• 한국약용작물학회:학술대회논문집
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• 2010.10a
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• pp.553-554
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• 2010

• Natural Product Sciences
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• v.14 no.4
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• pp.249-253
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• 2008

Two oleanane-type triterpenes (1, 2) and their glycosides (4-6), and one ursane-type triterpene (3) have been isolated from a methanolic extract of Patrinia saniculaefolia Hemsley (Valerianaceae) through repeated silica gel and reversed-phase C-18 column chromatography. Their chemical structures were determined as oleanolic acid (1), oleanonic acid (2), 23-hydroxyursolic acid (3), 3-O-${\alpha}$-L-arabinopyranosyl-oleanolic acid (4), 3-O-${\beta}$-D-glucopyranosyl-oleanolic acid (5), and oleanolic acid 3-O-[${\alpha}$-D-xylopyranosyl-($1{\rightarrow}3$)-${\beta}$-D-glucuronopyranoside-6-O-butyl-ester] (6) on the basis of their MS, $^1H$-, and $^{13}C$-NMR spectral data. All compounds were isolated from the whole plant of the P. saniculaefolia for the first time. These compounds were examined for their anti-complement activity against the classical pathway of the complement system. Among them, compounds 1 - 3 exhibited anti-complement activity with $IC_{50}$ values of 470.1, 212.2, and 121.0 ${\mu}M$, respectively, whereas compounds 4 - 6 were inactive. These results suggest that the carbonyl or hydroxy group at C-3 in the oleananeand/or ursane-triterpenes are important for the anti-complement activity against the classical pathway.

• Natural Product Sciences
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• v.17 no.2
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• pp.90-94
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• 2011

An in vitro bioassay-guide revealed that the methanol (MeOH) extract of the whole plant of Patrinia saniculaefolia (Valerianaceae) showed cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) dual inhibitory activity by assessing their effects on the production of prostaglandin $D_2$ ($PGD_2$) and leukotriene $C_4$ ($LTC_4$) in mouse bone marrow-derived mast cells (BMMCs). Phytochemical study of the MeOH extract of this plant led to the isolation of twelve compounds; ${\beta}$-farnesene (1), squalene (2), nardostachin (3), patridoid I (4), patridoid II (5), patridoid II-A (6), oleanolic acid (7), oleanonic acid (8), 23-hydroxyursolic acid (9), oleanolic acid 3-O-${\alpha}$-L-arabinopyranoside (10), oleanolic acid 3-O-${\beta}$-D-glucopyranoside (11), oleanolic acid 3-O-[${\beta}$-D-xylopyranosyl-(1${\rightarrow}$3)-${\beta}$-D-(6-O-butyl)glucuronopyranoside] (12). Among the compounds, 4 and 5 strongly inhibited both the COX-2-dependent $PGD_2$ generation with $IC_{50}$ values of 8.7 and 13.6 ${\mu}M$, respectively, and the generation of $LTC_4$ in the 5-LOX dependent phase with $IC_{50}$ values of 41.7 and 46.9 ${\mu}M$, respectively, which suggest that the anti-inflammatory activity of P. saniculaefolia might occur in part via the inhibition of both $PGD_2$ and $LTC_4$ generation by 4 and 5.

• Natural Product Sciences
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• v.19 no.2
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• pp.77-119
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• 2013

The genus Patrinia, belonging to the Valerianaceae family, includes ca. 20 species of herbaceous plants with yellow or white flowers, distributed in Korea, China, Siberia, and Japan. Among them, P. scabiosaefolia (yellow Patrinia), P. saniculaefolia, P. villosa (white Patrinia), and P. rupestris are found in Korea. Several members of this genus have long been used in folk medicine for the treatment of inflammation, wound healing, ascetics, and abdominal pain after childbirth. Thus far, ca. 217 constituents, namely flavonoids, iridoids, triterpenes, saponins, and others have been identified in this genus. Crude extract and isolated compounds have been found to exhibit anticancer, anti-inflammatory, antioxidant, antifungal, antibacterial, cytotoxic activities, lending support to the rationale behind several of its traditional uses. The present review compiles information concerning the phytochemistry and biological activities of Patrinia, with particular emphasis on P. villosa, as studied by our research group.

• The Korean Journal of Ecology
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• v.21 no.3
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• pp.291-300
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• 1998

The forest vegetation of Mt. Odae based on the interspecific relationship was classified into 4 groups : Quercus mongolica, Pinus densiflora, Quercus variabilis and Patrinia saniculaefolia. Thirty-one species of Quercus mongolica group including Quercus mongolica and Acer mone, 12 species of Pinus densiflora group comprising Pinus densiflora and Spodiopogon sibiricus, 6 species of Quercus variabilis group and 4 species of Patrinia saniculaefolia were positively correlated. in the results of species ordination by principal component analysis, 7 clusters by the humidity and acidity of soil, 4 clusters by the humidity and light intensity and 7 clusters by the acidity and light intensity were formed. The plot ordination showed that the distribution of species based on the humidity, soil acidity and total organic matters was in the order of Pinus densiflora, Quercus variabilis and Quercus mongolica groups, and based on the light intensity was in the order of Quercus variabilis, Pinus densiflora and Quercus mongolica groups.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2009.10a
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• pp.43-43
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• 2009

• Journal of the Korean Society of Environmental Restoration Technology
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• v.9 no.4
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• pp.13-23
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• 2006

