• Health Policy and Management
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• v.29 no.1
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• pp.4-10
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• 2019

The term new tobacco products (NTPs) refers to the new alternatives to conventional cigarettes. There are several kinds of NTPs in South Korea. The present study discusses the most widely used NTPs namely electronic cigarette (ECs) and heated tobacco products (HTPs). The aims of this study are to evaluate the risk related to the use of ECs and HTPs, introduce policy examples across different countries of management of this issue, and finally, present some policy implications of the problem and our response strategies. Since the advent of ECs, there has been a lot of debate about its risk. Some studies have reported that ECs are less harmful than conventional cigarettes and that they are effective in aiding smoking cessation. Nevertheless, the efficacy of ECs in smoking cessation and its potential health risks are still unclear. However, the obvious fact is that it is not harmless. Regulations on ECs differ from country to country. In many countries, they are strictly regulated as tobacco or toxic substances; however, in the United Kingdom, the use of ECs are included as part of their smoking cessation policy, and in Japan, they are treated as a form of medication. On the other hand, HTPs are the most recently introduced NTPs and they have attained sensational popularity because of the wrongly held belief that they are less harmful to health. So, what about our policy response to these two tobacco products? The research on ECs requires more systematic statistical monitoring, such as monitoring the ratio of dual-users. Further, the new EC smokers should be identified taking into account that the arguments for the use of ECs often emphasize smoking cessation or less risks to health, the government should further strengthen its policy to prevent those claims. The HTPs market experienced a very sharp growth and continues to grow because the government policy is too passive. Taking this as a lesson, it is necessary to approach NTPs, such as HTPs, proactively and increase their contribution to the National Health Promotion Fund by imposing greater taxes on them. Finally, considering the likelihood of NTPs being promoted as a less harmful tobacco product, it is essential to strictly regulate tobacco companies' publicity from the very beginning to ensure that potential consumer s are not mislead.

• Journal of Digital Convergence
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• v.17 no.1
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• pp.337-345
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• 2019

In this study, it focused on observational documentary based on observation. This study comparatively analyzed how differently the narrative style is implemented depending on the social and cultural background of East and West by analyzing the narrative style of Frederick Wiseman, a representative director of observational documentary who has been active in foreign countries for a long time, and Lee Seung-jun, recently become active in Korea. As a result of the analysis, It might be too early to judge by simple comparison of two directors, but it became an opportunity to see the difference between the long-standing observer style and the observer style documentary which actively accepts the new form. While it cannot be simply judged which style is better between the traditional observer style which shapes the simple contents into conflicts in the sequence structure and the recent style which sublimates the human inner conflict into the drama, a side could have been seen that the diversity is attained. It can be judged that the traditional documentary film can be gradually changed later. It was found that the documentary can emerge from the logic that it is difficult and boring, and that the same theme can be various and creative depending on what style is chosen.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.21 no.1
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• pp.141-148
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• 2021

In some intersections or busy traffic roads, there are more pedestrians in a specific period of time, and there are many traffic accidents caused by road congestion. Especially at the intersection where there are schools nearby, it is particularly important to protect the traffic safety of students in busy hours. In the past, when designing traffic lights, the safety of pedestrians was seldom taken into account, and the identification of motor vehicles and traffic optimization were mostly studied. How to keep the road smooth as far as possible under the premise of ensuring the safety of pedestrians, especially students, will be the key research direction of this paper. This paper will focus on person, motorcycle, bicycle, car and bus recognition research. Through investigation and comparison, this paper proposes to use YOLO v4 network to identify the location and quantity of objects. YOLO v4 has the characteristics of strong ability of small target recognition, high precision and fast processing speed, and sets the data acquisition object to train and test the image set. Using the statistics of the accuracy rate, error rate and omission rate of the target in the video, the network trained in this paper can accurately and effectively identify persons, motorcycles, bicycles, cars and buses in the moving images.

• Journal of Microbiology and Biotechnology
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• v.32 no.8
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• pp.1017-1025
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• 2022

Bone homeostasis is regulated by constant remodeling through osteogenesis by osteoblasts and osteolysis by osteoclasts and osteoporosis can be provoked when this balance is broken. Present pharmaceutical treatments for osteoporosis have harmful side effects and thus, our goal was to develop therapeutics from intrisincally safe natural products. Fucoidan is a polysaccharide extracted from many species of brown seaweed, with valuable pharmaceutical activities. To intensify the effect of fucoidan on bone homeostasis, we hydrolyzed fucoidan using AMG, Pectinex and Viscozyme. Of these, fucoidan biotransformed by Pectinex (Fu/Pec) powerfully inhibited the induction of tartrate-resistant acid phosphatase (TRAP) activity in osteoclasts differentiated from bone marrow macrophages (BMMs) by the receptor for activation of nuclear factor-κB ligand (RANKL). To investigate potential of lower molecular weight fucoidan it was separated into >300 kDa, 50-300 kDa, and <50 kDa Fu/Pec fractions by ultrafiltration system. The effects of these fractions on TRAP and alkaline phosphatase (ALP) activities were then examined in differentiated osteoclasts and MC3T3-E1 osteoblasts, respectively. Interestingly, 50-300 kDa Fu/Pec suppressed RANKL-induced osteoclasts differentiation from BMMs but did not synergistically enhance osteoblasts differentiation induced by osteogenic agents. In addition, this fraction inhibited the expressions of NFATc1, TRAP, OSCAR, and RANK, which are all key transcriptional factors involved in osteoclast differentiation, and those of Src, c-Fos and Mitf, as determined by RT-PCR. In conclusion, enzymatically low-molecularized 50-300 kDa Fu/Pec suppressed TRAP by downregulating RANKL-related signaling, contributing to the inhibition of osteoclasts differentiation, and represented a potential means of inducing bone remodeling in the background of osteoporosis.

