• Archives of Plastic Surgery
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• 제39권1호
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• pp.3-10
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• 2012

The free muscle-sparing transverse rectus abdominis myocutaneous (MS-TRAM) and deep inferior epigastric perforator (DIEP) flaps involve transferring skin and subcutaneous tissue from the lower abdominal area and have many features that make them well suited for breast reconstruction. The robust blood supply of the free flap reduces the risk of fat necrosis and also enables aggressive shaping of the flap for breast reconstruction to optimize the aesthetic outcome. In addition, the free MS-TRAM flap and DIEP flap require minimal donor-site sacrifice in most cases. With proper patient selection and safe surgical technique, the free MS-TRAM flap and DIEP flap can transfer the lower abdominal skin and subcutaneous tissue to provide an aesthetically pleasing breast reconstruction with minimal donor-site morbidity.

• Journal of information and communication convergence engineering
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• 제9권1호
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• pp.89-94
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• 2011

Telemedicine system means a remote support system among 4 remote telemedicine services of u-Health. A currently available service in Korea is the one checking and maintaining patient's status and supporting in emergency through video communication between an ambulance transferring patients and hospital under HSDPA and WiBro environment with coding of MPEG-2 and MPEG-4. With that, this paper improves the stability of the current telemedicine system service of ambulance confirms the improvement compared to the old system by generating a system communicating by RTP/RTCP under coding process through H.264/AVC after converting RGB video to YUV in order to improve network efficiency.

• 대한의생명과학회지
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• 제24권3호
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• pp.157-167
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• 2018

The concept of gene therapy is to treat a disease by transferring therapeutic nucleic acids to a patient's cells. It took several decades from the basic theoretical proposal of gene therapy to the current promising treatment option for some important human diseases. The encountered adverse effects in the early clinical studies boosted the development of sophisticated vectors and elaborate clinical designs. The gene therapy is now considered to have the potential to cure many diseases that are incurable with conventional medications. By the end of 2017, about 2,600 clinical trials of gene therapy have been performed or are ongoing for a variety of diseases such as cancers, monogenic diseases, cardiovascular diseases and neurological diseases etc. Here, we present a brief introduction of technical achievement in relation to gene therapy development, and a review of the current status of global gene therapy clinical development.

• 한국방사선학회논문지
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• 제13권3호
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• pp.433-438
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• 2019

의료기관에서는 환자의 진단 및 치료를 위해 방사선발생장치 및 방사성동위원소를 사용하고 있다. 환자이송원은 환자이송을 위해 불가피하게 방사선 관리구역에 출입하거나, 동위원소가 투여된 환자를 근거리에서 이송하는 등 일반인과 비교했을 때, 방사선에 노출될 확률이 높은 환경에서 업무를 수행한다. 따라서 환자이송원의 피폭 정도를 알아보고자 연구를 진행했다. 인천 A 종합병원에서 근무하고 있는 12명의 환자이송원을 대상으로 2019년 4월 1일부터 4월 30일까지 한 달 동안 선량계를 가슴에 패용하고, 누적된 선량을 측정했다. 사용된 선량계는 광자극발광선량계(OSLD), 선량판독은 OSLD Microstar Reading System을 사용했다. 한 달 동안 누적선량 측정 결과 심부선량은 평균 0.13 mSv, 표층선량은 평균 0.13 mSv로 측정되었고, 한 달 동안 누적된 선량에 12를 곱해 일 년 동안 업무를 수행할 시 받게 될 누적선량 예상치를 추정한 결과 심부선량은 평균 1.52 mSv, 표층선량은 평균 1.51 mSv로 나타났다. 환자이송원의 수시출입자 분류를 통해 피폭선량을 측정, 관리 하고, 교육훈련을 통해 방사선에 대한 방호지식을 높이며 건강진단을 통해 방사선장해 발생을 방지하기 위한 노력이 필요하다.

