• KOREAN JOURNAL OF CROP SCIENCE
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• v.27 no.1
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• pp.87-93
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• 1982

Dihaploid lines derived from the another of the $F_1$ of single cross, SC72 $\times$ Hicks (Nicotiana tabacum L.) were estimated the variation, heritablities, genetic correlations and path-co-efficients on agronomic characters and chemical compositions. Dinaploids exhibited reduced vigor and growth when comparecd with the mid-parent value but had increased nicotine contents, and the range of dihaploids characters were deviated more than that of their parents. Heritabilities of days to flowering, leaves per plant, nicotine. contents, leaf size and plant height appeared high value, and the yield, value per kg. and reducing sugar contents were low. There were positive genetic correlations between yield, and value per kg., leaf width, leaves per plant and reducing sugar contents and negative genetic correlations appeared between nicotine contents and the other characters except for index of leaf shape. Path-coefficient analysis of genotypic correlation coefficients showed that leaves per plant and leaf width lave a high direct effect, and plant height and days to flowering have a high indirect effect on yield, respectively.

• Journal of the Korean Geotechnical Society
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• v.25 no.4
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• pp.39-54
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• 2009

Large scale direct shear tests were carried out to analyze the shear behavior of crushed rocks at local representative quarries. Shear strength for each specimen was derived and the effects on shear behavior induced by the variation of factors such as particle size, water immersion, density, uniformity coefficient, and particle breakage were evaluated and quantitatively compared with previous studies. The opportunity was also taken to identify stress-dilatancy relation of crushed rocks following the energy-based theory and friction coefficients at critical state as well as peak friction angles and dilation angles were estimated. As a result of tests it was found that uniaxial compressive strength and particle breakage of the parent rocks have crucial effect on internal friction angles; in addition, dilatancy at the failure showed strong relationship as well.

• Korean Journal of Child Studies
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• v.16 no.1
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• pp.113-131
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• 1995

The objectives of this study were to investigate (1) the relations between infant-mother attachment and maternal sensitivity, maltreatment, stress, and childhood experience, and (2) relations between infant-mother attachment and infant temperament. The subjects of the study were 55 14 to 20 month-old infants (27 boys and 28 girls) and their mothers in Seoul. In order to assess the patterns of infant-mother attachment, each infant-mother dyad was videotaped in the modified Ainsworth's Strange Situation. Each dyad was filmed for 3 minutes in the Questionnaire Situation of Smith and Pederson(Smith, & Pederson, 1988) to assess maternal sensitivity responding to infant's cues. Each mother also was interviewed by using a semi-structured questionnaire made by author to measure maternal maltreatment. Each mother was asked to complete three Likert-type questionnaires, containing Parenting Stress Index (PSI) (Abidin, 1990) to measure the maternal stress, Mother-Father Peer Scale (MFPS) (Epstein, 1983) to measure childhood experience, and Emotionality, Activity, Sociality (EAS) (Buss, & Plomin, 1984) to measure infant's temperament. The statistical procedures used for data analyses were correlation, one-way ANOVA, multiple regression, and Cronbach's ${\alpha}$ coefficient. The results showed that (1) mothers of insecure-avoidant infants maltreated their infants more than mothers of secure infants, and (2) in the multiple regression analysis, maternal maltreatment was predicted by maternal education, maternal stress (parent domain), and maternal childhood experience in relation to her own mother (acceptance vs. rejection).