• Korean journal of aerospace and environmental medicine
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• v.31 no.1
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• pp.24-30
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• 2021

Purpose: The purpose of this study is to consider ways to strengthen it through comparison and curriculum while recognizing the importance of global competencies in liberal arts education in universities. Methods: In order to explore ways to reinforce the sub-competence of global competencies, this study was conducted at a four-year university in Chungcheong-do for one year in 2019, such as 'Global Culture Talk', 'Global Travel', 'Global Nanta', and 'Making Global Friends'. Cases of comparison and application of educational programs were analyzed. The program was attended by the Department of Business Administration, Department of Aviation Service, Department of Design, Department of Manga Animation, Department of Broadcasting and Film, and foreign exchange students. The competency-centered curriculum not only has clear educational goals, but is also very advantageous in establishing a feedback system by measuring its performance. This study will assess the effectiveness of the education plan by diagnosing the change in competencies before and after the comparison and curriculum is operated. Results: The overall global competency has increased by 0.2 points compared to 2017. By subsector, it was found that the flexibility increased by 1.4 points. In the field of cross-cultural understanding, it rose 0.6 points, and in the field of global understanding, it rose 2.2 points, showing the largest increase in the sub-fields. Nevertheless, the field of global interest remains at a low level. This is considerably low compared to flexibility and ability to understand other cultures, and it is expected that measures for improvement should be continuously sought. Since the understanding of other cultures has already exceeded 60 points, it is expected that the global competency of the university will be strengthened if the level is consistently maintained and the emphasis is placed on enhancing flexibility and improving global understanding. Conclusion: The importance of strengthening global capabilities is steadily rising. Universities are also reorganizing the curriculum by analyzing the needs and satisfaction of education consumers to respond to this. The programs operated and analyzed in this study were also made as part of this effort. However, since there are various factors that affect global competency, it cannot be but admitted that it is not easy to gauge the change in competency with only a few programs and short-term efforts. However, if the efforts pursued by this study are accumulated and supplemented through feedback from a long-term perspective, it can be expected that there are not a lot of contributions to strengthening global competencies in liberal arts education.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.33 no.5
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• pp.167-173
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• 2023

Li₃V₂(PO₄)₃ and Li₃V₂(PO₄)₃/C composite with single phase monoclinic structure for the cathode materials are successfully synthesized by direct co-precipitation method using N₂H₄·H₂O as the reducing agent and alginic acid as the carbon source, and their electrochemical properties were compared. The particles with approximately 1~2 ㎛ size and the uniform spherical-like morphology of the narrow particle size distribution were obtained. In addition, the residual carbon can also improve the electrical conductivity. The Li₃V₂(PO₄)₃/C composite has improved initial specific discharge capacity and excellent cycle characteristics to maintain capacity stably than Li₃V₂(PO₄)₃. The results indicate that the reducing agent and carbon composite can affect the good crystallinity and electrochemical performance of the cathode materials.

• Geophysics and Geophysical Exploration
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• v.13 no.1
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• pp.51-60
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• 2010

To determine subglacial topography and internal features of the Fourcade Glacier on King George Island in Antarctica, helicopter-borne and ground-towed ground-penetrating radar (GPR) data were recorded along four profiles in November 2006. Signature deconvolution, f-k migration velocity analysis, and finite-difference depth migration applied to the mixed-phase, single-channel, ground-towed data, were effective in increasing vertical resolution, obtaining the velocity function, and yielding clear depth images, respectively. For the helicopter-borne GPR, migration velocities were obtained as root-mean-squared velocities in a two-layer model of air and ice. The radar sections show rugged subglacial topography, englacial sliding surfaces, and localised scattering noise. The maximum depth to the basement is over 79m in the subglacial valley adjacent to the south-eastern slope of the divide ridge between Fourcade and Moczydlowski Glaciers. In the ground-towed profile, we interpret a complicated conduit above possible basal water and other isolated cavities, which are a few metres wide. Near the terminus, the GPR profiles image sliding surfaces, fractures, and faults that will contribute to the tidewater calving mechanism forming icebergs in Potter Cove.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.16
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• pp.6813-6823
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• 2015

