• Journal of Ginseng Research
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• v.46 no.4
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• pp.515-525
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• 2022

Background: The incidence of ischemic cerebrovascular disease is increasing in recent years and has been one of the leading causes of neurological dysfunction and death. Ginsenoside Rg1 has been found to protect against neuronal damage in many neurodegenerative diseases. However, the effect and mechanism by which Rg1 protects against cerebral ischemia-reperfusion injury (CIRI) are not fully understood. Here, we report the neuroprotective effects of Rg1 treatment on CIRI and its possible mechanisms in mice. Methods: A bilateral common carotid artery ligation was used to establish a chronic CIRI model in mice. HT22 cells were treated with Rg1 after OGD/R to study its effect on [Ca²⁺]_i. The open-field test and poleclimbing experiment were used to detect behavioral injury. The laser speckle blood flowmeter was used to measure brain blood flow. The Nissl and H&E staining were used to examine the neuronal damage. The Western blotting was used to examine MAP2, PSD95, Tau, p-Tau, NOX2, PLC, p-PLC, CN, NFAT1, and NLRP1 expression. Calcium imaging was used to test the level of [Ca²⁺]_i. Results: Rg1 treatment significantly improved cerebral blood flow, locomotion, and limb coordination, reduced ROS production, increased MAP2 and PSD95 expression, and decreased p-Tau, NOX2, p-PLC, CN, NFAT1, and NLRP1 expression. Calcium imaging results showed that Rg1 could inhibit calcium overload and resist the imbalance of calcium homeostasis after OGD/R in HT22 cells. Conclusion: Rg1 plays a neuroprotective role in attenuating CIRI by inhibiting oxidative stress, calcium overload, and neuroinflammation.

• International Journal of Aeronautical and Space Sciences
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• v.16 no.2
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• pp.254-263
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• 2015

In this study, numerical simulations are carried out to investigate the dynamic SGS model effects in a Kerosene-LOx coaxial swirl injector under high pressure conditions. The turbulent model is based on large-eddy simulation (LES) with real-fluid transport and thermodynamics. To assess the effect of the dynamic subgrid-scale (SGS) model, the dynamic SGS model is compared with that of the algebraic SGS model. In a swirl injector under supercritical pressure, the characteristics of temporal pressure fluctuation and power spectral density (PSD) present comparable discrepancies dependant on the SGS models, which affect the mixing characteristics. Mixing efficiency and the probability density (PDF) function are conducted for a statistical description of the turbulent flow fields according to the SGS models. The back-scattering of turbulent kinetic energy is estimated in terms of the film thickness of the swirl injector.

• Ocean Systems Engineering
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• v.6 no.2
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• pp.203-216
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• 2016

Over recent years the offshore wind turbines are becoming more feasible solution to the energy problem, which is crucial for Egypt. In this article a three floating support structure, tension leg platform types (TLP), for 5-MW wind turbine have been considered. The dynamic behavior of a triangular, square, and pentagon TLP configurations under multi-directional regular and random waves have been investigated. The environmental loads have been considered according to the Egyptian Metrological Authority records in northern Red sea zone. The dynamic analysis were carried out using ANSYS-AQWA a finite element analysis software, FAST a wind turbine dynamic software, and MATLAB software. Investigation results give a better understanding of dynamical behavior and stability of the floating wind turbines. Results include time history, Power Spectrum densities (PSD's), and plan stability for all configurations.

• Proceedings of the KIEE Conference
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• 2001.07b
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• pp.1309-1311
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• 2001

본 논문은 Substrate의 온도를 $200(^{\circ}C)$로 유지하며 진공 저항 가열 증착법을 이용하여 ITO/Si 태양전지를 제작한 후 그 전기적 특성을 조사하였다. 전지의 단락전류와 개방전압의 열처리 온도의존성은 약 $450(^{\circ}C)$이상부터 증가하여 $650(^{\circ}C)$부근에서 최대치를 나타내었다. 단락전류와 열처리 시간과의 관계에서는 증착 시간이 15분 정도에서 최대치를 나타내었다. 일정한 태양에너지 조도 하에서 $SnO_2$의 성분비율을 높여감에 따라 전지의 개방전압과 단락전류는 다소 감소한 후 일정한 값으로 안정되는 경향을 나타내었다.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.11
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• pp.464-467
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• 1997

In this study, ECG was recorded during sleep patients with obstructive sleep apnea. We detecte(heart rate variability) signal from the ECG wa QRS detection algorithm. And we observed HRV by the power spectrum density using autoregr modeling. The experimental results were analysis sleep stage 1, sleep stage 2, sleep stage 3, sleep s sleep stage REM. In experimental result, the PSD with obstructive sleep apnea patients was distributed low frequency band except sleep step 4. These effect means that the sympathetic nervous system affected the sleep stage 1, 2, REM and the parasympathetic nervous system affected the sleep stage 3, 4 with obstructive sleep apnea patients.

