• Journal of Pharmaceutical Investigation
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• 제40권spc호
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• pp.103-112
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• 2010

Pellets, which are multiple-unit dosage systems, have the several therapeutic advantages over single-unit dosage systems in oral drug delivery. This review focuses on the current status and explores extrusion-spheronization technique with special attention to controlled-release application of pellets including coated pellets for delayed release formulations, coated pellets for colon delivery, coated pellets for sustained drug delivery, sustained-release matrix pellets, pellets compressed into tablets, bioadhesive pellets, floating pellets, and pelletization with solubilization techniques.

• Journal of Forest and Environmental Science
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• 제30권4호
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• pp.362-369
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• 2014

This study investigated physical properties and combustion gas characteristics for 8 types of wood pellets (4 domestic and 4 imported products) distributed in the domestic market. Results showed that most pellet types were first-grade pellets in the wood pellet quality standards in Korea with the exception of 3 pellet types from K company (second-grade in mechanical durability), G company (off-grade in nitrogen content) and P company (second-grade in ash percentage). Mixed pellets which contained more lignin and sap content were higher in mechanical durability (%) than that of white pellets. From the combustion gas analysis results, NOx emitted from all pellets combustion was at acceptable levels for national emission standard of the Clean Air Conservation Act except for pellets from G company. In addition, CO levels from all types of wood pellets were acceptable except for pellets from D company and domestic pellets were higher CO levels than imported pellets. These results indicate the higher CO levels in domestic pellets due to the usage of forest thinning materials including logging debris which usually had the high content of bark.

• Fisheries and Aquatic Sciences
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• 제11권4호
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• pp.190-194
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• 2008

We estimated the digestibility and growth rate of juvenile olive flounder (Paralichthys olivaceus) on three diets: raw fish-based moist pellets, moist pellets, and extruded pellets. The diets were created using commercially available methods, and a basic formulated powder. A reference diet was used to compare feed digestibility and the fish growth rate achieved using the experimental diets. The apparent digestibility coefficients (ADCs) of protein for raw fish-based moist pellets and moist pellets were significantly higher (P<0.05) than those for extruded pellets and the reference diet. The ADCs of nitrogen-free extracts (NFE) of extruded pellets and moist pellets were significantly higher (P<0.05) than those for raw fish-based moist pellets and the reference diet. Fish that were fed with the raw fish-based moist pellets showed the greatest weight gain (452.4%), which was not significantly different from that of fish fed with extruded pellets (414.4%; P>0.05). These results indicate that the higher protein efficiency in fish fed with extruded pellets can result in good growth performance within flounder culture systems.

• Journal of the Korean Wood Science and Technology
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• 제50권2호
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• pp.126-133
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• 2022

In this study, I used wood pellets as an eco-friendly sound-absorbing material. The aim of the research was to analyze the effect of the filling height of wood pellets on sound absorption. This was done using two types of wood pellets of different lengths (A group: 1.5-3 cm, B group: less than 1.5 cm). With increasing filling height of the wood pellets, the optimum sound absorption shifted towards a lower frequency. The group B wood pellets had better sound absorption capacity than the group A ones. The optimum sound absorption coefficient of group A filled to a height of 7 cm was 0.722 at 864 Hz. On the other hand, that of group B filled to a height of 7 cm was 0.764 at 862 Hz, 5.82% higher than that of group A. While wood pellets are used as an eco-friendly fuel, the results of this study suggest the possibility of using wood pellets as an eco-friendly sound-absorbing material.

• 약학회지
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• 제39권6호
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• pp.593-599
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• 1995

Erythromycin was formulated as enteric-coated pellets in order to reduce degradation in stomach and gastromtestmal irritation, and to maximize the absorption in intestine followmg its oral administration. Core pellets were prepared using fluid-bed granulator with two different methods (powder layering and solvent spraying) and enteric-coated with two different coating polymers (HPMCP and Eudragit E30D). Physical characteristics md dissolution rates of core pellets and enteric-coated pellets were evaluated to optimize the formulation. Powder layering method resulted in shorter initial dissolution time than solvent spraying method, but physicochmical properties of the product were worse than solvent spraying method with respect to hardness, ftiability and density. The dissolution rate of the drug was increased with the addition of surfactants, showing concentration-dependence. The scanning electron microscopic observation of pellets revealed significant differences on the surface appearances prepared with solvent spraying method. The core pellet made with powder layering method had crystals on the surface, which resulted in poor physical properties of the pellets. The dissolution profiles of erythromycin pellets coated with HPMCP or Eudragit L30D were close to that of commercially available erythromycin enteric-coated product.

