• The Korean Journal of Physiology and Pharmacology
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• v.22 no.6
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• pp.649-660
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• 2018

Migraine is a neurological disorder characterized by recurrent and disabling severe headaches. Although several anticonvulsant drugs that block voltagedependent $Na^+$ channels are widely used for migraine, far less is known about the therapeutic actions of carbamazepine on migraine. In the present study, therefore, we characterized the effects of carbamazepine on tetrodotoxin-resistant (TTX-R) $Na^+$ channels in acutely isolated rat dural afferent neurons, which were identified by the fluorescent dye DiI. The TTX-R $Na^+$ currents were measured in medium-sized DiIpositive neurons using the whole-cell patch clamp technique in the voltage-clamp mode. While carbamazepine had little effect on the peak amplitude of transient $Na^+$ currents, it strongly inhibited steady-state currents of transient as well as persistent $Na^+$ currents in a concentration-dependent manner. Carbamazepine had only minor effects on the voltage-activation relationship, the voltage-inactivation relationship, and the use-dependent inhibition of TTX-R $Na^+$ channels. However, carbamazepine changed the inactivation kinetics of TTX-R $Na^+$ channels, significantly accelerating the development of inactivation and delaying the recovery from inactivation. In the current-clamp mode, carbamazepine decreased the number of action potentials without changing the action potential threshold. Given that the sensitization of dural afferent neurons by inflammatory mediators triggers acute migraine headaches and that inflammatory mediators potentiate TTX-R $Na^+$ currents, the present results suggest that carbamazepine may be useful for the treatment of migraine headaches.

• Journal of the Korean Magnetics Society
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• v.3 no.3
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• pp.229-233
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• 1993

The effects of differential partial pressures of oxygen during sputtering on the magnetic and recording characteristics of magneto-optical disks were investigated. Different flows of oxygen were deliberately introduced into the sputtering chamber to have a variety of partial pressures of oxygen during sputtering. A residual gas analyzer was employed to monitor the oxygen peak before, during, and after sputtering and to estimate the reacted oxygen amount. Most of the oxygen introduced into the chamaber was reacted during sputtering. As the partial pressure of oxygen increased, the oxygen content of the TbFeCoCr film increased also. The oxygen appeared to be bound as Tb-O, effectively decreasing the magnetically active Tb content of the film The coercivity decreased but the squareness of the Kerr hysteresis loops was still excellent. The perpendicular anisotropy was not significantly affected by oxygen amount. The carrier-to-noise ratio, includi!1g the write power sensitivity and bias field sensitivity did not change too much with oxygen content in the film The disks sputtered with oxygen showed better bias field sensitivity with lower write power threshold than the disk sputtered without oxygen, due to high demagnetization during domain formation. No significant degradation of coercivity for the disk sputtered oxygen was observed during an accelerated aging test.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.47 no.3
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• pp.1-6
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• 2010

A comparative analysis of quantum-mechanical and classical simulation regarding corner effect in a Saddle MOSFET has been carried out using a 3-D numerical simulator. The comparison has shown that quantum simulation gives correct description of device by providing accurate peak E-density position and magnitude at the Si-fin cross-section, hence accurate analysis of corner effect and its impact on device threshold voltage (Vth) characteristics is carried out. Moreover, rounding the Si-fin comers or lowering the body doping have been shown as two possible techniques to suppress the undesirable corner effect.

• Journal of Broadcast Engineering
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• v.16 no.3
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• pp.416-426
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• 2011

In this paper, we proposed an intra coding method with merging intra prediction mode to achieve intra coding gain. The proposed method uses signaling of prediction mode with merging prediction modes, which is different from the conventional method. If the number of blocks that has the same prediction mode compared to that to be predicted from neighboring blocks exceeds the predefined threshold, then the proposed method is used in order to reduce bits of intra prediction mode for coding efficiency. Otherwise the conventional method is used. Experimental results show the proposed method achieves the PSNR gain of about 0.05 dB in RD curve and reduces the bit rates about 1 % compared with H.264/AVC. In particular, the PSNR gain of about 0.1 dB in RD curve and reduces the bit rates about 1.7 % compared with H.264/AVC at low bit-rates. we can know that the proposed method is efficient tool at low bit-rates.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.27 no.3
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• pp.163-169
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• 2017

Objectives: This study was conducted toestimate quartz concentrations and contents in the airborne respirable dust from various industries. Methods: A total of 818 samples were collected from 174 industries. Respirable dust samples were collected using a cyclone equipped with a 37 mm, $5{\mu}m$ pore size PVC filter. The quartz concentrations were identified using the intensity of the absorption peak of quartz at $799cm^{-1}$ by Fourie Transformed Infrared Spectroscopy(FTIR). Results: The respective geometric means for quartz concentrations in the respirable dust were 0.0050, 0.0049, 0.0025, and $0.0019mg/m^3$ in foundries, ceramics, construction, and cement/stone. The geometric mean of quartz contents analyzed by FTIR were respectively 3.43, 1.99, 1.04, and 0.82% for ceramics, foundries, cement/stone, and construction. The rate of exceeding the Korean Occupational Exposure Limit($0.05mg/m^3$) was 2.03%, but rate of exceeding the American Conference of Governmental Industrial Hygienist(ACGIH) Threshold Limit Value($0.025mg/m^3$) was 7.12%. Conclusions: Given that foundries had a higher quartz concentration, there is a need to reduce respirable dust, such as through wet operation. In order to protect the health of workers exposed to mineral dust, it is necessary to actively consider strengthening the Korean Occupational Exposure Limit.