The vascular plants of the studied area in the Mt. Bangjang was listed 422 taxa : 106 families, 299 genera, 372 species, 1 subspecies, 46 varieties and 3 forms. Based on the list of the rare plants by the Forest Research Institute, 5 taxa were recorded in the studied areas; Lilium distichum(Preservation priority order : No. 159), Tricyrtis dilatata (No. 97), Aristolochia contorta (No. 151), Prunus yedoensis (No. 110), Patrinia saniculaefolia (No. 122) and based on the list of Korean endemic plants, 9 taxa were recorded; Cephalotaxus koreana, Carex okamotoi, Populus tomentiglandulosa, Salix purpurea var. japonica, Prunus yedoensis, Forsythia koreana, Paulownia coreana, Weigela subsessilis, Patrinia saniculaefolia. Specific plant species by floral region were total 29 taxa; Prunus yedoensis in class V, 3 taxa(Acer palmatum, Asperula lasiantha, Lonicera subhispida ) in class III, 5 taxa(Lilium distichum, Potentilla dickinsii, Caryopteris incana, Patrinia saniculaefolia, Ligularia fischeri) in class II, 20 taxa(Ulmus parvifolia, Clematis patens, Aconitum jaluense, Ilex macropoda, Grewia biloba var. parviflora etc.) in class I. The naturalized plants in this site were 13 families, 31 genera, 36 species, 2 varieties, 38 taxa and naturalization rate was 9.0% of all 422 taxa vascular plants. Because of recent rapid increase of cars and people around here, analysis shows many naturalized plants and high naturalized ratio. And wild plants disturbing ecosystem like Ambrosia artemisiifolia var. elatior have been increasing. So, it needs continuing control and conservation measures on the plant ecosystem.

• Korean Journal of Environment and Ecology
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• v.16 no.4
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• pp.387-403
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• 2003

The vascular plants in Manbokdae-Yeowonjae section of the Baekdudaegan were consisted of 502 taxa; 104 families,305 genus,439 species, 60 varieties, 3 forma. From the floristic point of view, the Baekdudaegan of Manbokdae-Yeowonjae section belongs to the southern province in Korea. The rare and endangered plants designated by Korea Forest Service were Abies koreana, Pedicularis verticillata, Patrinia saniculaefolia, Hololeion maximowiczii, Lilium callolsum, Paeonia obovate, Tricyrtis dizutata and VioEa diamantica, and Cymbidium goeringii. The Korean endemic species were Abies koreana, Patrinia saniculaefolia, Vicia unijuga, Stewartia koreana, Cornus walteri, Weigela subsessilis, Saussurea seoulensis, Tyicyrtis dilatata, Hosta capitata, Clematis trichotoma et at.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.321.2-321.2
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• 2002

Possible role of anti-inflammatory effects of a new iridoids, patridoid I. II and II-A which were isolated from Patrinia saniculaefolia. examined by assessing their effects on tumor necrosis factor $\alpha$ (TN F$\alpha$) and 2 enzymes, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the lipopolysaccaride (LPS)-stimulated murine macrophage-like cell line RAW 264.7. Among them. patridoid II consistently inhibited the production of TNF$\alpha$ and NO production in a dose dependent manner. But patridoid I and patrioid ll isomer palrioid ll-A. these compounds very weakly inhibited NO producion. Moreover. treatment of macrophage with these compounds, the decrease in NO products was accompanied by a decrease in iNOS protein level as assessed by Western Blot. But these compounds did not affect COX-2 protein expression in LPS-stimulated macrophage. Our results suggest that patridoid ll could become a leading compound for developing a novel of anti-inflammalory drugs.

• Journal of Korean Society of Forest Science
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• v.84 no.2
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• pp.247-257
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• 1995

This research carried out forest community classification on the basis of the methods of ZM school, in order to furnish useful information needed for forest management, and for afforestation and preservations of Abies koreana forest which was Korean native species, and the research results could be summarized as follows. Abies koreana forest was divided into 10 vegetation units ; This forest was divided into Abies koreana-Quercus mongolica community and Abies koreana-Sasa quelpartensis community. Abies koreana-Quercus mongolica community was divided into Tripterygium regelii group, Patrinia saniculaefolia group, and Typical group, and Tripterygium regelii group seas divided into Typical subgroup. Pimpinella brachycarpa subgroup, and Hemirocallis fulva subgroup. Abies koreana-Sasa quelpartensis community was divided into Berberis koreana group, Trachelospermum asiaticum var. intermedium group, and Typical group. Berberis koreana group was divided into Typical subgroup and Hepatica asiatica subgroup, and Tranchelospermum asiaticum var. intermedium group was divided into Hepatica asiatica subgroup and Typical subgroup. According to the results of the analysis by coincidence method, Abies koreana-Quercus mongolica community represented in Mt. Chiri, Mt. Deokyu and Mt. Kaya which were located in the Sobaek mountains, Abies koreana-Sasa quelpartensis community represented in Mt. Hanla. Therefore it was thought that Abies koreana forest was classified by geographical position, and vegetation units of Abies koreana forest tended to be classified by the altitude and topography. As for DBH and height of Abies koreana, mean DBH and height of Abies koreana-Quercus mongolica community were each 28.4cm, 10.6m that were larger than mean DBH and mean height(each 23.6cm, 6.3m) of Sasa quelpartensis community. Among Abies koreana-Quercus mongolica community, Patrinia saniculae-folia group had the smallest mean DBH and mean height(20cm, 5m), and among Abies koreana-Sasa quelpartensis community, Typical group had the smallest mean DBH and mean height(4cm, 3m).