Browse > Article
http://dx.doi.org/10.5392/JKCA.2013.13.12.880

Clinical Outcomes of Stent Thrombosis after Drug-Eluting Coronary Stent Implantation  

Kim, In-Soo (동신대학교 방사선학과)
Jeong, Myoung-Ho (전남대학교병원 심혈관센터)
Han, Jae-Bok (동신대학교 방사선학과)
Jang, Young Ill (광양보건대학교 방사선과)
Jang, Seong-Joo (동신대학교 방사선학과)
Publication Information
The Journal of the Korea Contents Association / v.13, no.12, 2013 , pp. 880-892 More about this Journal
Abstract
Stent thrombosis after successful drug-eluting stent(DES) implantation has been reported in around 1% of patients in clinical trials. However, the increased risk of ST associated with DES remains a matter of concern. From 1 June 2003 to 30 June 2013, we investigated clinical characteristics, in-hospital outcomes in 10,273 patients who underwent percutaneous coronary intervention in the Heart Center of CNUH. Overall incidence of ST was 1.30% (134 patients). The incidence of ST according to the stent generations and the timing of ST (n=total, early vs. late vs. very late) were 0.79% (n=81, 26 vs. 12 vs. 43) in first-generation, 0.38% (n=39, 21 vs. 9 vs. 9) in second-generation and 0.14% (n=14, 8 vs 3 vs. 3) in third-generation, (p=0.70). The mortality from ST was significantly higher in early ST group compared to the late and very late ST groups (18.2% vs. 8.3% vs. 3.6%, p=0.042). Overall incidence of ST after DES implantation was 1.30% (134 patients). The in-hospital mortality was significantly higher in early ST group compared to the late and very late ST groups.
Keywords
Drug-eluting Stents; Stent Thrombosis; Percutaneous Coronary Intervention;
Citations & Related Records
연도 인용수 순위
  • Reference
1 D. R. jr. Holmes, M. B. Leon, J. W. Moses, J. J. Popma, D. Cutlip, and P. J. Fitzgerald, "Analysis of 1-year clinical out comes in the SIRIUS trial: a randomized trial of a sirolimus -eluting stent versus a standard stent in patients at high risk for coronary restenosis," Circulation, Vol.109, pp.634-640, 2004.   DOI   ScienceOn
2 A. M. Salam, J. Suwaidi, and D. R. jr. Holmes "Drug-eluting coronary stents," Curr Probl Cardiol, Vol.31, pp.8-119, 2006.   DOI   ScienceOn
3 M. B. Leon and A. Bakhai, "Drug-eluting stents glycoprotein IIb/IIIa inhibitors combination therapy for the future," J. Am Heart, Vol.146, pp.S13-7, 2003.   DOI   ScienceOn
4 G. S. Mintz, A. Tinana, M. K. Hong, C. W. Lee, J. J. Kim, and N. E. Fearnot, "Impact of preinterventional arterial remodeling on neointimal hyperplasia after implantation of (non-polymer-encapsulated) paclitaxelcoated stents: a serial volumetric intravascular ultrasound analysis from the ASian Paclitaxel-Eluting Stent Clinical Trial (ASPECT)," Circulation, Vol.108, pp.1295-1298, 2013.
