• Title/Summary/Keyword: PVP-PVA

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Decrease in the Particle Size of Paclitaxel by Increased Surface Area Fractional Precipitation Process Using Hydrophilic Polymer (표면적이 증가된 분별침전에서 친수성 고분자물질을 이용한 paclitaxel의 입자 크기 감소)

  • Lim, Yong Kyu;Kim, Jin-Hyun
    • Microbiology and Biotechnology Letters
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    • v.43 no.4
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    • pp.343-349
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    • 2015
  • In this study, we applied an increased surface area fractional precipitation with hydrophilic polymer for decreasing the particle size of the anticancer agent paclitaxel from plant cell cultures. The addition of polymer resulted in a considerable decrease in the size of the paclitaxel precipitate. Among the polymers (HPMC 2910, PVP-K90, PVA) used, PVP-K90 was the most effective for the inhibition of precipitate growth. When PVP-K90 (0.2%, w/v) was used, the paclitaxel particles were four to five times smaller, having less than a $20{\mu}m$ radius, than those obtained in the absence of the polymer. In addition, the precipitate size was inversely correlated with the absolute value of zeta potential.

Poly(ε-caprolactone) Microcapsule with Encapsulated Nifedipine Prepared by Magnetic Stirrer

  • Lee, Hyeran;Lee, Deuk Yong;Song, Yo-Seung;Kim, Bae-Yeon
    • Journal of Biomedical Engineering Research
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    • v.40 no.1
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    • pp.7-14
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    • 2019
  • The microencapsulation of nifedipine (NF) with 4 wt% of poly(${\varepsilon}-caprolactone$) (PCL)/polyvinylpyrollidone (PVP) or PCL/polyethylene glycol (PEG) was carried out by solvent evaporation method in oil in water emulsion system to investigate the effect of PVP and PEG addition on drug release behavior of the microcapsules. The PVA (emulsifier) concentration of 1.0 wt% was chosen for the formation of PCL capsule having an average size of $154{\pm}25{\mu}m$ due to nearly spherical shape with a narrow size distribution. As PCL/PVP and PCL/PEG ratios were raised from 10/0 to 6/4, the capsule size increased gradually from $154{\pm}25{\mu}m$ to $236{\pm}32{\mu}m$ and $248{\pm}56{\mu}m$, respectively. The drug release rate of PCL/PVP and PCL/PEG capsules increased dramatically from 0 to 4 h at the beginning and then reached the plateau region from 20 h. As the concentration of PVP or PEG increased, the amount of drug release increased, suggesting that the larger capsule size was attributed to the higher drug content. However, the drug release behavior remained almost constant. The PCL capsules exhibited no evidence of causing cell lysis or toxicity regardless of NF loading, implying that the microcapsules are clinically suitable for use as drug delivery systems.

Study on Facilitated Olefin Transport Phenomena of Poly(vinyl alcohol)/AgCF3SO3/Al(NO3)3 Electrolyte (Poly(vinyl alcohol)/AgCF3SO3/Al(NO3)3 전해질의 올레핀 촉진수송 현상 연구)

  • Park, Young Sung;Kang, Sang Wook
    • Membrane Journal
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    • v.26 no.1
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    • pp.32-37
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    • 2016
  • The poly(vinyl alcohol) $(PVA)/AgCF_3SO_3/Al(NO_3)_3$ electrolyte membrane was fabricated to prepare for highly permeable facilitated olefin transport membrane, compared with poly(vinylpyrrolidone) $(PVP)/AgCF_3SO_3/Al(NO_3)_3$ complex. In order to examine the characteristics of $PVA/AgCF_3SO_3/Al(NO_3)_3$ membrane, we used the analytical methods such as SEM, FT-IR, and FT-Raman. The best separation performance was observed at the mole ratio of 1 : 1 : 0.01 $PVA/AgCF_3SO_3/Al(NO_3)_3$ among various $Al(NO_3)_3$ concentration. As a result, the selectivity was 12 and mixed-gas permeability was 3.5 Barrer. Furthermore, the selectivity and permeability remained constant for up to 115 h.

Preparation of melamine-formaldehyde microcapsule by surfactants (안정화제에 따른 멜라민-포름알데히드 마이크로캡슐의 제조)

  • Oh, Seong-Dae;Choi, Seong-Ho;Lee, Se-Hee;Lee, Kwang-Pill;Kim, Sang-Ho
    • Analytical Science and Technology
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    • v.18 no.2
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    • pp.97-103
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    • 2005
  • The various size and morphology microcapsules were prepared to produce smell sweet by heating condensation reaction of melamine and formaldehyde using 5-types of surfactants such as the laurylbenzenesulfonic acid sodium salt (SDS), polyvinylpyrrolidon (PVP), polyvinyl alcohol (PVA), Span-80 and 2-acrylamido-2-methyl-1-1 propanesulfonic acid (AMP). As result it was found that the size and morphology of microcapsule is intimately associated with a kind of surfactants. In order to prepare microcapsule with antibacterial, the silver nanoparticle was prepared by gamma-irradiation. microcapsule with silver nanoparticle was prepared.

