconate 2:98, 4:96, 8:92 and 1:9 mixed formulas also showed significant increased anti-inflammatory and inhibitory effects against alveolar bone losses as compared with those of each single formula. Among them, Polycan and calcium gluconate 2:98 showed the highest efficacy against to ligation-induced experimental periodontitis and related alveolar bone losses. Conclusion : The results obtained in this study suggest that appropriated mixtures of Polycan and calcium gluconate showed synergic inhibitory effects against ligation-induced experimental periodontitis and related alveolar bone losses in rats. Moreover, Polycan and calcium gluconate 2:98 showed the highest efficacies in this experiment, suggesting the fittest composition for further developing as effective agents to ameliorate periodontal diseases.

• 한국치위생학회지
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• 제8권1호
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• pp.119-131
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• 2008

This study was peformed in order to find out the relationship between the causing factors and the production of each gas 01 oral malodor, to contribute the oral malodor control at dental clinic as well as to establish the effective application of malodor control project for public oral health program 127 patients from 20 to 40 years old who had been visited for preventive dental cares were participated for the study. Such items as caries status, periodontal status, salivary flow, viscosity, pH. Snyder test, plaque deposit and tongue plaque were checked through the oral examination in order to find out the contributing factors Hydrogen sulfide, Methyl mercaptan, Di-methyl sulfide and Ammonia gas components were checked with Oral-Chroma and Attain, the oral malodor check units. Not only the corelation coefficiencies but also the multi-way variance analysis were calculated between each causing factor and each component of oral malodor gases to estimate the contributing factors of the oral malodor. 1. There was no relationship between the caries status and each component pf the oral malodor such as sulfur compound or Ammonia, both in laboratory test and VAS test (pF0.05). It revealed negative relationship between Hydrogen sulfide and FT(rM-0.1904. pE0.05) as well as the VAS and FT (rM-0.210. pE0.05). S0, it was estimated that the less oral malador was recognized when caries state changed to filled state in Hydrogen sulfide laboratory test or VAS test 2. High relationship was showed between salivary flow and Hydrogen sulfide (rM-0.183, pM0.039), Methyl mercaptan(rM-0.234, p-0.008). Dimethyl sulfide(rM-0.234, pM0.008) and Ammonia(-0.361. pM0.001) gas(pE0.05). 3. There was a high relationship between M-PHP(Modified-Patient Hygiene Performance Index) and tong plaque all kinds of sulfide(rM0.249. pM0.005). Ammonia gas component(rM0.232, pM0.009). 4. It was found that considerable relationship was appeared between the periodontal status and Ammonia gas (rM0.274, pM0.002), so, it should be needed to control Ammonia. Such dental Cares as the prevention or early treatment of periodontal disease and the accelerating the salivary flow as well as reducing the amounts and activities of filament or spiral typed oral micro-organism were recommended for adults, not only for dental care program at the dental clinics but also for public health programs, in order to promote the oral health and quality of file for individual and community peoples.

• Journal of Periodontal and Implant Science
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• 제51권3호
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• pp.147-162
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• 2021

