• Archives of Pharmacal Research
• /
• v.13 no.2
• /
• pp.180-186
• /
• 1990

A bioequivalence study of ranitidine tablets was conducted according to the Korean Guidine for the Bioequivalence Test using twelve healthy male subjects. The plasma concentration-timecurves of ranitidine from the test and reference tablets showed profound multiple peak phenomenon in each subject as reported earlier. However, the area under the plasma concentration-time curve (AUC) and the maximum ploasma concentration at the first peak ($C_{max1}$) of the two preparations was proven to be equal when analyzed satistically according to the criteria of the guidline;i. e., statistical power (1-$\beta$)was calculated to be over 0.8 under the condition of $\alpha$ = 5% and $\Delta$(minimum detectable difference) = 20%, and the confidence interval of the difference in AUC at 95% confidence level was in the range of $\pm$ 20%, which statisfied the criteria of bioequivalence. Equivalence of the peak concentration of ranitidine at the second peak ($C_{max2}$), and the time to reach the first ($T_{max1}$) and second verify the bioequivalence of $c_{max2}$ , $T_{max1}$ and $T_{max2}$ between the two tablets. However, we conclude that the test and reference tablets are bioequivalent taking the therapeutic characteristics of the ranitidine preparations into consideration.

• Bulletin of the Korean Chemical Society
• /
• v.23 no.4
• /
• pp.580-586
• /
• 2002

We investigated the effect of ionic component on crystalline morphology development during isothermal annealing in a sodium neutralized sulfonated poly(ethylene terephthalate) ionomer (Ion-PET) by time-resolved small-angle x-ray scattering (TR-SAX S) using synchrotron radiation. At early stage in Ion-PET, SAXS intensity at a low annealing temperature (Ta = 120 $^{\circ}C)$ decreased monotonously with scattering angle for a while. Then SAXS profile showed a peak and the peak position progressively moved to wider angles with isothermal annealing time. Finally, the peak intensity decreased, shifting the peak angle to wider angle. It is revealed that ionic aggregates (multiplets structure) of several nm, calculated by Debye-Bueche plot, are formed at early stage. They seem to accelerate the crystallization rate and make fine crystallites without spherulite formation (supported by optical microscopy observation). From decrease of peak intensity in SAXS,it is suggested that new lamellae are inserted between the preformed lamellae so that the concentration of ionic multiplets in amorphous region decreases to lower the electron density difference between lamellar crystal and amorphous region. In addition, analysis on the annealing at a high temperature (Ta = 210 $^{\circ}C)$ by optical microscopy, light scattering and transmission electron microscopy shows a formation of spherulite, no ionic aggregates, the retarded crystallization rate and a high level of lamellar orientation.

• Journal of Biosystems Engineering
• /
• v.23 no.1
• /
• pp.57-66
• /
• 1998

This study was conducted to investigate the relationships between parameters affecting internal quality of watermelon and its acoustic characteristics. The measuring and analyzing system was established to study the acoustic characteristics of watermelon. Algorithms for analyzing sound signals were developed. Sound signals which was detected with the microphone were filtered, and their spectrum was computed by means of the Fast Fourier Transform. As watermelon changed from the unripe stage to ripe, acoustic waves in time domain became complicated, and several components appeared in frequency domain. The correlationship was investigated between some parameters affecting internal quality of the watermelon and several peak frequencies. Results indicated that weight, density and sugar content had high correlations with several frequencies(the first peak frequency, the second peak frequency, and the third peak frequency). And the sugar content and the volume of the watermelon were highly correlated with the third peak frequency.

• Korean Journal of Applied Biomechanics
• /
• v.23 no.3
• /
• pp.225-233
• /
• 2013

The purpose of this study was to estimate the potential injury via analyzing ground reaction force components that were resulted from a prolonged-run-induced fatigue. For the present study, passive and active components of the vertical ground reaction force were determined from time and frequency domain. Shear components of GRF also were calculated from time and frequency domain. Twenty subjects with rear foot contact aged 20 to 30, no experience in injuries of the extremities, were requested to run on the instrumented tread-mill for 160 minutes at their preference running speed. GRF signals for 10 strides were collected at 5, 35, 65, 95, 125, and 155 minute during running. In conclusions, there were no significant difference in the magnitude of passive force, impact load rate, frequency of the passive and active components in vertical GRF between running times except the magnitude of active force (p<.05). The magnitude of active force was significantly decreased after 125 minute run. The magnitude of maximum peak and maximum frequency of the mediolateral GRF at heel strike and toe-off have not been changed with increasing running time. The time up to the maximum peak of the anteroposterior at heel-strike moment tend to decrease (p<.05), but the maximum peak and frequency of that at heel and toe-off moment didn't depend significantly on running time.