• Asian-Australasian Journal of Animal Sciences
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• v.22 no.6
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• pp.893-899
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• 2009

Few studies have reported the existence of imprinted genes in cattle compared to the human and mouse. Genomic imprinting is expressed in monoallelic form and it depends on a single parent-specific form of the allele. Comparative analysis of mammals other than the human is a valuable tool for explaining the genomic basis of imprinted genes. In this study, we investigated 34 common imprinted genes in the human and mouse as well as 35 known non-imprinted genes in the human. We found short interspersed nuclear elements (SINEs), long interspersed nuclear elements (LINEs), and long terminal repeats (LTRs) in imprinted (human and mouse) and control (cattle) genes. Pair-wise comparisons for the three species were conducted using SINEs, LINEs, and LTRs. We also calculated 95% confidence intervals of frequencies of repetitive sequences for the three species. As a result, most genes had a similar interval between species. We found 11 genes with conserved SINEs, LINEs, and LTRs in the human, mouse, and cattle. In conclusion, eleven genes (CALCR, Grb10, HTR2A, KCNK9, Kcnq1, MEST, OSBPL5, PPP1R9A, Sgce, SLC22A18, and UBE3A) were identified as candidate imprinted genes in cattle.

• Journal of Pharmaceutical Investigation
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• v.22 no.2
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• pp.139-148
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• 1992

A prodrug of cefazolin pivaloyloxymethyl ester (CFZ-PV) was synthesized to improve oral absorption and bioavailability of parent drug by esterification of sodium cefazolin (CFZ) with chloromethyl pivalate. The successful synthesis of CFZ-PV was confirmed by spectroscopic analysis. Partition coefficient studies showed that CFZ-PV is more lipophilic than CFZ. The pharmacokinetic characteristics of CFZ-PV and CFZ preparations were compared following oral administrations of these compounds to rabbits. The analysis of CFZ in plasma was conducted by HPLC method. The ester compound (prod rug) was not detected in plasma following oral administration of CFZ-PV, and although CFZ-PV had not microbiological activity in vitro, the plasma taken after CFZ-PV administration had microbiological activity. From above observations, it was noted that CFZ-PV is rapidly hydrolyzed to CFZ in the body. And it was found that the oral absorption of CFZ-PV was increased, yielding 2-fold higher bioavailability than CFZ. From the results of this experiment, it was concluded that CFZ-PV could be a novel prodrug of CFZ which can improve the oral bioavailability of CFZ.

• Journal of Pharmaceutical Investigation
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• v.23 no.2
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• pp.61-69
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• 1993

Prodrug of cefazolin (CFZ) was prepared with the objective of improving its oral bioavailability. Cefazolin phthalidyl ester (CFZ-PT) was synthesized and evaluated as potential prodrug form. The successful synthesis of CFZ-PT was identified by spectroscopic analysis. Partition coefficient studies showed that CFZ-PT is more lipophilic than CFZ and the ester was hydrolyzed enzymatically into the parent drug in blood, liver and intestinal homogenates. The pharmacokinetic characteristics of CFZ-PT and CFZ were compared following oral administrations to rabbits. Serum CFZ concentration was determined by HPLC method and the ester compound (prodrug) was not detected in serum following oral administration of CFZ-PT. CFZ-PT did not have antimicrobial activity in vitro against Bacillus subtilis ATCC 6633, whereas CFZ-PT in serum after oral administration to rabbits had antimicrobial activity. From above observations, it was noted that CFZ-PT is rapidly hydrolyzed to CFZ in the body and the bioavailability of CFZ-PT was increased by 3.5-fold than that of CFZ. From these results of this study, it was concluded that CFZ-PT may be a novel prodrug of CFZ which can improve the oral absorption of CFZ.

• Plant Biotechnology Reports
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• v.4 no.3
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• pp.237-242
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• 2010

Six parent and their 12 gamma ray-induced somatic flower colour mutants of garden rose were characterized to discriminate the mutants from their respective parents and understanding the genetic diversity using Random amplification of polymorphic DNA (RAPD) markers. Out of 20 primers screened, 14 primers yielded completely identical fragments patterns. The other 7 primers gave highly polymorphic banding patterns among the radiomutants. All the cultivars were identified by using only 7 primers. Moreover, individual mutants were also distinguished by unique RAPD marker bands. Based on the presence or absence of the 48 polymorphic bands, the genetic variations within and among the 18 cultivars were measured. Genetic distance between all 18 cultivars varied from 0.40 to 0.91, as revealed by Jaccard's coefficient matrix. A dendrogram was constructed based on the similarity matrix using the Neighbor Joining Tree method showed three main clusters. The present RAPD analysis can be used not only for estimating genetic diversity present in gamma ray-induced mutants but also for correct identification of mutant/new varieties for their legal protection under plant variety rights.