Glioblastoma, also known as glioblastoma multiforme (GBM), is the most aggressive of human brain tumors and has a stunning progression with a mean survival of one year from the date of diagnosis. High cell proliferation, angiogenesis and/or necrosis are histopathological features of this cancer, which has no efficient curative therapy. This aggressiveness is associated with particular heterogeneity of the tumor featuring multiple genetic and epigenetic alterations, but also with implications of aberrant signaling driven by growth factors. The transforming growth factor ${\beta}$ ($TGF{\beta}$) superfamily is a large group of structurally related proteins including $TGF{\beta}$ subfamily members Nodal, Activin, Lefty, bone morphogenetic proteins (BMPs) and growth and differentiation factor (GDF). It is involved in important biological functions including morphogenesis, embryonic development, adult stem cell differentiation, immune regulation, wound healing and inflammation. This superfamily is also considered to impact on cancer biology including that of GBM, with various effects depending on the member. The $TGF{\beta}$ subfamily, in particular, is overexpressed in some GBM types which exhibit aggressive phenotypes. This subfamily impairs anti-cancer immune responses in several ways, including immune cells inhibition and major histocompatibility (MHC) class I and II abolishment. It promotes GBM angiogenesis by inducing angiogenic factors such as vascular endothelial growth factor (VEGF), plasminogen activator inhibitor (PAI-I) and insulinlike growth factor-binding protein 7 (IGFBP7), contributes to GBM progression by inducing metalloproteinases (MMPs), "pro-neoplastic" integrins (${\alpha}v{\beta}3$, ${\alpha}5{\beta}1$) and GBM initiating cells (GICs) as well as inducing a GBM mesenchymal phenotype. Equally, Nodal promotes GICs, induces cancer metabolic switch and supports GBM cell proliferation, but is negatively regulated by Lefty. Activin promotes GBM cell proliferation while GDF yields immune-escape function. On the other hand, BMPs target GICS and induce differentiation and sensitivity to chemotherapy. This multifaceted involvement of this superfamily in GBM necessitates different strategies in anti-cancer therapy. While suppressing the $TGF{\beta}$ subfamily yields advantageous results, enhancing BMPs production is also beneficial.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.19
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• pp.8265-8270
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• 2014

Background: Smoking tobacco is considered as a leading cause of preventable death, mostly in developing countries like India. One of the primary goals of international tobacco control is to educate smokers about the risks associated with tobacco consumption. Tobacco warning labels (TWLs) on cigarette packages are one of the most common statutory means to communicate health risks of smoking to smokers, with the hope that once educated, they will be more likely to quit the habit. Materials and Methods: The present survey was conducted to assess the effectiveness of TWLs in communicating health risks of tobacco usage among 263 adult smokers working as bus drivers in Karnataka State Road Transport Corporation (KSRTC), Mangalore, India. Information was collected on demographic details, exposure and response to health warnings on tobacco products, intention to quit and nicotine dependency. Results: The majority (79.5%) of the respondents revealed negative intentions towards quitting smoking. Nearly half of the participants had a 'low' nicotine dependency (47.5%) and 98.1% of the respondents had often noticed warning labels on tobacco packages. These health warnings made 71.5% of the respondents think about quitting smoking. Respondents who noticed advertisement or pictures about dangers of smoking had better knowledge, with respect to lung cancer and impotence as a consequence of tobacco. A higher exposure to warning labels was significantly associated with lower nicotine dependency levels of smokers among the present study population. A significantly higher number of respondents who noticed advertisement or pictures about the dangers of smoking thought about the risks of smoking and were more inclined to think about quitting smoking. As exposure increased, an increase in the knowledge and response of participants was also observed. Conclusions: Exposure to tobacco warning labels helps to educate smokers about health risks of tobacco smoking. It may be possible to promote oral health among bus drivers by developing strategies to educate them about these risk factors.

• Journal of Families and Better Life
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• v.32 no.6
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• pp.125-138
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• 2014

The purpose of this study is to examine the effects a music group therapy program has on cognitive function and life satisfaction. We targeted the elderly who are receiving service at a daycare center. This study monitored seventeen elderly subjects who were available for language communication, walking, and defecation function even if the subject had a slight mind-body function disorder based on using the service of the daycare facilities. The subjects visited each of the welfare centers one week prior to the Korean classical music group therapy program. We conducted a pre-test of MMSE-K(Mini-Mental State Examination, Korean version) modified by Park and Gwon(1989). We also supplemented the MMSE developed by Folstein(1975) and LSI-A(Life Satisfaction Index) for the elderly developed by Neugarten, Havighurst and Tobin(1961). We conducted the Korean classical music group therapy program for 15 sessions at 50 minutes each for 1~2 times a week from July 9 to September 13, 2013 at the daycare center for OO senior welfare center. The welfare center belongs to the experimental group, excluding the OO general welfare center, which is the control group. Finally, we carried out the post-test of the MMSE-K and LSI-A in the same manner as the pre-test. We carried out the post-test on July 17, 2013, 4 days after concluding the Korean classical music group therapy program. A t-test was used in order to analyze the differences in cognitive function and life satisfaction according to each group. We used SPSS/WIN 18.0 program. This study has significance by proving that the use of Korean classical music is conducive in the improvement of cognitive function and life satisfaction of the elderly at the daycare facilities. Also, we presented the actual contents of the study to the clinical field.