• Title/Summary/Keyword: Peak period

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EFFECT OF ADMINSTRATION METHOD OF FLUMAZENIL ON THE PLASMA CONCENTRATION AND THE REVERSAL OF SEDATION INDUCED BY MIDAZOLAM (Flumazenil의 투여 방법에 따른 혈장내 농도와 midazolam에 의해 유도된 진정 상태의 환원 효과)

  • Park, Seong-Kyu;Lee, Sang-Ho;Lee, Chang-Seop;Lee, Nan-Young;Oh, You-Hyang
    • Journal of the korean academy of Pediatric Dentistry
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    • v.32 no.3
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    • pp.499-508
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    • 2005
  • The purpose of this study were to evaluate the effect on the reversion of sedation induced by midazolam with flumazenil and to determine the plasma concentration of flumazenil according to the method of administration. Intranasal and intravenous flumazenil were administered to sedated health volunteers aged from 23 to 25 years, in doses typical of those used clinically to induce sedation with midazolam and for reversal with flumazenil. Objective assessment for degree of sedation and vital signs, plasma concentration were made for 2 hours period. 1. Systolic and diastolic blood pressure, $SpO_2$ were not changed by adminstration of flumazenil in sedated subject with midazolam, but pulse rate was increased temporarily. 2. Flumazenil showed the reversal of the sedative effect induced by midazolam regardless of administration methods. But intravenous administration showed more effect on the degree and the duration of reversion than intranasal administration with the exception of on set time. 3. Peak plasma concentration of flumazenil administered by intranasal route reached after 2 min and that of flumazenil administered by intravenous route was 4 min. Thus uptake of flumazenil did not showed any difference in accordance with the adminstration route. 4. Administration of flumazenil resulted in the temporary increase of midazolam plasma concentration.

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Progesterone Production and Oocyte Maturatf on of Frog (Rona nigromaculata and Rana rugoBa) Follicles in vitro (참개구리와 옴개구리 여포의 프로제스테론 생성과 난자의 성숙)

  • 권혁방;김지열;고선근
    • The Korean Journal of Zoology
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    • v.33 no.2
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    • pp.175-182
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    • 1990
  • Progesterone production and oocyte maturation in ovarian follicles of Rana nigromaculata and Rana rugosa were investigated. Addition of frog pituitary homogenate (FPH) to the in utiro cultured follicles of R. nigromaculata stimulated a marked increase in the accumulation and secretion of progesterone (P$_4$) by the follicles and induced their oocyte maturation (germinal vesicle breakdown, GVBD) in a dose dependent manner. The FPH (0.1 pituitary equivalent/2 ml)-inducted P4 peak appeared in 3-6 hours and followed by the oocyte GVBD in 9-12 hours after the hormone stimulation. lncreae of intrafollicular cAMP levels with forskolin (an adenylatecyclase stimulator) and 3-isobutyl-1-methylxanthine (IBMX, a phosphodiesterase inhibitor) mimic the FPH action in the stimulation of P$_4$ production but not in the induction of oocyte maturation. The in uitro cultured follicies of R. rugosa behaved very differently from other amphibian follicles. Addition of FPH-(0. 1 pit. equivl2 ml) to the culture medium neither stimulated P$_4$ production by the follicles nor induced the oocyte GVBD. However, treatment of the follicles with forskolin and IBMX drastically stimulated both the intrafollicular accumulation (800 pg/follicle) and secretion (1700 pg/follicle) of P$_4$ by the follicles during culture period. Thus, the data suggest that the follicles are ready to respond to cAMP increase but not to the FPH stimulation in terms of P$_4$ production.

