• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.306.1-306.1
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• 2002

Cefodizime has originally been developed for treating infections as antibiotics. However. according to some of recent studies. cefodizime. a third generation cephalosporin. may potentially have the capability of stimulating chemotactic activity of neutrophils and monocytes as well as the strong immuno-modulator. In this study. we studied to learn about the expressive effect of dentritic cells and macrophage. With this background. We have studied to see if cefodizime can be a potential substance inducing an immunological function in dendritic cells and peritoneal macrophages. IL-12 activates NK cell and macrophage, and shows antiviral effect by excreting INF-${\gamma}$. In vitro. total RNAs were extracted from murine dentritic cell at 4, 8, 12, 24hr after the application of 10, 50, 100${\gamma}g$/ml of cefodizime wighout other stimulators. And we analyzed IL-12 mRNA using RT-PCR method. In conclusion. IL-12 mRNA was increased. and the results suggest that cefodizime activate TH1 cell induction, CTL differentiation as well as accelerating the increase of NK. LAK cell.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.272.1-272.1
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• 2002

We have carried out collaborative study to evaluate a preparation of antithrombin concentrate whether or not it was suitable to serve as the candidate for a Korea National Biological Standard. Six laboratories. including three manufacturers and three National Control Laboratories. participated in this study. The potency of this candidate preparation was determined using the heparin cofactor chromogenic method. (omitted)

• International Journal of Computer Science & Network Security
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• 제24권3호
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• pp.182-188
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• 2024

Hardware components are an integral part of Hardware Define Radio (HDR) for seamless operations and optimal performance. On the other hand, Software Define Radio (SDR) is a program that does not rely on any hardware components for its performance. Both of the latter radio programmers utilize modulation functions to make their core components from signal processing viewpoint. The following paper concentrates on SDR based modulation and their performance under different modulations. The bit error rate (BER) of modulations such as PSK, QAM, and PSAM were used as indicators to test channel quality estimation in planar Rayleigh fading. Though it is not commonly used for channel fading, the method of the adder determines the regionally segmented channel fading. Thus, the estimation error of the channel change substantially reduces the performance of the signal, hence, proving to be an effective option. Moreover, this paper also elaborates that BER is calculated as a function of the sample size (signal length) with an average of 20 decibels. Consequently, the size of the results for different modulation schemes has been explored. The analytical results through derivations have been verified through computer simulation. The results focused on parameters of amplitude estimation error for 1dB reduction in the average signal-to-noise ratio, while the combined amplitude deviation estimation error results are obtained for a 3.5 dB reduction

• 한국음향학회지
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• 제27권7호
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• pp.342-349
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• 2008

수중통신 시 다중 음파 경로의 생성은 명확한 메시지전송을 어렵게하는 원인중 하나이다. 본 논문에서는 이러한 문제점의 해결을 위하여 각기 다른 경로에 따라 형성된 다중 경로간의 지연 시간을 계산하여 변조주파수변환구간을 생성하는 방법을 제안하였다. 송신단에서는 생성된 변조주파수변환구간의 크기에 따라 메시지를 분할하여 두 개의 주파수를 사용하여 QPSK(Quadrature Phase Shift Keying)방식을 교대로 호핑하여 메시지를 전송 하였다. 이에 대응하여 수신단에서는 수신된 메시지를 알고리즘 설계 시 구축한 프로토콜에 의하여 복조하여 원신호로 복원하는 적응 BISMO 알고리즘을 제안 하였고 모의실험을 통하여 적응적 변조주파수변환구간, 추정 오류율을 계산하였다.

