• Journal of Ginseng Research
• /
• 제45권1호
• /
• pp.108-118
• /
• 2021

Background: Korean ginseng (Panax ginseng Meyer) contains a variety of ginsenosides that can be metabolized to a biologically active substance, compound K. Previous research showed that compound K could be enriched in the red ginseng extract (RGE) after hydrolysis by pectinase. The current study investigated whether the enzymatically hydrolyzed red ginseng extract (HRGE) containing a notable level of compound K has cognitive improving and neuroprotective effects. Methods: A scopolamine-induced hypomnesic mouse model was subjected to behavioral tasks, such as the Y-maze, passive avoidance, and the Morris water maze tests. After sacrificing the mice, the brains were collected, histologically examined (hematoxylin and eosin staining), and the expressions of antioxidant proteins analyzed by western blot. Results: Behavioral assessment indicated that the oral administration of HRGE at a dosage of 300 mg/kg body weight reversed scopolamine-induced learning and memory deficits. Histological examination demonstrated that the hippocampal damage observed in scopolamine-treated mouse brains was reduced by HRGE administration. In addition, HRGE administration increased the expression of nuclear-factor-E2-related factor 2 and its downstream antioxidant enzymes NAD(P)H:quinone oxidoreductase and heme oxygenase-1 in hippocampal tissue homogenates. An in vitro assay using HT22 mouse hippocampal neuronal cells demonstrated that HRGE treatment attenuated glutamate-induced cytotoxicity by decreasing the intracellular levels of reactive oxygen species. Conclusion: These findings suggest that HRGE administration can effectively alleviate hippocampus-mediated cognitive impairment, possibly through cytoprotective mechanisms, preventing oxidative-stress-induced neuronal cell death via the upregulation of phase 2 antioxidant molecules.

• 인간식물환경학회지
• /
• 제24권2호
• /
• pp.153-167
• /
• 2021

Background and objective: With the revision of the Act on Urban Parks, Green Areas, Etc. in 2013, the "urban agricultural park" was newly established under the subcategory of "themed park," thereby establishing the institutional basis for the creation of urban agricultural parks. However, urban agricultural parks are still in the early stages of their introduction. There is a lack of research on direction setting and specific operation management that considers urban residents' needs and the city's physical infrastructure. Methods: We utilized the public service design process suggested by the Ministry of the Interior and Safety of the Republic of Korea in 2019 to identify problems and develop directions for urban agricultural parks. The process consisted of the following four steps: Understanding, Discovering people's needs, Defining real problems, and Developing ideas. Results: As four types of ideas for revitalizing urban agricultural parks, 'information users want to know,' 'user participation in design,' 'venue for local communities,' and 'urban agricultural parks as health and rest areas' were derived. This means that urban agricultural parks must provide the information users want; users must plan, decide, and implement such information by directly participating in the creation and efficient management and operation of urban agricultural parks; and urban agricultural parks must be used as a venue for local communities. Urban agricultural parks should also be spaces for health and relaxation. Conclusion: Urban agricultural parks should avoid the unified space and passive participation patterns of existing urban parks, and become real spaces for resident participation that can satisfy all the production, leisure, landscape, ecology, and psycho-social needs of the users of urban agricultural parks. Furthermore, it is necessary to introduce a more systematic and diverse operating system so that it can work to revitalize the local community and connect organically with the function of the city.

• Biomolecules & Therapeutics
• /
• 제21권4호
• /
• pp.299-306
• /
• 2013

In the present study, we investigated the effect of ethanolic extract of the seed of Zizyphus jujuba var. spinosa (EEZS) on cholinergic blockade-induced memory impairment in mice. Male ICR mice were treated with EEZS. The behavioral tests were conducted using the passive avoidance, the Y-maze, and the Morris water maze tasks. EEZS (100 or 200 mg/kg, p.o.) significantly ameliorated the scopolamine-induced cognitive impairment in our present behavioral tasks without changes of locomotor activity. The ameliorating effect of EEZS on scopolamine-induced memory impairment was significantly reversed by a sub-effective dose of MK-801 (0.0125 mg/kg, s.c.). In addition, single administration of EEZS in normal naive mouse enhanced latency time in the passive avoidance task. Western blot analysis was employed to confirm the mechanism of memory-ameliorating effect of EEZS. Administration of EEZS (200 mg/kg) increased the level of memory-related signaling molecules, including phosphorylation of extracellular signal-regulated kinase or cAMP response element-binding protein in the hippocampal region. Also, the time-dependent expression level of brain-derived neurotrophic factor by the administration of EEZS was markedly increased from 3 to 9 h. These results suggest that EEZS has memory-ameliorating effect on scopolamine-induced cognitive impairment, which is mediated by the enhancement of the cholinergic neurotransmitter system, in part, via NMDA receptor signaling, and that EEZS would be useful agent against cognitive dysfunction such as Alzheimer's disease.