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Assessment of Flood Flow Conveyance for Urban Stream Using XP-SWMM (XP-SWMM을 이용한 도시하천에서의 홍수소통능력 평가)

  • Hong, Jun-Bum;Kim, Byung-Sik;Seoh, Byung-Ha;Kim, Hung-Soo
    • Journal of Korea Water Resources Association
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    • v.39 no.2 s.163
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    • pp.139-150
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    • 2006
  • In recent, increasing of the impervious area gives rise to short concentration time and high peak discharge comparing with natural watershed and it is a cause of urban flood damage. Therefore, we have performed for structural and non-structural plans to reduce the damage from inundation. The Gulpo-cheon basin had been frequently inundated and damaged due to the water level of Han river. So, the Gulpo-cheon floodway was constructed with 20 meters width for flood control in the basin but it was not enough for our expectation and now we have a plan to expand the floodway to 80 meters. We use a XP-SWMM model developed based on EPA-SWMM version for analyzing the capacity of flood conveyance by the expansion of Gulpo-cheon floodway with the same 100 years return period design storm and the same tidal conditions of the Yellow sea. The flood conveyance after the expansion of floodway becomes three times comparing it with before the expansion. Also we simulate the flood discharge at the diversion point of Gulpo-cheon for the expanded condition of floodway and know that the discharge of about 300 m3/sec is flowing backward to the expanded floodway. Therefore we may need some kinds of hydraulic structures to prevent the back water.

Evaluation of EGR applicability for NOx reduction in lean-burn LPG direct injection engine (초희박 LPG 직접분사식 엔진에서 질소산화물 저감을 위한 배기재순환 적용성 평가)

  • Park, Cheolwoong;Cho, Seehyeon;Kim, Taeyoung;Cho, Gyubaek;Lee, Janghee
    • Journal of the Korean Institute of Gas
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    • v.19 no.4
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    • pp.22-28
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    • 2015
  • In order to keep the competitiveness of LPG fuel for transportation fuel, the difference in fuel consumption with gasoline and cost for an aftertreatment system should be reduced with continuous development of technology for LPG engine. In the present study, spray-guided type direct injection combustion system, whose configuration is composed of direct injector in the vicinity of spark plug, was employed to realize stable lean combustion. A certain level of nitrogen oxides($NO_x$) emits due to a locally rich mixture regions in the stratified mixture. With the application of EGR system for the reduction of $NO_x$, 15% of $NO_x$ reduction was achieved whereas fuel consumption and hydrocarbon emission increased. By the application of EGR, the combustion speed reduced especially appeared at initial flame development period and peak heat release rates and increasing rates for heat release rate decreased as EGR rate increased due to the dilution effect of intake air.

Composting Effectiveness of A Sundry System with A Bin-type Composter for Recyle of Animal Wastes (축분뇨처리를 위한 Bin형 부숙조- Sundry 시스템의 퇴비화효율 평가)

  • 최홍림;김현태;정영윤
    • Magazine of the Korean Society of Agricultural Engineers
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    • v.35 no.2
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    • pp.92-103
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    • 1993
  • A sunday system with a horizontal bin-type composter was constructed and operated to evaluate its composting performance for four days for each test in October, 1992. A sundry system is one of popular systems for composting livestock manure, of which main benefit is to utilize unlimited, clean, and free solar radiation. A rectangular concrete bin(composter) with dimension of 300cm(length) X90cm(width) X60cm(height) was bedded alternatively with four lanes of aeration pipes and heating pipes, and was insulated at three walls with 50mm styrofoam. Each aeration pipe of a diameter of 25mm had 4mm perforated holes at every 15cm longitudinally, and supplied air of about 2m$^3$/min to the composter to maintain aerobic condition . A stirrer rotating at 1 rpm made one round trip every 20 minutes on the conveying chain along the the length of the composter. Five tests (Test 1~Test 5) were implemented to evaluate the composting effectiveness of a sundry system with a horizontal bin-type composter. Treatments of two levels of the mixture ratio of swine manure and paper sludge cakes(manure : paper sludge cakes= 1 : 4 and 1 : 2) and two levels of the water content(W/C ; 70% and 50%) were made to test the significance of the physicochemical properties for decomposition of the mixture materials. Temperature, C/N ratio, water content, microbial activity of the composting materials were taken measurements to evaluate its performance with the lapse of composting time for tests. A small-scale sundry system with a bin-type composter did not appear to be an appropriate system for composting livestock manure. Since heat generation by the composting materials could not overcome heat loss due to areation in a small-scale composter, a proper thermal enviroment could not be maintained to propagate massively thermopilic microorganism relatively in a short period of time. Different from the result of Chol et al.(1992) 6), a temperature variation of the composting materials did not show the peak clearly and C/N ratio didn't lower with time as expected. Mesophilic microoragnism seemed to play an important role for decomposition of the mixture materials. A sundry system with a bin-type composter may be good for a large-scale livestock farm household which may produce enough animal manure. Therefore a decision should be made very carefully to choose a system for composting livestock waste.

