• 한국산학기술학회논문지
• /
• 제16권3호
• /
• pp.2029-2037
• /
• 2015

본 연구의 목적은 척수분절레벨에 적용한 간섭전류의 자극수준에 따른 정상성인의 자율신경계에 미치는 영향을 알아보고자 하였다. 간섭전류는 T1-T4 분절에 접착식 패드전극을 2극 배치 후 20분간 전기자극하여, 전기자극 전과 후, 30분 후의 변화를 확인하였다. 연구대상은 광주시에 소재한 N대학교에 다니는 건강한 성인남녀 45명을 대상으로 감각자극수준은 100 bps, 10~12 mA, 운동자극수준은 5 bps, 45~50 mA, 유해자극수준은 100 bps, 80~90 mA으로 각각 15명씩 무작위 배치하여 연구를 수행하였으며 연구 결과는 다음과 같다. 각 집단의 교감신경활성도의 변화는 시간과 집단 간의 상호작용에 유의한 차이가 없었으나, 시간에 따라 유의한 변화를 보여주었다(p<.05). 사후 분석결과 전기자극 직후와 전기자극 후 30분에서 유의한 차이를 보여주었다(p<.05). 각 집단의 부교감신경활성도의 변화는 시간과 집단 간의 상호작용에 유의한 차이가 없었으나, 시간에 따라 유의한 변화를 보여주었다(p<.05). 사후 분석결과 전기자극 직후와 전기자극 후 30분에서 유의한 차이를 보여주었다(p<.05). 이상의 결과로 전기자극 수준은 특정목적과 상황에 따라 다양하게 적용되어야 할 것으로 생각된다.

• BMB Reports
• /
• 제57권4호
• /
• pp.167-175
• /
• 2024

Cancer progression is driven by genetic mutations, environmental factors, and intricate interactions within the tumor microenvironment (TME). The TME comprises of diverse cell types, such as cancer cells, immune cells, stromal cells, and neuronal cells. These cells mutually influence each other through various factors, including cytokines, vascular perfusion, and matrix stiffness. In the initial or developmental stage of cancer, neurotrophic factors such as nerve growth factor, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor are associated with poor prognosis of various cancers by communicating with cancer cells, immune cells, and peripheral nerves within the TME. Over the past decade, research has been conducted to prevent cancer growth by controlling the activation of neurotrophic factors within tumors, exhibiting a novel attemt in cancer treatment with promising results. More recently, research focusing on controlling cancer growth through regulation of the autonomic nervous system, including the sympathetic and parasympathetic nervous systems, has gained significant attention. Sympathetic signaling predominantly promotes tumor progression, while the role of parasympathetic signaling varies among different cancer types. Neurotransmitters released from these signalings can directly or indirectly affect tumor cells or immune cells within the TME. Additionally, sensory nerve significantly promotes cancer progression. In the advanced stage of cancer, cancer-associated cachexia occurs, characterized by tissue wasting and reduced quality of life. This process involves the pathways via brainstem growth and differentiation factor 15-glial cell line-derived neurotrophic factor receptor alpha-like signaling and hypothalamic proopiomelanocortin neurons. Our review highlights the critical role of neurotrophic factors as well as central nervous system on the progression of cancer, offering promising avenues for targeted therapeutic strategies.

• 척추신경추나의학회지
• /
• 제4권2호
• /
• pp.47-60
• /
• 2009

Objectives : The purpose of this study is to investigate the effect of chuna treatment on cervical sprain caused by traffic accident in early stage. Methods : This study carried out on 20 patients who have received hospital treatment in Daejeon Univ. cheonan Oriental Hospital. Non-chuna group got acupunture-therapy, herbal medication, physical therapy and Chuna group got chuna treatment besides. We measured Heart Rate Variability(HRV) and Visual Analog Scale(VAS) on 2nd, 4th day. Results : After being treated by our methods, Chuna Group showed the inclination to balance the sympathetic and parasympathetic nerve. In chuna group, an autonomic nerve activity showed the inclination to increase. But there were no significant difference between both groups. Chuna group's VAS were significantly decreased(p=0.043). Conclusions : The results suggest that Chuna treatment help traffic accident patients in early stage to reduce pain. Refer to autonomic nerve system, chuna treatment seem to do positive effect but Further long tenn study in a large scale is needed.