Purpose: This systematic review and meta-analysis was conducted to assess the effects of glycine powder air-polishing (GPAP) in patients during supportive periodontal therapy (SPT) compared to hand instrumentation and ultrasonic scaling. Methods: The authors searched for randomized clinical trials in 8 electronic databases for relevant studies through November 15, 2019. The eligibility criteria were as follows: population, patients with chronic periodontitis undergoing SPT; intervention and comparison, patients treated by GPAP with a standard/nozzle type jet or mechanical instrumentation; and outcomes, bleeding on probing (BOP), patient discomfort/pain (assessed by a visual analogue scale [VAS]), probing depth (PD), gingival recession (Rec), plaque index (PI), clinical attachment level (CAL), gingival epithelium score, and subgingival bacteria count. After extracting the data and assessing the risk of bias, the authors performed the meta-analysis. Results: In total, 17 studies were included in this study. The difference of means for BOP in patients who received GPAP was lower (difference of means: -8.02%; 95% confidence interval [CI], -12.10% to -3.95%; P<0.00001; I²=10%) than that in patients treated with hand instrumentation. The results of patient discomfort/pain measured by a VAS (difference of means: -1.48, 95% CI, -1.90 to -1.06; P<0.001; I²=83%) indicated that treatment with GPAP might be less painful than ultrasonic scaling. The results of PD, Rec, PI, and CAL showed that GPAP had no advantage over hand instrumentation or ultrasonic scaling. Conclusions: The findings of this study suggest that GPAP may alleviate gingival inflammation more effectively and be less painful than traditional methods, which makes it a promising alternative for dental clinical use. With regards to PD, Rec, PI, and CAL, there was insufficient evidence to support a difference among GPAP, hand instrumentation, and ultrasonic scaling. Higher-quality studies are still needed to assess the effects of GPAP.

• 대한소아치과학회지
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• 제43권4호
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• pp.354-364
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• 2016

청소년기 구강건강 상태를 파악하고 그에 따른 치과치료 필요도를 평가할 목적으로, 양산시 소재 중고등학교에 재학중인 14-17세 청소년 2,062명을 대상으로 임상검사 및 설문조사를 시행하여 다음과 같은 결론을 얻었다. 치아우식증의 치료필요도는 66.7%, 치아침식증의 치료필요도는 27.8%, Molar incisor hypomineralization(MIH)의 치료필요도는 14.7%였다. 부정교합은 양호한 교합 군 67.8, 치료 불필요 군 19.7%, 약간의 치료가 필요한 군 6.8%, 치료가 반드시 필요한 군 4.5%, 가장 심한 부정교합 군 1.1%로 나타났고, 치료필요도는 12.5%였다. 치주질환은 71.2%의 유병률을 보였고, 치료 필요도도 이와 동일한 71.2%였다. 측두하악장애는 무증상 군 67.1%, 경미한 증상 군 13.4%, 심한 증상 군 19.5%의 분포를 보였으며, 치료필요도는 20.6%로 나타났다. 가장 높은 치료 필요도를 보인 질환은 치주질환이었고, 뒤를 이어 치아우식증, 치아침식증, MIH, 측두하악장애, 부정교합의 순으로 나타났다. 본 연구 결과를 통해 청소년의 전반적 구강건강상태 및 치과치료 필요도를 파악할 수 있었고, 이는 우리나라 청소년 구강건강 증진을 위한 계획수립에 있어서 기초자료로서 기여하게 되기를 기대되는 바이다.

• 대한수의학회지
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• 제58권2호
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• pp.87-94
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• 2018

This study assessed the effects of Weissella cibaria (W. cibaria) CMU on oral health in male and female beagles (n = 18) by measuring oral malodor and periodontal disease-related parameters (calculus, plaque, and gingivitis indices). Oral malodor and indicators of periodontal disease were assessed in five treatment groups: negative control (scaling and 0.24 mg of maltodextrin, n = 3), positive control (0.24 mg of maltodextrin, n = 3), and W. cibaria CMU groups (each n = 4) at low (CMU-L, $2{\times}10^7$ colony forming unit [CFU]), medium (CMU-M, $2{\times}10^8CFU$), and high (CMU-H, $2{\times}10^9CFU$) concentrations. After feeding with W. cibaria CMU for 6 weeks, total volatile sulfur compound concentrations in the CMU-L ($2.0{\pm}1.04ng/10mL$), CMU-M ($2.4{\pm}1.05ng/10mL$), and CMU-H ($2.6{\pm}1.33ng/10mL$) groups were significantly lower than in the positive control group ($3.2{\pm}1.65ng/10mL$). Also, CMU-L ($1.4{\pm}0.83ng/10mL$) and CMU-H ($1.9{\pm}1.14ng/10mL$) groups had methyl mercaptan levels lower than that in the positive control group ($2.4{\pm}1.21ng/10mL$) at week 2. The plaque index was significantly lower in the CMU-H group ($4.5{\pm}0.28$) than in the positive control group ($5.9{\pm}1.08$) at week 6. W. cibaria CMU could be useful as a novel oral hygiene probiotics for reducing volatile sulfur compounds production and inhibiting plaque growth in companion animals.

