• 대한영상의학회지
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• 제85권2호
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• pp.428-433
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• 2024

이중 좌전하행 관상 동맥은 일반 인구에서 약 1%의 유병률을 보이는 드문 선천성 기형이다. 지금까지 이중 좌전하행 관상동맥 기형은 10가지 유형으로 보고되었다. 그중 제4형 이중 좌전하행 관상동맥은 가장 희귀한 유형 중 하나이다. 이중 좌전하행 관상동맥에 대한 지식과 인식은 정확한 진단과 관상동맥 우회 수술 및 경피적 관상동맥 중재술을 계획하는 데 중요하다. 저자들은 수개월 동안 소화불량과 발한을 주소로 내원하였고 짧은 좌전하행 관상동맥의 주요 대각분지에 약 50%-70% 협착이 있었던, 제4형 이중 좌전하행 관상동맥 기형을 가진 59세 남성의 증례를 보고하고자 한다.

• 수면정신생리
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• 제24권2호
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• pp.118-123
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• 2017

일반적으로 폐쇄성 수면 무호흡이 중추성 수면 무호흡보다 발생 비율이 높지만 심부전 환자에서는 체인-스토크스 호흡이 동반된 중추성 수면 무호흡이 흔하며, 실제로 심부전 환자에서 25~40%까지 중추성 수면 무호흡이 발생한다고 한다. 저자들은 호흡곤란으로 내원하여 심부전으로 진단된 환자가 관상동맥 중재술을 시행하고 난 이후 추적 시행한 심초음파 결과에 비해 주관적인 호흡곤란이 해결되지 않은 경우, 의료진의 자세한 병력 청취를 통해 환자가 평소 코골이와 수면 무호흡이 심하다는 소견을 바탕으로 조기에 수면 다원검사를 시행했다. 환자는 체인-스토크스 호흡을 동반한 중추성 수면 무호흡으로 진단 되어 지속적 상기도 양압술을 적용 후 호흡곤란 및 주간 졸림증이 호전 되었다. 심부전 환자에서 중추성 수면 무호흡이 동반된 경우, 피로감, 주간 졸림증 등과 같은 수면 무호흡의 일반적인 증상이 심부전 자체로 인한 증상으로 오인되어 중추성 수면 무호흡의 진단이 늦어 질 수 있으며, 이 경우 환자의 예후에 나쁜 영향을 끼칠 수 있다. 본 증례의 경우와 같이 심부전 환자의 치료 시 수면 무호흡을 의심할 만한 증상이 있는 경우 중추성 수면 무호흡의 동반 가능성을 염두해 두고 수면다원검사를 통해 중추성 수면 무호흡을 조기에 진단하는 것이 증상 호전 및 예후에 긍정적인 영향을 끼치는 것을 경험하였기에 보고하는 바이다.

• 대한의생명과학회지
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• 제17권4호
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• pp.329-336
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• 2011

The female has previously been shown to be an independent risk factor for mortality and morbidity after coronary artery bypass grafting surgery (CABG). The aim of this retrospective study is to evaluate gender differences of the perioperative outcomes in elderly patients underwent CABG. Data for seventy elderly patients (>70 years) that underwent CABG (between January 2005 and July 2011) were divided into two groups: male patients (n=33, male group) and female patients group (n=37, female group). Heights, body weights, body surface area and coronary artery obstruction rate (right coronary artery territory) in the female group were lower than those of the male group ($P$ <0.05). History of hypertension, hyperlipidemia, congestive heart failure and percutaneous coronary artery intervention in the female group was higher than that of the male group ($P$ <0.05). Total cholesterol and brain natriuretic peptide levels in the female group were higher than those of the male group ($P$ <0.05). Platelet count in the female group was higher than the male group at preoperative (Pre-OP) period ($P$ <0.05). Erythrocyte count, hematocrit and hemoglobin levels in the female group were lower than those of the male group at Pre-OP period ($P$ <0.05). But, erythrocyte count, hematocrit and hemoglobin levels in the female group were higher than those of the Male group at postoperative (Post-OP) period ($P$ <0.05). Left ventricular ejection fraction in the female group was higher than the male group at Post-OP period ($P$ <0.05). Hospital stay length in the female group was higher than the male group ($P$ <0.05). Post-OP bleeding volume and incidence of ventricular premature contraction in the female group were lower than those of the male group ($P$ <0.05). These results suggest that despite female gender have a greater risk factors and require a longer hospitalization than male, there was no significant difference incidence of mortality and complication.

