• Journal of Sasang Constitutional Medicine
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• v.24 no.3
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• pp.17-33
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• 2012

Objectives We aimed to analyze the meanings of ordinary symptoms and the developing aspects of present symptoms according to the ordinary symptoms based on the Soeumin pathology, and present the new methodology to make use of the ordinary symptoms in the clinical field. Methods The Soeumin symptomatology and pathology of the Sinchuk Edition (the upgraded and revised edition) of "Donguisusebowon" were reviewed and examined for relevant information on the ordinary symptoms. Results and Conclusions 1) In the Soeumin symptomatology, the representative symptoms, by which the aspects of whole physio-pathological conditions can be decided, were showed as ordinary symptoms, and especially the aggravated state of the deflection of Seong-Jeong are presented additionally in the ordinary symptoms of the unfavorable patterns of Exterior and Interior symptomatologies. 2) In the Soeumin symptomatology, the ordinary symptoms have the clinical meanings as 'pathological predisposition', and can be estimated as one symptomatology in the whole schemes of symptomatology. 3) In the Soeumin symptomatology, the ordinary symptoms can affect the present symptoms, and can be the principal factors in the pattern identifications of the present symptoms and the determinations of therapeutical prescriptions. 4) In the Soeumin symptomatology, the ordinary symptoms can develop to the present symptoms across the Interior or the Exterior symptomatologies within the categories of the favorable and unfavorable patterns, and this developing aspects can be explained from the Soeumin pathological perspective.

• Journal of Life Science
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• v.17 no.12
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• pp.1717-1722
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• 2007

In the present study, all of the treadmill exercise-trained SHR expressed clear adaptive changes such as reduced resting heart rate and blood pressures, LPOA, homocysteine Therefore, treadmill exercise was sufficient to induce physiological adaptation in the SHR. Endurance training is known to induce physiological cardiac hypertrophy, while hypertension induces patho logical cardiac hypertrophy that increases cardiomyocyte apoptosis. The pathological adaptation to pressure overload has also been associated with a further increase in the expression of several marker genes including cardiomyocyte ET-1 in the SHR, but not in the exercise-trained SHR. Additionally, there is an increase in the endothelial nitricoxide synthases (eNOS) protein expression of soleus, gastrocnemius, and extensor digitorum longus muscle in the exercise-trained SHR but not in the SHR in the present study. Thus, compared to pathological adaptation to pressure overload, physiological adaptation to exercise training is associated with distinct alterations in cardiac and molecular phenotypes. based on these results, exercise training improves hypertension by cardiovascular regulating genes and hemodynamic parameters.

• Journal of Korean Medicine for Obesity Research
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• v.13 no.1
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• pp.10-16
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• 2013

Objectives: This work aimed to investigate differentiations of Korean medicine's pathological symptoms and SF-12 sub scales among normal, overweight and obese subjects from multi-center case report. Methods: From 2009 to 2011 survey were carried out to 1,589 subjects who took treatment or were hospitalized in 7 Korean medicine hospitals and 3 Korean medicine clinic. Survey include Korean medicine's pathological symptoms and SF-12. Whole survey were obtained from subjects with interviewers. Obesity degree was divided into three groups by body mass index: Normal group is from 18.5 below 23, overweight from 23 below 25 and obese group is over 25. Chi-square test was performed to reveal differentiation response rate of pathologic symptoms among obesity groups. ANOVA test was carried out for compare each group's SF-12 sub scales. Results: Patients of overweight or obesity have more symptoms such as skin itching, swelling, weakness in lower legs, and feverish with swollen joints. Contrary, normal weight group responded symptoms of dry skin more than those of obese group. As a fatigue, obese group have more fatigue feeling at afternoon and evening, compared to high frequency response of normal weight groups' morning fatigue. Obese groups shows low physical scores of health related quality of life, in contrast, high mental scores of that. Conclusions: This is first work of pathologic symptoms shown by obese groups. This would contribute to standardization of Korean medicine's pattern identification as suggestion of classification point for obese groups.

