Browse > Article
http://dx.doi.org/10.4333/KPS.2002.32.4.305

Effect of Poloxamer Content on Dissolution of Diltiazem Hydrochloride from Core Pellets  

Lee, Seung-Woo (ChoongWae Pharma Co.)
Kam, Sung-Hoon (College of Pharmacy, Sungkyunkwan University)
Hong, Ji-Woong (College of Pharmacy, Sungkyunkwan University)
Choi, Ki-Song (College of Pharmacy, Sungkyunkwan University)
Park, Eun-Seok (College of Pharmacy, Sungkyunkwan University)
Chi, Sang-Cheol (College of Pharmacy, Sungkyunkwan University)
Publication Information
Journal of Pharmaceutical Investigation / v.32, no.4, 2002 , pp. 305-311 More about this Journal
Abstract
In order to evaluate the effect of poloxamer 407 content on the dissolution profiles of pellets, diltiazem HCl (DTL) core pellets were prepared with poloxamer 407 (50-90% w/w, with lactose as filler) using an extruder and a spheronizer. Any possible interaction between the drug and excipients was evaluated using DSC, IR and TLC. Dissolution tests were performed using USP basket method. In addition, scanning electron micrograph was performed to examine the surface roughness and cross sections. The release of DTL from the core pellets was decreased with increasing poloxamer 407 content. Cracks appeared on the surface of the core pellets with increasing the poloxamer 407 content, which may play a role on the retardation of the release of DTL from core pellets. There was no any significant interaction between the drug and excipients employed to prepare the core pellets.
Keywords
Diltiazem HCl; Extrusion-spheronization; Pellets; Poloxamer;
Citations & Related Records
연도 인용수 순위
  • Reference
1 G.K. McEvoy, Diltiazem hydrochloride in AHFS Drug Information, American Society of Health-System Pharma- cists, Wisconsin, 1317-1324 (1998)
2 F. Carli, G. Capone, I. Colombo, L. Magarotto and A. Motta, Surface and transport properties of acrylic polymers influencing drug release from porous matrices, Int. J. Pharm., 21, 317-329 (1984)   DOI   ScienceOn
3 M. Lovrecich, F. Nobile, F. Rubessa and G. Zingone, Effect of ageing on the release of indomethacin from solid dispersion with Eudragits, Int. J. Pharm., 131, 247-255 (1996)   DOI   ScienceOn
4 R. Bianchini, G. Bruni, A. Gazzaniga and C. Vecchio, Influence of extrusion-spheronization processing on the physical properties of d-indobufen pellets containing pH adjusters, Drug Dev. Ind. Pharm., 18, 1485-1503 (1992)   DOI
5 S.L. Law, F.M. Lin and C.H. Chaing, Dissolution and absorption of nifedipine in polyethylne glycol solid dispersion containing phosphatidylcholine, Int. J. Pharm., 84, 161-166 (1992)   DOI   ScienceOn
6 C.M. Won and A.K. Iula, Kinetics of hydrolysis of diltiazem, Int. J. Pharm., 79, 183-190 (1992)   DOI   ScienceOn
7 O.I. Corrigan, E.M. Holohan and M.R. Reilly, Physico- chemical properties of indomethacin and related compounds co-spray dried with polyvinylpyrrolidone, Drug Dev. Ind. Pharm., 11, 677-695 (1985)   DOI
8 K. Uekama, T. Horikawa, Y. Horiuchi and F. Hirayama, In vitro and in vivo evaluation of delayed-release behavior of diltiazem from its O-carboxymethyl-O-ethyl-$\beta$-cyclodextrin complex, J. Contr. Rel., 25, 99-106 (1993)   DOI   ScienceOn
9 K. Klokkers-Bethke and W. Fisher, Development of a multiple unit drug delivery system for positioned release in the gastrointestinal tract, J. Contr. Rel., 15, 105-112 (1991)   DOI   ScienceOn
10 W.L. Rocco, C. Morphet and S.M. Laughlin, Solid-state characterization of Zanoterone, Int. J. Pharm., 122, 17-25 (1995)   DOI   ScienceOn
11 K.P.R. Chowdary and K.V.V.S. Babu, Dissolution, bioavailability and ulcerogenic studies on solid dispersions of indomethacin in water soluble cellulose polymers, Drug Dev. Ind. Pharm., 20, 799-813 (1994)   DOI   ScienceOn
12 S. Eerikainen, Effect of spheronization on some properties of uncoated and coated granules containing different kinds of fillers, Int. J. Pharm., 77, 89-106 (1991)   DOI   ScienceOn
13 K.E. Fielden, J.M. Newton and R.C. Rowe, The influence of lactose paricle size on spheronization of extrudate processed by a ram extruder, Int. J. Pharm., 81, 205-224 (1992)   DOI   ScienceOn
14 S. Eerikainen and A.S. Lindqvist, The behaviour of various fillers in spheronized uncoated and film-coated granules containing slightly water-soluble indomethacin, Int. J. Pharm., 75, 181-192 (1991)   DOI   ScienceOn