• Archives of Pharmacal Research
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• 제13권2호
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• pp.180-186
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• 1990

A bioequivalence study of ranitidine tablets was conducted according to the Korean Guidine for the Bioequivalence Test using twelve healthy male subjects. The plasma concentration-timecurves of ranitidine from the test and reference tablets showed profound multiple peak phenomenon in each subject as reported earlier. However, the area under the plasma concentration-time curve (AUC) and the maximum ploasma concentration at the first peak ($C_{max1}$) of the two preparations was proven to be equal when analyzed satistically according to the criteria of the guidline;i. e., statistical power (1-$\beta$)was calculated to be over 0.8 under the condition of $\alpha$ = 5% and $\Delta$(minimum detectable difference) = 20%, and the confidence interval of the difference in AUC at 95% confidence level was in the range of $\pm$ 20%, which statisfied the criteria of bioequivalence. Equivalence of the peak concentration of ranitidine at the second peak ($C_{max2}$), and the time to reach the first ($T_{max1}$) and second verify the bioequivalence of $c_{max2}$ , $T_{max1}$ and $T_{max2}$ between the two tablets. However, we conclude that the test and reference tablets are bioequivalent taking the therapeutic characteristics of the ranitidine preparations into consideration.

• Bulletin of the Korean Chemical Society
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• 제23권4호
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• pp.580-586
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• 2002

We investigated the effect of ionic component on crystalline morphology development during isothermal annealing in a sodium neutralized sulfonated poly(ethylene terephthalate) ionomer (Ion-PET) by time-resolved small-angle x-ray scattering (TR-SAX S) using synchrotron radiation. At early stage in Ion-PET, SAXS intensity at a low annealing temperature (Ta = 120 $^{\circ}C)$ decreased monotonously with scattering angle for a while. Then SAXS profile showed a peak and the peak position progressively moved to wider angles with isothermal annealing time. Finally, the peak intensity decreased, shifting the peak angle to wider angle. It is revealed that ionic aggregates (multiplets structure) of several nm, calculated by Debye-Bueche plot, are formed at early stage. They seem to accelerate the crystallization rate and make fine crystallites without spherulite formation (supported by optical microscopy observation). From decrease of peak intensity in SAXS,it is suggested that new lamellae are inserted between the preformed lamellae so that the concentration of ionic multiplets in amorphous region decreases to lower the electron density difference between lamellar crystal and amorphous region. In addition, analysis on the annealing at a high temperature (Ta = 210 $^{\circ}C)$ by optical microscopy, light scattering and transmission electron microscopy shows a formation of spherulite, no ionic aggregates, the retarded crystallization rate and a high level of lamellar orientation.

• Journal of Biosystems Engineering
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• 제23권1호
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• pp.57-66
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• 1998

This study was conducted to investigate the relationships between parameters affecting internal quality of watermelon and its acoustic characteristics. The measuring and analyzing system was established to study the acoustic characteristics of watermelon. Algorithms for analyzing sound signals were developed. Sound signals which was detected with the microphone were filtered, and their spectrum was computed by means of the Fast Fourier Transform. As watermelon changed from the unripe stage to ripe, acoustic waves in time domain became complicated, and several components appeared in frequency domain. The correlationship was investigated between some parameters affecting internal quality of the watermelon and several peak frequencies. Results indicated that weight, density and sugar content had high correlations with several frequencies(the first peak frequency, the second peak frequency, and the third peak frequency). And the sugar content and the volume of the watermelon were highly correlated with the third peak frequency.