• 지역사회간호학회지
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• 제33권4호
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• pp.357-371
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• 2022

Purpose: This study aims to investigate factors related to long-term length of stay (LOS) of patients with chronic diseases in Korean veterans hospitals. Methods: The subjects were 196 elderly patients with chronic disease staying in the hospital for more than 10 days, Data were collected by the survey of patients with structured questionnaires and medical records review by nurses from July 15 to August 10, 2019. Collected data were analyzed using t-test, ANOVA, Pearson's correlation coefficient and stepwise multiple regression. Results: The present and desired LOS were 37.78±32.66 days and 60.87±45.95 days, respectively. Factors affecting hospital LOS were found to be main disease (genitourinary) (p<.001), assistance in activities of daily living (p<.001), area of hospital (p<.001), payment of medical fees (p=.026), hospital satisfaction (p=.036) and the explanatory power of these variables was 26.4%. The most common health problems that need to be solved after discharge were symptom alleviation and health promotion. These problems can be solved using community-based facility services or visiting medical-welfare services (especially home care nursing). Conclusion: In order to reduce hospital LOS, the following measures are required: personalized self-management education, provision of transportation services for dialysis therapy of inactive patients, linking patients with visiting medical-welfare services including home care nursing and mobile healthcare services, operation of the case management system including the notice of the discharge date at admission, interim check of patient status, and connecting the patient with community resources or transferring the patient to long-term care facilities at discharge.

• 대한치과보철학회지
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• 제61권1호
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• pp.44-54
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• 2023

기능적이고 심미적인 보철물을 제작하기 위해서 환자의 교합평면에 관한 정보를 정확하게 전달하는 과정은 필수적이다. 특히, 완전 무치악 환자의 경우 교합평면은 의치가 연조직을 올바르게 지지하고 안모와 심미적 조화를 이루며 제대로 된 발음을 할 수 있도록 중요한 기준을 제시하고, 안정적인 저작작용을 위한 균형 있는 교합관계를 형성하는데 매우 중요한 역할을 한다. 전통적으로 환자의 악간 관계와 교합평면에 대한 정보를 진료실에서 기공실로 전달하기 위해 교합기에 연결하여 사용하는 다양한 안궁(facebow) 시스템을 이용하였으나, CAD 상으로 이를 옮기는 과정에서는 여러 한계점이 있었다. 이 과정을 단순화하기 위하여 최근 조립식의 POP(PNUD Occlusal Plane) Bow system이 개발되었다. 본 증례에서는 완전 무치악 환자의 치료 과정에서 POP Bow system을 적용하여 환자의 교합평면 정보가 잘 반영된 CAD-CAM(Computer-aided design-computer-aided manufacturing) 치료 의치를 제작하였고, 심미적이고 기능적인 만족도를 얻을 수 있었다.

• 대한치과보철학회지
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• 제55권2호
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• pp.164-170
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• 2017

다른 보철 수복에 비하여 전치부의 수복을 위해서는 치료 계획 단계에서 환자 요구도를 반영해야 할 필요성이 증가된다. 임상 사진과 프리젠테이션 소프트웨어를 이용한 Digital Smile Design (이하 DSD)방식은 치료 계획을 효과적으로 시각화할 수 있어 환자 및 기공사과의 의사 소통이 용이하다. 본 증례에서는 기존 보철물에 대하여 심미적 불만을 갖고 있는 환자에서, 두 가지 방식으로 재수복을 진행하였다: (1) 심미 진단, 미소 설계와 의사소통을 위하여 DSD 방식을 이용하고, 임시 및 최종 보철물 제작에 전적으로 디지털 방식을 사용한 경우 (2) 미소 설계를 위해 진단 납형을 이용하고 보철물은 통법대로 제작한 경우. 이 증례에서 의사 소통의 측면에서는 DSD방식이 수월하였으나, (1)의 방법으로는 심미적 목적을 달성하지 못하여, 예지성 있는 결과를 위해서는 성공적 의사 소통 이외에도 다양한 심미 요소를 고려한 진보된 형태의 미소 설계 도구가 필요할 것으로 생각되었다.