5 J. R. Nebeker, R. Virmani, C. L. Bennett, J. M. Hoffman, M. H. Samore, and J. Alvarez, "Hypersensitivity cases associated with drug-eluting coronary stents: a review of available cases from the Research on Adverse Drug Events and Reports (RADAR) project," J Am Coll Cardiol, Vol.47, pp.175-181, 2006.   DOI   ScienceOn
6 R. Virmani, A. Farb, G. Guagliumi, and F. D. Kolodgie, "Drug-eluting stents:caution and concerns for long-term outcome," Coron Artery Dis, Vol.15, pp.313-318, 2004.   DOI   ScienceOn
7 P. W. Serruys, B. van Hout, H. Bonnier, V. Legrand, E. Garcia, and C. "Macaya, Randomised comparison of implantation of heparin-coated stents with balloon angioplasty in selected patients with coronary artery disease (Benestent II)," Lancet, Vol.352, pp.673-681, 1998.   DOI   ScienceOn
8 B. L.van der Hoeven, S. S. Liem, and J. W. Jukema, "Sirolimus-eluting stents versus bare-metal stents in patients with ST -segment elevation myocardia infarction: 9-month angiographic and intravascular ultrasound results and 12-month clinical outcome results from the MISSION! Intervention Study," J Am Coll Cardiol, Vol.51, pp.618-626, 2008.   DOI   ScienceOn
9 N. Guo, A. Maehara, and G. S. Mintz, "Incidence, mechanisms, predictors and clinical impact of acute and late stent malapposition after primary intervention in patients with acute myocardial infarction:an intravascular ultrasound substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) trial," Circulation, Vol.122, pp.1077-1084.
10 G. Nakazawa, A. V. Finn, and M. Joner, "Delayed arterial healing and increased late stent thrombosis at culprit sites after drug-eluting stent placement for acute myocardial infarction patients an autopsy study," Circulation, Vol.118, pp.1138-1145, 2008.   DOI   ScienceOn
11 S. Cook, P. Wenaweser, M. Togni, M. Billinger, C. Morger, C. Seiler, R. Vogel, O. M. Hess, B. Meier, and S. Windecker, "Incomplete stent apposition and late stent thrombosis followingdrug-eluting stent implantation," Circulation, Vol.115, pp.2426-2434, 2007.   DOI   ScienceOn
12 R. Virmani, G. Guagliumi, A. Farb, G. Musumeci, N. Grieco, T. Motta, L. Mihalcsik, M. Tespili, O. Valsecchi, and F. D. Kolodgie, "Localized hypersensitivity and late coronary thrombosis secondary to a sirolimus-eluting stent," Circulation, Vol.109, pp.701-705, 2004.   DOI   ScienceOn
13 D. E. Cutlip, S. Windecker, and R. Mehran, "Clinical end points in coronary stent trials: a case for standardized definitions," Circulation, Vol.115, pp.2344-2351, 2007.   DOI   ScienceOn
14 J. R. Nebeker, R. Virmani, C. L. Bennett, J. M. Hoffman, M. H. Samore, J. Alvarez, C. J. Davidson, J. M. McKoy, D. W. WRaisch, B. K. Whisenant, P. R. S. M. Yarnold, D. P. Belknap, J. E. West, Gage, R. E. G. F. Morse Gligoric, L. Davidson, and M. D. Feldman, "Hypersensitivity cases associated with drug-eluting coronary stents," J Am Coll Cardiol, Vol.47, pp.175-181, 2006.   DOI   ScienceOn
15 M. J oner, A. V. Finn, A. Farb, E. K. Mont, F. D. Kolodgie, E. Ladich, R. Kutys, K. Skorija, H. K. Gold, and R. Virmani, "Pathology of drugeluting stents in humans," J Am Coll Cardiol, Vol.48, pp.193-202, 2006.   DOI   ScienceOn
16 I. S. Kim, N. G. Choi, J. B. Han, S. J. Jang, and Y. I. Jang, "Clinical outcome of stent thrombosis in patients with acute myocardial infarction," J. of Contents Association, Vol.12, No.7, pp.273-283, 2012.
