• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2010년도 심포지엄 및 추계학술발표회
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• pp.553-554
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• 2010

• Natural Product Sciences
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• 제14권4호
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• pp.249-253
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• 2008

Two oleanane-type triterpenes (1, 2) and their glycosides (4-6), and one ursane-type triterpene (3) have been isolated from a methanolic extract of Patrinia saniculaefolia Hemsley (Valerianaceae) through repeated silica gel and reversed-phase C-18 column chromatography. Their chemical structures were determined as oleanolic acid (1), oleanonic acid (2), 23-hydroxyursolic acid (3), 3-O-${\alpha}$-L-arabinopyranosyl-oleanolic acid (4), 3-O-${\beta}$-D-glucopyranosyl-oleanolic acid (5), and oleanolic acid 3-O-[${\alpha}$-D-xylopyranosyl-($1{\rightarrow}3$)-${\beta}$-D-glucuronopyranoside-6-O-butyl-ester] (6) on the basis of their MS, $^1H$-, and $^{13}C$-NMR spectral data. All compounds were isolated from the whole plant of the P. saniculaefolia for the first time. These compounds were examined for their anti-complement activity against the classical pathway of the complement system. Among them, compounds 1 - 3 exhibited anti-complement activity with $IC_{50}$ values of 470.1, 212.2, and 121.0 ${\mu}M$, respectively, whereas compounds 4 - 6 were inactive. These results suggest that the carbonyl or hydroxy group at C-3 in the oleananeand/or ursane-triterpenes are important for the anti-complement activity against the classical pathway.

• Natural Product Sciences
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• 제17권2호
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• pp.90-94
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• 2011

An in vitro bioassay-guide revealed that the methanol (MeOH) extract of the whole plant of Patrinia saniculaefolia (Valerianaceae) showed cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) dual inhibitory activity by assessing their effects on the production of prostaglandin $D_2$ ($PGD_2$) and leukotriene $C_4$ ($LTC_4$) in mouse bone marrow-derived mast cells (BMMCs). Phytochemical study of the MeOH extract of this plant led to the isolation of twelve compounds; ${\beta}$-farnesene (1), squalene (2), nardostachin (3), patridoid I (4), patridoid II (5), patridoid II-A (6), oleanolic acid (7), oleanonic acid (8), 23-hydroxyursolic acid (9), oleanolic acid 3-O-${\alpha}$-L-arabinopyranoside (10), oleanolic acid 3-O-${\beta}$-D-glucopyranoside (11), oleanolic acid 3-O-[${\beta}$-D-xylopyranosyl-(1${\rightarrow}$3)-${\beta}$-D-(6-O-butyl)glucuronopyranoside] (12). Among the compounds, 4 and 5 strongly inhibited both the COX-2-dependent $PGD_2$ generation with $IC_{50}$ values of 8.7 and 13.6 ${\mu}M$, respectively, and the generation of $LTC_4$ in the 5-LOX dependent phase with $IC_{50}$ values of 41.7 and 46.9 ${\mu}M$, respectively, which suggest that the anti-inflammatory activity of P. saniculaefolia might occur in part via the inhibition of both $PGD_2$ and $LTC_4$ generation by 4 and 5.

• Natural Product Sciences
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• 제19권2호
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• pp.77-119
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• 2013

The genus Patrinia, belonging to the Valerianaceae family, includes ca. 20 species of herbaceous plants with yellow or white flowers, distributed in Korea, China, Siberia, and Japan. Among them, P. scabiosaefolia (yellow Patrinia), P. saniculaefolia, P. villosa (white Patrinia), and P. rupestris are found in Korea. Several members of this genus have long been used in folk medicine for the treatment of inflammation, wound healing, ascetics, and abdominal pain after childbirth. Thus far, ca. 217 constituents, namely flavonoids, iridoids, triterpenes, saponins, and others have been identified in this genus. Crude extract and isolated compounds have been found to exhibit anticancer, anti-inflammatory, antioxidant, antifungal, antibacterial, cytotoxic activities, lending support to the rationale behind several of its traditional uses. The present review compiles information concerning the phytochemistry and biological activities of Patrinia, with particular emphasis on P. villosa, as studied by our research group.

• The Korean Journal of Ecology
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• 제21권3호
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• pp.291-300
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• 1998

The forest vegetation of Mt. Odae based on the interspecific relationship was classified into 4 groups : Quercus mongolica, Pinus densiflora, Quercus variabilis and Patrinia saniculaefolia. Thirty-one species of Quercus mongolica group including Quercus mongolica and Acer mone, 12 species of Pinus densiflora group comprising Pinus densiflora and Spodiopogon sibiricus, 6 species of Quercus variabilis group and 4 species of Patrinia saniculaefolia were positively correlated. in the results of species ordination by principal component analysis, 7 clusters by the humidity and acidity of soil, 4 clusters by the humidity and light intensity and 7 clusters by the acidity and light intensity were formed. The plot ordination showed that the distribution of species based on the humidity, soil acidity and total organic matters was in the order of Pinus densiflora, Quercus variabilis and Quercus mongolica groups, and based on the light intensity was in the order of Quercus variabilis, Pinus densiflora and Quercus mongolica groups.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2009년도 추계학술발표회
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• pp.43-43
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• 2009

• 한국환경복원기술학회지
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• 제9권4호
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• pp.13-23
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• 2006

