• 한국광과학회:학술대회논문집
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• 한국광과학회 2001년도 학술대회지
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• pp.26-26
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• 2001

• 대한약학회:학술대회논문집
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• 대한약학회 2000년도 NEW STRATEGY FOR DRUG DEVELOPMENT IN POST-GENOMIC ERA(대한약학회)
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• pp.177.2-178
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• 2000

• Journal of Ginseng Research
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• 제18권3호
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• pp.165-174
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• 1994

To investigate the significant indicators Improving the undisturbed memory in animal behavior, we employed several behavioral methods (learning, relearning in radial maze, and active avoidance) with ginseng components. Results showed that the repeated intranasal administration of $Rb_1$ and total saponins from Korean red ginseng induced direct effects on the brain mechanisms in rats, and improved the spatial memory during the learning, relearning and retention in the 12-arm radial maze test. The intranasal treatment of the total saponins also effectively improved the disturbed memory (amnesia) by pentylentetrazole, and simultaneously protected the brain by decreasing the severity of motor epileptic seizures. The intraperitonial administration of polysaccharide fraction of Korean red ginseng could improve avoidance behavior (amount of the total ecapes) in the active-avoidance test. In addition, local changes of the temperature and resistance of skin observed after Rb, administration were suggested to reflect some action of sympathetic nerve Key words Memory, intranasal administration, pentylenetetrazole, Korea red ginseng.

• Journal of Information Processing Systems
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• 제17권1호
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• pp.191-202
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• 2021

In an Internet of Things (IoT)-configured system, each device executes on-chip software. Recent IoT devices require fast execution time of complex services, such as analyzing a large amount of data, while maintaining low-power computation. As service complexity increases, the service requires high-performance computing and more space for embedded space. However, the low performance of IoT edge devices and their small memory size can hinder the complex and diverse operations of IoT services. In this paper, we propose a remote on-demand software code execution unit using the cloudification of on-chip code memory to accelerate the program execution of an IoT edge device with a low-performance processor. We propose a simulation approach to distribute remote code executed on the server side and on the edge side according to the program's computational and communicational needs. Our on-demand remote code execution unit simulation platform, which includes an instruction set simulator based on 16-bit ARM Thumb instruction set architecture, successfully emulates the architectural behavior of on-chip flash memory, enabling embedded devices to accelerate and execute software using remote execution code in the IoT environment.

• 해양환경안전학회지
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• 제28권4호
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• pp.469-476
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• 2022

본 연구는 조위 관측자료를 이용하여 부산항에서의 장기 조위 자료를 생성하는 Long Short-Term Memory (LSTM)으로 구현된 순환신경망 모델을 개발하였다. 국립해양조사원의 부산 신항과 통영에서 관측된 조위 자료를 모델 입력 자료로 사용하여 부산항의 조위를 예측하였다. 모델에 대하여 2019년 1월 한 달의 학습을 수행하였으며, 이후 2019년 2월에서 2020년 1월까지 1년에 대하여 정확도를 계산하였다. 구축된 모델은 부산 신항과 통영의 조위 시계열을 함께 입력한 경우에 상관계수 0.997 및 평균 제곱근 오차 2.69 m로 가장 성능이 높았다. 본 연구 결과를 바탕으로 딥러닝 순환신경망 모델을 이용하여 임의 항만의 장기 조위 자료 예측이 가능함을 알 수 있었다.

• 생물정신의학
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• 제12권1호
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• pp.32-41
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• 2005

Objective:Impaired processing of working memory is one of the cognitive deficits seen in patients with schizophrenia. This aimed at corroborating the differences in the brain activities involved in the process of working memory between patients with schizophrenia and the control subjects. Method:Fourteen patients with schizophrenia and 12 healthy volunteers were recruited in this study. Functional magnetic resonance imaging(fMRI) was used to assess cortical activities during the performance of a 2-back visual working memory paradigm using the Korean alphabet as mnemonic content. Results:Group analysis revealed that left lateral prefrontal cortex and right parietal lobule showed decreased cortical activities in the patient group. On the other hand, an increased activation in left superior and middle frontal gyrus, left middle temporal gyrus, right cuneus, both occipital lobes, right fusiform gyrus and right cingulate gyrus. The activation in left anterior lobe and both declive of cerebellum was also increased. Conclusions:This study showed a decreased activation in left lateral prefrontal and right parietal neural networks from the patient group and confirmed the earlier findings on the impaired working memory of patients with schizophrenia using fMRI investigation. The regions implicated in our study suggest an abnormal functioning of the fronto-parietal cortical areas that are critical to the information processing stream, which might be correspondent to common pathophysiology rather than a common etiology in schizophrenia.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제31권4호
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• pp.207-213
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• 2020