• 한국전산유체공학회지
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• 제22권1호
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• pp.15-25
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• 2017

Swirl flow is often found in proximal coronary arteries, because the aortic valves can induce swirl flows in the coronary artery due to vortex formation. In addition, the curvature and tortuosity of arterial configurations can also produce swirl flows. The present study was performed to investigate fractional flow reserve alterations in a post-stenotic distal part due to the presence of pre-stenotic swirl flow by computational fluid dynamics analysis for virtual stenotic models by quantifying fractional flow reserve(FFR). Simplified stenotic coronary models were divided into those with and without pre-stenotic swirl flow. Various degrees of virtual stenosis were grouped into three grades: mild, moderate, and severe, with degree of stenosis of 0 ~ 40%, 50 ~ 60%, and 70 ~ 90%, respectively. In this study, three-dimensional computational hemodynamic simulations were performed under hyperemic conditions in virtual stenotic coronary models by coupling with a zero-dimensional lumped parameter model. The results showed that the influence of pre-stenotic swirl inflow is dominant on FFR alteration in mild stenosis, whereas stenosis is dominant on FFR alteration in moderate/severe stenosis. The decrease in FFR caused by swirl flow is more significant in mild stenosis than moderate/severe stenosis. Biomechanical modeling is useful for clinicians to provide insight for medical intervention strategies. This hemodynamic-based parameter study could play a critical role in the development of a non-invasive imaging-based strategy-support system for percutaneous transluminal angioplasty in cases of mild/moderate stenosis.

• 한국콘텐츠학회논문지
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• 제13권12호
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• pp.880-892
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• 2013

약물방출 스텐트 (drug-eluting stents, DES)는 일반금속 스텐트에 비하여 재협착을 현저하게 줄었지만, DES의 구조적인 특성으로 인한 스텐트 혈전증 (stent thrombosis, ST)이 증가한다고 알려져 있다. 혈전증 유형의 정의는 Early ST ; (EST)은 30일 이내, Late ST ; (LST)은 31일 이상에서 1년 이내 그리고 Very late ST ; (VLST)은 1년 이상으로 분류 하였다. 스텐트 세대별 (시장 출시와 스텐트 디자인, Polymer 향상에 따른) ST발생빈도, 임상 양상 및 예후를 알아보았다. 2003년 6월부터 2013년 6월까지의 전남대학교병원 심혈관센터에서 경피적 관상동맥 중재술을 시행 받은 10,273명 중 ST 발생은 134명 (1.30%) 이었다. 세대별 발생빈도는 1세대에서 81명 (0.79%)으로 높았으며, 세대별 ST 유형은 1세대에서는 VLST의 발생률이 높았고 (p=0.002), 2세대에서는 EST와 LST의 발생률이 높았지만 (p=0.025), 3세대에서는 유의한 차이가 없었다(p=0.278). ST로 인하여 사망한 14명은 EST 10명 (18.2%), LST 2명 (8.3%), VLST 2명 (3.6%)로서 EST에서 사망률이 높았다 (p=0.042). DES 시술 후 발생하는 ST는 1.3% 이였고, VLST는 1세대 스텐트에서 많았으며, 입원 중 사망률은 EST에서 높았다.

• 약학회지
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• 제51권3호
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• pp.186-193
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• 2007

This study was performed to analyse the economic value of abciximab which is used in PCI to prevent high-risk patients with ischemic complications. The effectiveness of abciximab was extracted from published clinical trials by search-ing CCIS, and the direct medical costs relevant to using abciximab were estimated from the NHI claims database. The results in terms of cost per life-year gained (LYG) and cost per QALY gained showed that abciximab was cost-effective enough to deserve its cost. Social net benefit resulting from abciximab in PCI was estimated to be 60-70 billion Won per year.

• 고신대학교 의과대학 학술지
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• 제33권2호
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• pp.235-239
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• 2018

A report of a 79 year old male patient suffering from acute myocardial infarction with Mallory-Weiss tear after successful cardiopulmonary resuscitation(CPR) by emergency medical technician in the swimming pool is presented. Successful percutaneous coronary intervention(PCI) was done after appropriate transfusion. The patient survived and discharged without major complications after admitting 11days in the hospital. Importance of CPR in AMI patient is reiterated as complication such as Mallory-Weiss tear may arise.