• Journal of Gastric Cancer
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• v.20 no.4
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• pp.395-407
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• 2020

Purpose: A phase II study was conducted to evaluate the safety and efficacy of preoperative, intra-arterial perfusion of epirubicin, etoposide, and oxaliplatin combined with oral chemotherapy S-1 (SEEOX) for the treatment of type 4 gastric cancer. Materials and Methods: A single-center, single-arm phase II trial was conducted on 36 patients with histologically proven type 4 gastric cancer without distant peritoneal or organ metastasis. Patients received 3, 21-day courses of SEEOX preoperative chemotherapy. The primary endpoint was overall survival (OS) and the secondary outcomes assessed were chemotherapeutic response, radical resection rate, pathological regression, toxicities, postoperative morbidity, and mortality. Results: All patients were at an advanced stage of cancer (stage III or IV) and completed the entire course of treatment. Based on changes in tumor volume and peritoneal metastasis, the objective response rate was 55.6% (20/36; 95% confidence interval [CI], 38.5%-72.6%) and the disease control rate was 69.4% (25/36; 95% CI, 53.6%-85.3%). The radical resection rate was 75% (27/36; 95% CI, 60.1%-89.9%) and the proportion of R0 resections was 66.7% (21/36; 95% CI, 50.5%-82.8%). The pathological response rate was 33.3%, of which 13.9% showed complete pathological regression. The median survival was 27.1 months (95% CI, 22.24-31.97 months), and the 2-year OS was 48.5% (95% CI, 30.86%-66.1%). Conclusions: Preoperative SEEOX is a safe and effective treatment for type 4 gastric cancer. Based on these preliminary data, a phase III study will be conducted to confirm the superiority of this regimen over standard treatment.

• Journal of Korean Neurosurgical Society
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• v.64 no.4
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• pp.585-591
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• 2021

Objective : Filum transection is one of the most commonly performed operative procedure in pediatric neurosurgery. However, the clinical and pathological features as well as the surgical indication are not well-established. This study aimed to analyze the characteristics of patients who underwent transection of the filum during the last 10 years in a single institute. Methods : A total of 82 patients underwent transection of the filum during the period. As a general rule, we performed the transection in patients who are symptomatic or have abnormality in the urologic or neuromuscular evaluations. There were exceptions as asymptomatic patients who only fit the definition of thickened filum (width greater than 2.0 mm or conus level below L3 vertebral body) were operated by parent's wish or surgeon's preference according to radiological findings, etc. Results : Seventy-six out of 82 patients had fibrous tissue in the pathologic specimen of filum. Interestingly, patients who had glial cells were more correlated with no preoperative syrinx, and no progression of syrinx even for those who did have syrinx initially. Also, larger percentage of symptomatic patients had peripheral nerve twigs than asymptomatic patients. No difference in conus level or thickness of filum was found between patients with or without preoperative syrinx. Significantly more patients with syrinx (56%) were chosen to be operated without any symptom or abnormality in study i.e., solely based on radiological findings than those without syrinx (21%). The surgical outcome for syrinx was favorable, as all but one patient had either improved or static syrinx. The exceptional case had increase in size due to the upward displacement of the proximal end of the cut filum. Conclusion : This study evaluated the pathological, clinical, radiological features of patients who underwent transection of the filum. Interesting correlations between pathological findings and clinical features were found. Excellent outcome regarding preoperative syrinx was also shown.

• Journal of Korean Medical classics
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• v.35 no.3
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• pp.21-31
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• 2022

Objectives : The Gyotae-hwan formula has traditionally been applied to conditions of fearful throbbing[怔忡] and insomnia due to disharmony of the Heart and Kidney, of which experimental and clinical research has been carried out while those on its pathological mechanism and constituent compatibility have been inadequate. Methods : Pathological mechanism and constituent compatibility of the Gyotae-hwan formula as listed in the 『Comprehensive Medicine According to Master Han』(韓氏醫通) and the『Simple Recipes for Four Disciplines』(四科簡效方) were analyzed. Findings from recent researches searched using the keywords '交泰丸' and '교태환' in the OASIS and CNKI databases were referenced as well. Results : The Gyo-tae hwan was first mentioned in the text 『Comprehensive Medicine According to Master Han』by Mao Han in terms of constituent medicinals and application while measurements and name of formula were not listed while the concept of harmony between the Heart and Kidney was mentioned. In the『Simple Recipes for Four Discipline s』 written by Shixiong Wang, measurements of constituent medicinals, usages and name of formula were finally mentioned, along with its efficacy to treat fearful throbbing and insomnia due to disharmony between the Heart and the Kidney. Conclusions : In conclusion, the Gyo-tae hwan uses Coptidis Rhizoma as chief herb and Cinnamomi Cortex as assistant herb to change the state of disharmony between the Heart and Kidney to a harmonious state, treating insomnia and fearful throbbing.

