• Nuclear Engineering and Technology
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• v.22 no.1
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• pp.12-19
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• 1990

The Loss of Offsite Power Transient at 77.5% power which occurred on June 9, 1981 at the Kori Unit 1 PWR (Pressurized Water Reactor) is simulated using the RELAP5/MOD2 system thermal-hydraulics computer code. Major thermal-hydraulic parameters are compared with the available plant data. The comparison of the analysis results with the plant data demonstrates that the RELAP5/MOD2 code has the capability to simulate the thermal-hydraulic behaviour of PWRs under accident conditions of this type with accuracy, except the pressurizer pressure and level. The pressurizer pressure increase is sensitive to the in surge now it is believed that the interracial heat transfer in a horizontal stratified flow regime may be estimated low and the compression effect due to insurge flow may be high. In the nodalization sensitivity study it is found that S/G noding with junctions between bypass plenum and steam dome is preferred to simulate the S/G water level decreasing and avoid the spurious level peak at trubine trip.

• Nuclear Engineering and Technology
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• v.22 no.1
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• pp.66-74
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• 1990

The thermal-hydraulic characteristics of the 17$\times$17 OFA (Optimized Fuel Assembly) used in the KNU 7&8 are analyzed and compared with that of the 17$\times$17 SFA (Standard Fuel Assembly) loaded in the KNU 5&6. The thermal-hydraulic characteristics analyzed are minimum DNBR, fuel centerline temperature and exit void fraction at normal operation and design over power transient. Additionally, local linear rod power, which will cause fuel centerline melting, is calculated. The DNBR sensitivity calculations are performed with respect to the reactor operating parameters. COBRA-IV-I code is used for these calculations. The modified W-3 correltion and the drift-flux model are applied for the critical heat flux calculation and the void fraction calculation, respectively. From the calculated results, it has been found that the possibility of DNB occurrence is higher in the OFA than in the SFA. The other hand, the local linear power resulting in fuel centerline moiling of the OFA is nearly equal to that of the SFA.

• Genomics & Informatics
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• v.18 no.4
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• pp.42.1-42.9
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• 2020

Chromatin immunoprecipitation coupled with high-throughput DNA sequencing (ChIP-Seq) is a powerful technology to profile the location of proteins of interest on a whole-genome scale. To identify the enrichment location of proteins, many programs and algorithms have been proposed. However, none of the commonly used peak calling programs could accurately explain the binding features of target proteins detected by ChIP-Seq. Here, publicly available data on 12 histone modifications, including H3K4ac/me1/me2/me3, H3K9ac/me3, H3K27ac/me3, H3K36me3, H3K56ac, and H3K79me1/me2, generated from a human embryonic stem cell line (H1), were profiled with five peak callers (CisGenome, MACS1, MACS2, PeakSeq, and SISSRs). The performance of the peak calling programs was compared in terms of reproducibility between replicates, examination of enriched regions to variable sequencing depths, the specificity-to-noise signal, and sensitivity of peak prediction. There were no major differences among peak callers when analyzing point source histone modifications. The peak calling results from histone modifications with low fidelity, such as H3K4ac, H3K56ac, and H3K79me1/me2, showed low performance in all parameters, which indicates that their peak positions might not be located accurately. Our comparative results could provide a helpful guide to choose a suitable peak calling program for specific histone modifications.

• Nano
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• v.13 no.11
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• pp.1850126.1-1850126.10
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• 2018

Flexible strain sensors, as the core member of the family of smart electronic devices, along with reasonable sensing range and sensitivity plus low cost, have rose a huge consumer market and also immense interests in fundamental studies and technological applications, especially in the field of biomimetic robots movement detection and human health condition monitoring. In this paper, we propose a new flexible strain sensor based on thick CVD graphene film and its low-cost fabrication strategy by using the commercial adhesive tape as flexible substrate. The tensile tests in a strain range of ~30% were implemented, and a gage factor of 30 was achieved under high strain condition. The optical microscopic observation with different strains showed the evolution of cracks in graphene film. Together with commonly used platelet overlap theory and percolation network theory for sensor resistance modeling, we established an overlap destructive resistance model to analyze the sensing mechanism of our devices, which fitted the experimental data very well. The finding of difference of fitting parameters in small and large strain ranges revealed the multiple stage feature of graphene crack evolution. The resistance fallback phenomenon due to the viscoelasticity of flexible substrate was analyzed. Our flexible strain sensor with low cost and simple fabrication process exhibits great potential for commercial applications.

• Journal of the Korean Society of Mineral and Energy Resources Engineers
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• v.55 no.6
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• pp.624-634
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• 2018

Indonesia has become a net crude oil importer because of the reduction of a new oil field discovery, and Indonesia is attempting to raise investment funds through the Kerja Sama Operasi (KSO) contract to develop a small-scale field. However, the KSO has a high-risk and low-return contract system for investors, necessitating an economic evaluation to examine the feasibility of the project. This study performed economic evaluation on the development of an Indonesian small-scale field by applying the KSO contract conditions, and identified the major economic parameters through a sensitivity analysis. As a result, the oil price, CAPEX and OPEX were identified as influential factors for economic evaluation. The results also indicate that commercial production in small-scale fields is difficult. In the future, this study can be used as a reference resource for investment in oil and gas development projects in Indonesia.