Objectives: Although aggressive behavior in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) has previously shown correlations with hyperactivity/impulsivity, few studies have examined its association with inattention or the effect of working memory on aggressive behavior. This study aimed to assess the relationship between inattention and aggressive behavior and the effect of working memory on the relationship between inattention and aggressive behavior in children and adolescents with ADHD. Methods: Thirty-one children and 26 adolescents with ADHD were retrospectively investigated. The subjects completed the Korean Wechsler Intelligence Scale for Children-Fourth Edition (K-WISC-IV), the Korean Child Behavior Checklist (K-CBCL), and the Korean Children's Depression Inventory (CDI). Results: Inattention was positively correlated with aggressive behavior in children and adolescents with ADHD and working memory showed an insignificant correlation. However, working memory had a significant moderating effect on aggressive behavior by interacting with inattention. The moderating effect of working memory manifested when the working memory index score on the K-WISC-IV was 73.5 points or higher, and it had a significant effect on aggressive behavior. Conclusion: This study shows that the severity of inattention and hyperactivity/impulsivity should be addressed to provide appropriate treatment to children and adolescents with ADHD who exhibit aggressive behavior.

• Journal of the Korean Data and Information Science Society
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• 제26권5호
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• pp.1035-1045
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• 2015

최근 빅데이터 분야에서 데이터를 메모리에 적재 후 빠르게 처리하는 인메모리 컴퓨팅 기술이 새롭게 부각되고 있다. 인메모리 컴퓨팅 기술은 과거 대용량 메모리와 다중 프로세서를 탑재한 고성능서버에 적용 가능하였지만, 점차 일반 컴퓨터를 초고속 네트워크로 연결하여 분산 병렬처리가 가능한 구조로 변화하고 있다. 본 논문은 In-memory data grid (IMDG) 기술을 택시 애플리케이션에 접목하여 기존의 데이터베이스의 변경 없이 성능을 향상시키는 기법을 제안한다. IMDG 기술을 적용한 경우 기존의 데이터베이스 기반의 웹서비스에 비해 처리속도와 처리량이 평균 6~9배정도 증가하며, 또한 부하량에 따른 처리량 변화의 폭이 매우 작음을 확인 하였다.

• Archives of Pharmacal Research
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• 제28권3호
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• pp.335-342
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• 2005

The effects of ginsenosides Rg$_3$(R) , Rg$_3$(S) and Rg$_5$/Rk$_1$ (a mixture of Rg$_5$ and Rk$_1$ 1:1, w/w), which are components isolated from processed Panax ginseng C.A. Meyer (Araliaceae), on memory dysfunction were examined in mice using a passive avoidance test. The ginsenosides Rg3(R), Rg3(S) or Rg$_5$/Rk$_1$, when orally administered for 4 days, significantly ameliorated the memory impairment induced by the single oral administration of ethanol. The memory impairment induced by the intraperitoneal injection of scopolamine was also significantly recovered by ginsenosides Rg3(S) and Rg$_5$/Rk$_1$. Among the three ginsenosides tested in this study, Rg$_5$/Rk$_1$ enhanced the memory function of mice most effectively in both the ethanol­and scopolamine-induced amnesia models. Moreover, the latency period of the Rg$_5$/Rk$_1$­treated mice was 1.2 times longer than that of the control (no amnesia) group in both models, implying that Rg$_5$/Rk$_1$ may also exert beneficial effects in the normal brain. We also evaluated the effects of these ginsenosides on the excitotoxic and oxidative stress-induced neuronal cell damage in primary cultured rat cortical cells. The excitotoxicity induced by glutamate or N­methyl-D-aspartate (NMDA) was dramatically inhibited by the three ginsenosides. Rg$_3$(S) and Rg$_5$/Rk$_1$ exhibited a more potent inhibition of excitotoxicity than did Rg$_3$(R). In contrast, these ginsenosides were all ineffective against the H$_2$O$_2$- or xanthine/xanthine oxidase-induced oxidative neuronal damage. Taken together, these results indicate that ginsenosides Rg$_3$(S) and Rg$_5$/Rk$_1$ significantly reversed the memory dysfunction induced by ethanol or scopolamine, and their neuroprotective actions against excitotoxicity may be attributed to their memory enhancing effects.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2006년도 춘계학술대회 논문집
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• pp.517-518
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• 2006

In this study, a commercial fixation device, BioFlex, which was designed with shape memory alloy(SMA) for dynamic stabilization of spine was biomechanically evaluated. The finite element model of intact lumbar spine from L1 to S was developed using CT images. Also, low FE models of 2-level(L4-L5-S) and 3-level(L3-L4-L5-S) posteriori fixation using titanium(Ti) rod and BioFlex(SMA) rod. The rotations of bone segments in the intact model and four models were predicted. Although the rotations of the BioFlex fixation model were smaller than those of the intact model, they were relatively larger than those of Ti fixation. The present can be applied for not only evaluation of the stability of interbody fixator, but also development of new implant.