• Journal of Dental Rehabilitation and Applied Science
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• v.38 no.1
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• pp.60-68
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• 2022

A patient with severe periodontitis has causative factors that cause pathological tooth movement, the occlusion is disintegrated, and the vicious cycle of worsening periodontitis is repeated. In particular, when pathological tooth movement occurs in the maxillary anterior region, the patient has an aesthetic sense of atrophy, and the quality of life was reduced. Therefore, when orthodontic treatment was added to patients with severe periodontitis, it promotes the formation of new bone, reduces periodontal cysts, and obtains clinical attachment, which leads to favorable results in prosthetic restoration, thereby enabling ideal occlusion, function and aesthetics. Periodontal treatment, orthodontic treatment, natural tooth restoration, and implant prosthesis were planned for patients with pathological tooth movement in the anterior region due to loss of occlusal support in the posterior region. As a result, an ideal restoration space was secured, a stable restoration of occlusal contact was formed, and the maxillary anterior teeth were aesthetically improved.

• Herbal Formula Science
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• v.32 no.2
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• pp.193-201
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• 2024

Objectives : This paper is written to find the meaning of Left & Right Tan pulse at Cun, Guan and Chi area under pathological situation at Yangjiaomai(陽蹻脈), Daimai(帶脈) & Yinjiaomai(陰蹻脈) through Qikoujiudaomai Diagnosis of Nine places of three-dimensional division(⼨⼝, ⼨關尺, 浮·中·沈按). Methods : In terms of Qikoujiudaomai, the position to diagnosis the Yangjiaomai, Daimai & Yinjiaomai is Cun·Gua n·Chi position and the pulse is Left & Right Tan pulse. This is to find the meaning of Left & Right Tan pulse Results : Yangjiaomai pulse, Daimai & Yinjiaomai are closely related to pathological situation. By finding the meaning of Qikoujiudaomai, we can use acupuncture & moxibustion treatment and medicine more precisely(Yangjiaomai ⦷○○, Daimai ○⦷○, Yinjiaomai ○○⦷). Conclusion : Qibing, a pathological condition caused by xieqi leaking from twelve meridians into eight extra meridians, can be diagnosed with Qikoujiudaomai and be treated with Herbal formula study and Acupuncture & Moxibustion study.

• Clinical Endoscopy
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• v.57 no.5
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• pp.637-646
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• 2024

Background/Aims: During endoscopy, white spots (WS) are sometimes observed around benign or malignant colorectal tumors; however, few reports have investigated WS, and their significance remains unknown. Therefore, we investigated the significance of WS from clinical and pathological viewpoints and evaluated its usefulness in endoscopic diagnosis. Methods: Clinical data of patients with lesions diagnosed as epithelial tumors from January 1, 2019, to December 31, 2020, were analyzed (n=3,869). We also performed a clinicopathological analysis of adenomas or carcinomas treated with endoscopic resection (n=759). Subsequently, detailed pathological observations of the WS were performed. Results: The positivity rates for WS were 9.3% (3,869 lesions including advanced cancer and non-adenoma/carcinoma) and 25% (759 lesions limited to adenoma and early carcinoma). Analysis of 759 lesions showed that the WS-positive lesion group had a higher proportion of cancer cases and larger tumor diameters than the WS-negative group. Multiple logistic analysis revealed the following three statistically significant risk factors for carcinogenesis: positive WS, flat lesions, and tumor diameter ≥5 mm. Pathological analysis revealed that WS were macrophages that phagocytosed fat and mucus and were white primarily because of fat. Conclusions: WS are cancer-related findings and can become a new criterion for endoscopic resection in the future.

• The Journal of the Korean dental association
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• v.12 no.8
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• pp.619-622
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• 1974

The purpose of this study was to investigate biological tissue reactions to various restorative dental materials. An experimental pellects was implanted into subdermal tissue in dog subjects observing 1 week, 3 weeks, and 8 weeks respectively. The obtained histo-pathological findings were as follows: 1. Experimental pellets such as gold, ticonium and amalgam alloy are considered biologically acceptable. 2. Experimental results in 1 week dog showed acute inflammatory changes. 3. Experimental results in 8 week dog showed fibrotic and chronic inflammatory changes. 4. Active irritans such as silicate cements revealed acute inflammatory changes in all observed period. 5. Biological tissue to irritants observed.