• Journal of Korea Water Resources Association
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• v.45 no.12
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• pp.1227-1241
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• 2012

In this study, a novel water surface detection method was proposed. In the method water surface is detected by analysis on correlation coefficients obtained from rectangular control areas of the same vertical position in two successive images including both water surface and staff gauge. Four methods respectively based on threshold, peak, slope and variance ratio, are used to identify water surface from vertical distribution of correlation coefficient. In addition, swaying correction algorithm and statistical filtering are applied to minimize outliers caused by positional image mismatch. Images taken from 28 different sites during low flow were tested to evaluate the method. Mean relative error to eye measurement was approximately from 3.4 to 5.7 cm. As long as water surface moves, this method can be used to improve image stage gauge by supplementing the previous water surface detection method.

• Journal of Biosystems Engineering
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• v.28 no.1
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• pp.45-52
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• 2003

Red ginsengs are inspected manually by examining those in the dark room with back light illumination. Manual inspection is often influenced by physical condition of inspectors. Sometimes. the best grade, heaven. has some inner holes though it was inspected by a specialist. In order to resolve this problem, this study was performed to develop image processing algorithm to detect the inner holes in the x-ray image of ginseng. Because of little gray value difference between background and ginseng in the image. simple thresholding method was not appropriate. Modified watershed algorithm was used to differentiate the inner holes from background and normal ginseng body. Inner hole edge region detected by watershed algorithm consists of many number of blobs including normal portions. With line profile analysis with scanning one line at a time beginning the starting point. it shelved two peaks both ends representing extracting each blobs. in which setting threshold value as of lower peak value enabled us to obtain inner hole image. Once this procedure has to be done till the finishing point it is completing inner hole detection for one blob. Thus. conducting ail blobs by this procedure is completing inner detection of one whole ginseng. Detection results of the inner holes fer various size of red ginsengs were good even though there was small detection variation. 6.2%. according to position of x-rat tube.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.48 no.4
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• pp.479-486
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• 2012

In order to obtain the fundamental data about the behavior of conger by underwater audible sound, this experiment was carried out to investigate the hearing ability of Conger eel Conger myriaster which was in the coast of Jeju Island by heartbeat conditioning method using pure tones coupled with a delayed electric shock. The audible range of conger eel extended from 50Hz to 300Hz with a peak sensitivity at 80Hz including less sensitivity over 200Hz. The mean auditory thresholds of conger eel at the frequencies of 50Hz, 80Hz, 100Hz, 200Hz and 300Hz were 105dB, 92dB, 96dB, 128dB and 140dB, respectively. The positive response of conger eel was not evident after the sound projection of over 200Hz. At the results, the sensitive frequency range of conger eel is narrow in spite of swim bladder. Auditory masking was determined for Conger eel by using masking stimuli with the spectrum level range of about 60~70dB (0dB re $1{\mu}Pa/\sqrt{Hz}$). According to white noise level, the auditory thresholds increased as compared with thresholds in a quiet background noise including critical ratio at 68dB of white noise from minimum 26dB to maximum 30dB at test frequencies of 80Hz and 100Hz. The noise spectrum level at the start of masking was distributed at the range of about 68dB within 80~100Hz.

• Journal of Biomedical Engineering Research
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• v.23 no.4
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• pp.309-315
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• 2002

Since the discovery, in the 1980s, of erosion-pit-induced fractures in implanted mechanical heart valves. cavitation on the surface of mechanical heart valves has been widely studied as a possible cause of pitting. Several factors, including peak dp/dt of the ventricular pressure. maximum closing velocity of the leaflet, and squeeze flow. have been studied as indices of the cavitation threshold. In the present study. cavitation erosion on the surface of a mechanical valve was examined by focusing on squeeze flow and the water hammer phenomenon during the closing period of the valve. In this study, we measures pressure wave forms near a valve and closing velocities of a disk, which were placed in a holder with and without compliance. In case of all holders, pressure drop of below vapor pressure expect at near the surface disk. It was also found that the closing velocity of the disk increased and that cavitation erosion was enhanced too. These results suggest that disk closing velocity during the closing phase has signifiant effects on pitting erosion.

• Nuclear Engineering and Technology
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• v.46 no.6
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• pp.837-846
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• 2014

A lead slowing down spectrometer (LSDS) is under development for analysis of isotopic fissile material contents in pyro-processed material, or spent fuel. Many current commercial fissile assay technologies have a limitation in accurate and direct assay of fissile content. However, LSDS is very sensitive in distinguishing fissile fission signals from each isotope. A neutron spectrum analysis was conducted in the spectrometer and the energy resolution was investigated from 0.1eV to 100keV. The spectrum was well shaped in the slowing down energy. The resolution was enough to obtain each fissile from 0.2eV to 1keV. The detector existence in the lead will disturb the source neutron spectrum. It causes a change in resolution and peak amplitude. The intense source neutron production was designed for ~E12 n's/sec to overcome spent fuel background. The detection sensitivity of U238 and Th232 fission chamber was investigated. The first and second layer detectors increase detection efficiency. Thorium also has a threshold property to detect the fast fission neutrons from fissile fission. However, the detection of Th232 is about 76% of that of U238. A linear detection model was set up over the slowing down neutron energy to obtain each fissile material content. The isotopic fissile assay using LSDS is applicable for the optimum design of spent fuel storage to maximize burnup credit and quality assurance of the recycled nuclear material for safety and economics. LSDS technology will contribute to the transparency and credibility of pyro-process using spent fuel, as internationally demanded.