• Journal of Korean Society of Transportation
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• v.27 no.1
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• pp.143-155
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• 2009

A dynamic traffic assignment (DTA) has recently been implemented in many practical projects. The core of dynamic model is the inclusion of time scale. If excluding the time dimension from a DTA model, the framework of a DTA model is similar to that of static model. Similar to static model, with given exogenous travel demand, a DTA model loads vehicles on the network and finds an optimal solution satisfying a pre-defined route choice rule. In most DTA models, the departure pattern of given travel demand is predefined and assumed as a fixed pattern, although the departure pattern of driver is changeable depending on a network traffic condition. Especially, for morning peak commute where most drivers have their preferred arrival time, the departure time, therefore, should be modeled as an endogenous variable. In this paper, the authors point out some shortcomings of current DTA model and propose an alternative approach which could overcome the shortcomings of current DTA model. The authors substitute a traditional definition for time-dependent OD table by a new definition in which the time-dependent OD table is defined as arrival time-based one. In addition, the authors develop a new DTA model which is capable of finding an equilibrium departure pattern without the use of schedule delay functions. Three types of objective function for a new DTA framework are proposed, and the solution algorithms for the three objective functions are also explained.

• Journal of the Korean Association of Geographic Information Studies
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• v.21 no.4
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• pp.14-25
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• 2018

The operation of high-speed rail (HSR) has an effect on the agglomeration economies, and the impact is shown as a relocation of individual firm and worker to where business activity can be maximized. The proximity to the HSR station could be considered as a core district to maximize the industrial benefit through the HSR network. From this perspective, this study considers the agglomeration effect of HSR within the HSR station-area and analyzed the agglomerated spatial pattern through hotspot analysis by service industry in the cases of Korea and Japan using GIS. This study analyzed the service industry within 1km distance from 8 HSR stations of Korea and 4 Kyushu Shinkansen stations of Japan. The results suggest that the hotspot patterns are observed in the service industry within 1km distance from the HSR station of Korea and Japan, except for two HSR stations of Gupo station and Kagoshima-Chuo station. Leisure, amusement, association, and other specific service industries could be affected by HSR passengers and knowledge-spillovers through HSR station. Therefore, the observed hotspot districts near the HSR station-area could explain an agglomeration pattern of the service industry through a closeness to the HSR station. Further, we could expect that the impact of HSR affects the service industry, and the impact could attract business activities of the service-area to maximize their benefit from HSR travelers. With the result, it is required to build up a supportive policy to maximize the HSR's impact on the service industry when considering the HSR station-area development.

• Biotechnology and Bioprocess Engineering:BBE
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• v.9 no.2
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• pp.137-142
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• 2004

In this study, a simple procedure is described for patterning biotin on a glass substrate and then selectively immobilizing proteins of interest onto the biotin-patterned surface. Microcontact printing (CP) was used to generate the micropattern of biotin and to demonstrate the selective immobilization of proteins by using enhanced green fluorescent protein (EGFP) as a model protein, of which the C-terminus was fused to a core streptavidin (cSA) gene of Streptomyces avidinii. Confocal fluorescence microscopy was used to visualize the pattern of the immobilized protein (EGFP-cSA), and surface plasmon resonance was used to characterize biological activity of the immobilized EGFP-cSA. The results suggest that this strategy, which consists of a combination of $\mu$CP and cSA-fused proteins. is an effective way for fabricating biologically active substrates that are suitable for a wide variety of applications. one such being the use in protein-protein assays.