The vascular plants of the studied area in the Mt. Bangjang was listed 422 taxa : 106 families, 299 genera, 372 species, 1 subspecies, 46 varieties and 3 forms. Based on the list of the rare plants by the Forest Research Institute, 5 taxa were recorded in the studied areas; Lilium distichum(Preservation priority order : No. 159), Tricyrtis dilatata (No. 97), Aristolochia contorta (No. 151), Prunus yedoensis (No. 110), Patrinia saniculaefolia (No. 122) and based on the list of Korean endemic plants, 9 taxa were recorded; Cephalotaxus koreana, Carex okamotoi, Populus tomentiglandulosa, Salix purpurea var. japonica, Prunus yedoensis, Forsythia koreana, Paulownia coreana, Weigela subsessilis, Patrinia saniculaefolia. Specific plant species by floral region were total 29 taxa; Prunus yedoensis in class V, 3 taxa(Acer palmatum, Asperula lasiantha, Lonicera subhispida ) in class III, 5 taxa(Lilium distichum, Potentilla dickinsii, Caryopteris incana, Patrinia saniculaefolia, Ligularia fischeri) in class II, 20 taxa(Ulmus parvifolia, Clematis patens, Aconitum jaluense, Ilex macropoda, Grewia biloba var. parviflora etc.) in class I. The naturalized plants in this site were 13 families, 31 genera, 36 species, 2 varieties, 38 taxa and naturalization rate was 9.0% of all 422 taxa vascular plants. Because of recent rapid increase of cars and people around here, analysis shows many naturalized plants and high naturalized ratio. And wild plants disturbing ecosystem like Ambrosia artemisiifolia var. elatior have been increasing. So, it needs continuing control and conservation measures on the plant ecosystem.

• 한국환경생태학회지
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• 제16권4호
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• pp.387-403
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• 2003

여원재에서 만복대 사이 백두대간에 해당되는 지역에 분포하는 식물상을 조사한 결과 104과 305속 439종 60변종 3품종 총 502종류로 확인되었다. 산림청이 지정한 회귀 및 멸종위기종은 구름송이풀, 구상나무 금마타리, 께묵, 눈향나무(식), 땅나리. 목련(식). 산작약. 뻐꾹나리. 금강제비꽃의 총 10종류와 환경부의 자연환경보전법에 의한 멸종위기 및 보호야생식물종은 보춘화 1종류가 조사되었다. 한국특산식물 종은 개나리(식), 구상나무, 금마타리, 꽃마리, 나비나물, 노각나무, 말채나무, 병꽃나무, 분취, 뻐꾹나리, 일월비비추, 할미밀망 등의 총 24종류가 확인되 었다.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.321.2-321.2
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• 2002

Possible role of anti-inflammatory effects of a new iridoids, patridoid I. II and II-A which were isolated from Patrinia saniculaefolia. examined by assessing their effects on tumor necrosis factor $\alpha$ (TN F$\alpha$) and 2 enzymes, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the lipopolysaccaride (LPS)-stimulated murine macrophage-like cell line RAW 264.7. Among them. patridoid II consistently inhibited the production of TNF$\alpha$ and NO production in a dose dependent manner. But patridoid I and patrioid ll isomer palrioid ll-A. these compounds very weakly inhibited NO producion. Moreover. treatment of macrophage with these compounds, the decrease in NO products was accompanied by a decrease in iNOS protein level as assessed by Western Blot. But these compounds did not affect COX-2 protein expression in LPS-stimulated macrophage. Our results suggest that patridoid ll could become a leading compound for developing a novel of anti-inflammalory drugs.

• 한국산림과학회지
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• 제84권2호
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• pp.247-257
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• 1995

우리나라 특산 수종인 구상나무림(林)의 보존과 조림 및 임업경영에 필요한 정보를 체계화 시킬 목적으로 ZM방식을 통한 군락분류를 하였던 바 다음과 같이 요약할 수 있었다. 구상나무림(林)은 구상나무-신갈나무군락과 구상나무 제주조릿대군락으로 구분되었으며 구상나무 신갈나무군락은 미역줄나무군, 금마타리군 및 전형군으로 구분되었고, 미역줄나무군은 전형소군, 참나물소군 미 원추리 소군으로 구분되었다. 구상나무-제주조릿대군락은 매발톱나무군, 마삭줄군 및 전형군으로 구분되었으며 매발톱나무군은 전형소군과 노루귀소군으로, 마삭줄근은 노루귀소군과 전형소군으로 구분되는 등 총 10개의 식생단위로 구분되었다. 일치법으로 검토한 바 구상나무-신갈나무군락은 소백산맥에 위치하는 지리산, 덕유산, 가야산에서 출현하였고, 구상나무-제주조릿대군락은 한라산에서 출현하는 등 지리적으로 구분되었고, 군락단위간에는 해발과 지형이 복합적으로 영향을 미치는 경향이었다. 식생단위와 구상나무의 흉고직경 및 수고간에는 구상나무-신갈나무군락의 평균흉고직경과 평균수고가 각각 28.4cm, 10.6m로서 구상나무-제주조릿대군락의 평균흉고직경과 수고가 23.6cm, 6.3m인데 비하여 큰 편이었고 구상나무-신갈나무군락 중에서는 금마티리군이 평균흉고직경과 수고가 20cm, 5m로서 가장 작었으며, 구상나무-제주조릿대군락 중에서는 전형군의 평균흉고직경과 수고가 4cm와 3m로서 가장 작았다.