• Korean Journal of Acupuncture
• /
• 제36권3호
• /
• pp.162-170
• /
• 2019

Objectives : Increasing evidence suggests that parasympathetic vagus nerve activity plays a role in modulating acupuncture-induced anti-inflammatory reaction, but the function of sympathetic nerve is not known. Here, we investigated whether splanchnic sympathetic nerve activity was involved in the regulation of splenic expression of $TNF-{\alpha}$ mRNA by electroacupuncture (EA) in LPS-injected animals. Methods : DiI was injected into the stomach or celiac ganglion (CG) for retrograde labeling of the target tissues. EA was given at ST36 and the electrical stimulation on the sciatic nerve in LPS-injected mice. c-Fos signals in the tissues were analyzed by immunofluorescence staining, and $TNF-{\alpha}$ mRNA was analyzed by real-time PCR. Results : Application of EA at ST36 or electrical stimulation on the sciatic nerve induced c-Fos expression in neurons of the spinal cord and celiac ganglion (CG). Then, the vagotomy reduced c-Fos levels in CG neurons but not in the spinal cord in animals given EA. Expression of $TNF-{\alpha}$ mRNA which was induced in the spleen after LPS was significantly inhibited by EA, then the vagotomy elevated $TNF-{\alpha}$ mRNA level similar to that in LPS-injected animals. Splanchnectomy in animals given LPS and EA also increased $TNF-{\alpha}$ mRNA though it was less effective than vagotomy. Conclusions : Our data suggest that EA delivered to the spleen via the splanchnic sympathetic nerve may be involved in attenuating splenic inflammatory responses in LPS-injected animals.

• 한국산림과학회지
• /
• 제113권1호
• /
• pp.107-117
• /
• 2024

본 연구는 시간에 따른 산림환경의 물리환경요소 변화와 이에 따른 온열환경 쾌적성, 인체의 생리·심리적 반응의 차이를 종합적으로 규명하기 위하여 수행되었다. 9시부터 18시까지 산림환경의 물리환경요소(공기온도, 평균복사온도, 풍속, 상대습도)와 예상평균한서감지수(PMV), 예상불만족률(PPD)를 연속 측정하고, 1시간 간격으로 남자 대학생 30명(평균 연령: 21.7±1.9세)이 눈을 감고 5분 동안 안정을 취할 때의 생리·심리적 반응(심박변이도, 심박수, 구강체온, 혈압, 맥박수, 주관적 온열감과 쾌적감 및 인상)을 조사하였다. 더불어 물리환경요소와 생리적 반응 사이의 상관관계를 조사하였다. 그 결과, ① 공기온도, 평균복사온도, 풍속, 상대습도 모두 시간에 따라 유의하게 변화하였다. ② PMV와 PPD도 시간에 따라 유의하게 변화하였다. 주관적 온열감은 PMV와 일치하였으나, 주관적 쾌적감은 PPD와 일치하지 않았다. ③ 생리적 반응 중 ln(HF), ln(LF/HF), 심박수, 이완기혈압이 시간에 따라 유의하게 변화하였다. 공기온도가 가장 높았던 14~16시에 ln(HF)는 가장 낮았고, ln(LF/HF)는 가장 높았다. ④ 공기온도, 평균복사온도, 풍속은 ln(HF)와 음의 상관관계, ln(LF/HF)와 양의 상관관계를 나타내었다. 이를 통해 산림환경을 이용하는 시간대에 따라 이용객의 쾌적감과 생리·심리적 안정 효과가 달라질 수 있으며, 시간에 따른 산림환경의 물리환경요소 변화가 이러한 차이에 영향을 미친다는 사실이 밝혀졌다.

• 대한의료기공학회지
• /
• 제10권1호
• /
• pp.130-157
• /
• 2007

The purpose of this research is to seek for efficient health maintenance device and to suggest desirable daily habit, based on the inquiry on interrelationship between workers' daily lives and their heartbeat change level. The paper survey about general features, case history and daily habits was conducted on workers during medical examination in Jeollabukdo, and examined their change of heartbeat as well. The results of research deducted from data analysis are as follows; 1. There found very positive interrelations between time-domain analysis and frequency-domain analysis, and MHR and LF/HF ratio had negative connection with other analyses. 2. The recipient showed high time-domain analysis when they are younger, have worked shorter or have spouse, and it contributes to stable sympathetic nerve and parasympathetic nerve as it stimulates autonomic nervous system. 3. According to the result of frequency-domain analysis, recipients showed higher TP and LF when they are younger, and the highest HF when they are under 34.The level of VLF was higher for university graduates than the ones who finished high school. The recipients showed higher TP and HF when they don't have spouse, and lower TP, LF and HF when they have worked longer. 4. The level of RMSSD and TSRD was high for the people who don't have case history, and HF was high when they don't have any disease in progress. 5. According to the result concerning correlation of daily habits with time-domain analysis and frequency-domain analysis, cigarette, alcohol and sleeping hours don't affect heartbeat change, but the ones who regularly workout showed higher result in every analysis. It shows that the autonomic nervous system of recipients who regularly exercise response more actively. The result mentioned above suggests that the change of heartbeat is a direct index which shows the change of autonomic nervous system, and it depends on the exercise the most. Thus, workout is proved to be the best method in order for workers to take care of their health.