• 약학회지
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• 제59권3호
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• pp.98-106
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• 2015

Analytical method for related substances can be categorized into two methods depending on the necessity of reference standard (RS). The analytical method of related substances with RS is fast and accurate, but it's very expensive and technically difficult to synthesize RS due to their complicated structure. Another method is using relative retention time (RRT) and relative response factor (RRF) which are already validated with RS. Validation of this method is not easy and time consuming, but once it has been developed, it can save cost and time. In this study, we developed the analytical method for related substances of fenofibrate using RRT and RRF. We validated the method by evaluating specificity, linearity, accuracy and precision according to the "Manual for Guideline Application for Validation of Analytical Procedures" of MFDS. Also, we calculated RRT and RRF between fenofibrate and fenofibrate related substances. The results of this study showed high specificity for fenofibrate and fenofibrate related substances. Correlation coefficient(r) of all substances were more than 0.99, and the recovery of fenofibrate, fenofibrate related substance I, II and III were 99.44%, 100.84%, 99.14% and 101.58%, respectively. Precision of fenofibrate and its related substances were ranged between RSD 0.29% and 0.93%. Quantification limits of fenofibrate, fenofibrate related substance I, II and III were determined to be $0.03{\mu}g/ml$, $0.05{\mu}g/ml$, $0.04{\mu}g/ml$ and $0.02{\mu}g/ml$, respectively by confirming signal to noise ratio of each chromatogram. The RRT for fenofibrate related substance I, II and III were determined to be 0.35, 0.41 and 1.34, respectively. Also, the RRF for fenofibrate related substance I, II and III were determined to be 1.28, 0.98 and 0.79, respectively. The developed method was applied to determine contents for fenofibrate related substances in commercial fenofibrate (active pharmaceutical ingredient). As a result, developed analytical methods of related substances will be used for revising the monograph of fenofibrate in Korean Pharmacopoeia revision and contribute quality control of drugs by improving cost and time consuming problem of RS.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.300.2-301
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• 2002

HCV is transmitted via various plasma-derived medicinal products. The transmission of HCV could. however, be prevented by screening plasma pools with NAT and validating HCV viral clearance during the manufacturing of plasma derivatives, Although various screening methods including commercial kits are available. it is yet to develop an analytical method to detect HCV in both plasma and plasma derivatives. The objective of this study was to develop a reliable in house method for reliable for the HCV RNA detection from plasma and plasma derivatives. (omitted)

• 약학회지
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• 제60권3호
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• pp.112-117
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• 2016

A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of caffeine in forensic aqueous sample. The centrifuged sample ($100{\mu}l$) was diluted 50-fold with distilled water. The diluted sample ($400{\mu}l$) was then diluted further with $200{\mu}l$ of 0.1% formic acid solution and $400{\mu}l$ of acetonitrile containing 500 ng of caffeine-(3-methyl-$^{13}C_3$) prior to LC-MS/MS analysis. The mobile phase was composed of 0.1% formic acid in distilled water (A) and acetonitrile (B). Chromatographic separation was performed by using a Zorbax SB-C18 ($100mm{\times}2.1mm$ i.d., $3.5{\mu}m$) column and caffeine was eluted within 1.1 min. Linear least-squares regression with a 1/x weighting factor was used to generate a calibration curve with the coefficients of determination ($r^2=0.9983$). The lower limit of quantification was $25ng/ml$ for the analyte. The process efficiency was 98.6~100.1%. Intra- and inter-day precisions were not more than 2.1% and 1.7%, while intra- and inter-day accuracies were ranged from -6.8 to 4.5%, respectively. The suitability of the method was examined by analyzing unknown forensic aqueous samples.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제15권8호
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• pp.2900-2922
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• 2021