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A Case Study on the Management for Mid-to Senior Age Human Resources of Enterprises following the Extension of Retiring Age Law (정년연장 법제화에 대응하는 기업의 장년인력관리 사례연구)

  • Oh, Ji-hyun;Lee, Young-min
    • Journal of Practical Engineering Education
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    • v.6 no.2
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    • pp.119-126
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    • 2014
  • The purpose of this study is to take a look at the cases on managing the senior human resources of business enterprises following the significant number of retirement of baby-boom generation and obligatory retirement age of 60 years of age and present the implication points in policies. With respect to the implication of the company, it would urgently require the introduction of programs with long-term point of view for career management strategy from the time of employment to the resignation, settlement of company leave system called chulhyang, expansion of wage peak system, full-time job transfer support center within the enterprise for retirement management, expansion of various consulting, conversion of paradigm on senior human resource management of top management in the enterprise level. In the government level, it is considered as required for systematic supplementation of the chulhyang system, improvement of support system for employment encouragement fund, expansion of national work capability standard-based senior employment field as well as task development, support for innovation of personnel management system, supply of management manual and implementation of job transfer education for life-time conversion period in the government level.

산란계 육성기 계란급이가 초기 산란 특징에 미치는 영향

  • 김상호;장병귀;최철환;서옥석;이상진;류경선
    • Proceedings of the Korea Society of Poultry Science Conference
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    • 2003.11a
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    • pp.97-98
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    • 2003
  • This experiment was conducted to investigate the effect of restricted feeding to pullet on growth and laying Performance, egg qualify and endocrine Profile in brown layers. 1,080 brown-layer chicks divided to three diet treatments, conventional diet and two restricted diets, for 70 weeks. Conventional diets(C) was formulated by NRC recommendation, and one of restricted diet started from seven to seventeen week of age(T1), and another started from twelve to seventeen(T2) with adjusted eighty percentage amount of conventional diet. Body weight decreased with starting restriction of feeding comparing to the C(P<0.05), but reached to similar weight in all treatments at twenty week regardless restriction. All of birds started to lay egg around 1,400 to 1,450gram of body weight though the age was in order of C, T2 and T1. Overall e99 Production was the highest in T1 (P<0.05) and there were not difference in C and T2. Average egg weight also showed similar to the tendency of egg production. Feed intake was higher in T1 during maximum production(P<0.05), but there were not difference in all treatments after the peak. Overall feed conversion ratio improved in T1 compared to C and T1(p<0.05). Restriction feeding in rearing period could be beneficial to improve egg productivity and to decrease feed cost.

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Studies on the Performance of Korean Native Chickens II. A Comparison of Performance of Various Korean Native Chickens (한국재래닭의 능력에 관한 연구 II. 한국재래닭의 계통별 능력 비교)