• 한국환경농학회지
• /
• 제40권4호
• /
• pp.330-334
• /
• 2021

BACKGROUND: More recently, it has been shown that atmospheric ammonia (NH₃) plays a primary role in the formation of secondary particulate matter by reacting with the acidic species, e.g. SO₂, NOx, to form PM2.5 aerosols in the atmosphere. The Jeonbuk region is an area with high concentration of particulate matter. Due to environmental changes in the Saemangeum reclaimed land with an area of 219 km², it is necessary to evaluate the impact of the particulate matter and atmospheric ammonia in the Jeonbuk region. METHODS AND RESULTS: Atmospheric ammonia concentrations were measured from June 2020 to May 2021 using a passive sampler and CRDS analyzer. Seasonal and annual atmospheric ammonia concentration measured using passive sampler was significantly lower in Jangjado (background concentration), and the concentration ranged from 11.4 ㎍/m³ to 18.2 ㎍/m³. Atmospheric ammonia concentrations in Buan, Gimje, Gunsan, and Wanju regions did not show a significant difference, although there was a slight seasonal difference. The maximum atmospheric ammonia concentration measured using the CRDS analyzer installed in the IAMS near the Saemangeum reclaimed land was 51.5 ㎍/m³ in autumn, 48.0 ㎍/m³ in summer, 37.6 ㎍/m³ in winter, and 32.7 ㎍/m³ in spring. The minimum concentration was 4.9 ㎍/m³ in spring, 4.2 ㎍/m³ in summer, and 3.5 ㎍/m³ in autumn and winter. The annual average concentration was 14.6 ㎍/m³. CONCLUSION(S): Long term monitoring of atmospheric ammonia in agricultural areas is required to evaluate the formation of fine particulate matter and its impact on the environment. In addition, continuous technology development is needed to reduce ammonia emitted from farmland.

• 수산경영론집
• /
• 제45권3호
• /
• pp.85-98
• /
• 2014

This study aimed to segment Chinese fisheries consumer market by means of cluster analysis based on Shanghai region consumers. The survey is conducted to 350 shanghai people on March 17-21 in 2014 and investigate demographic characteristics and consumer's behaviors unique to each segmented market by preference, labelling, quality, price, safety. The result of cluster analysis identified four market segments such as Catering type market, Worth pursuing type market, Substance pursuing type market, Trend pursuing type market. Catering type market is a passive fisheries consumption market and is not high attractive for Korea fisheries export market. Value pursuing type market consider importance to labelling, origin, brand and require high-quality and differentiation strategies. This market's main target species are high price fisheries such as tuna, salmon, crocker. Substance pursuing type market consider fisheries's safety and quality and purchases more popular fisheries such as crocker, hairtail, promfret, mackerel, squid. Trend pursuing type market's consumers prefer to purchase brands and trendy seafood rather than taste.

• Journal of Pharmaceutical Investigation
• /
• 제23권3호spc1호
• /
• pp.19-30
• /
• 1993

The influence of emulsion type of tegafur, an oral anticancer agent, on lymphatic transport was studied in rats. The water-in-oil-type of emulsion and the oil-in-water-type emulsion of tegafur each in 50 mg, calculated in terms of tegafur, were prepared by adding tegafur aqueous solution to sesame oil containing hydrogenated castor oil following ultrasonic treatment, and then the prepared emulsions and aqueous solution as a comparative formulation were administered orally to rats (50 mg/5 ml/kg). The concentration levels of tegafur in plasma of femoral artery and lymph from thoracic duct cannula were measured simultaneously along a time course after administration and the pharmacokinetic parameters were investigated. At the same time, we examined the above described factors of 5-FU which is known as an active metabolite of tegafur. In comparison with tegafur solution, AUC and mean residence time of plasma tegafur were significantly increased in w/o-emulsion but significantly decreased in o/w-emulsion. Lymph flow rates were similar in both solution and w/o-emulsion but half in o/w-emulsion. Ratios between area under the lymph and plasma concentration time curves were always less than 1 reflecting the passive lymphatic delivery after oral administration of the prepared tegafur emulsions, but those to the 5-FU in the case of w/o-emulsion were more than 1. These results suggested that lymphatic delivery of tegafur by w/o-emulsion was more effective than that by o/w-emulsion due to its differences of formation ability of chylomicrons.