• Journal of Periodontal and Implant Science
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• 제44권3호
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• pp.126-133
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• 2014

Purpose: Smokeless tobacco-based oral-use products like gutka are popular in India. Gutka usage leads to increased periodontal destruction and inflammation; however, the relevant mechanism remains unknown. This study aimed to elucidate the role of gutka in periodontitis by examining its effect on the levels of interleukin (IL) $1{\beta}$ and IL-8 from the gingival crevicular fluid (GCF). Methods: A total of 45 patients were enrolled in this study. Thirty patients with periodontitis (15 gutka chewers [GCP] and 15 nongutka chewers [NGC]) and 15 periodontally healthy controls (HC) were selected. The full-mouth plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAL), and recession (RC) were recorded. The IL-$1{\beta}$ and IL-8 levels in the GCF of all subjects were assessed through an enzyme-linked immunosorbent assay (Quantikine). Results: The IL-$1{\beta}$ and IL-8 levels were not significantly higher in the GCP group (IL-$1{\beta}$, $369.01{\pm}273.44{\mu}L$; IL-8, $205.97{\pm}196.78{\mu}L$) as compared to those in the NGC group (IL-$1{\beta}$, $195.57{\pm}96.85{\mu}L$; IL-8, $178.61{\pm}149.35{\mu}L$). More gingival RC and loss of attachment was seen among the GCP group (RC: $2.02{\pm}0.31$, P=0.013; CAL: $4.60{\pm}0.56$, P<0.001) than among the NGC group (RC, $1.21{\pm}1.15$; CAL, $3.70{\pm}0.32$); however, PD was deeper among the NGC subjects (P=0.002). PI and GI were significantly higher for the periodontitis group (P<0.001) when compared to the HC, but there was no difference among gutka chewers and non-chewers (P=0.22 and P=0.89). A positive correlation was found between the IL-8 levels and the duration of gutka chewing (r=-0.64, P<0.01). Conclusions: Gutka chewing leads to increased gingival RC and clinical loss of attachment. There was no effect seen in the proinflammatory cytokine levels in the GCF of gutka users.

• Journal of Periodontal and Implant Science
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• 제29권3호
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• pp.539-553
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• 1999

The purpose of this 6-months study was to compare the clinical and radiographic outcomes following guided tissue regeneration treating human mandibular Class II furcation defects with a bioabsorbable BioMesh barrier(test treatment) or a nonabsorbable ePTFE barrier(control treatment). Fourteen defects in 14 patients(mean age 44 years) were treated with BioMesh barriers and ten defects in 10 patients(mean age 48 years) with ePTFE barriers. After initial therapy, a GTR procedure was done. Following flap elevation, root planing, and removal of granulation tissue, each device was adjusted to cover the furcation defect. The flaps were repositioned and sutured to complete coverage of the barriers. A second surgical procedure was performed at control sites after 4 to 6 weeks to remove the nonresorbable barrier. Radiographic and clinical examinations(plaque index, gingival index, tooth mobility, gingival margin position, pocket depth, clinical attachment level) were carried out under standardized conditions immediately before and 6 months after surgery. Furthermore, digital subtraction radiography was carried out. All areas healed uneventfully. Surgical treatment resulted in clinically and statistically equivalent changes when comparisons were made between test and control treatments. Changes in plaque index were 0.7 for test and 0.4 for control treatments; changes in gingival index were 0.9 and 0.5. In both group gingival margin position and pocket depth reduction was 1.0mm and 3.0mm; clinical attachment level gain was 1.9mm. There were no changes in tooth mobility and the bone in radiographic evaluation. No significant(p${\leq }$0.05) difference between the two membranes could be detected with regard to plaque index, gingival index, gingival margin position, pocket depth, and clinical attachment level. In conclusion, a bioabsorbable BioMesh membrane is effective in human mandibular Class II furcation defects and a longer period study is needed to fully evaluate the outcomes.