• The Journal of Engineering Geology
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• v.19 no.4
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• pp.459-474
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• 2009

By the analysis of discontinuity at the outcrop and lineament on the satellite image, the joints have deeply relationship with the lineaments. The joint spaces at the drilling core are mostly 1~20 cm but at the rhyolite which is distributed near fault they have more closely. These volcanic rocks belong to the subalkaline series tuff, rhyolite, basalt in the study area from the diagram of $Nb/Y-Zr/TiO_2$. The composition diagram of Hf/3-Th-Nb/16 show destructive plate-margin basalt and their differentiates. The environment of formation of volcanics are normal continental arc. Most of LREE show high enriched pattern but HREE show depleted pattern. The K/Ar age of intermediate volcanics, tuff, rhyolite, crystal tuff are 55.3Ma, 77.25 Ma~91.22Ma, 63.16~64.39Ma, 54.49 Ma respectively.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.10 no.12
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• pp.2283-2288
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• 2006

As development in technology of bioinformatics recently makes it possible to operate micro-level experiments, we can observe the expression pattern of total genome through on chip and analyze the interactions of thousands of genes at the same time. Thus, DNA microarray technology presents the new directions of understandings for complex organisms. Therefore, it is required how to analyze the enormous gene information obtained through this technology effectively. In this thesis, We used sample data of bioinformatics core group in harvard university. It designed and implemented system that evaluate accuracy after dividing in class of two using Bayesian algorithm, ASA, of feature extraction method through normalization process, reducing or removing of noise that occupy by various factor in microarray experiment. It was represented accuracy of 98.23% after Lowess normalization.

• Journal of Haehwa Medicine
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• v.20 no.1
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• pp.1-10
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• 2011

By studying the portions and layers(分部), left and right, superior and inferior, location of yin and yang, and beginning and end of diseases of skin, which is the core point of the theory of cutaneous region(皮部論) in "Naejing(內經)", in the physiological and pathological perspective, based on opinion of historic memorial doctors, arrived to the conclusion as below. Cutaneous region means not only the distribution of three yin and three yang(三陰三陽) of the surface, but also inside and outside, shallowness and depth, and it is the system which unites meridians, networks, and vessels. It is divided into portions and layers. The origin and beginning of diseases and the rule of favorable pattern and unfavorable pattern can be known through it. The portion of skin is not only the area that meridian vessels belongs to skin, but also the area that activation of twelve meridian vessels are expressed in the surface. The layer of skin is consisted in order of skin-tertiary collateral vessel-collateral vessel-meridian vessel-bone. In "Naejing", there are two preconditions to divide three yin and three yang into yin and yang. The first is standing while looking the south, and second is the quotation "outside is side of yang(外者爲陽 內者爲陰)." According to this preconditions, yang of outside of yang brightness, lesser yang, and greater yang is the whole body, except inside of hand and foot which yin of lesser yin, pericardium, and greater yin. Superior and inferior of the portions and the layers is designated as hand and foot, theological basis of which superior and inferior work in same diagnostic method can be found in the root and the basis(標本) and the origin and the insertion(根結). In conclusion, cutaneous region not only manages layer of the skin, but also it is divided into layers and portions, so it has close relations between meridian vessels and collateral vessels. The in-depth study of cutaneous region and meridians should be progress, in order to practice of diagnosis and acupuncture and moxibustion more.

• Advances in pediatric surgery
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• v.12 no.2
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• pp.137-146
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• 2006

Pediatric surgery could establish a definitive position in the medical field on the basis of a stable patient population. Neonatal surgery, the core of pediatric surgery, requires highly skilled surgeons. However, recent advancement of prenatal diagnosis followed by intervention and decreased birth rate has resulted in a significant decrease in the neonatal surgical population and the number of surgical operations. The purpose of this study is to examine the outcome of neonatal surgeries and to propose a guide for the future surgeries. A total of 359 neonatal surgical patients operated upon at the Department of Surgery, Ewha Medical Center, during past 21 years were studied. The study period hasbeen divided into two time periods: from 1983 to 1993 and from 1994 to 2004. Analysis was based on the Clinical Classification System and mortality pattern, frequency of disorders, occurrence and cause of death, and other changes. Neonatal surgery was 6.4 % of all pediatric surgery during the total 21 year period, 9.9 % in the first period and 4.8 % in the second. Male to female ratio increased from 2.7:1 to 2.1:1. The overall mortality was 6.7 %, and there was significant decrease from 7.4 % in the first period to 6.0 % in the second. The clinical classification system (CCS) for death cases included class II 2, III 4, and IV 7 during the first period and class III 3, and IV 8 during the second, respectively. According to the mortality pattern by Hazebroek, there were 6 preventable death cases during the first period, and only one in the second, and 2 non-preventable death cases during the first period and 8 in second, respectively. Although the patients in the second period had more serious diseases, surgical mortality has been decreased in the second period, which may be the result of improved surgery methods for newborns and advanced patient care.