  • 김상호;이상진;강보석;최철환;장병귀;오봉국
    • Korean Journal of Poultry Science
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    • v.25 no.4
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    • pp.177-183
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    • 1998
  • A feeding trial was conducted to investigate the performance of various Korean Native Chickens (KNC) for 64 weeks. Eight hundreds and ten KNC one-day birds were arranged to three strains, Dark Brown(D), Light Brown(L) and Black(B). Each strain had three replicates of 90 birds a replicate. Birds fed same diet with Korean standard feeding. Data were obtained growing performance to 20 week of age and laying performance from twenty one to sixty four week. During the growing stage from hatch to 20 week of age, there were not significant difference to three strains on viability, body weight and feed intake. L strain tended to be earlier 50% egg production day than that of other strains, but was not significantly different. Egg production of L strain was the highest of strains. It showed significantly higher egg production compared to that of D strain(P<0.05), but was not statistically different from that of B strain. Laying peak period was between 28 to 32 week of age in all strains, Egg weight was heavier in D strain(P<0.05). Feed intake was the same as 105g, and feed conversion improved in L strain(P<0.05). There were not difference on interior egg and eggshell quality by strains although eggshell thickness improved slightly in D strain. Fertility of D strain was the highest compared to others(P<0.05) regardless laying stages. Hatchability was not influenced by strains at 39 weeks old, but was significantly higher in B strain at 62 week of age(P< 0.05). The results of this experiment indicated that KNC 3 strains were not effect on egg production, feed intake and feed conversion ratio.

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Water Supply forecast Using Multiple ARMA Model Based on the Analysis of Water Consumption Mode with Wavelet Transform. (Wavelet Transform을 이용한 물수요량의 특성분석 및 다원 ARMA모형을 통한 물수요량예측)

  • Jo, Yong-Jun;Kim, Jong-Mun
    • Journal of Korea Water Resources Association
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    • v.31 no.3
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    • pp.317-326
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    • 1998
  • Water consumption characteristics on the northern part of Seoul were analyzed using wavelet transform with a base function of Coiflets 5. It turns out that long term evolution mode detected at 212 scale in 1995 was in a shape of hyperbolic tangent over the entire period due to the development of Sanggae resident site. Furthermore, there was seasonal water demand having something to do with economic cycle which reached its peak at the ends of June and December. The amount of this additional consumption was about $1,700\;\textrm{cm}^3/hr$ on June and $500\;\textrm{cm}^3/hr$ on December. It was also shown that the periods of energy containing sinusoidal component were 3.13 day, 33.33 hr, 23.98 hr and 12 hr, respectively, and the amplitude of 23.98 hr component was the most humongous. The components of relatively short frequency detected at $2^i$[i = 1,2,…12] scale were following Gaussian PDF. The most reliable predictive models are multiple AR[32,16,23] and ARMA[20, 16, 10, 23] which the input of temperature from the view point of minimized predictive error, mutual independence or residuals and the availableness of reliable meteorological data. The predicted values of water supply were quite consistent with the measured data which cast a possibility of the deployment of the predictive model developed in this study for the optimal management of water supply facilities.

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19 years of change in community structure of Quercus acutissima dominant stand on Mt. Danseok-san in Gyeongju national park, South Korea (경주 단석산 상수리나무 우점식분 군집구조의 19년간의 변화)

  • Ko, Jae Ki
    • Journal of Wetlands Research
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    • v.20 no.3
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    • pp.243-248
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    • 2018
  • This study was carried out to clarify changes in community structure of Quercus acutissima dominant stand on the south slope of Mt. Danseok-san with fixed twenty quadrates. Five field surveys were conducted from Aug. 1999 to May 2018. During the period, the density lessened to 0.20 in 2012 comparing with 0.33 in 1999. However recent field study in 2018 showed moderate rising to 0.24. In 1999, the DBH class distribution of all trees formed reverse J curve. However, the reverse J curve was torn down, forming bell curve. In 2018, the curve showed similar shape of reverse J shape on the group of young trees, forming bell shape on the group of mature trees. It reveals that DBH 13cm is on the threshold of trees competition trend where the downtrend in the trees are on uptrend. The most dominant Q. acutissima formed bell curve. The peak of the curve shows the shift to the right of the graph as it gets lower by year.In case of Q. mongolica, shows a change in the shape of a low bell as the distribution curve increases. The oak stand in this study is in the process of changing from the initial stage of the secondary forest succession to the intermediate stage. The most dominant tree is Q. acutissima, and the sub-dominant tree is Q. mongolica in present. Considering the age distribution of the two competing tree species, the succession of this stand is expected to transfer to the Q. mongolica-dominant community.