• Title/Summary/Keyword: Pathology

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Status of Pathology Services and Molecular Pathology in Sub-Saharan Africa: Implications for Combating Breast Cancer

  • Wajana Lako LABISSO
    • Korean Journal of Clinical Laboratory Science
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    • v.55 no.3
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    • pp.121-131
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    • 2023

  • African breast cancer patients benefit less from classical pathology services owing to the complex molecular and clinicopathological nature of the disease, poor quality of laboratory supplies, and shortage of experts in the field. This review presents evidence and confirms the need for improving anatomic pathology services in Africa. Peer-reviewed international journal articles available in Medline, Scopus, PubMed, and Google scholars, describing the status of pathology services in Africa, were included. Besides the late presentation of patients, anatomic pathology laboratories are accountable for the escalated mortality of breast cancer patients in several parts of Africa. Conversely, molecular diversity and biological heterogeneity of breast cancers, which disprove the one-size-fits-all therapeutic approach, have been reported from different parts of the continent. Irrespective of the geographical background, the choice of therapeutic options and predicting disease outcome depends on the right identification of the molecular signature of the cancer type. In conclusion, we propose that upgrading and integrating anatomic pathology with molecular diagnostic pathology is essential in order to provide better diagnostic results that will profoundly impact curbing mortality from breast cancers.

  • https://doi.org/10.15324/kjcls.2023.55.3.121 인용 PDF

Biological Control of Apple Ring Rot on Fruit by Bacillus amyloliquefaciens 9001

  • Li, Yan;Han, Li-Rong;Zhang, Yuanyuan;Fu, Xuechi;Chen, Xinyi;Zhang, Lixia;Mei, Ruhong;Wang, Qi
    • The Plant Pathology Journal
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    • v.29 no.2
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    • pp.168-173
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    • 2013

  • Apple ring rot disease, caused by Botryosphaeria dothidea (Moug. ex. Fr) Ces. et de Not., is one of the most important diseases on apple fruits. In this study, strain 9001 isolated from healthy apple fruits from an infested orchard was evaluated for its biocontrol activity against apple ring rot in vitro and in vivo. Strain 9001 showed obvious antagonistic activity to B. dothidea YL-1 when plated on potato dextrose agar. Soaking healthy apples in the bacterial suspensions of strain 9001 prior to artificial inoculation of fungal pathogen resulted in a dramatic decrease in disease incidence when compared to the control. Moreover, either field application in the growth season or postharvest treatment of apples from infected orchards with bacterial suspensions of strain 9001 resulted in significantly reduced disease incidence within the storage period for 4 months at room temperature. Based on the phylogenetic analysis of 16S rRNA and the gyrA gene, strain 9001 was identified as Bacillus amyloliquefaciens. These results indicated that B. amyloliquefaciens 9001 could be a promising agent in biocontrol of apple ring rot on fruit, which might help to minimize the yield loss of apple fruit during the long postharvest period.

  • https://doi.org/10.5423/PPJ.SI.08.2012.0125 인용 PDF KSCI