• Journal of Korean Academy of Nursing
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• v.45 no.5
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• pp.650-660
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• 2015

Purpose: The purpose of this study was to develop an instrument to measure the parenting behavior of primary caregivers of children in early childhood. Methods: An instrument was developed according to Devellis's instrument development process. The participants in this study who completed the main survey were 370 mothers and grandmothers. The survey was conducted from June 1 to July 30, 2014, and collected data were analyzed using item analysis, half-split reliability and Cronbach's ${\alpha}$ coefficient, exploratory and confirmatory factor analysis, convergent validity. Results: The factor structure of the instrument showed the cumulative variance as 55.7% in the factor analysis. As a result of a confirmatory factor analysis, a four-factor structure was found to be appropriate, and the construct validity and convergent validity of the instrument were thereby confirmed. The finalized parenting behavior instrument consisted of 26 items and four independent factors: affectionate, laissez-faire, educational and impulsive. A five-point Likert scale was employed, and a higher score in a particular factor showed that most of the behaviors belonged to the factor. Conclusion: The instrument developed in this study was found to be reliable and valid, and can be used to develop parent-child relationship building.

• Child Health Nursing Research
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• v.22 no.4
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• pp.370-378
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• 2016

Purpose: The purpose of this study was to examine current status of somatic symptoms of late school-aged children using the school health clinic and to investigate the influence of perceived attachment security and social support on their somatic symptoms. Methods: For this descriptive study, self-report questionnaires were completed by fifth and sixth graders attending 'A' elementary school in Gyeonggi-do. Data from 216 students were included. Data analysis included descriptive statistics, t-test, ANOVA, Pearson correlation coefficient, and multiple regression analysis. Results: Most frequent somatic symptoms were headache, fainting, backache, numbness in a body part, and muscle ache in that order. More frequent somatic symptoms were reported by girls, students who recognized their family SES as low, students who used school health clinic often and students who were dissatisfied with school life. Somatic symptom showed negative correlations with attachment stability and perceived social support from family and teachers. In the regression analysis, the variables; low attachment stability, female gender, and low satisfaction with school affected more frequent somatic symptoms. Conclusion: Careful monitoring of late school-aged children expressing frequent somatic symptoms is required. Intervention programs to improve attachment security and satisfaction with school should be developed for school children, especially girls, presenting with somatic symptoms.

• Korean Journal of Child Studies
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• v.4
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• pp.11-21
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• 1983

The purpose of this study was to investigate the relationship between internal locus of control in children and parents' child rearing attitudes which children perceive. For this purpose, 198 fifth grade boys and 163 fifth grade girls were randomly selected and their perception of their parents' child rearing attitudes and their locus of control were measured. Children's locus of control was measured by A Locus of Control Scale For Children of Nowicki & Strickland (1973) which was translated into Korean and item analysis of which was done. Ami Children's perception of their Darents' child rearing attitudes measured by Parent-Child Relationship Inventory which was constructed in Korean Testing Center. For the data analysis, t-test and two-way analysis of variance were applied and Pearson correlation coefficient was computed. The results of the present study were as follows; 1. The correlations between children's perception of their parents' child rearing attitudes and locus of control in children were significant partly. Especially, internal children reported their parents as showing less rejective attitude and less different child rearing attitude between father and mother. 2, Sons were more influenced by their parents' child Learing attitudes than daughters in the development of locus of control 3. Maternal child rearing attitude was more influential than paternal child rearing attitude in the development of locus of control.