• YAKHAK HOEJI
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• v.42 no.5
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• pp.494-499
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• 1998

As part of a drug discovery program to discover more effective platinum-based anticancer drugs, a series of platinum complexes of 1,2-bis(diphenylphosphino)ethane(1,2-diaminopro pane)platinum(II)dinitrate (KHPC-070) has been evaluated in vitro against various tumor cell lines and normal kidney cells. The structure of this new compound was determined by elemental analysis, infrared spectroscopy (IR) and $^{13}carbon$ nuclear magnetic resonance (NMR). With the use of nine tumor cell lines, KHPC-070 exhibited a comparable cytotoxic to cisplatin. The cytotoxicity of KHPC-070 in normal cells was quite less than that of cisplatin using 3-(4.5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) and [$^3H$]-thymidine uptake tests in rabbit renal proximal tubular cells and human renal cortical cells. Based on these results, KHPC-070 is considered to have more selective cytotoxicity toward cancer cells than normal human/rabbit kidney cells.

• Korean Institute of Interior Design Journal
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• v.15 no.6 s.59
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• pp.150-158
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• 2006

The purpose of this study is to evaluate environment-friendly planning feature in Environment-friendly Certificated apartments and to use the basic planning data of housing. Seven Environment-friendly Certificated apartments have been analyzed. The findings of this study are as follows: Environment-friendly planning features are categorized into 4 items; floor planning feature, material planning feature, universal planning feature and environmental planning feature. Among floor planning features, natural sunlight, built-in closets, and differentiated floor plans are well considered, but the flexible floor plan for resident's lifestyle and green space are lack. Among material planning features, environment-friendly finishing materials, environment-friendly products and energy-efficient double-pane windows are well considered, but implementation for resource savings using recycled materials are lack. Among universal design planning features, removal of threshold and installation of safety device in bathroom are not well considered. Among environmental planning features, usage of alternative energy like solar energy are not applied. The environment-friendly planning features in interior space should be introduced in diverse ways.

• Korea journal of population studies
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• v.35 no.1
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• pp.77-99
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• 2012

This study aimed at developing a model for estimating fertility rates for Korea under some conditions. The model is expected to provide the basic information for establishing and evaluating the polices in prompt and adequate response to low fertility and population ageing. The model was established on the basis of experiences by some OECD countries in Europe, having experienced the fertility increase trend and being economically well-developed, because Korea has never experienced the steady increase in fertility rate since 1960. This study collected about 20 years' time series data for each of selected countries and applied to the regression model, which is called a 'panel analysis' to take into considerations both cross-sectional and longitudinal aspects of fertility change simultaneously. Simulation of the model for Korea and some panel countries showed a very small difference, less than 0.1, between the estimated rate and the observed rate for each year during 2006~2010. Thus, the model, as established in this study, is evaluated as accurate or well-fitted to a considerable extent.

• Transactions of the Korean Society of Automotive Engineers
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• v.20 no.4
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• pp.46-51
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• 2012

Injection pressure, an important factor in filling process, should be minimized to enhance injection molding quality. Injection pressure can be controlled by valve gate open timing. In this work, we decided the valve gate open timing to minimize the injection pressure. To solve this design problem, we integrated MAPS-3D (Mold Analysis and Plastic Solution-3Dimension), a commercial injection molding CAE tool, to PIAnO (Process Integration, Automation and Optimization), a commercial PIDO (Process Integration, and Design Optimization) tool using the file parsing method. In order to reduce computational cost, we performed an approximate optimization using meta-models that replaced expensive computer simulations. At first, we carried out DOE (Design of Experiments) using OLHD (Optimal Latin Hypercube Design) available in PIAnO. Then, we built Kriging models using the simulation results at the sampling points. Finally, we used micro GA (Genetic Algorithm) available in PIAnO. Using the proposed design approach, the injection pressure has been reduced by 13.7% compared to the initial one. This design result clearly shows the validity of the proposed design approach.

• Smart Structures and Systems
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• v.30 no.3
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• pp.327-332
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• 2022

In building envelope, transparent components play an important role. The structural glazing systems are the weak element of the casing in terms of mechanical resistance, thermal and acoustic insulation. In the present work, new structural glass panels with granular aerogel in interspace were investigated from different points of view. In particular, the mechanical characterization was carried out in order to assess the resistance to bending of the single glazing pane. To this end, a special instrument system was built to define an alternative configuration of the coaxial double ring test, able to predict the fracture strength of glass large samples (400 × 400 mm) without overpressure. The thermal and lighting performance of an innovative double-glazing façade with granular aerogel was evaluated. An experimental campaign at pilot scale was developed: it is composed of two boxes of about 1.60 × 2 m² and 2 m high together with an external weather station. The rooms, identical in terms of size, construction materials, and orientation, are equipped with a two-wing window in the south wall surface: the first one has a standard glazing solution (double glazing with air in interspace), the second room is equipped with the innovative double-glazing system with aerogel. The indoor mean air temperature and the surface temperature of the glass panes were monitored together with the illuminance data for the lighting characterization. Finally, a brief energy characterization of the performance of the material was carried out by means of dynamic simulation models when the proposed solution is applied to real case studies.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.19 no.2
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• pp.13-22
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• 2005

This research aimed to generate two points of daylighting application as follows: 1) providing daylight performance data with a variety of glazing materials for a large window and 2) designing and evaluating an experimental type of differentiated window. For this purpose, we compared the daylight and distribution performance of new defined type of window configuration to the conventional window counterpart with a variety of glazing materials. The comparison was made for a deep, south-facing perimeter zone with large window, without any interior obstruction. The conventional window is the base single homogeneous glass pane, where as the differentiated window uses of two different glazings; an upper daylight glazing with high visible transmission and lower view window with lower transmittal glass. The daylight performance data was translated into a ratio between outdoor illuminance and the interiors. The simulated analysis of the conventional window indicates that the interior light levels have been changed proportionally dependent on the transmittance of the applied glass. The comparison of daylight distribution analysis showed that the differentiated window has lots of photometric advantage by the optical function of upper daylight window. In particular, the contribution of higher daylight window into deep rear space must be stressed for daylighting application.