• 대한의용생체공학회:의공학회지
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• 제22권3호
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• pp.269-273
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• 2001

Proper determination of pacing threshold is important for patient safety and pacemaker longevity. In general, cardiac muscle contractions caused by pacing pulses are verified by observing the morphology of surface ECG displayed on a monitor. In this study, a method of automatic pacing threshold determination based on morphological difference between intrinsic and paced ECGs was developed. First, characteristics of intrinsic ECG and paced ECG were analyzed in time and frequency domain and a proper discrimination parameter was extracted. Then, the automatic capture verification method based on the parameter was developed and applied to 23 pacemaker patients. The selected parameter was the area of ventricular depolarization wave during 80ms after pacing stimulus. It was found that the method was reliable and effective in identifying paced ECG and, thereby, determing a proper pacing threshold.

• 한국임상수의학회지
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• 제25권5호
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• pp.400-404
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• 2008

10살된 암컷 요오크셔테리어(체중 3 kg)가 심한 호흡곤란 청색증, 간헐성 발작 증상으로 진료가 의뢰되었다 신체검사 결과 지속성 맥박결손을 동반한 불규칙 서맥이 부정기적으로 관찰되었다. 심전도 검사에서 고도의 방실차단이, 방사선검사에서 중증 기관허탈이 진단되었다. 피부경유 심박조절 하에 자동확장 기관내 스텐트를 성공적으로 장착할 수 있었다.

• Journal of Chest Surgery
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• 제10권2호
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• pp.219-225
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• 1977

Pacemaker therapy has been established as a routine procedure in a variety of disturbances of :cardiac rhythm. Cardiac pacing has greatly reduced the mortality rate in patients suffering from bradyarrhythmias complicated by Stokes-Adams attacks. However, in spite of the simplicity of the treatment and reliability of the devices available today, patients and physicians alike are invovled in a multitde of pacemaker specific problems. Clinical experience with permanent transvenous pacing during a 3 year period is presented. A total of 20 pacemaker operations were performed in 13 patients. The complications in our 20 pacemaker operations were headed by skin ulceration of 3 generator pockets and early dislocation of 3 electrodes. In an additional 2 patient, stimulation of diaphragm due to a position of electrode in the coronary sinus was noticed in one and battery failure of pulse generator was detected in the other. Literatures were reviewed.

• Journal of Chest Surgery
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• 제16권2호
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• pp.190-198
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• 1983

The management of cardiac arrhythmias by cardiac pacing has increased greatly since the treatment of complete heart block with an external transcutaneous pacemaker in 1952, followed by the use of myocardial wires connected to an external pulse generation, by external transvenous pacing, and then by transvenous pacing with implantable components in thoracic wall.By now, the three bases of modern cardiac pacing for bradyarrhythmias had been established [1] an implantable device [2] the transvenous approach [3] the ability of the pacemaker to sense cardiac activity and modify its own function accordingly. In transvenous implantation of a pacemaker, any one of four vessels at the root of the neck is suitable for passage of the electrode - cephalic vein, external jugular vein, internal jugular vein, costo-axillary branch of the axillary vein. The new technique of direct puncture of the subclavian vein, either percutaneously or after skin incision only has been made, is invaluable & is used routinely. We have experienced one 25 years old patient who had rheumatic mitral stenosis & minimum aortic regurgitation with sinus bradycardia associated with premature atrial tachycardia & another 54 years old female patient who was suffered from sick sinus syndrome with sinus bradycardia & sinus arrest. The 1st patient was taken open mitral commissurotomy & aortic valvuloplasty and then was taken atrlal pace-maker implantation through If subclavian puncture method in post-op 14 days, and the second patient was taken atrial pacemaker implantation through If subclavian puncture method. Their postop course was in uneventful & were discharged, without complication. Their condition have been good to now.

• 한국임상수의학회지
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• 제24권3호
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• pp.414-418
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• 2007

2.8살 된 암컷 비글종 개 (체중 11kg)가 운동 불내성과 간헐적인 실신증상을 보여 내원하였다. 청진상 불규칙하게 불규칙한 심장박동과 지속적인 맥박결손이 청진되었다. 심전도상에 3도 방실차단 소견이 관찰되었다. 환자는 임상증상 개선을 위하여 경정맥을 통한 영구적인 박동조절기(pacemaker)를 장착하였다. 그 결과 환자는 더 이상 실신증상을 보이지 않았고 주인과 함께 산책을 나갈 수 있을 만큼 임상증상이 개선되었다. 현재까지 박동조절기 장착과 관련된 합병증 없이 잘 생존하고 있다.

