• 음성과학
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• 제14권1호
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• pp.151-162
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• 2007

This study focuses on the classification of pathological voice using GMM (Gaussian Mixture Model) and compares the results to the previous work which was done by ANN (Artificial Neural Network). Speech data from normal people and patients were collected, then diagnosed and classified into two different categories. Six characteristic parameters (Jitter, Shimmer, NHR, SPI, APQ and RAP) were chosen. Then the classification method based on the artificial neural network and Gaussian mixture method was employed to discriminate the data into normal and pathological speech. The GMM method attained 98.4% average correct classification rate with training data and 95.2% average correct classification rate with test data. The different mixture number (3 to 15) of GMM was used in order to obtain an optimal condition for classification. We also compared the average classification rate based on GMM, ANN and HMM. The proper number of mixtures on Gaussian model needs to be investigated in our future work.

• 약학회지
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• 제22권4호
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• pp.226-232
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• 1978

It was to investigate the absorption, excretion, protein binding of ampicillin in the pathological animals pretreated with carbon tetrachloride and mercuric chloride. The absorption of ampicillin was not affected in rats with damaged liver and kidney as compared with that of normal rats. The blood level of ampicillin after oral administration was increased significantly in rabbits with damaged kidney and liver. The blood level of ampicillin in rabbit with damaged kidney was more increased than that in rabbits with damaged liver. In severly damaged rabbits, it was more increased than that of mildly damaged rabbits. Urinary excretion of ampicillin in pathological animals was more inhibited than that of ampicillin in normals. Hepatic excretion of ampicillin was accelerated in rabbits with damaged kidney. However, in rabbits with damaged liver, it was inhibited as compared with that in normals. Protein binding of ampicillin was slightly enhanced by the various concentration of carbon tetrachloride and mercuric chloride, respectively. The results suggest that the increase of blood level of ampicillin in pathological animals was due to the inhibition of renal excretion.

• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.1047-1049
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• 2015

Background: This systematic analysis was conducted to investigate pathological diagnosis of vertebral tumor metastasis with unknown primaries. Methods: Clinical studies conducted to pathologically investigate vertebral tumor metastasis were identified using a predefined search strategy. Pooled diagnosis (PD) of each pathological confirmation was calculated. Results: For vertebral tumor metastasis, 5 clinical studies which included 762 patients were considered eligible for inclusion. Systematic analysis suggested that, for all patients with vertebral tumor metastasis, dominant PD was pathologically confirmed with lung cancer in 21.7% (165/762), with breast cancer in 26.6% (203/762) and with prostate cancer in 19.2% (146/762). Other diagnosis that could be confirmed included lymphoma, multiple myeloma, renal cancer, for example, in this cohort of patients. Conclusions: This systemic analysis suggested that breast, lung and prostate lesions could be the most common pathological types of cancer for vertebral tumor metastasis formunknown primaries, and other common diagnoses could include lymphoma, multiple myeloma, renal cancer.

• 대한간호학회지
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• 제43권4호
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• pp.497-506
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• 2013

Purpose: This study was done to examine the intervention effects on the family of a family education program for pathological gamblers based on Community Reinforcement and Family Training (CRAFT). Methods: A quasi-experimental, nonequivalent control group pretest-posttest design was used. The participants were 44 families of pathological gamblers from G center in Gyung-gi Province and 5 Gam-Anon groups in Seoul City and Gyung-gi Province. The experimental group (n=22) attended the 6 weekly 2 hour-long CRAFT family education program. The control group (n=22) attended the 12-step program of Gam-Anon. Data were collected from November, 2011 to May, 2012. Results: Compared with the control group, the experimental group showed significant decrease in depression (p=.001) and state anger (p=.039). There were no significant differences between groups in the level of interpersonal communication, trait anger, the mode of anger expression and self-esteem. Conclusion: Findings from this study suggest that the CRAFT family education program is effective in decreasing depression and state anger in families of pathological gamblers.

• 말소리와 음성과학
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• 제2권1호
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• pp.113-120
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• 2010

In this paper, we investigate the acoustic characteristics of sustained voices from normal subjects and patients with laryngeal pathologies. Perturbation methods (including jitter and shimmer), signal-to-noise ratio (SNR), and nonlinear dynamic methods (such as correlation dimension) are used to analyze normal and pathological voices. We find that jitter does not statistically discriminate between normal and pathological voices, but a significant difference is found for shimmer, SNR, and correlation dimension. The results suggest that nonlinear dynamic analysis may be valuable for the analysis of normal and pathological voices but perturbation analysis should be applied with caution for pathological voice analysis.

• 대한한의학방제학회지
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• 제20권1호
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• pp.133-147
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• 2012

Objectives : This study was intended to understand characteristics of symptoms, oriental medicine prescription and laboratory test results according to elapsed time of stroke. Methods : Through the medical records of 205 stroke inpatients in the oriental medical hospital in the year 2010, we investigated manifested symptoms, administered oriental medicine prescription and clinical pathological examination results. Collected items were classified to depend on stroke types, cerebral infarction and hemorrhage. We analyzed association between manifested symptoms, the oriental medicine prescription, and laboratory test results of stroke patients and elapsed time. Chi-square tests were performed to determine the significance level of association. Results : All symptoms, prescriptions and laboratory test results in cerebral infarction patients were associated with elapsed time. Especially, symptoms, prescriptions and pathological examination results showed very high statistical significance with elapsed time (a symptom; chi-square(df)=164.3(22), p<0.001, prescription; chi-square(df)=93.5(22), p<0.001, and pathological examination results; chi-square(df)=164.3(22), p<0.0004). But in the case of cerebral hemorrhage, there was not statistical significance. Conclusions : The elapsed time of stroke may be an essential requisite in catching symptoms and prescribing for stroke patients in oriental medical treatment.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9759-9761
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• 2014

