• Geotechnical Engineering
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• v.13 no.4
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• pp.13-24
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• 1997

A predicting method for ultimate vertical and horizontal bearing capacity by means of PAR(Pile Analysis Routines) was suggested. Based on the static pile load test data, case studies by means of PAR were performed. Ultimate pile capacity predicted by PAR was within 15% error range of that determined by stairs pile load tests. Also, the results of static pile load test, statnamic tests and PDA data performed on pipe piles were compared and, by using PAR, ultimate pile capacity was determined. Distributions of atrial pile load could be predicted and load transfer analysis could be done approximately by those distributions.

• Proceedings of the KSR Conference
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• 2011.10a
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• pp.2745-2754
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• 2011

In this paper, we propose a Peak to Average power Ratio(PAR) reduction algorithm by using the Adaptive Block Coding(ABC). The problem of a PAR due to each sub-carrier overlap phenomenon in the OFDM (Orthogonal Frequency Division Multiplexing) system causes the an increasing in the complexity of the A/D converter in the transmitter and a reduction in the efficiency of the amplifier. The proposed ABC algorithm selects the block coding which provides the lowest PAR value based on the various check bit position. It is shown that a PAR of the ABC algorithm can be reduced from 8.35dB to 6.02dB in 16 sub-carriers compared to theconventional block coding scheme. We also extended the ABC algorithm to a larger number of sub-carriers and estimated their PAR values.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2002.11a
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• pp.163-166
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• 2002

OFDM should be used for the fourth generation communication for high speed communication. Because of high spectral efficiency and high tolerance to fading channel, OFDM is applied to many high speed wire and wirless communication such as DAB(Digital Audio Broudcast), DVB(Digital Video Broadcast), IMT 2000 etc. Inter-modulation, however, is derived from PAR(Peak to Average Power Ratio) of OFDM signals. The paper describes PTS(Partial Transmit Sequence) and SLM(Select Mapping) of an existing methods which can reduce PAR. And then the document introduces the new method that is called "Combine PAR method". The method proposed in this paper is to combine PTS and SLM. As a result of the simulation, Combine PAR method is better than the existing methods.g methods.

• Journal of Life Science
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• v.20 no.4
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• pp.503-510
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• 2010

Most allergens have protease activities, suggesting that proteases may be a key link between Th2-type immune reactions in allergic responses. Protease activated receptor (PAR) 2 is activated via the proteolytic cleavage of its N-terminal domain by proteinases. To know the role of PAR2 in Aspergillus protease allergen activated Th2 immune responses in airway epithelial cells, we investigated and compared immune cell recruitment and level of chemokines and cytokines between PAR2 knock out (KO) mice and wild type (WT) mice. There were evident immune cell infiltrations into the bronchial alveolar lavage fluid (BALF) of WT mice, but the infiltrations in PAR2 KO mice were significantly lowered than those of WT mice. The IL-25, TSLP, and eotaxin gene expressions were profoundly increased after Aspergillus protease, but their expression was significantly lowered in PAR2 KO mice in this study. Compared to PAR2 KO mice, OVA specific IgE concentrations in serum of WT mice were quite increased; moreover, the IgE level of PAR2 KO mice was lower than in WT mice. The IL-25 expression by Aspergillus protease stimulation was significantly reduced by p38 specific inhibitor treatment. In this study, we determined that Th2 response was initiated with IL-25 and TSLP mRNA up-regulation in lung epithelial cells via PAR2 after Aspergillus protease allergen treatment.

• Molecules and Cells
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• v.37 no.11
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• pp.804-811
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• 2014

The protease-activated receptor (PAR)-2 is highly expressed in endothelial cells and vascular smooth muscle cells. It plays a crucial role in regulating blood pressure via the modulation of peripheral vascular tone. Although several mechanisms have been suggested to explain PAR-2-induced hypotension, the precise mechanism remains to be elucidated. To investigate this possibility, we investigated the effects of PAR-2 activation on N-type $Ca^{2+}$ currents ($I_{Ca-N}$) in isolated neurons of the celiac ganglion (CG), which is involved in the sympathetic regulation of mesenteric artery vascular tone. PAR-2 agonists irreversibly diminished voltage-gated $Ca^{2+}$ currents ($I_{Ca}$), measured using the patch-clamp method, in rat CG neurons, whereas thrombin had little effect on $I_{Ca}$. This PAR-2-induced inhibition was almost completely prevented by ${\omega}$-CgTx, a potent N-type $Ca^{2+}$ channel blocker, suggesting the involvement of N-type $Ca^{2+}$ channels in PAR-2-induced inhibition. In addition, PAR-2 agonists inhibited $I_{Ca-N}$ in a voltage-independent manner in rat CG neurons. Moreover, PAR-2 agonists reduced action potential (AP) firing frequency as measured using the current-clamp method in rat CG neurons. This inhibition of AP firing induced by PAR-2 agonists was almost completely prevented by ${\omega}$-CgTx, indicating that PAR-2 activation may regulate the membrane excitability of peripheral sympathetic neurons through modulation of N-type $Ca^{2+}$ channels. In conclusion, the present findings demonstrate that the activation of PAR-2 suppresses peripheral sympathetic outflow by modulating N-type $Ca^{2+}$ channel activity, which appears to be involved in PAR-2-induced hypotension, in peripheral sympathetic nerve terminals.