• Physical Therapy Rehabilitation Science
• /
• v.12 no.2
• /
• pp.130-139
• /
• 2023

Objective: This study aimed to analyze the effects and characteristics of the height of the treatment table on the force and time of ground reaction (GR) and contact hand (CH) generated from the therapist's feet to generate thrust during spinal manipulation (SM). Design: A cross-sectional survey study Methods: Thirty-six healthy subjects were recruited. SM was performed on the ilium using a knee-high table, where the therapist felt it was easy to control the subject's posture and body shape and comfortable to generate force, as well as a relatively high thigh-high table. The force and time generated by the therapist's GR and CH were simultaneously measured through a force plate. Results: As a result, there was a significant difference in peak force and rundown force at the therapist's GR according to the table height (p < 0.05). In the therapist's CH, there was a significant difference between PreMin (preload minimum) force and peak force (p < 0.05), and there was a significant difference between the time from PreMin to peak and the time of the entire section (p < 0.05). Conclusions: As a result, the generation of increased CH force and faster thrust duration were confirmed by mobilizing the reduced GR force of the therapist to generate thrust than the relatively high table on the knee-high table.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.31 no.1D
• /
• pp.7-15
• /
• 2011

The travel time value is important factor for the evaluation of feasibility the transportation facility investment. The existing method for calculation of the travel time for each mode uses daily average trip purpose. So the value of travel time is constant because it is estimated with only daily average proportion. This daily constant time value can distort the results of future demands of toll roads or economic appraisals for the projects. The proportion of the trip purpose varies by time periods. Accordingly the value of travel time also varies by time periods. In this study, times periods are classified as morning peak, evening peak, business time off-peak, and non-business time off-peak. And trip purpose proportions are sorted by each time period from raw data of Seoul household trip study, then the value of travel time for each time period is estimated with these sorted purpose proportions. A case study of Seoul Jung-gu and Yongsan-gu performed with newly estimated time value by time periods. The result of benefit calculation with the daily constant time value is overestimated approximately annual 2.5 billion Won compared by time values by time periods. The demands of toll roads are also overestimated with the existing daily constant time value by daily 3,500 vehicles and total revenue of toll roads are overestimated by annually 1 billion Won. In conclusion, the value of travel time by each time period enables the more precise economic evaluation of the transportation facility investment projects, mode choice behavior, and route choice behavior especially for toll roads.

• Restorative Dentistry and Endodontics
• /
• v.24 no.2
• /
• pp.265-285
• /
• 1999

The purposes of this investigation were to observe the reaction kinetics of five commercial dual cured resin cements (Bistite, Dual, Scotchbond, Duolink and Duo) when cured under varying thicknesses of porcelain inlays by chemical or light activation and to evaluate the effect of the porcelain disc on the rate of polymerization of dual cured resin cement during light exposure by using thermal analysis. Thermogravimetric analysis(TGA) was used to evaluate the weight change as a function of temperature during a thermal program from $25{\sim}800^{\circ}C$ at rate of $10^{\circ}C$/min and to measure inorganic filler weight %. Differential scanning calorimetry(DSC) was used to evaluate the heat of cure(${\Delta}H$), maximum rate of heat output and peak heat flow time in dual cured resin cement systems when the polymerization reaction occured by chemical cure only or by light exposure through 0mm, 1mm, 2mm and 4mm thickness of porcelain discs. In 4mm thickness of porcelain disc, the exposure time was varied from 40s to 60s to investigate the effect of the exposure time on polymerization reaction. To investigate the effect on the setting of dual cured resin cements of absorption of polymerizing light by porcelain materials used as inlays and onlays, the change of the intensity of the light attenuated by 1mm, 2mm and 4mm thickness of porcelain discs was measured using curing radiometer. The results were as follows 1. The heat of cure of resin cements was 34~60J/gm and significant differences were observed between brands (P<0.001). Inverse relationship was present between the heat of reaction and filler weight % the heat of cure decreased with increasing filler content (R=-0.967). The heat of reaction by light cure was greater than by chemical cure in Bistite, Scotchbond and Duolink(P<0.05), but there was no statistically significant difference in Dual and Duo(P>0.05). 2. The polymerization rate of chemical cure and light cure of five commercially available dual cured resin cements was found to vary greatly with brand. Setting time based on peak heat flow time was shortest in Duo during chemical cure, and shortest in Dual during light cure. Cure speed by light exposure was 5~20 times faster than by chemical cure in dual cured resin cements. The dual cured resin cements differed markedly in the ratio of light and chemical activated catalysts. 3. The peak heat flow time increased by 1.51, 1.87, and 3.24 times as light cure was done through 1mm, 2mm and 4mm thick porcelain discs. Exposure times recommended by the manufacturers were insufficient to compensate for the attenuation of light by the 4mm thick porcelain disc. 4. A strong inverse relationship was observed between peak heat flow and peak time in chemical cure(R=0.951), and a strong positive correlations hip was observed between peak heat flow and the heat of cure in light cure(R=0.928). There was no correlationship present between filler weight % or heat of cure and peak time. 5. The thermal decomposition of resin cements occured primarily between $300^{\circ}C$ and $480^{\circ}C$ with maximum decomposition rates at $335^{\circ}C$ and $440^{\circ}C$.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.23 no.1
• /
• pp.237-244
• /
• 2009