Preparation of Nitrifier Immobilized PVA(Polyvinyl Alcohol) Bead and Removal of Ammonia Nitrogen (질화세균군이 고정화된 PVP(Polyvinyl Alcohol) bead 제조 및 암모니아성 질소 제거)

  • 서근학;조진구
    • Journal of Environmental Science International
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    • v.10 no.3
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    • pp.233-237
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    • 2001
  • Immobilized nitrifier bead in airlift bioreactor were used to remove high levels of ammonia nitrogen from synthetic wastewater. Polyvinylalcohol(PVA) bead for immmobilization of nitrifier consortium were prepared by PVA-boric acid method by varying concentration of PVA and nitrifier consortium. By determining viscosity, sphercity and tailing, the characteristics of prepared beads were investigated and the continous immobilization process was developed. Synthetic wastewater containg 25g/$\textrm{m}^3$ of ammonia nitrogen could be treated within 0.5 hour and the highest removal rate of ammonia nitrogen was 934.2g/$\textrm{m}^3{\cdot}$ day.

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Selection and Technical Development for Seed Pelleting Material of Codonopsis lanceolata Trautv (더덕 종자의 펠렛팅을 위한 소재 탐색 및 기술개발)

  • Choi, Kyeong-Gu;Lee, Youn-Su;Cha, Kwang-Ho
    • Korean Journal of Medicinal Crop Science
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    • v.14 no.3
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    • pp.130-133
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    • 2006
  • This study was conducted to select Codonopsis lanceolata seed's new pelleting particulate materials and adhesives. Different adhesives (Polyvinyl alcohol (PVA), Carboxymethyl cellulose (CMC), Polyvinyl pyrrolidone (PVP), Xanthan gum (XG), Arabic gum (AG)) and particulate materials (Illite, Diatomite, Pyrophyllite + Illite + Diatomite (PID), Pyrophyllite + Illite + Talc (PIT), Bentonite + Talc (BT)) were tested for seed pelleting. PID for Codonopsis lanceolata seed pelleting appeared to be the best particulate material. Among the pelleting adhesives, PVP was the best adhesive for seed pelleting, and the optimum concentration for germination of pelleting seed was 1 %. Germination rate of the pelleted seeds treated with PID particulate material and PVP adhesive was higher (86.8%) than those of raw seeds (85.5%). $T_{50}$ and MDG of pelleted Codonopsis lanceolata seed required five and eight days at soil moisture content of 50%, respectively.

A Study on the Controlled Release of Naproxen from Hydrophilic Polymer Matrix (친수성고분자 매트릭스의 Naproxen 제어방출에 관한 연구)

  • 김종국;조은실
    • YAKHAK HOEJI
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    • v.31 no.1
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    • pp.25-32
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    • 1987
  • The effect of loading dose, plasticiser and PVA molecular weight on naproxen release from hydrophilic polymer matrix was examined. Hydrophilic polymer matrix was prepared with PVA and PVP by adding glycerine as plasticiser. The release of naproxen from polymer matrix was determined in phosphate buffer medium. The release rate of naproxen from the polymer matrix increased as drug loading dose and plasticiser percentage increased. Raproxen released from the polymer matrix showed the time square root kinetics. Without changing the release-pattern, the release rate of naproxen could not be changed by varying molecular weight of PVA. Linearly released time range increased as drug loading dose increased, whereas decreased as plasticiser percentage increased up to 30%.

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Study on OTFT-Backplane for Electrophoretic Display Panel (전기영동 디스플레이 패널용 OTFT-하판 제작 연구)

  • Lee, Myung-Won;Ryu, Gi-Sung;Song, Chung-Kun
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.45 no.7
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    • pp.1-8
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    • 2008
  • We fabricated flexible electrophoretic display(EPD) driven by organic thin film transistors(OTFTs) on plastic substrate. We designed the W/L of OTFT to be 15, considering EPD's transient characteristics. The OTFTs employed bottom contact structure and used Al for gate electrode, the cross-linked polyvinylphenol for gate insulator, pentacene for active layer. The plastic substrate was coated by PVP barrier layer in order to remove the islands which were formed after pre-shrinkage process and caused the electrical short between bottom scan and top data metal lines. Pentacene active layer was confined within the gate electrodes so that the off current was controlled and reduced by gate electrodes. Especially, PVA/Acryl double layers were inserted between EPD panel and OTFT-backplane in order to protect OTFT-backplane from the damages created by lamination process of EPD panel on the backplane and also accommodate pixel electrodes through via holes. From the OTFT-backplane the mobility was $0.21cm^2/V.s$, Ion/Ioff current ratio $10^5$. The OTFT-EPD panel worked successfully and demonstrated to display some patterns.