• 한국콘텐츠학회논문지
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• 제14권8호
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• pp.257-265
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• 2014

본 연구는 주관적 치주건강인식 수와 진료내용(임플란트, 교정진료, 일반진료)에 따른 행복지수를 파악하고, 구강보건측면의 영향요인을 파악함으로써 구강보건관리 프로그램을 개발하여 행복지수를 향상시킬 수 있는 기초자료를 제공하고자 한다. 부산.경남지역에 위치한 치과병 의원에 내원한 환자를 대상으로 2013년 3월부터 약 7개월간 총 400명을 대상으로 실시하여 불성실한 응답 16명을 제외하고 최종적으로 384명을 대상으로 하여 진료내용에 따른 행복지수는 단일문항(p<0.001), 5문항(p=0.037) 모두 교정치료를 받는 경우 높았고, 임플란트 진료를 받는 경우 낮았다. 주관적 치주건강인식 수에 따른 행복지수는 단일문항, 5문항 행복지수 모두 구강증상이 없는 경우 높았고(p<0.001), 주관적 건강상태와 주관적 구강건강 상태에서 매우 건강하다고 인식할수록 행복지수가 높았다(p<0.001). 단일문항 행복지수에 영향요인은 소득이 많을수록(${\beta}$=0.198), 주관적 건강상태가 좋을수록(${\beta}$=0.340) 행복지수가 높았으며, 당뇨질환이 있을수록(${\beta}$=-0.103), 치주질환수가 많을수록(${\beta}$=-0.204) 행복지수가 낮게 나타났다. 5문항 행복지수에 영향요인은 연령이 높을수록(${\beta}$=0.241), 소득이 많을수록(${\beta}$=0.198), 진료내용이 일반일 때(${\beta}$=0.107), 주관적 건강상태가 좋을수록(${\beta}$=0.275), 주관적 구강건강상태가 좋을수록(${\beta}$=0.132) 행복지수가 높았으며, 치주질환수가 많을수록(${\beta}$=-0.195) 행복지수가 낮았다. 병 의원에 내원한 환자를 대상으로 주관적 구강건강 인식을 향상하기 위한 구강건강프로그램이 마련되어야할 것이다.

• 농촌의학ㆍ지역보건
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• 제21권1호
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• pp.75-84
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• 1996