• Herbal Formula Science
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• v.19 no.2
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• pp.23-38
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• 2011

Objectives : Atractylodes chinensis(AC) and Phellodendron amurense Ruprecht(PAR) have been used as anti-inflammatory medicines. However, the effects of AC, PAR and Yimyosan on AP were not examined. To prove this, We decocted the dried prescription of AC and PAR with boiling distilled water and freeze-dried to be powdered. AC, PAR and Yimyosan was administrated intraperitoneally. Methods : 1h after administration, cerulein was injected hourly six times. 6hrs after last cerulein injection, mice were sacrificed, then the pancreas and blood were harvested. Serum amylase and lipase, neutrophil infiltration, pancreatic cytokines were used as the parameter of severity of AP. Results : As a result of assessment the parameters of AP, AC alone treatment did not inhibit the severity of AP, however PAR treatment inhibited the severity of AP significantly. Yimyosan also showed the protective effects against AP at lower doses, however AC alone plus PAR alone extract did not show the protective effects significantly. Conclusions : In conclusion, PAR extract has a protective effects on AP, and the effects could be increased by co-treatment with AC.

• The Journal of Korean Obstetrics and Gynecology
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• v.23 no.1
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• pp.12-29
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• 2010

Purpose: This study was conducted to investigate the effect on factors related lactation after administration of Palmul-tang in postpartum C57BL/6N mice. Materials and Methods: Experimental groups were divided into control group post-par group and pre-par group. Pre-par and post-par group were administered Palmul-tang(p.o) twice a week for 4 weeks or 3 weeks respectively. Control group was administered normal saline for 3 weeks. Then we observed morphological change, immunohistochemical density and milk protein gene expression of factors related lactation within mammary gland of postpartum mice. Results: In post-par and pre-par groups, adipose tissue within mammary gland significantly decreased, and ductal branch and alveoli prominently developed than that of control group at 1~3 weeks after administraion of Palmul-tang. In post-par and pre-par groups, density of immunoreactivity on oxytocin, prolactin, estrogen and progesterone receptors in mammary glandular tissue significantly increased than that of control group. mRNA expression of $\beta$-casein and placental lactogen (PL)-1 in post-par group was more increased than that of control and pre-par groups. Conclusion: These results suggest that Palmul-tang significantly improved factors related lactation at postpartum period.

• The korean journal of orthodontics
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• v.31 no.4 s.87
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• pp.393-401
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• 2001

The purposes of this study were to assess the treatment results in orthodontic department, Kyung Hee University, to evaluate the occlusion at 2 year follow-up control, in relation to the original malocclusion, and changes occurring in the follow-up period, and to determine whether treatment and posttreatment changes of the PAR index were related to the original Angle classification Dental study casts of 25 patients in permanent dentition were evaluated using Peer Assessment Rating (PAR) index. The PAR index was measured at the pretreatment stage, immediately after treatment, and at 2 yews posttreatment. The following results were obtained : 1. The treatment reduced the PAR index by 85.05% and it indicates that KHDC clinic has a high standard of treatment 2. The follow-up result of 75.40% PAR score reduction implies a gain of 9.55% of posttreatment PAR score during follow-up period. 3. There is no relationship between the treatment changes of the PAR index and the orignal Angle classification.

• Proceedings of the Korean Environmental Sciences Society Conference
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• 2008.11a
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• pp.538-544
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• 2008

Activated protein C (APC) is thought to exert antiinflammatory activities through the endothelial protein C receptor (EPCR)-dependent cleavage of protease activated receptor 1 (PAR-1) in endothelial cells. Since thrombin cleaves PAR-1 with $\sim$3-4-orders of magnitude higher efficiency, and PAR-1 is a target for proinflammatory activities of thrombin, it is not understood how APC can elicit protective responses through the cleavage of PAR-1. In this study, we demonstrate that EPCR is associated with caveolin-1 in endothelial lipid rafts, but its occupancy by protein C leads to its dissociation from caveolin-1 and subsequent recruitment of PAR-1 to protective signaling pathways through the coupling of PAR-1 to Gi-protein. When EPCR is bound by protein C, the PAR-1-dependent protective response in endothelial cells can be mediated by either thrombin or APC. These results provide a new paradigm for understanding the mechanism through which PAR-1 and EPCR participate in cellular signaling events in endothelial cells.

• Journal of Advanced Marine Engineering and Technology
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• v.40 no.2
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• pp.112-119
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• 2016

Many studies have been conducted on the performance of a passive autocatalytic recombiner (PAR), but not many have focused on the locations where the PAR is installed. During a severe accident in a nuclear reactor containment, a large amount of hydrogen gas can be produced and released into the containment, leading to hydrogen deflagration or a detonation. A PAR is a hydrogen mitigation method that is widely implemented in current and advanced light water reactors. Therefore, for this study, a PAR was installed at different locations in order to investigate the difference in hydrogen reduction rate. The results indicate that the hydrogen reduction rate of a PAR is proportional to the distance between the hydrogen induction location and the bottom wall.