• Title/Summary/Keyword: Parallel administration

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AN EXPERIMENTAL STUDY ON THE PERIODONTAL TISSUE REACTION TO TOOTH MOVEMENT IN THE RAT (치아이동(齒牙移動)이 백서(白鼠) 치주조직(齒周組職)에 미치는 영향(影響)에 관(關)한 실험적(實驗的) 연구(硏究))

  • Yoo, Nam Soon
    • The korean journal of orthodontics
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    • v.9 no.1
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    • pp.99-103
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    • 1979
  • For the purpose of investigating the response of the periodontal tissue in relation to the experimental tooth movement, the rats were inhibited from collagen formation by adminstration of aminoacetonitrile. Findings were as follows: 1) In experimental group, the principal fibers of the periodontal ligament came to run parallel along the alveolar bone or root surface on the pressure side, while the decrease in density, irregular arrangement, and partial loss of principal fibers were observed on the tension side. 2) Sharpey's fibers at the alveolar bone decreased in number, and as the aminoacetonitrile administration continued, the capability of matrix formation decreased on the tension side, the narrowing of the alveolar septum and poor-bony trabeculation appeared on the pressure side. 3) In cementum, Sharpey's fibers were distributed irregularly. The formation of acellura cementum was decreased on the tension side, while the formative capability of cellular cementum was increased. 4) The degree of staining by Herovici technique decreased in the periodontal membrane. By PAS and ninhydrine -Schiff reaction it was appeared weakly positive in the region where the Sharpey's fibers existed.

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Age-related Increase of Sister Chromatid Exchange Frequency in Bone Marrow Cells of Senescence Accelerated Mouse and Its Inhibition by Chronic Treatment of Ginseng

  • Lim, Heung-Bin;Sohn, Hyung-Ok;Lee, Young-Gu;Kim, Seung-Hyung;Lee, Dong-Wook
    • Toxicological Research
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    • v.11 no.2
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    • pp.261-266
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    • 1995
  • Age-related change in the frequency of spontaneous sister chromatid exchange (SCE) and chromosornal aberrations were investigated in bone marrow cells of accelerated senescence-resistant mice (SAM R1) and senescence accelerated ones (SAM P1). And the effect of chronic treatment of ginseng extract (Panax ginseng C.A. Meyer) on these chromosomal abnormalities was tested in SAM P1. SCE frequency in the cells was progressively increased with age in both mice, but it was consistently higher in SAM P1 than in SAM R1 at all corresponding age. Chromosomal aberrations were, however, not significantly changed with age except that it was slightly increased in only aged SAM P1. Interestingly, the rate of these genetic instabilities in SAM P1 was remarkably retarded by long-term administration of ginseng water extract (0.05% in drinking water). These results suggest that frequency of spontaneous SCE in bone marrow cells increase in parallel with senescence of the mice, and SAM P1 is in the condition of being more exposed than SAM R1 to DNA damaging factors. These also indicate that long-term treatment of ginseng may reduce the genetic damage.

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Interference effect by electric utilities at electric resistivity Survey of fill dam (필댐의 전기비저항 탐사시 전기매체에 의한 영향 분석 연구)

  • Kim, Jae-Hong;Shin, Dong-Hoon;Im, En-Sang
    • Proceedings of the Korean Geotechical Society Conference
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    • 2009.09a
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    • pp.1037-1040
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    • 2009
  • Using much most electricity electric resistivity survey by nondestructiveness inquiry enforcement design of country base equipment business and facilities preservation administration dimension electric resistivity survey sends and cause much effects in survey believability by electricity medium of survey personality survey contiguity that grasp base special quality by potential difference flowing current artificially in base. Is item that enforce in most in-suite although when make electric resistivity survey until present, electricity medium or effect research by electricity origination was gone much. There is shortcoming that must be difficult to know correct underground utilities establishment state in-suite in this research and do comparison examination running parallel drilling investigation to heighten believability of electric resistivity survey. Did to dam that censure data that regulate grading from construction and is censure construction which can know correctly interior base situation comparatively to electricity medium of interior and electricity eruption won of contiguity and base condition (base rock).

