• Earthquakes and Structures
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• v.6 no.4
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• pp.409-436
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• 2014

Although it is widely accepted that the interaction -between masonry infill and structural members significantly affects the seismic response of reinforced concrete (RC) frames, this interaction is generally neglected in current design-oriented seismic analyses of structures. Moreover, the role of masonry infill is expected to be even more relevant in the case of existing frames designed only for gravitational loads, as infill walls can significantly modify both lateral strength and stiffness. However, the additional contribution to both strength and stiffness is often coupled to a modification of the global collapse mechanisms possibly resulting in brittle failure modes, generally related to irregular distributions of masonry walls throughout the frame. As a matter of principle, accurate modelling of masonry infill should be at least carried out by adopting nonlinear 2D elements. However, several practice-oriented proposals are currently available for modelling masonry infill through equivalent (nonlinear) strut elements. The present paper firstly outlines some of the well-established models currently available in the scientific literature for modelling infill panels in seismic analyses of RC frames. Then, a parametric analysis is carried out in order to demonstrate the consequences of considering such models in nonlinear static and dynamic analyses of existing RC structures. Two bay-frames with two-, three- and four-storeys are considered for performing nonlinear analyses aimed at investigating some critical aspects of modelling masonry infill and their effects on the structural response. Particularly, sensitivity analyses about specific parameters involved in the definition of the equivalent strut models, such as the constitutive force-displacement law of the panel, are proposed.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.43 no.8 s.350
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• pp.35-43
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• 2006

In the paper, we propose a new method for power optimization that uses path balancing based on stochastic estimation of glitch in Statistical Static Timing Analysis (SSTA). The proposed method estimates the probability of glitch occurrence using tightness probability of each node in timing graph. In addition, we propose efficient gate sizing technique for glitch reduction using accurate calculation of sizing effect in delay considering probability of glitch occurrence. The efficiency of proposed method has been verified on ISCAS85 benchmark circuits with $0.16{\mu}m$ model parameters. Experimental results show up to 8.6% of accuracy improvement in glitch estimation and 9.5% of optimization improvement.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.18
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• pp.8431-8438
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• 2016

Doxorubicin (DOX) was introduced as an effective chemotherapeutic for a wide range of cancers but with some severe side effects especially on myocardia. 2-Deoxy-D-glucose (2DG) enhances the damage caused by chemotherapeutics and ionizing radiation (IR) selectively in cancer cells. We have studied the effects of $1{\mu}M$ DOX and $500{\mu}M$ 2DG on radiation induced cell death, apoptosis and also on the expression levels of p53 and PTEN genes in T47D and SKBR3 breast cancer cells irradiated with 100, 150 and 200 cGy x-rays. DOX and 2DG treatments resulted in altered radiation-induced expression levels of p53 and PTEN genes in T47D as well as SKBR3 cells. In addition, the combination along with IR decreased the viability of both cell lines. The radiobiological parameter (D0) of T47D cells treated with 2DG/DOX and IR was 140 cGy compared to 160 cGy obtained with IR alone. The same parameters for SKBR3 cell lines were calculated as 120 and 140 cGy, respectively. The sensitivity enhancement ratios (SERs) for the combined chemo-radiotherapy on T47D and SKBR3 cell lines were 1.14 and 1.16, respectively. According to the obtained results, the combination treatment may use as an effective targeted treatment of breast cancer either by reducing the single modality treatment side effects.