In this paper, the power spectral density(PSD) for Multilevel Minimum Shift Keyed signal with modulation index h = 1/2 (M-ary MSK) are derived using the mathematical method of the Markov Chain model. At first, according to an essential requirement of the phase continuity characteristics of MSK signals, a complete model of the whole process of signal generation is built. Then, the derivations for autocorrelation functions are carried out precisely. After that, we verified the correctness and accuracy of the theoretical derivation by comparing the derived results with numerical simulations using MATLAB. We also divided the spectrum into four components according to the derivation. By analyzing these figures in the graphic, each component determines the characteristics of the spectrum. It is vital for enhanced spectral characteristics. To more visually represent the energy concentration of the main flap and the roll-down speed of the side flap, the specific out-of-band power of M-ary MSK is given. OMLCD(Optimum Maximum Likelihood Coherent Detection) of M-ary MSK is adopted to compare the signal received with prepared in advance in a code element T to go for the best. And M-ary MSK BER(Bit Error Rate) is compared with the same ary PSK (Phase Shift Keying) with M=2,4,6,8. The results show the detection method could improve performance by increasing the length of L(memory inherent) in the phase continuity.

• 약학회지
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• 제60권2호
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• pp.64-72
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• 2016

Jakyakgamcho-tang is a well-known traditional herbal medicine and has been used for the treatment of mainly pains in oriental medicine. In this study, analytical method for the quantitative determination of the eleven marker components, gallic acid (1), oxypaeoniflorin (2), paeoniflorin (3), albiflorin (4), liquiritin (5), isoliquiritin (6), ononin (7), liquiritigenin (8), benzoylpaeoniflorin (9), paeonol (10), and glycyrrhizin (11) in Jakyakgamcho-tang decoction was performed using an ultra-performance liquid chromatography-electrospray ionization-mass spectrometer. The analytical column for separation of the compounds 1~11 was used an UPLC BEH $C_{18}$ ($100{\times}2.1mm$, $1.7{\mu}m$) column and column oven temperature was maintained at $45^{\circ}C$. The mobile phase consisted of 0.1% (v/v) aqueous formic acid (A) and acetonitrile (B) by gradient elution. The flow rate was 0.3 ml/min and injection volume was $2.0{\mu}l$. Correlation coefficient in the calibration curves of the compounds 1~11 were showed a good linearity with more than 0.99. The limit of detection and limit of quantification values of the compounds 1~13 were detected in the ranges 0.06~18.43 ng/ml and 0.18~58.29 ng/ml, respectively. Among the compounds 1~11, the compounds 10 were not detected in this sample, while the ten compounds, 1~9 and 11, were detected $44.05{\sim}19,289.05{\mu}g/g$ in Jakyakgamcho-tang extract.

• 한국위성정보통신학회논문지
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• 제9권3호
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• pp.1-4
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• 2014

무선통신 시스템은 동일채널 또는 인접채널에서 동작하는 무선 송신기에 의해서 간섭을 받는다. 때문에 새로운 서비스를 도입할 경우에는 도입하는 시스템과 기존 시스템 상호 간에 미치는 간섭분석을 통해서 서로 공존할 수 있는 기술기준을 마련해야 한다. FTS(Flight Termination System)는 공공의 안전을 보장하고 발사체의 비정상적인 임무수행을 막기 위해서 사용된다. 최근에는 보안성을 높이고 여러 발사체나 비행체에서 동시에 운용할 수 있는 차세대 FTS에 대한 연구가 진행 중이며, EFTS(Enhanced FTS)는 이러한 목적에 적합하다. 본 논문에서는 간섭신호가 EFTS의 성능에 미치는 영향을 분석하였다. EFTS의 변조방식으로는 비동기 DPSK(Differential PSK)와 비동기 CPFSK(Continuous Phase FSK)를 고려하였고, 간섭원으로는 FMCW(Frequency Modulated Continuous Wave) 신호와 펄스레이더를 고려하였다. 간섭원의 전력은 FMCW의 경우 원신호보다 20.3dB가 작고, 펄스레이더의 경우에는 원신호보다 19.1dB가 작은 것으로 설정하고 간섭 영향을 시뮬레이션하였으며, 시뮬레이션 결과 FMCW 간섭의 경우 $E_b/N_o$가 1dB 정도 악화되었고, 펄스레이더 간섭 신호의 경우 $E_b/N_o$가 약 0.5dB 악화되었다.