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Simultaneous Determination of α-Amanitin and β-Amanitin in Mouse Plasma Using Liquid Chromatography-High Resolution Mass Spectrometry

  • Bang, Young Yoon;Lee, Min Seo;Lim, Chang Ho;Lee, Hye Suk
    • Mass Spectrometry Letters
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    • v.12 no.3
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    • pp.112-117
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    • 2021
  • α-Amanitin and β-amanitin are highly toxic bicyclic octapeptides responsible for the poisoning of poisonous mushrooms such as Amanita, Galerina, and Lepiota by inhibiting RNA polymerase II, DNA transcription, and protein synthesis. A sensitive, simple, and selective liquid chromatography-high resolution mass spectrometric method using parallel reaction monitoring mode was developed and validated for the simultaneous determination of α- and β-amanitin in mouse plasma to evaluate the toxicokinetics of α- and β-amanitin in mice. Protein precipitation of 5 μL mouse plasma sample with methanol as sample clean-up procedure and use of negative electrospray ionization resulted in better sensitivity and less matrix effect. The calibration curves for α- and β-amanitin in mouse plasma were linear over the range of 0.5-500 ng/mL. The intra- and inter-day coefficient of variations and accuracies for α- and β-amanitin at four quality control concentrations were 3.1-14.6% and 92.5-115.0%, respectively. The present method was successfully applied to the toxicokinetic study of α- and β-amanitin after an oral administration of α- and β-amanitin at 1.5 mg/kg dose to male ICR mice.

Workability and Life Satisfaction: Effects of Workers' Positive Perceptions on Their Return to Jobs

  • Kang, Dongsuk
    • Safety and Health at Work
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    • v.13 no.3
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    • pp.286-293
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    • 2022
  • Background: The death rate of workers due to industrial accidents in South Korea (3.61 persons in 2017) is higher than the Organization for Economic Cooperation and Development average (2.43) and the fifth highest among Organization for Economic Cooperation and Development member countries. Although the pandemic of novel coronavirus (COVID-19) has changed, the socioeconomic aspects of Korean society, the number of Koreans suffering accidents and the number of deaths in 2020 have increased. It is necessary to take measures to prevent accidents and make comprehensive efforts to return to work. This study proposes research questions about the effect of workers' positive perception on whether to work after accidents and the impact of the experience of rehabilitation services on the return to work. Methods: This research performed a panel logistic regression analysis using data on workers' compensation insurance in Korea for two years (2018-2019). Results: This research finds that workers' positive perceptions of workability and life satisfaction contributed affirmatively to their re-employment. Several factors related to employment (e.g., work period, the number of job qualifications) also positively affect their return to work. However, the experience of rehabilitation services did not have a significant effect on re-employment. The variables of their health conditions (e.g., disability grade, feelings of health problems, age) negatively influenced their return to jobs. Conclusion: These results suggest the importance of workers' mental recovery and the need to innovate rehabilitation services for their employment. Positive thinking and self-rehabilitation could be critical for workers, parallel with social welfare policies.

The Effect of Trainer's Communication Style on Rehabilitation Ability and Rehabilitation Satisfaction of Elite Athletes

  • Seung-Jea, Lee
    • International Journal of Internet, Broadcasting and Communication
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    • v.15 no.1
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    • pp.281-289
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    • 2023
  • The purpose of this study was to objectively explore and discuss the effect of trainer's communication style on rehabilitation ability and rehabilitation satisfaction of elite athletes. we observed the relationship between rehabilitation trainers and injured athletes and found that communication between them plays an important role. In this study, we criticized that most of the studies related to rehabilitation were conducted from the point of view of natural science. The results of this study emphasized that rehabilitation-related research should broadly accept social science positions such as business administration. The main research findings are as follows. As a result of analyzing the relationship between trainer's communication style and rehabilitation ability, first, the trainer's cooperative and professional communication style affects emotional factors of injured players. Second, the trainer's cooperative and controlled communication style affects the cognitive factors of injured players. Third, the trainer's cooperative and professional communication style affects the behavioral factors of injured players. Fourth, the trainer's cooperative and professional communication style affects the rehabilitation satisfaction of injured players. Based on these results, this study was conducted to validate the necessity of discussing the trainer's communication style preference according to the individual background such as the injured player's gender, personality, and injury level, and the classification and composition of communication styles that match Korean culture and sentiment. As suggestions for follow-up research, active sharing of problems with adjacent disciplines such as sports sociology, sports education, and sports marketing, and parallel qualitative research centered on individual cases were suggested

Quantification of Fargesin in Mouse Plasma Using Liquid Chromatography-High Resolution Mass Spectrometry: Application to Pharmacokinetics of Fargesin in Mice

  • Lee, Min Seo;Lim, Chang Ho;Bang, Young Yoon;Lee, Hye Suk
    • Mass Spectrometry Letters
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    • v.13 no.1
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    • pp.20-25
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    • 2022
  • Fargesin, a tetrahydrofurofuranoid lignan isolated from Flos Magnoliae, shows anti-inflammatory, anti-oxidative, anti-allergic, and anti-hypertensive activities. To evaluate the pharmacokinetics of fargesin in mice, a sensitive, simple, and selective liquid chromatography-high resolution mass spectrometric method using electrospray ionization and parallel reaction monitoring mode was developed and validated for the quantification of fargesin in mouse plasma. Protein precipitation of 6 µL mouse plasma with methanol was used as sample clean-up procedure. The standard curve was linear over the range of 0.2-500 ng/mL in mouse plasma with the lower limit of quantification level at 0.2 ng/mL. The intra- and inter-day coefficient variations and accuracies for fargesin at four quality control concentrations including were 3.6-11.3% and 90.0-106.6%, respectively. Intravenously injected fargesin disappeared rapidly from the plasma with high clearance values (53.2-55.5 mL/min/kg) at 1, 2, and 4 mg/kg doses. Absolute bioavailability of fargesin was 4.1-9.6% after oral administration of fargesin at doses of 1, 2, and 4 mg/kg to mice.