• 대한한방내과학회지
• /
• 제27권4호
• /
• pp.798-810
• /
• 2006

Objectives : This study was designed to investigate heart rate variability(HRV) in patients with abnormality on EKG by power spectrum analysis of HRV. Methods : The patient group consisted of 147 patients diagnosed as abnormal on EKG at the Oriental Medical Hospital of Dong-eui University from November 2003 to September 2005. We divided the patient group into 9 subgroups (bradycardia, arrhythmia, PVC, AF, AV block, RBBB, LVH, cardiac ischemia, LAD ). The control group consisted of 117 patients who were diagnosed as normal on EKG at the same hospital during the same period. We checked HRV of the two groups over 5 minutes and compared the HRV index between groups. Results and Conclusions : In the time domain analysis, SDNN was significantly higher in the PVC and AF groups than control group and RMSSD was significantly higher in the all patient group and the bradycardia, PVC and AF groups than in the control group. In the frequency domain analysis, Ln(LF) was significantly higher in the all patient group and the PVC and AF groups than the control group but lower in the LAD group. Ln(HF) was significantly higher in The all patient group and bradycardia, PVE and AF groups than control group. LF/HF ratio was significantly lower in the all patient group and bradycardia, arrhythmia, AF, AV block and LAD groups than control group. The autonomic nerve system and parasympathetic nerve system were higher in the patient group with abnormal EKG compared with the control group.

• 감성과학
• /
• 제17권3호
• /
• pp.29-38
• /
• 2014

본 연구에서는 LED 면조명을 이용한 감성조명시스템의 인체 생리학적 반응을 검증하였다. 실험은 시각 질환이 없는 건강한 20대 남성 10명을 대상으로 LED 면조명의 색상에 따른 인체의 반응을 평가하였다. LED 조명은 빨간색, 주황색, 노란색, 초록색, 파란색, 보라색, 무채색(하얀색)을 사용하여 5분간 조명 자극을 주었다. 평가 방법으로 심리적 상태를 분석하기 위하여 뇌파와 심박변이도를 평가하였고 피부의 온도 변화를 살펴보기 위해 체열을 평가하였다. 분석 결과 뇌파의 경우 무채색, 빨간색, 주황색 LED 면조명 자극 시 ${\alpha}$파 비율이 감소하였다. 또한 무채색, 빨간색, 주황색, 노란색 LED 면조명 자극을 받을 때 부교감신경에 비하여 교감신경이 활성화되고, 체열이 증가하였다. 이에 비해 초록색, 파란색, 보라색 LED 면조명 자극을 받을 때에는 ${\alpha}$파 비율의 증가와 교감신경에 비하여 부교감신경의 활성화가 발생하였고 체열이 감소하였다. 향후 각 색상을 조합하여 상황별 모드를 구성한 실험과 시각적 자극 외에 아로마와 같은 후각 자극, 음악과 자연의 소리를 이용한 청각 자극 등을 이용한 복합한 시너지 효과에 대한 연구가 필요할 것으로 사료된다.

• The Korean Journal of Physiology and Pharmacology
• /
• 제20권1호
• /
• pp.111-117
• /
• 2016

Vagal nerve activity has been known to play a crucial role in the induction and maintenance of atrial fibrillation (AF). However, it is unclear how the distribution and concentration of local acetylcholine (ACh) promotes AF. In this study, we investigated the effect of the spatial distribution and concentration of ACh on fibrillation patterns in an in silico human atrial model. A human atrial action potential model with an ACh-dependent $K^+$ current ($I_{KAch}$) was used to examine the effect of vagal activation. A simulation of cardiac wave dynamics was performed in a realistic 3D model of the atrium. A model of the ganglionated plexus (GP) and nerve was developed based on the "octopus hypothesis". The pattern of cardiac wave dynamics was examined by applying vagal activation to the GP areas or randomly. AF inducibility in the octopus hypothesis-based GP and nerve model was tested. The effect of the ACh concentration level was also examined. In the single cell simulation, an increase in the ACh concentration shortened $APD_{90}$ and increased the maximal slope of the restitution curve. In the 3D simulation, a random distribution of vagal activation promoted wavebreaks while ACh secretion limited to the GP areas did not induce a noticeable change in wave dynamics. The octopus hypothesis-based model of the GP and nerve exhibited AF inducibility at higher ACh concentrations. In conclusion, a 3D in silico model of the GP and parasympathetic nerve based on the octopus model exhibited higher AF inducibility with higher ACh concentrations.

• 동의신경정신과학회지
• /
• 제19권2호
• /
• pp.265-278
• /
• 2008

Stress reaction can be shown widely in the systems of psychology, endocrinology, immunology and so on. Stress promotes catecholamine from the autonomic nerve system, and this activates the sympathetic nerve system. As the sympathetic nerve system is activated, high blood pressure, tachycardia, vertigo, anxiety, diaphoresis, myotonic reaction and others can happen. Autonomic imbalance is the syndrome that people suffer from various symptoms accompanying no organic lesions and no psychological disorders by losing the hormonies between the sympathetic and parasympathetic nerve system. We experienced a 55 year-old female who complained of sudden abdominal pain after being frightened at trouble with her husband. Her abdominal pain was very characteristic, "Something is like rising in my abdomen.", that occurred several times a day. We diagnosed 'Bun-Ton Disease' from her abdominal sign. Several oriental medicine books recorded aspects of Bun-Ton disease and treatments, we had given herbal medicine and treated acupuncture be based on those. Results from studies to date suggest the Bun-Ton Disease's main cause is fright or shock, and they stimulate releasing epinephrine or norepinephrine, that result in various symptoms. In this case report, we will present this patient's case and review the Bun-Ton Disease.