• Bulletin of the Korean Chemical Society
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• v.26 no.9
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• pp.1403-1409
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• 2005

A sensitive and selective electrochemical method was developed for the amperometric determination of ascorbic acid (AA) at a glassy carbon electrode (GCE) modified with single-wall carbon nanotubesdihexadecyl hydrogen phosphate (SWNT-DHP) composite film. The SWNT-DHP composite film modified GCE was characterized with SEM. The SWNT-DHP composite film modified GCE exhibited excellent electrocatalytic behaviors toward the oxidation of AA. Compared with the bare GCE, the oxidation current of AA increased greatly and the oxidation peak potential of AA shifted negatively to about -0.018 V (vs. SCE) at the SWNT-DHP composite film modified GCE. The experimental parameters, which influence the oxidation current of AA, were optimized. Under the optimal conditions, the amperometric measurements were performed at a applied potential of -0.015 V and a linear response of AA was obtained in the range from 4 ${\times}$ $10^{-7}$ to 1 ${\times}$ $10^{-4}$ mol $L^{-1}$ and with a limit of detect (LOD) of 1.5 ${\times}$ $10^{-7}$ mol $L^{-1}$. The interferences study showed that the SWNT-DHP composite film modified GCE exhibited good sensitivity and excellent selectivity in the presence of high concentration uric acid and dopamine. The proposed procedure was successfully applied to detect AA in human urine samples with satisfactory results.

• Journal of the Korea Society of Computer and Information
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• v.18 no.7
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• pp.37-45
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• 2013

Context dependent fusion (CDF) is a fusion algorithm that combines multiple outputs from different classifiers to achieve better performance. CDF tries to divide the problem context into several homogeneous sub-contexts and to fuse data locally with respect to each sub-context. CDF showed better performance than existing methods, however, it is sensitive to noise due to the large number of parameters optimized and the innate linearity limits the application of CDF. In this paper, a variant of CDF using support vector machines (SVMs) for fusion and kernel principal component analysis (K-PCA) for context extraction is proposed to solve the problems in CDF, named CDF-SVM. Kernel PCA can shape irregular clusters including elliptical ones through the non-linear kernel transformation and SVM can draw a non-linear decision boundary. Regularization terms is also included in the objective function of CDF-SVM to mitigate the noise sensitivity in CDF. CDF-SVM showed better performance than CDF and its variants, which is demonstrated through the experiments with a landmine data set.

• Journal of the Korean Institute of Telematics and Electronics B
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• v.29B no.7
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• pp.52-61
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• 1992

An iterative scheme for computing the three-dimensional position and the surface orientation of an opaque object from a singel shaded image is proposed. This method demonstrates that calculating the depth(distance) between the camera and the object from one shaded video image is possible. Most previous research works on $'Shape from Shading$' problem, even in the $'Photometric Stereo Method$', invoved the determination of surface orientation only. To measure the depth of an object, depth of the object, and the reflectance properties of the surface. Assuming that the object surface is uniform Lambertian the measured intensity level at a given image pixel*x,y0becomes a function of surface orientation and depth component of the object. Derived Image Irradiance Equation can`t be solved without further informations since three unknown variables(p,q and D) are in one nonlinear equation. As an additional constraints we assume that surface satisfy smoothness conditions. Then equation can be solved relaxatively using standard methods of TEX>$'Calculus of VariationTEX>$'. After checking the sensitivity of the algorithm to the errors ininput parameters, the theoretical results is tested by experiments. Three objects (plane, cylinder, and sphere)are used. Thees initial results are very encouraging since they match the theoretical calculations within 20$\%$ error in simple experiments.> error in simple experiments.

• JSTS:Journal of Semiconductor Technology and Science
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• v.17 no.1
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• pp.141-146
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• 2017

In this letter, we propose the use of tunneling field effect transistors (TFET) as a biosensor that detects bio-molecules on the gate oxide. In TFET sensors, the charges of target molecules accumulated at the surface of the gate oxide bend the energy band of p-i-n structure and thus tunneling current varies with the band bending. Sensing parameters of TFET sensors such as threshold voltage ($V_t$) shift and on-current ($I_D$) change are extracted as a function of the charge variation. As a result, it is found that the performances of TFET sensors can surpass those of conventional FET (cFET) based sensors in terms of sensitivity. Furthermore, it is verified that the simultaneous sensing of two different target molecules in a TFET sensor can be performed by using the ambipolar behavior of TFET sensors. Consequently, it is revealed that two different molecules can be sensed simultaneously in a read-out circuit since the multi-sensing is carried out at equivalent current level by the ambipolar behavior.