Purpose: To compare tumor size by mammography and sonography and align with pathological results in primary breast cancer cases. Materials and Methods: We retrospectively reviewed 95 primary breast cancer patients who underwent mammography and sonography from January 2011 to June 2012. The largest tumor diameter was chosen as sizing reference for each imaging modality. The measurements of mammography and sonography were considered concordant if they were within the measurement of pathological results ${\pm}0.5cm$. Pearson's correlation coefficient was calculated for imaging results. Results: The range of the maximum diameter was 0.6cm-10.5cm and mean value was $3.81{\pm}2.04cm$ by pathological results, 0.7cm-12.4 cm and $3.99{\pm}2.19cm$ by mammography, and 0.9cm-11.0cm and $3.63{\pm}2.01cm$ by sonography, respectively. Sonography (R: 0.754), underestimated tumor size, but had a better correlation with pathological tumor size compared to mammography (R: 0.676), which overestimated tumor size. Conclusions: Sonography is superior to mammography in assessment of primary breast cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7975-7979
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• 2015

Purpose: This study aimed to explore the value of IHC4 in predicting pathological response after neoadjuvant chemotherapy in patients with hormonal receptor (HR)-positive breast cancer (BC). Materials and Methods: In this retrospective exploratory study, data for 68 HR-positive BC patients who received neoadjuvant chemotherapy were recorded. IHC4 scores were calculated based on estrogen receptors/progesterone receptors, Ki-67 and HER2 status. Logistic and ordinal regression analyses in addition to likelihood ratio test were used to explore associations of IHC4 scores and other clinico-pathological parameters with pathological complete response (pCR) and pathological stage. Results: Taking the 25th percentile as the cut-off, a lower IHC4 score was associated with an increased probability of pCR (low; 52.9% vs. High; 21.6%, OR=4.1, 95% CI=1.28-13.16, p=0.018) and a lower pathological stage (OR=3.9, 95% CI=1.34-11.33, p=0.012). When the IHC4 score was treated as a continuous variable, a lower score was again associated with an increased probability of pCR (OR=1.010, 95% CI=1.001-1.018, p=0.025) and lower pathological stage (OR=1.009, 95% CI=1.002-1.017, P=0.008). Lower clinical stage was associated with a better pCR rate that was of borderline significance (P=0.056). When clinical stage and IHC4 score were incorporated together in a logistic model, the likelihood ratio test gave a P-value of 0.004 after removal of the IHC4 score and 0.011 after removal of the stage, indicating a more significant predictive value of the IHC4 score for pCR. Conclusions: This study suggests that the IHC4 score can predict pathological response to neoadjuvant chemotherapy in HR-positive BC patients. This finding now needs to be validated in a larger cohort of patients.

• 한국어병학회지
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• 제18권2호
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• pp.105-118
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• 2005

어류의 빈혈은 병어 또는 임상적으로 건강한 어류에서 확인되는 증상으로 심하면 아가미가 창백해 보이거나 채혈 혈액의 물성으로 인지될 수 있다. 어류의 적혈구 수는 일반적으로 1-3${\times}10^6$개이며, 헤마토크리트 (Ht)는 35-45%로 포유류와 유사범위로 보고되는 경우가 많으나 아직 그 정상치에 대하여 체계적으로 제대로 정리된 자료가 없다. 어류에서도 출혈성, 용혈성, 재생불량성 빈혈로 나누고 있다. 포유류와 유사한 병리학적 영향이 예상되지만, 어류의 경우 10% 이하의 극단적으로 낮은 Ht에서도 생존이 가능하며, antarctic icefish (Chanenocephalus aceratus)에서는 적혈구가 없이 생존하고 있다는 점 등으로부터, 포유류와 다른 병리학적 영향이 예상되나 그 정보가 매우 부족하다. 양식현장에서 어류 질병에 따른 경제적 피해가 해마다 증가하고 있는 시점에서, 빈혈 소견은 어체의 건강평가에 중요한 파라메타의 하나로 볼 수 있는 병리학적 측면을 가지고 있다. 따라서 저자는 지금까지 알려진 각종 어류 질병에 대하여 기술된 임상병리 및 병리조직학 변화 내용을 검토함으로써, 어류에서의 빈혈 관련 질병을 정리하고, 저자 등의 예비적 실험 결과와 함께, 그 병리학적 영향에 대하여 고찰하였다.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제5권10호
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• pp.489-496
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• 2016

병리 정보시스템(Pathological Information System: PIS)은 매일 수천 장씩 생산되는 환자 병리 이미지를 관리하는데 활용되고 있으며, 이 이미지 정보들을 어떻게 효과적으로 처리할 것인지는 병리 정보 처리에 있어서 중요한 연구 과제 중 하나이다. 이미지의 외곽선을 추출하는 것은 병리 이미지 처리에 있어 가장 중요한 작업이지만 현재 사용되는 알고리즘은 정확도에 있어 많은 개선점을 가지므로, 본 논문에서는 이미지의 외곽선 검측에 있어서 기존의 Canny 알고리즘의 원리를 바탕으로 적응적 임계값 설정이 가능하며 눈금자를 임계값 설정의 기준으로 삼는 방식을 제안하여 기존 외곽선 추출 방식보다 정확한 방식을 제안한다. 제안 방식은 기존 방식과의 비교실험을 통해 성능을 검증하였으며, 이 실험에서는 임의로 선정된 병리 이미지 군, 기존 방식으로는 식별이 제한되었던 병리 이미지 군 및 의도적으로 노이즈를 추가한 이미지 군을 대상으로 실험하였고, 실험 결과를 비교하여 제안하는 이미지 외곽선 식별 방식의 향상된 성능을 증명했다.