• Journal of the Korean Wood Science and Technology
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• 제39권3호
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• pp.258-268
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• 2011

본 연구는 낙엽송과 백합나무 톱밥을 이용한 펠릿의 제조 과정에서 톱밥의 크기 및 함수율, 펠릿제조 온도 및 성형시간이 펠릿의 내구성에 미치는 영향을 알아보기 위하여 수행하였다. 수종별 내구성의 비교에서 낙엽송 펠릿의 내구성이 백합나무 펠릿보다 높았으며, 낙엽송 펠릿의 경우 18 mesh (1.00 mm) 이상 크기의 톱밥으로 제조한 펠릿이 8~18 mesh (1.00~2.38 mm)의 톱밥으로 제조한 펠릿보다 내구성이 높았다. 펠릿제조 온도를 높이고 펠릿 성형시간을 연장함에 따라 펠릿의 내구성은 증가하였으며, 톱밥의 함수율이 올라감에 따라 펠릿의 내구성은 향상되는 것으로 나타났다. 한편, 본 연구에서 제조된 낙엽송 및 백합나무 펠릿은 대조구로 사용된 산림조합 및 일도에서 제조한 목재 펠릿보다 내구성은 낮았으나, 대부분의 낙엽송 펠릿은 국립산림과학원에서 고시한 목재펠릿의 내구성 1등급 기준(97.5%)을 만족하였으며, 백합나무 펠릿은 3등급 기준(95%)을 모두 상회하였다. 전자현미경을 이용한 펠릿의 관찰에서 펠릿제조 온도를 높이고 펠릿 성형시간을 연장함에 따라 펠릿내에서 톱밥 간의 거리가 감소하고, 특히 $180^{\circ}C$의 온도에서 3분의 성형시간으로 제조한 펠릿의 경우 대조구 시편과 크게 차이가 없는 것을 육안으로 확인할 수 있었다.

• The Korean Journal of Ceramics
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• 제5권3호
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• pp.245-249
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• 1999

A new type of nonthermal plasma reactor utilizing ferroelectric pellets is proposed to generate nonthermal plasma efficiently, which is used for simultaneous control of various pollutant gases. Electric charges stored on ferroelctric pellets by corona discharge between a corona tip and a mesh electrode provide partial electrical discharges among ferroelectric pellets. These partial electrical discharges can enhance partial discharges around the surface of ferroelectric pellets. This method utilizes wide reacting area of ferroelectric pellets and partial discharge. Positive and negative dc voltage are applied to the corona tip to generate partial discharges, and corona currents are estimated to investigate charge storage on ferroelectric pellets as function of time and charge relaxation time constants of ferroelectric pellects. As a result, charge relaxationtime, dielectric constants of ferroelectric pellets, polarity of applied voltage and applied time influence partial discharges among ferroelectric pellect.

• 한국환경보건학회지
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• 제19권1호
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• pp.77-89
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• 1993

Effects of fermented milk were tested in Sprague-Dawley male rats. In six treatment 150 rats were fed for 12 months: (1) normal control synthetic pellets+water, (2) cholesterol control synthetic pellets containing 1% of cholesterol and 500, 000 IU of vitamin D2/100 g (cholesterol pellets) +water, (3) cholesterol pellets+25% fermented milk, (4) cholesterol pellets+50% fermented milk, (5) cholesterol pellets+75% fermented milk, (6) cholesterol pellets+100% fermented milk. In 3, 6, 9, 12 months, rats were sacrificed for analysis of samples. Rats received the fermented milk had significantly lower (p<0.05) serum cholesterol levels and higher ratios of HDL-cholesterol to total cholesterol than did the water fed rats. Stomach, heart, abdominal aorta and kidney of rat from fermented milk group showed slighter calcification or necrosis than did those of rat from cholesterol control group. Weight gain, diet intake, and drink consumption were significantly different among groups. Results indicate that fermented milk had a helpful effect of experimental hypercholesteremia and atherosclerosis.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2003년도 춘계학술대회 논문집 유기절연재료 방전 플라즈마연구회
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• pp.57-60
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• 2003

This paper explained electric field distribution's characteristics of dielectric pellets with a shape of ball to voltage. When discharge gap of electrode and input voltage are each 20[mm], 10000[V], the electric field simulation results of dielectric pellets with a shape of ball with relative dielectric constant of several kind measured stronger electric field near electric pellets with a shape of ball of ${\phi}5$[mm] than $1{\phi}$[mm] and $3.33{\phi}$[mm] at atmosphere. And the maximum electric field of dielectric pellets with a shape of ball over ${\phi}5$[mm] increased about 5[%] to maximum electric field of electric pellets with a shape of ball ${\phi}5$[mm]. And the result of simulation, when relative dielectric constant of dielectric pellets with a shape of ball is 100, it measured about 90[%] of maximum electric field of dielectric pellets with a shape of ball with relative dielectric constant over 1000.

• Journal of Pharmaceutical Investigation
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• 제32권4호
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• pp.305-311
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• 2002

In order to evaluate the effect of poloxamer 407 content on the dissolution profiles of pellets, diltiazem HCl (DTL) core pellets were prepared with poloxamer 407 (50-90% w/w, with lactose as filler) using an extruder and a spheronizer. Any possible interaction between the drug and excipients was evaluated using DSC, IR and TLC. Dissolution tests were performed using USP basket method. In addition, scanning electron micrograph was performed to examine the surface roughness and cross sections. The release of DTL from the core pellets was decreased with increasing poloxamer 407 content. Cracks appeared on the surface of the core pellets with increasing the poloxamer 407 content, which may play a role on the retardation of the release of DTL from core pellets. There was no any significant interaction between the drug and excipients employed to prepare the core pellets.