• Journal of Chest Surgery
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• 제17권3호
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• pp.356-361
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• 1984

During the period from January 1982 to June 1984 we implanted permanent pacemakers in 18 patients who received open heart surgery at Yonsei University Hospital. 1.In 11 patients, open heart surgery was performed at Yonsei University Hospital and new surgical induced heart blocks were developed and implantations of permanent pacemaker were done. 2.Total 1035 open heart surgeries were done and implantations of pacemaker were performed in 11 cases. [1.06%]. After total correction of TOF [215 cases] implantations of pacemaker were done in 3 cases. [1.4%] Implantations of pacemaker were 0.37% after VSD repair, 0.78% after ASD repair, 5.9% after ECD repair, 0.48% after MVR and 2.0% after AVR. 3.Causes were complete A-V block, sick sinus syndrome and A-V dissociation. 4.Heart blocks were developed immediately after bypass stop in 8 patients. 5.Implantations of pacemaker were done at more than 2 weeks after open heart surgery. 6.Local anesthesia was done in adult and general anesthesia in infants. Locations of pulse generator were subxiphoid, subcostal & subclavian. Position of pulse generator was between subcutaneous fat layer and muscle layer. 7.Types of pulse generator were VVI, VDD and AAI. 8.The postoperative complications included infection, pacing failure, sensing failure and lead dislodgment.

• 한국임상수의학회지
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• 제27권5호
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• pp.569-572
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• 2010

간헐적인 기절과 운동 불내성의 주요증상을 호소하는 4살 령의 중성화된 암컷 페키니즈 개 (체중 3.6 kg)가 내원하였다. 신체검사상 지속적인 맥박 결손을 가진 아주 불규칙한 심박동(irregularly irregular heart rhythm)이 나타났다. 12 유도 표면 심전도에서는 동방결절 기능 부전군을 의미하는 간헐적인 방실 접합부 이탈박동과 함께 특이적인 동정지가 나타났다. 본 환자에 대한 심장 박동수 반응형의 양극성 심장 박동조절기(VVIR type)를 이용한 영구적 경정맥형 심박 조율시술은 우심실 내에서 실시되었다. 심장 박동기 장착 이후, 환자의 임상증상은 눈에 띠게 호전되었다. 시술이후 아직까지 기절의 증상은 더 이상 나타나지 않고 있다.

• The Korean Journal of Physiology and Pharmacology
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• 제10권3호
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• pp.149-154
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• 2006

Selective inhibition of phosphodiesterase (PDE) 5 opened a new therapeutic approach for cardiovascular disorders. Therefore, the effect of PDE5 inhibition on the cardiac function should thoroughly be defined. The purpose of the present study was to define the effects of sildenafil, a selective inhibitor of PDE5, on the atrial cGMP efflux, atrial dynamics, and the release of atrial natriuretic peptide (ANP). By perfusing rabbit left atria to allow atrial pacing, changes in atrial stroke volume and pulse pressure, transmural extracellular fluid translocation, cGMP efflux, and ANP secretion were measured. SIN-I, an NO donor and soluble (s) guanylyl cyclase (GC) activator, and C-type natriuretic peptide (CNP), an activator of particulate (p) GC activator, were used. Sildenafil increased basal levels of cGMP efflux slightly but not significantly. Sildenafil in a therapeutic dose increased atrial dynamics (for atrial stroke volume, $2.84{\pm}1.71%$, n=12, vs $-0.71{\pm}0.86%$, n=21; p<0.05) and decreased ANP release ($-9.02{\pm}3.36%$, n=14, vs $1.35{\pm}3.25%$, n=23; p < 0.05), however, it had no effect on the SIN-1- or CNP-induced increase of cGMP levels. Furthermore, sildenafil in a therapeutic dose accentuated SIN-1-induced, but not CNP-induced, decrease of atrial pulse pressure and ANP release. These data indicate that PDE5 inhibition with sildenafil has a minor effect on cGMP levels, but has a distinct effect on pGC-cGMP- and sGC-cGMP-induced contractile and secretory function.