• 한국운동역학회지
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• 제23권3호
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• pp.225-233
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• 2013

The purpose of this study was to estimate the potential injury via analyzing ground reaction force components that were resulted from a prolonged-run-induced fatigue. For the present study, passive and active components of the vertical ground reaction force were determined from time and frequency domain. Shear components of GRF also were calculated from time and frequency domain. Twenty subjects with rear foot contact aged 20 to 30, no experience in injuries of the extremities, were requested to run on the instrumented tread-mill for 160 minutes at their preference running speed. GRF signals for 10 strides were collected at 5, 35, 65, 95, 125, and 155 minute during running. In conclusions, there were no significant difference in the magnitude of passive force, impact load rate, frequency of the passive and active components in vertical GRF between running times except the magnitude of active force (p<.05). The magnitude of active force was significantly decreased after 125 minute run. The magnitude of maximum peak and maximum frequency of the mediolateral GRF at heel strike and toe-off have not been changed with increasing running time. The time up to the maximum peak of the anteroposterior at heel-strike moment tend to decrease (p<.05), but the maximum peak and frequency of that at heel and toe-off moment didn't depend significantly on running time.

• Physical Therapy Rehabilitation Science
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• 제12권2호
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• pp.130-139
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• 2023

Objective: This study aimed to analyze the effects and characteristics of the height of the treatment table on the force and time of ground reaction (GR) and contact hand (CH) generated from the therapist's feet to generate thrust during spinal manipulation (SM). Design: A cross-sectional survey study Methods: Thirty-six healthy subjects were recruited. SM was performed on the ilium using a knee-high table, where the therapist felt it was easy to control the subject's posture and body shape and comfortable to generate force, as well as a relatively high thigh-high table. The force and time generated by the therapist's GR and CH were simultaneously measured through a force plate. Results: As a result, there was a significant difference in peak force and rundown force at the therapist's GR according to the table height (p < 0.05). In the therapist's CH, there was a significant difference between PreMin (preload minimum) force and peak force (p < 0.05), and there was a significant difference between the time from PreMin to peak and the time of the entire section (p < 0.05). Conclusions: As a result, the generation of increased CH force and faster thrust duration were confirmed by mobilizing the reduced GR force of the therapist to generate thrust than the relatively high table on the knee-high table.

• 대한토목학회논문집
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• 제31권1D호
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• pp.7-15
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• 2011

통행시간가치는 교통시설 투자사업 시 통행시간 절감효과를 화폐단위로 환산하여 사업의 타당성을 판단하는데 있어 그 중요성이 매우 크다. 또한, 통행시간가치는 도로이용자가 유료도로를 이용할 때의 통행시간단축을 위해 어느 정도의 비용을 지불할 의사가 있는지를 나타내는 지표로서 장래수요예측 시 유료도로의 통행량 예측을 가능하게 한다. 현재 타당성조사 등 수요예측 시에 적용하는 통행시간가치는 기존에 추정한 목적별 시간가치를 이용하여 해당 지역의 전일 통행목적을 업무통행 및 비업무통행으로 구분한 후 이 비율에 따라 수단별 시간가치를 추정하고 있다. 하지만 실제로 시간대에 따라 통행목적의 비율이 상이하기 때문에 시간대별 통행시간가치가 달라짐에도 불구하고 일률적인 통행시간가치를 적용하여 이에 따른 장래 유료도로 이용 패턴 및 편익산정에 왜곡이 발생할 수 있다. 따라서 본 연구에서는 우선 분석시간대를 오전첨두, 오후첨두, 업무시간 비첨두 및 기타 비첨두시간으로 분류한 후 서울시 가구통행실태조사를 이용하여 화물차를 제외한 승용차, 버스 이용자의 시간대별 통행목적 비율을 분석하여 이를 이용하여 시간대별 통행시간가치를 추정하였다. 추정한 시간대별 통행시간 가치를 이용하여 서울 도심부에 대한 사례연구를 실시하였고 그 결과 시간대별 시간가치를 적용하였을 때, 기존 값을 적용했을 때에 비해 유료도로 연간수입이 약 25억원이 적게 산정되었고, 통행시간 절감편익 역시 기존 값을 적용했을 때에 비해 약 10억원이 적게 추정되어, 기존 전일평균 시간가치를 적용하였을 때 유료도로 이용과 편익이 과다추정되는 경향이 있다고 판단된다.