• Biomedical Science Letters
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• v.13 no.3
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• pp.239-244
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• 2007

Hoxc8 is one of the homeotic developmental control genes regulating the expression of many downstream target genes, through which animal body pattern is established during embryonic development. In previous proteomics analysis, proliferating cell nuclear antigen (PCNA) which is also known as cyclin, has been implied to be regulated by Hoxc8 in F9 murine embryonic teratocarcinoma cell. When the 5' upstream region of PCNA was analyzed, it turned out to contain 20 Hox core binding sites (ATTA) in about 1.17 kbp (kilo base pairs) region ($-520{\sim}-1690$). In order to test whether this region is responsible for Hoxc8 regulation, the upstream 2.3 kbp fragment of PCNA was amplified through PCR and then cloned into the pGL3 basic vector containing a luciferase gene as a reporter. When the luciferase activity was measured in the presence of effector plasmid (pcDNA : c8) expressing murine Hoxc8, the PCNA promoter driven reporter activity was reduced. To confirm whether this reduction is due to the Hoxc8 protein, the siRNA against Hoxc8 (5'-GUA UCA GAC CUU GGA ACU A-3' and 5'-UAG UUC CAA GGU CUG AUA C-3') was prepared. Interestingly enough, siRNA treatment up regulated the luciferase activity which was down regulated by Hoxc8, indicating that Hoxc8 indeed regulates the expression of PCNA, in particular, down regulation in NIN3T3 cells. These results altogether indicate that Hoxc8 might orchestrate the pattern formation by regulating PCNA which is one of the important proteins involved in several processes such as DNA replication and methylation, chromatin remodeling, cell cycle regulation, differentiation, as well as programmed cell death.

• Journal of KIISE:Software and Applications
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• v.31 no.10
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• pp.1276-1285
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• 2004

A web-based model for implementation of mobile compliance analysis system for software contents is proposed. It is said that the content is compliant if the content can be executed properly in mobile environment. The mobile compliance analysis of contents is very important because contents can't be serviced if they arc not proper for mobile environment. The categories of mobile compliance analysis for software contents are proposed. The model of this paper uses the Factory Method pattern and the Facade pattern. The workflow of the s${\gamma}$stem is described through collaborations of classes in the model. As a case study, core Java APIs for implementation of the model arc represented and the mobile compliance analysis system for HDML contents has been built. The model is flexible so that it is easy to add new modules or remove some modules for contents analysis. Although the model is based on the JSP and Java beans, it can be expanded to support any other programming technique such as EJB.

• Journal of the Korean association of regional geographers
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• v.14 no.4
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• pp.367-381
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• 2008

The purpose of this paper is to analyze the change in the distribution and hierarchical structure of commercial land use. Tools for analyzing the spatial structure are index of concentration, coefficient of localization and location quotient. This research is applied to Daegu, focusing on the period 1985-2003. During the 1985-2003 period, the growth rate of commercial land use volume amounted to 330%, compared with a population growth rate of 118%. The biggest component of commercial land use is the retail sector. As the lodging, medical, transportation-warehouse and entertainment sectors have the propensity for concentration and comprise the specialized commercial areas in the suburbs, the other sectors arc evenly distributed. Jung-gu has functioned as a downtown core in the hierarchical structure of commercial areas. So, in the structure of commercial land use, Daegu has continued to be a single nuclear structure. But, Dongdaegu Station influence area has evolved into the second order center since 2000. This is the sign of change in spatial structure from single-nuclear pattern to multi nuclear pattern.