• 유통과학연구
• /
• 제16권6호
• /
• pp.15-23
• /
• 2018

Purpose - This paper aims to explore the distribution and application of community-based disaster risk information and employ a case study as a qualitative research method to make some implications and suggestions for disaster management in the future. Research design, data, and methodology - This research has basically adopted an idiographic approaches to examine the basic policy of integrated flood risk management of Shiga prefecture in Japan. The methodology is based on a retrospective analysis, which starts from critical events and traces backwards processes to find out what goes well or wrong. Results - The results of this paper support that the multiple stakeholders in a community have to share and distribute disaster risk information in the proper time. The distribution and application of community-based disaster risk information cannot be overemphasized in that the local communities are culturally rich in traditional flood management knowledge, have voluntary organizations and have enjoyed mutual support and human network to cope with floods. Conclusions - The study results also imply that local residents of the community will be abe to have an important role in coping with natural disasters, which involves more proactive actions than passive actions for the enhancement of disaster management.

• 복식문화연구
• /
• 제26권3호
• /
• pp.427-449
• /
• 2018

The current study aimed to segment Mongolian female consumers based on luxury consumption values and to compare lifestyle, demographic characteristics, purchase behavior, and perceived brand personality among the segments. The survey was administered to consumers who had purchased luxury products in Ulaanbaatar, Mongolia. A total of 184 surveys were used for data analysis. Exploratory factor analysis revealed five luxury values: quality value, hedonic value, conspicuous value, social value, and unique value. Using the five luxury values, clustering analysis was conducted, showing that there were four distinct segments: passive shoppers, showoffs, rational value groups, and hedonists. ANOVAs and chi-square analyses revealed that these four segments differed in consumption values, demographic characteristics, lifestyle dimensions (including appearance consciousness, leisure orientation, life enjoyment, and achievement orientation), and purchase behavior (including purchase frequency, price of products purchased, and product selection criteria). Moreover, value segments showed differences in five dimensions of luxury brand personality: sincerity, professionalism/attractiveness, excitement, materialism, and sophistication. The results suggest that consumption values serve as a significant basis for segmentation. Furthermore, the current study indicates that value segments can be described as consumers' perceived brand personality. The study concludes with a discussion of the results, theoretical and practical implications, and limitations.

• 간호행정학회지
• /
• 제15권2호
• /
• pp.233-243
• /
• 2009

Purpose: The purposes of the study were to examine whether nurses' followership style influence organizational effectiveness and to test the model of organizational effectiveness including the factors of nursing organizational culture, leadership style, and followership style. Methods: Data were collected from July 10th to september 20th in 2006 from 451 nurses working in four acute care hospitals. Data analysis were performed by Chi-square test, ANOVA, Duncan test, Pearson Correlation, and maximum likelihood estimation, using the SAS and LISREL 8.30 program. Results: The findings showed that the types of nurses' followership were classified as passive (21.1%), alienated (8.2%), conformist (16.4%), pragmatist (35.9%), and effective style (18.4%). There was significant difference in the organizational effectiveness among the nurses with different followership styles. In testing the path model, transformational, transactional leadership directly influenced followership style. Followership directly influenced organizational effectiveness. Conclusion: The overall fitness of the model was good, evidenced by general fitness index (GFI)=.94, adjusted goodness of fitness index (AGFI)=.82, and root mean square residual (RMSEA)=.06. Based on the findings, it is recommended to develop a program for enhancing effective followership in nursing organization.

• 대한원격탐사학회:학술대회논문집
• /
• 대한원격탐사학회 2003년도 Proceedings of ACRS 2003 ISRS
• /
• pp.828-830
• /
• 2003

We have constructed a level-1 processor to generate brightness temperatures using the direct-broadcast data from the passive microwave radiometer onboard Aqua satellite. Although 50-minute half-orbit data, called a granule, are being routinely produced, to our knowledge, this is the first attempt to process about 10-minute long direct-broadcast data. We modified the processor designed for a granule to process the direct-broadcast data. After the modification, our brightness temperature product differs from the reference by 0.2K rms. Sea surface temperatures are retrieved to demonstrate the utility of AMSR-E.