17 D. E. Cutlip, D. S. Baim, K. K. Ho, J. J. Popma, A. J. Lansky, D. J. Cohen, J. P. jr Carrozza, M. S. Chauhan, O. Rodriguez, and R. E. Kuntz, "Stent thrombosis in the modern era: a pooled analysis of multicenter coronary stent clinical trials," Circulation, Vol.103, pp.1967-1971, 2001.   DOI   ScienceOn
18 J. M. Brennan, J. P. Curtis, D. Dai, S. Fitzgerald, A. K. Khandelwal, J. A. Spertus, S. V. Rao, M. Singh, R. E. Shaw, K. K. Ho, R. J. Krone, W. S. Weintraub, W. D. Weaver, and E. D. Peterson, "National Cardiovascular Data Registry. Enhanced Mortality Risk Prediction With a Focus on High-Risk Percutaneous Coronary Intervention: Results From 1,208,137 Procedures in the NCDR(National Cardiovascular Data Registry)," JACC Cardiovasc Interv, Vol.6, No.8, pp.790-799, 2013.   DOI   ScienceOn
19 K. W. Park, S. J. Hwang, D. A. Kwon, B. H. Oh, Y. B. Park, I. H. Chae, H. C. Gwon, S. J. Park, K. B. Seung, T. Ahn, J. H. Yoon, Y. S. Jang, M. H. Jeong, S. J. Tahk, and H. S. Kim, "Korea Stent Thrombosis Investigators. Characteristics and predictors of drug-eluting stent thrombosis" results from the multicenter 'Korea Stent Thrombosis (KoST)' registry," Circ J, Vol.75, pp.1626-1632, 2011.   DOI   ScienceOn
20 J. Daemen, P. Wenaweser, K. Tsuchida, L. Abrecht, S. Vaina, C. Morger, N. Kukreja, P. Jüni, G. Sianos, G. Hellige, R. T. van Domburg, O. M. Hess, E. Boersma, B. Meier, S. Windecker, and P. W. Serruys, "Early and late coronary stent thrombosis of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice: data from a large two-institutional cohort study," Lancet, Vol.369, pp.667-678, 2007.   DOI   ScienceOn
21 J. Daemen, P. Wenaweser, K. Tsuchida, L. Abrecht, S. Vaina, and C. Morger, "Early and late coronary stent thrombosis of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice: Data from a large two-institutional cohort study," Lancet, Vol.369, pp.667-678, 2007.   DOI   ScienceOn
22 G. W. Stone, J. W. Moses, S. G. Ellis, J. Schofer, K. D. Dawkins, and M. C. Morice, "Safety and efficacy of sirolimus- and paclitaxel-eluting coronary stents," N Engl J Med, Vol.356, pp.998-1008, 2007.   DOI   ScienceOn
23 L. Mauri, W. H. Hsieh, J. M. Massaro, K. K. Ho, R. D'Agostino, and D. E. Cutlip, "Stent thrombosis in randomized clinical trials of drug-eluting stents," N Engl J Med, Vol.356, pp.1020-1029, 2007.   DOI   ScienceOn
24 A. T. Ong, A. Hoye, J. Aoki, C. A. van Mieghem, G. A. Rodriguez Granillo, and K. Sonnenschein, "Thirty-day incidence and six-month clinical outcome of thrombotic stent occlusion after bare-metal, sirolimus, or paclitaxel stent implantation," J Am Coll Cardiol, Vol.45, pp.947-953, 2005.   DOI   ScienceOn
25 A. A. Bavry, D. J. Kumbhani, T. J. Helton, and D. L. Bhatt, "Risk of thrombosis with the use of sirolimus-eluting stents for percutaneous coronary intervention," Am J Cardiol, Vol.95, pp.1469-1472, 2005.   DOI   ScienceOn
26 I. Iakovou, T. Schmidt, E. Bonizzoni, L. Ge, G. M. Sangiorgi, and G. Stankovic, "Incidence, predictors and outcome of thrombosis after successful implantation of drug-eluting stents," JAMA, Vol.293, pp.2126-2130, 2005.   DOI   ScienceOn
27 A. A. Bavry, D. J. Kumbhani, T. J. Helton, and D. L. Bhatt, "What is the risk of stent thrombosis associated with the use of paclitaxel-eluting stents for percutaneous coronary intervention?," J Am Coll Cardiol, Vol.245, pp.941-946, 2005.