• 융합신호처리학회논문지
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• 제12권3호
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• pp.157-162
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• 2011

본 연구는 심폐소생술 (CPR) 중 인공호흡의 무선 전송 시스템 구현에 관한 것으로, 병원 전 단계에서의 CPR 성과를 높임으로써 응급환자의 생존율을 높이기 위한 환자-병원간 무선 통신 시스템이다. 기도삽관 기반 호흡기류센서를 적용하여 호흡량을 측정하였는데, 기도삽관을 통한 인공호흡은 기류량의 손실을 최소화하여 보다 정확한 흡기-호기량 계측이 가능하고, 기도-식도 구분을 통해 식도팽창을 방지하여 다른 인공호흡 방법에 비해 장점을 입증하였다. 또, 인공호흡 주요지표인 분당 평균호흡량 (V), 호기말 이산화탄소 농도 ($EtCO_2$), 기도압력 (Ptr)을 디지털화하여 정의하였으며 정의된 데이터를 무선 통신 시스템을 이용하여 전송망의 대역폭 및 지연시간을 확인하였다. 호흡신호를 전송하기 위해 필요한 최대대역폭 (815 Kbps) 에 비해 Wireless LAN의 대역폭 (54 Mbps) 이 충분하여 네트워크 부하는 1.5 % 미만이었으며, 전송지연시간은 0.3 초 이내로 측정되었다.

• Journal of Korean Medical Science
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• 제33권48호
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• pp.295.1-295.7
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• 2018

Background: Vancomycin-resistant enterococci (VRE) infections have become a major healthcare-associated pathogen problem worldwide. Nosocomial VRE infections could be effectively controlled by screening patients at high risk of harboring VRE and thereby lowering the influx of VRE into healthcare centers. In this study, we evaluated factors associated with VRE colonization in patients transferred to emergency departments, to detect patients at risk for VRE carriage. Methods: This study was conducted in the emergency department of a medical college-affiliated hospital in Korea. Every patient transferred to the emergency department and admitted to the hospital from January to December 2016 was screened for VRE using rectal cultures. In this cross-sectional study, the dependent variable was VRE colonization and the independent variables were demographic and clinical factors of the patients and factors related to the transferring hospital. Patients were divided into two groups, VRE and non-VRE, and previously collected patient data were analyzed. Then we performed logistic regression analyses of characteristics that differed significantly between groups. Results: Out of 650 patients, 106 (16.3%) had positive VRE culture results. Significant variables in the logistic analysis were transfer from geriatric long-term care hospital (adjusted odds ration [aOR]: 8.017; 95% confidence interval [CI]: 1.378-46.651), hospital days (4-7 days; aOR: 7.246; 95% CI: 3.229-16.261), duration of antimicrobial exposure (1-3 days; aOR: 1.976; 95% CI: 1.137-3.436), and age (aOR: 1.025; 95% CI: 1.007-1.043). Conclusion: VRE colonization in patients transferred to the emergency department is associated primarily with factors related to the transferred hospitals rather than demographic and clinical characteristics.

• Journal of Pharmaceutical Investigation
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• 제34권5호
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• pp.351-362
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• 2004

The basic concept underlying gene therapy is that human diseases may be treated by the transfer of genetics material into specific cells of a patient in order to correct or supplement defective genes responsible for disease development. There are several systems that can be used to transfer foreign genetic material into the human body. Both viral and non-viral vectors are developed and evaluated for delivering therapeutic genes. Viral vectors are biological systems derived from naturally evolved viruses capable of transferring their genetics materials into host cells. However, the limitations associated with viral vectors, in terms of their safety, particularly immunogenecity, and their limited capacity of transgenic materials, have encouraged researchers to increasingly focus on non-viral vectors as an alternative to viral vectors. Although non-viral vectors are less efficient than viral ones, they have the advantages of safety, simplicity of preparation and high gene encapsulation capability. This article reviews the most recent studies highlighting the advantages and the limitation of gene delivery systems focused on non-viral systems compared to viral systems.