대학 신입생들의 구강위생상태와 구강보건 인식도와의 관련성을 알아보기 위해 대구시내 모대학 신입생 남자 216명, 여자 205명 총 421명을 대상으로 1993년 4월 1일부터 4월 30일까지 구강검사를 실시하여 구강위생상태를 평가하고, 설문조사를 통해 치주질환 인식도를 조사하여 분석한 결과 다음과 같은 결론을 얻었다. 조사대상자들의 구강위생 상태는 421명 중 34.7%가 양호, 59.1%가 보통, 6.2%가 불량한 것으로 평가되었다. 성별 분포에서 여자의 구강위생상태는 41.9%가 양호, 4.4%가 불량하였고 남자의 경우는 27.8%가 양호, 7.8%가 불량하여 여자의 구강위생상태가 유의하게 양호하였다(p=0.006). 프라그 인식도에서 구강위 생상태가 양호한 군에서 52.1%, 불량한 군에서 15.4%가 치과질환 원인 세균막이라고 응답했으며, 치주질환 예방 인식도에 있어서 구강위생상태가 양호한 군에서는 91.8%가, 불량한 군에서는 15.4%가 치주질환은 예방가능한 것이라고 응답해 구강위생상태가 양보할 수록 치주질환 인식도는 유의하게 높았다(p=0.001). 스케일링 경험도는 구강위생상태가 양호한 군에서는 30.1%, 불량한 에서는 7.7%가 스케일링을 경험한 것으로 나타나 구강위생상태가 양호할수록 스케일링 경험도는 유의하게 높았다(p=0.023). 또한 스케일링이 치주건강에 미치는 영향에 대해 구강위생상태가 양호한 군에서 68.5%, 불량한 군에서 23.1%가 스케일링은 치주 건강에 도움이 된다고 인식하고 있어서 구강위생상태가 양호할 수록 인식도는 유의하게 높았다(p=0.001). 잇솔질 교육을 받은 경험은 구강위생상태가 양호한 군에서 86.2%이었고 불량한 군에서는 7.6%이었다. 또한 구강위생상태가 양호한 군에서의 잇솔질 빈도는 3회 이상이 53.4%로 가장 많았고, 구강위생상태가 양호한 군에서의 매 식후 잇솔질 빈도는 41.8%로 잇솔질 빈도와 잇솔질 시기는 구강위생상태와 유의하게 관련성이 있는 것으로 나타냈다(p=0.001). 구강위생지수와 관련성이 있으리라고 예상되는 변수를 선정하여 중회귀분석을 한 결과 잇솔질 빈도, 치주질환 예방에 관한 인식, 잇솔질 교육을 받은 경험, 잇솔질 시기가 구강위생상태에 영향을 미치는 것으로 나타났다(p=0.001). 구강위생상태를 향상시키기 위해서 올바른 잇솔질과 주기적인 치석제거의 중요성에 대한 구강보건교육이 필요하다고 사료된다.

• Journal of Periodontal and Implant Science
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• 제24권2호
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• pp.261-270
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• 1994

The purpose of this study was to evaluate relationship of probing attachment levels, radiographic measurements and surgical measurements according to gingival inflammatory condition. Patients with incipient to moderate periodontitis were selected. Upper and lower premolar and molar teeth excluding third molars were measured. At first visit, gingival index and bleeding on probing were taken, and subjects were grouped into 4 categories as follows : Experimental group I : gingival index 1 and no bleeding on probing. Experimental group II : gingival index 2 and no bleeding on probing absent. Experimental group III : gingival index 1 and bleeding on probing present. Experimental group IV : gingival index 2 and bleeding on probing present. Probing attachment levels were measured with manual probe on mesial and distal surfaces from cementoenamel junctions to terminal ends of probe. Radiographic measurements were made to assess bone loss by measuring the distance from cementoenamel junction to the alveolar crest. After thorough scating, a flap was raised exposing the alveolar bone and surgical measurements were made from cementoenamel junction to alveolar bone. The results were as follows: 1. Differences between probing attachment level and radiographic measurements showed $1.01{\pm}0.73mm$ for experimental group I, $0.98{\pm}0.48mm$ for experimental group II, $0.59{\pm}0.66mm$ for experimental group III, $0.98{\pm}0.38mm$ for experimental group IV and with no significant difference between groups. 2. Differences between probing attachment level and surgical measurements showed $1.36{\pm}0.80mm$ for experimental group I, $1.47{\pm}0.54mm$ for experimental group II, $1.06{\pm}0.39mm$ for experimental group III, $1.41{\pm}0.40mm$ for experimental group IV and with no significant difference between groups. 3. Differences between surgical and radiographic measurements showed $0.36{\pm}0.48mm$ for experimental group I, $0.51{\pm}0.54mm$ for experimental group II, $0.57{\pm}0.72mm$ for experimental group III, $0.41{\pm}0.49mm$ for experimental group IV and with significant difference between experimental group I and experimental group II, III, IV(P<0.05).