• Journal of Gastric Cancer
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• v.16 no.3
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• pp.141-151
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• 2016

Purpose: The aim of the present study was to elucidate the clinicopathological significance and diagnostic accuracy of immunohistochemistry (IHC) for determining the mesenchymal epidermal transition (c-MET) expression in patients with gastric cancer (GC). Materials and Methods: The present meta-analysis investigated the correlation between c-MET expression as determined by IHC and the clinicopathological parameters in 8,395 GC patients from 37 studies that satisfied the eligibility criteria. In addition, a concordance analysis was performed between c-MET expression as determined by IHC and c-MET amplification, and the diagnostic test accuracy was reviewed. Results: The estimated rate of c-MET overexpression was 0.403 (95% confidence interval [CI], 0.327~0.484) and it was significantly correlated with male patients, poor differentiation, lymph node metastasis, higher TNM stage, and human epidermal growth factor receptor 2 (HER2) positivity in IHC analysis. There was a significant correlation between c-MET expression and worse overall survival rate (hazard ratio, 1.588; 95% CI, 1.266~1.992). The concordance rates between c-MET expression and c-MET amplification were 0.967 (95% CI, 0.916~0.987) and 0.270 (95% CI, 0.173~0.395) for cases with non-overexpressed and overexpressed c-MET, respectively. In the diagnostic test accuracy review, the pooled sensitivity and specificity were 0.56 (95% CI, 0.50~0.63) and 0.79 (95% CI, 0.77~0.81), respectively. Conclusions: The c-MET overexpression as determined by IHC was significantly correlated with aggressive tumor behavior and positive IHC status for HER2 in patients with GC. In addition, the c-MET expression status could be useful in the screening of c-MET amplification in patients with GC.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.1
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• pp.223-228
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• 2017

In this paper, we are proposing an optimal design of wideband pulsed type gamma-ray sensors. These sensors were manufactured based on the design results and after word electrical properties were analyzed. The sensor input parameters were derived on the basis of pulsed gamma-ray spectrum and time-dependent energy rate, and the output current which were derived on the basis of the sensor sensitivity control circuit. Pulsed gamma-ray sensors were designed using the TCAD simulators. The design results show that the optimal Epi layer thickness is 45um with the applied voltage 3.3V and the diameter is 2.0mm. The doping concentrations are as follows : N-type is an Arsenic as $1{\times}10^{19}/cm^3$, P-type is a Boron as $1{\times}10^{19}/cm^3$ and Epi layer is Phosphorus as $3.4{\times}10^{12}/cm^3$. The fabricated sensor was a leakage current, 12pA at voltage -3.3V and fully depleted mode at voltage -5V. A test result of pulsed radiation shows that the sensor gives out the optimal photocurrent.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.24 no.8A
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• pp.1115-1125
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• 1999

This paper forecasts the number of GMPCS(Global Mobile Communications by Satellite) subscribers in Korea. Since GMPCS adopts nor only a new tecnology cor proved in the market yet, bot also a global service principle, it's service market involves a great deal of nucertainties in terms of technological and regulatory perspectives. This paper develops a modified diffusion which considers those uncertainties by identifying three environmental group of tactors. The parameters of the model are estimated through a scenario-based approach. By assuming a pessimistic and an optimistic scenarios with three environmental group of factors, the model forecasts 4,000 and 7,000 substcribers in the first year, and then 100,000 and 600,000 subscribers in 2005 respectively. The sensitivity analysis of the model also gives an implication of the future market growth. In the early period, regulatoyu and technological issues are found to be relatively important, but, in the later period, the interconnection issues and price-competitiveness will become increasingly important.