• The Journal of the Korea Contents Association
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• v.19 no.1
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• pp.132-140
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• 2019

Recently, many cities around the world introduced and operated shared bicycle system to reduce the traffic and air pollution. Seoul also provides shared bicycle service called as "Ddareungi" since 2015. As the use of shared bicycle increases, the demand for bicycle in each station is also increasing. In addition to the restriction on budget, however, there are managerial issues due to the different demands of each station. Currently, while bicycle rebalancing is used to resolve the huge imbalance of demands among many stations, forecasting uncertain demand at the future is more important problem in practice. In this paper, we develop forecasting model for demand for Seoul shared bicycle using statistical time series analysis and apply our model to the real data. In particular, we apply Holt-Winters method which was used to forecast electricity demand, and perform sensitivity analysis on the parameters that affect on real demand forecasting.

• Journal of Cancer Prevention
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• v.23 no.4
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• pp.191-196
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• 2018

Background: Type 2 diabetes mellitus (T2DM) and cancer are serious health problems worldwide, and their prevalences have been on the rise in recent years. It has been reported that adropin plays an important role in the development of T2DM, oxidative stress, inflammation, and obesity. However, there is limited information available on T2DM from human studies, especially for the Korean population. In this study, we aimed to investigate the correlation between adropin levels and obesity of Korean T2DM patients. Methods: Thirty-six T2DM patients were recruited for this study. The participants were further classified into female (n = 12) and male (n = 24). Their body composition, metabolic parameters, inflammatory factors, and oxidative stress were measured. Results: The severity of obesity is more manifested in male than in female. Plasma triglyceride (TG) and high-sensitivity C-reactive protein (hs-CRP) levels of male were significantly higher than female. The plasma adropin and adiponectin level of female was significantly higher than male. The body weight, body mass index (BMI), body fat mass were negatively correlated with the plasma adropin level in female, whereas adropin has positive correlation with adiponectin in female. The hs-CRP was negatively correlated with the plasma adropin level in female and male. malondialdehyde, reactive oxidative species, and $TNF-{\alpha}$ was not significantly correlated with adropin in patients with T2DM. Conclusions: These findings suggest that adropin may be more used as a biomarker for predicting the risk of obesity and inflammation in Korean patients with T2DM, especially women.

• Journal of Korean Tunnelling and Underground Space Association
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• v.20 no.6
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• pp.973-987
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• 2018

Most of the previous seismic analyses have been carried out by separating the ground and structures, and there is a lack of comparative study on the dynamic behavior of high-rise and low-rise buildings. Therefore, in this study, the sensitivity analysis was performed with selected parameters by using a finite element analysis program in order to grasp the dynamic behavior of high-rise and low-rise buildings. As a result, it was turned out that the horizontal displacement, the interstory drift ratio, and the bending stress of a high-rise building were more affected by a long seismic wave than a low-rise buildings. Also, the weak parts of a high-rise and low-rise building were more affected by type of seismic wave than the ground conditions. Therefore, it is inferred that it will be helpful for seismic designs to consider the influence of ground conditions and seismic wave type on buildings.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.22 no.4
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• pp.369-376
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• 2019

Purpose: The aim of this study was to evaluate the clinical significance of inflammatory biomarkers in acute infectious diarrhea among children. Methods: Clinical parameters including fever, bacterial and viral etiology based on stool culture and multiplex polymerase chain reaction, and nine biomarkers including C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and leukocytes in blood and calprotectin, lactoferrin, myeloperoxidase, polymorphonuclear elastase, leukocytes, and occult blood in feces were evaluated in children who were hospitalized due to acute diarrhea without underlying disease. Results: A total of 62 patients were included. Among these patients, 33 had fever, 18 showed bacterial infections, and 40 patients were infected with 43 viruses. Of all the biomarkers, CRP was significantly correlated with fever (p<0.001). CRP, ESR, calprotectin, lactoferrin, myeloperoxidase, fecal leukocytes, and occult blood were significantly associated with infection with bacterial pathogens (p<0.001, p=0.04, p=0.03, p=0.003, p=0.02, p=0.03, p=0.002, respectively). The combination of CRP and fecal lactoferrin at their best cut-off values (13.7 mg/L and $22.8{\mu}g/mL$, respectively) yielded a sensitivity of 72.2%, and a specificity of 95.5% for bacterial etiology compared with their individual use. Conclusion: Blood CRP is a useful diagnostic marker for both fever and bacterial etiology in acute pediatric diarrhea. The combination of CRP and fecal lactoferrin yields better diagnostic capability for bacterial etiology than their use alone for acute diarrhea in children without underlying gastrointestinal disease.

• Journal of the Korean GEO-environmental Society
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• v.20 no.10
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• pp.5-14
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• 2019

Recently, earthquakes have occurred in our country and seismic stability of high-rise buildings in large cities is being a growing interest and thus the related studies have been increased. Also the grounds are considered indirectly in most of seismic designs and analyses and seismic researches based on 3D dynamic analysis are insufficient. In this study, therefore, 2D and 3D dynamic analyses were performed based on the SSI complete model including grounds and the behavior was compared and analyzed. For dynamic modeling, linear time history analyses were performed by using MIDAS GTS NX. For this purpose, a high-rise building was assumed to be constructed on top of the bedrock and surrounded by a surface layer. A sensitivity analysis was performed with the selected parameters. The dynamic behavior was compared and analyzed in terms of horizontal displacements, drift ratios, bending stresses, and weak parts. In most cases, 2D dynamic behavior was calculated to be larger than 3D's and thus it shows more conservative results with increasing number and size of weak parts.