• Journal of Chest Surgery
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• 제46권6호
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• pp.433-438
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• 2013

Background: Surgical repair of post-infarct ventricular septal defect (VSD) is considered one of the most challenging procedures having high surgical mortality. This study aimed to evaluate the outcomes of the surgical repair of post-infarct VSD. Methods: From May 1991 to July 2012, 34 patients (mean age, $67.1{\pm}7.9$ years) underwent surgical repair of post-infarct VSD. A retrospective review of clinical and surgical data was performed. Results: VSD repair involved the infarct exclusion technique using a patch in all patients. For coronary revascularization, 12 patients (35.3%) underwent concomitant coronary artery bypass graft, 3 patients (8.8%) underwent preoperative percutaneous coronary intervention, and 9 patients (26.5%) underwent both of these procedures. The early mortality rate was 20.6%. Six patients (17.6%) required reoperation due to residual shunt or newly developed VSD. During follow-up (median, 4.8 years; range, 0 to 18.4 years), late death occurred in nine patients. Overall, the 5-year and 10-year survival rates were $54.4%{\pm}8.8%$ and $44.3%{\pm}8.9%$, respectively. According to a Cox regression analysis, preoperative cardiogenic shock (p=0.069) and prolonged cardiopulmonary bypass time (p=0.008) were independent predictors of mortality. Conclusion: The early surgical outcome of post-infarct VSD was acceptable considering the high-risk nature of the disease. The long-term outcome, however, was still dismal, necessitating comprehensive optimal management through close follow-up.

• 대한물리의학회지
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• 제12권2호
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• pp.9-20
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• 2017

PURPOSE: The purpose of this study is to understand the difference in the risk factors of coronary artery disease (CAD) between Korean and American CAD patients to determine the discriminant factor for each group, as well as to provide useful information to be reflected in the national concern of health. METHODS: Data were collected from 248 Korean and 107 American CAD patients who underwent either percutaneous coronary intervention or coronary artery bypass grafting. By using t-test and $X^2$-test, risk factors were compared between the Koreans and Americans. To elucidate which risk factor was the most discriminant for each group, logistic regression analysis was performed. RESULTS: All risk factors, except diastolic blood pressure, showed a significant difference between the two groups. $X^2$-test showed statistical significance with respect to the smoking rate between the female groups. Moreover, there was a statistically significant difference between the two groups regarding blood total cholesterol (TC) and triglyceride, and between the male groups, here was a statistically significant difference with respect to blood high-density lipoprotein cholesterol (HDL). Diabetes mellitus (DM) was the most discriminant factor for Korean patients while TC/HDL is the most discriminant for the Americans. CONCLUSION: The characteristics of CAD risk factors were determined to be different between Koreans and Americans in this study. TC/HDL was a discriminant factor for Americans while DM was a discriminant factor for Koreans. This result implies that DM should primarily be given attention to prevent CAD in Korean adults.

• The Korean Journal of Physiology and Pharmacology
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• 제27권2호
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• pp.143-155
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• 2023

Percutaneous coronary intervention and acute coronary syndrome are both closely tied to the frequently occurring complication of coronary microembolization (CME). Resveratrol (RES) has been shown to have a substantial cardioprotective influence in a variety of cardiac diseases, though its function and potential mechanistic involvement in CME are still unclear. The forty Sprague-Dawley rats were divided into four groups randomly: CME, CME + RES (25 mg/kg), CME + RES (50 mg/kg), and sham (10 rats per group). The CME model was developed. Echocardiography, levels of myocardial injury markers in the serum, and histopathology of the myocardium were used to assess the function of the cardiac muscle. For the detection of the signaling of TLR4/MyD88/NF-κB along with the expression of pyroptosis-related molecules, ELISA, qRT-PCR, immunofluorescence, and Western blotting were used, among other techniques. The findings revealed that myocardial injury and pyroptosis occurred in the myocardium following CME, with a decreased function of cardiac, increased levels of serum myocardial injury markers, increased area of microinfarct, as well as a rise in the expression levels of pyroptosis-related molecules. In addition to this, pretreatment with resveratrol reduced the severity of myocardial injury after CME by improving cardiac dysfunction, decreasing serum myocardial injury markers, decreasing microinfarct area, and decreasing cardiomyocyte pyroptosis, primarily by blocking the signaling of TLR4/MyD88/NF-κB and also reducing the NLRP3 inflammasome activation. Resveratrol may be able to alleviate CME-induced myocardial pyroptosis and cardiac dysfunction by impeding the activation of NLRP3 inflammasome and the signaling pathway of TLR4/MyD88/NF-κB.