28 A. Kastrati, J. Mehilli, J. Pache, C. Kaiser, M. Valgimigli, and H. Kelbaek, "Analysis of 14 trials comparing sirolimus-eluting stents with bare-metal stents," N Engl J Med, Vol.356, pp.1030-1039, 2007.   DOI   ScienceOn
29 D. W. Park, S. W. Park, K. H. Park, B. K. Lee, Y. H. Kim, and C. W. Lee, "Frequency of and risk factors for stent thrombosis after drug-eluting stent implantation during long-term follow-up," Am J Cardiol, Vol.98, pp.352-356, 2006.   DOI   ScienceOn
30 A. T. Ong, A. Hoye, J. Aoki, C. A. van G. A. Mieghem, Rodriguez Granillo, and K. Sonnenschein, "Thirty-day incidence and six-month clinical outcome of thrombotic stent occlusion after bare-metal, sirolimus, or paclitaxel stent implantation," J Am Coll Cardiol, Vol.45, pp.947-953, 2005.   DOI   ScienceOn
31 J. M. Lasala, D. A. Cox, D. Dobies, K. Baran, W. B. Bachinsky, and E. W. Rogers, "Drug-eluting stent thrombosis in routine clinical practice: Two-year outcomes and predictors from the TAXUS ARRIVE registries," Circ Cardiovasc Interv, Vol.2, pp.285-293, 2009.   DOI   ScienceOn
32 F. Airoldi, A. Colombo, N. Morici, A. Latib, J. Cosgrave and L. Buellesfeld, "Incidence and predictors of drug-eluting stent thrombosis during and after discontinuation of thienopyridine treatment," Circulation, Vol.116, pp.745-754, 2007.   DOI   ScienceOn
33 G. G. Stefanini, B. Kalesan, P. W. Serruys, D. Heg, P. Buszman, A. Linke, T. Ischinger, V. Klauss, F. Eberli, W. Wijns, M. C. Morice, C. Di Mario, R. Corti, D. Antoni, H. Y. Sohn, P. Eerdmans, G. A. van Es, B. Meier, S. Windecker, and P. Juni, "Long-term clinical outcomes of biodegradable polymer biolimus-eluting stents versus durable polymer sirolimus-eluting stents in patients with coronary artery disease (LEADERS): 4 year follow-up of a randomised non-inferiority trial," Lancet, Vol.378, pp.1940-1948, 2011.   DOI   ScienceOn
34 Y. S. Ahn, J. H. Cho, D. H. Kim, Y. J. Hwang, H. M. Jung, and M. S. Choi, "A fatal case of simultaneous, very late thrombosis involving three drug-eluting stents in three coronary arteries," Korean Circ J, Vol.38, pp.564-569, 2008.   과학기술학회마을   DOI   ScienceOn
35 O. K. Siddiqi and D. P. Faxon, "Very late stent thrombosis: current concepts," Curr Opin Cardiol, Vol.27, pp.634-641, 2012.   DOI
36 K. Sudhir, J. B. Hermiller, J. M. Ferguson, and C. A. Simonton, "Risk Factors for Coronary Drug-Eluting Stent Thrombosis: Influence of Procedural, Patient, Lesion and Stent Related Factors and Dual Antiplatelet Therapy," ISRN Cardiol, Vol.748736, 2013(6).
37 H. Kitabata, J. P. Loh, L. K. Pendyala, S. Badr, D. Dvir, I. M. Barbash, S. Minha, R. Torguson, F. Chen, L. F. Satler, W. O. Suddath, K. M. Kent, A. D. Pichard, and R. Waksman, "Safety and efficacy outcomes of overlapping second generation everolimus eluting stents versus first generation drug eluting stents," Am J Cardiol, Vol.112, No.8, pp.1093-1098, 2013(10).   DOI   ScienceOn