The Relationship between Self-control Behavior, Social Comparison Attitude, Self-efficacy and Health Promotion Activities of College Students (대학생의 통제감, 사회비교추구성향 및 자기효능감이 건강행위에 미치는 영향)

  • Song, So-Hyeon;Jang, Youn-Kyoung;Kim, Joo-Hyung
    • Journal of Korean Public Health Nursing
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    • v.23 no.1
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    • pp.27-39
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    • 2009
  • Purpose: This study was conducted to evaluate the relationship between self-control behavior, social comparison attitude, self-efficacy and health promotion activities of college students who had health related majors (nursing, dental hygiene, health administration). Methods: The subjects consisted of 413 college students. Data were collected by self reported questionnaires that were designed to evaluate self-control behavior, social attitudes, self-efficacy and health promotion lifestyle (HPLP). Data were analyzed using the SPSS/PC win 14.0 program. Results: Upward & parallel comparison, self-efficacy and parents income were positively correlated with health promotion activities by college students. The most significant predictors of health promotion activities for college students were self-efficacy and self-control behavior. Conclusion: Health promotion activities for college students are influenced by self-efficacy, self-control behavior, and upward comparison. In conclusion, to increase the health promotion activities of college students, methods designed to increase self-efficacy should be prepared while considering the self-control behavior and comparative propensity towards others.

Differential Impacts of Discretionary Accrual Directions on Accounting Conservatism

  • Sangkwon CHA;HyeongTae CHO
    • The Journal of Economics, Marketing and Management
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    • v.12 no.3
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    • pp.13-22
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    • 2024
  • Purpose: While there has been extensive research on discretionary accruals (hereafter, 'DA') and accounting conservatism, interpretations have varied among researchers depending on how discretionary accruals are determined as proxies. This study investigates the relationship between discretionary accruals (DA) and accounting conservatism, focusing on the distinctions between signed DA and absolute DA. Research design, data and methodology: Using financial data from companies listed on the KOSPI and KOSDAQ markets from 2010 to 2020, we employ regression analysis to explore how signed and absolute DA impact accounting conservatism. This approach allows us to parse out the effects of positive versus negative discretionary accruals systematically. Results: Our findings indicate a divergent impact of DA on accounting conservatism. Specifically, in cases of negative DA, an increase in DA corresponds with heightened accounting conservatism. Conversely, when DA is positive, increases in DA do not exhibit a significant relationship with changes in accounting conservatism. These effects suggest that the nature of DA-whether it represents upward or downward earnings adjustments-critically influences its relationship with conservatism. Conclusions: The results elucidate the nuanced role of discretionary accruals in influencing accounting conservatism. The decrease in accounting conservatism associated with absolute increases in DA appears primarily driven by groups with downward earnings adjustments. This suggests that as negative DA diminishes toward zero, accounting conservatism intensifies, whereas positive DA does not have a parallel effect.

Effect of Accelerated Storage on the Microstructure and Water Absorption Characteristics of Korean Adzuki Bean (Vigna angularis L.) Cultivar (팥의 가속화 저장에 따른 미세구조 및 수분흡수 특성)

  • Jieun Kwak;Seon-Min Oh;You-Geun Oh;Yu-Chan Choi;Hyun-Jin Park;Suk-Bo Song;Jeong-Heui Lee;Jeom-Sig Lee
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.68 no.3
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    • pp.167-174
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    • 2023
  • This study investigated the microstructure and water absorption characteristics of the Korean adzuki bean (Vigna angularis L.) cultivar under accelerated storage. The germination rate, acid value, redness (a*), and yellowness (b*) values showed no significant differences after three months of storage compared to pre-storage under low temperatures (4℃). However, a statistically significant difference was observed under accelerated high temperatures (45℃). In particular, after storage for three months, the germination rate and acid value were 0% and 33.63 mg KOH/100g, respectively, under accelerated high temperatures. After storage for three months, the holes, hilum damage, and spaces between the seed coat and cotyledon shortened the time and speed of water absorption under accelerated high temperatures compared to that under low temperatures. Conversely, further research is required to investigate the reason for the low rate of parallel water absorption.