• Restorative Dentistry and Endodontics
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• 제24권2호
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• pp.265-285
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• 1999

The purposes of this investigation were to observe the reaction kinetics of five commercial dual cured resin cements (Bistite, Dual, Scotchbond, Duolink and Duo) when cured under varying thicknesses of porcelain inlays by chemical or light activation and to evaluate the effect of the porcelain disc on the rate of polymerization of dual cured resin cement during light exposure by using thermal analysis. Thermogravimetric analysis(TGA) was used to evaluate the weight change as a function of temperature during a thermal program from $25{\sim}800^{\circ}C$ at rate of $10^{\circ}C$/min and to measure inorganic filler weight %. Differential scanning calorimetry(DSC) was used to evaluate the heat of cure(${\Delta}H$), maximum rate of heat output and peak heat flow time in dual cured resin cement systems when the polymerization reaction occured by chemical cure only or by light exposure through 0mm, 1mm, 2mm and 4mm thickness of porcelain discs. In 4mm thickness of porcelain disc, the exposure time was varied from 40s to 60s to investigate the effect of the exposure time on polymerization reaction. To investigate the effect on the setting of dual cured resin cements of absorption of polymerizing light by porcelain materials used as inlays and onlays, the change of the intensity of the light attenuated by 1mm, 2mm and 4mm thickness of porcelain discs was measured using curing radiometer. The results were as follows 1. The heat of cure of resin cements was 34~60J/gm and significant differences were observed between brands (P<0.001). Inverse relationship was present between the heat of reaction and filler weight % the heat of cure decreased with increasing filler content (R=-0.967). The heat of reaction by light cure was greater than by chemical cure in Bistite, Scotchbond and Duolink(P<0.05), but there was no statistically significant difference in Dual and Duo(P>0.05). 2. The polymerization rate of chemical cure and light cure of five commercially available dual cured resin cements was found to vary greatly with brand. Setting time based on peak heat flow time was shortest in Duo during chemical cure, and shortest in Dual during light cure. Cure speed by light exposure was 5~20 times faster than by chemical cure in dual cured resin cements. The dual cured resin cements differed markedly in the ratio of light and chemical activated catalysts. 3. The peak heat flow time increased by 1.51, 1.87, and 3.24 times as light cure was done through 1mm, 2mm and 4mm thick porcelain discs. Exposure times recommended by the manufacturers were insufficient to compensate for the attenuation of light by the 4mm thick porcelain disc. 4. A strong inverse relationship was observed between peak heat flow and peak time in chemical cure(R=0.951), and a strong positive correlations hip was observed between peak heat flow and the heat of cure in light cure(R=0.928). There was no correlationship present between filler weight % or heat of cure and peak time. 5. The thermal decomposition of resin cements occured primarily between $300^{\circ}C$ and $480^{\circ}C$ with maximum decomposition rates at $335^{\circ}C$ and $440^{\circ}C$.

• 동의생리병리학회지
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• 제23권1호
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• pp.237-244
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• 2009

We investigated the effects of acupuncture stimulation on pulse wave variables and heart rate variability (HRV) in healthy adults. To evaluate twenty healthy volunteers (10 men, 10 women) had acupuncture into both Hapkok (Ll4) and Taechung (Liv3) for 15 minutes. Radial pulse, Heart Rate Variability, body temperature and blood pressure were checked before and after acupuncture to evaluate Pulse Wave Variability and Autonomous Function. The results were as follows; Heart rate was significantly increased while systolic blood pressure (mmHg) and diastolic blood pressure (mmHg) were significantly increased after acupuncture treatment. Sixteen subjects didn't change representative pulse wave variables after acupuncture treatment. Energy, height of main peak (H1), height of pre-dicrotic valley (H2) and height of descending valley (H4) were decreased while height of dicrotic peak (H5) was significantly decreased after acupuncture treatment. Time to main peak (T1), time to pre-dicrotic valley (T2), time to dicrotic peak (T5), total time (T) and T-T4 were decreased while time to descending valley (T4) was increased after acupuncture treatment. Total area (At), area of main peak (Aw) and ratio of diastolic period area (Ad) were decreased while ratio of systolic period area (As) and angle of main peak (MPA) were increased after acupuncture treatment. The standard deviation of all normal RR intervals (SDNN) was increased while the root mean square of successive differences between the normal heart beats (RMSSD) was significantly increased after acupuncture treatment by time domain analysis. Low frequency power (LF) and LF/HF ratio were decreased while high frequency power (HF) was significantly increased after acupuncture treatment by frequency domain analysis. This study suggests that acupuncture treatment changes pulse wave variability and heart rate variability. Further study on various acupuncture treatment for pulse wave variability and heart rate variability is required.