We investigated the effects of acupuncture stimulation on pulse wave variables and heart rate variability (HRV) in healthy adults. To evaluate twenty healthy volunteers (10 men, 10 women) had acupuncture into both Hapkok (Ll4) and Taechung (Liv3) for 15 minutes. Radial pulse, Heart Rate Variability, body temperature and blood pressure were checked before and after acupuncture to evaluate Pulse Wave Variability and Autonomous Function. The results were as follows; Heart rate was significantly increased while systolic blood pressure (mmHg) and diastolic blood pressure (mmHg) were significantly increased after acupuncture treatment. Sixteen subjects didn't change representative pulse wave variables after acupuncture treatment. Energy, height of main peak (H1), height of pre-dicrotic valley (H2) and height of descending valley (H4) were decreased while height of dicrotic peak (H5) was significantly decreased after acupuncture treatment. Time to main peak (T1), time to pre-dicrotic valley (T2), time to dicrotic peak (T5), total time (T) and T-T4 were decreased while time to descending valley (T4) was increased after acupuncture treatment. Total area (At), area of main peak (Aw) and ratio of diastolic period area (Ad) were decreased while ratio of systolic period area (As) and angle of main peak (MPA) were increased after acupuncture treatment. The standard deviation of all normal RR intervals (SDNN) was increased while the root mean square of successive differences between the normal heart beats (RMSSD) was significantly increased after acupuncture treatment by time domain analysis. Low frequency power (LF) and LF/HF ratio were decreased while high frequency power (HF) was significantly increased after acupuncture treatment by frequency domain analysis. This study suggests that acupuncture treatment changes pulse wave variability and heart rate variability. Further study on various acupuncture treatment for pulse wave variability and heart rate variability is required.

• Journal of the Korean Society of Environmental Restoration Technology
• /
• v.11 no.5
• /
• pp.79-91
• /
• 2008

Research was initiated to investigate germination characteristics of creeping bentgrass (CB, Agrostis palustris Huds.). Seven varieties of CB were evaluated with different experiments. An alternative environment condition requiring for a CB germination test by International Seed Testing Association (ISTA) was applied in the Experiment I, consisting of 8-hr light at $25^{\circ}C$ and 16-hr dark at $15^{\circ}C$(ISTA conditions). Experiment II was conducted under a room temperature condition of 5 to $25^{\circ}C$(natural conditions). In each experiment, data such as seed germinating vigor, early germination characteristics, germination speed and germination peak time were measured. Significant differences were observed in seed germinating vigor, early germination characteristics, germination speed and germination peak time. Seed germinating vigor was variable with different environments and varieties. It was 61.50 to 98.25% under ISTA conditions and 55.00 to 98.50% under natural conditions. There were considerable variations in early germination characteristics among CB varieties according to different conditions. Early germination characteristics indicated that all varieties were 1 to 4 days faster in germination under ISTA conditions, when compared with natural conditions. The germination speed, measured as days to seed germination of 70% and 90%, was much faster with Penn A-1, Penn A-4 and Penncross under ISTA conditions. But it was even faster with L-93 and Penncross when grown under natural conditions. Differences were also observed in germination peak time with varieties and growing conditions. It was 0.57 to 2.86 days under ISTA conditions and 0.74 to 1.74 days under natural conditions. Regardless of the environment conditions, the shortest variety was L-93 and the longest one T-1. Considering germinating vigor, early germination characteristics, germination speed and germination peak time, Penn A-1, Penn A-4 and Penncross were regarded as excellent varieties under ISTA conditions in terms of early establishment characteristics, while L-93, Penn A-1 and Penncross under natural conditions. These results suggest that an intensive germination test be needed prior to planting, for the early germinating vigor, germination speed and germination peak time. Also, a proper variety selection and comprehensive site analysis for the growing environmental conditions should be done before golf course construction.

• The Journal of Society for e-Business Studies
• /
• v.24 no.4
• /
• pp.119-133
• /
• 2019

Recently, the importance prediction of photovoltaic power (PV) is considered as an essential function for scheduling adjustments, deciding on storage size, and overall planning for stable operation of PV facility systems. In particular, since most of PV power is generated in peak time, PV power prediction in a peak time is required for the PV system operators that enable to maximize revenue and sustainable electricity quantity. Moreover, Prediction of the PV power output in peak time without meteorological information such as solar radiation, cloudiness, the temperature is considered a challenging problem because it has limitations that the PV power was predicted by using predicted uncertain meteorological information in a wide range of areas in previous studies. Therefore, this paper proposes the LSTM (Long-Short Term Memory) based the PV power prediction model only using the meteorological, seasonal, and the before the obtained PV power before peak time. In this paper, the experiment results based on the proposed model using the real-world data shows the superior performance, which showed a positive impact on improving the PV power in a peak time forecast performance targeted in this study.