• 한국환경복원기술학회지
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• 제11권5호
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• pp.79-91
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• 2008

Research was initiated to investigate germination characteristics of creeping bentgrass (CB, Agrostis palustris Huds.). Seven varieties of CB were evaluated with different experiments. An alternative environment condition requiring for a CB germination test by International Seed Testing Association (ISTA) was applied in the Experiment I, consisting of 8-hr light at $25^{\circ}C$ and 16-hr dark at $15^{\circ}C$(ISTA conditions). Experiment II was conducted under a room temperature condition of 5 to $25^{\circ}C$(natural conditions). In each experiment, data such as seed germinating vigor, early germination characteristics, germination speed and germination peak time were measured. Significant differences were observed in seed germinating vigor, early germination characteristics, germination speed and germination peak time. Seed germinating vigor was variable with different environments and varieties. It was 61.50 to 98.25% under ISTA conditions and 55.00 to 98.50% under natural conditions. There were considerable variations in early germination characteristics among CB varieties according to different conditions. Early germination characteristics indicated that all varieties were 1 to 4 days faster in germination under ISTA conditions, when compared with natural conditions. The germination speed, measured as days to seed germination of 70% and 90%, was much faster with Penn A-1, Penn A-4 and Penncross under ISTA conditions. But it was even faster with L-93 and Penncross when grown under natural conditions. Differences were also observed in germination peak time with varieties and growing conditions. It was 0.57 to 2.86 days under ISTA conditions and 0.74 to 1.74 days under natural conditions. Regardless of the environment conditions, the shortest variety was L-93 and the longest one T-1. Considering germinating vigor, early germination characteristics, germination speed and germination peak time, Penn A-1, Penn A-4 and Penncross were regarded as excellent varieties under ISTA conditions in terms of early establishment characteristics, while L-93, Penn A-1 and Penncross under natural conditions. These results suggest that an intensive germination test be needed prior to planting, for the early germinating vigor, germination speed and germination peak time. Also, a proper variety selection and comprehensive site analysis for the growing environmental conditions should be done before golf course construction.

• 한국전자거래학회지
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• 제24권4호
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• pp.119-133
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• 2019

최근 태양광 발전량 예측은 태양광 발전량 설비 시스템의 안정적인 작동을 위한 조정 계획, 설비 규격 결정 및 생산 계획 일정을 수립하기 위해 필수적인 요소로 고려된다. 특히, 대부분의 태양광 발전량은 피크시간에 측정되기 때문에, 태양광 시스템 운영자의 이익 최대화와 전력 계통량 안정화를 위해 피크시간의 태양광 발전량 예측은 매우 중요한 요소이다. 또한, 기존 연구들은 광범위한 지역에서 예측된 불확실한 기후 정보들을 이용하여 태양광 발전량을 예측하는 한계점 때문에 일사량, 운량, 온도 등과 기상정보 없이 피크시간의 태양광 발전량을 예측하는 것은 매우 어려운 문제로 고려된다. 따라서 본 논문에서는 피크이전의 기후, 계절 및 관측된 태양광 발전량을 이용하여 미래의 기후 및 계절 정보 없이 피크시간의 태양광 발전량을 예측할 수 있는 LSTM(Long-Shot Term Memory) 기반의 태양광 발전량 예측 기법을 제안한다. 본 연구에서 제안한 모델을 기반으로 실 데이터를 통한 실험 결과, 단기 및 장기적 관점에서 높은 성능을 보였으며, 이는 본 연구에서 목표로 한 피크시간의 태양광 발전량 예측 성능 향상에 긍정적인 영향을 나타내었음을 보여준다.