• Transactions of the Korean Society of Automotive Engineers
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• v.20 no.2
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• pp.85-89
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• 2012

This paper presents a study on the system identification of the in-situ output shaft torque measurement system using a non-contacting magneto-elastic torque transducer installed in a vehicle drivline. The frequency response (transfer) function (FRF) analysis is conducted to interpret the dynamic interaction between the output shaft torque and road side excitation due to the road roughness. In order to identify the frequency response function of vehicle driveline system, two power spectral density (PSD) functions of two random signals: the road roughness profile synthesized from the road roughness index equation and the stationary noise torque extracted from the original torque signal, are first estimated. System identification results show that the output torque signal can be affected by the dynamic characteristics of vehicle driveline systems, as well as the road roughness.

• Proceedings of the KIEE Conference
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• 2001.07e
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• pp.40-42
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• 2001

본 논문은 Substrate의 온도를 200[$^{\circ}C$]로 유지하며 진공 저항 가열 증착법을 이용하여 ITO/Si 태양전지를 제작한 후 그 전기적 특성을 조사하였다. 전지의 단락전류와 개방전압의 열처리 온도의존성은 약450[$^{\circ}C$]이상부터 증가하여 650[$^{\circ}C$]부근에서 최대치를 나타내었다. 단락전류와 열처리 시간과의 관계에서는 증착시간이 15분 정도에서 최대치를 나타내었다. 일정한 태양에너지 조도 하에서 $SnO_2$의 성분비율을 높여감에 따라 전지의 개방전압과 단락전류는 다소 감소한 후 일정한 값으로 안정되는 경향을 나타내었다.

• Journal of Korea Water Resources Association
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• v.39 no.2 s.163
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• pp.161-178
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• 2006

Heathcote (1998) identified a systematic, seven-step approach to general watershed planning and management. It consists of 1) understanding watershed components and processes, 2) identifying and ranking problems to be solved, 3) setting clear and specific goals, 4) developing a list of management options, 5) eliminating infeasible options 6) testing the effectiveness of remaining feasible options, and 7) developing the final options. In this study the first five steps of that process were applied to the Anyangcheon watershed in Korea, which experiences streamflow depletion, frequent flood damages, and poor water quality typical of highly urbanized watersheds. This study employed four indices: Potential Flood Damage(PFD), Potential Streamflow Depletion(PSD), Potential Water Quality Deterioration(PWQD) and Watershed Evaluation Index(WEI) to identify and quantify problems within the watershed. WEI is the integration index of the others. Composite programming which is a method of multi-criteria decision making is applied for the calculation of PSD, PWQD and WEI (Step 2). The primary goal of the study is to secure instreamflow in the Anyangcheon during dry seasons. The second management goals of flood damage mitigation and water quality enhancement are also set (Step 3). Management options include not only structural measures that can alter the existing conditions, but also nonstructural measures that rely on changes in human behavior or management practices (Step 4). Certain management options which are not technically, economically, and environmentally feasible, are eliminated (Step S). Therefore, this study addresses a Pre-feasibility study, which established a master plan using Steps 1 through 5.

• Journal of Life Science
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• v.23 no.7
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• pp.941-946
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• 2013

Local protein synthesis at subsynaptic sites plays a key role in the regulation of the protein composition in local domains. In this study, we carried out immunocytochemistry of cultured rat hippocampal neurons in various developmental stages to investigate the expression of eIF4E and its binding protein, eIF4EBP1. Both proteins were distributed in dendrites. In addition, eIF4EBP1 was highly expressed in the nucleus throughout the development, whereas eIF4E was not expressed in the nucleus. Punctate expression of eIF4E and eIF4EBP1 was evident in DIV 3. The colocalization rates of eIF4E or eIF4EBP1 puncta with PSD95 were higher in the dendrogenic than in the mature stages. In contrast, the colocalization rates of eIF4E and eIF4EBP1 puncta were higher in the mature than in the dendrogenic stages. As eIF4E is inactive when it is bound to eIF4EBP1, these data indicate that most dendritic eIF4E's are active during development but that they are mostly under inhibition in mature neurons.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.26 no.1
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• pp.37-48
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• 2021

A new high speed rotation type-passive sampling device (HSR-PSD), which can rotate seawater at high speed and absorb easily and quickly the freely dissolved hydrophobic organic contaminants from seawater, was developed and then applied around the Korean Peninsula. Freely dissolved concentrations (Cfree) of polycyclic aromatic hydrocarbons (PAHs) were determined using the HSR-PSD with low density polyethylene (LDPE) sheets as a passive sampler. Furthermore, dissolved concentrations (Cdissolved) of PAHs in seawater were also obtained from high volume water sampling as a conventional method to account for actual bioavailability. When the LDPE sheets were rotated in the HSR-PSD at 900 rpm, PAHs with log KOW 3.4 ~ 5.2 were equilibrated between the LDPE and water in 5 hours. Although the high molecular weight PAHs with log KOW 5.6 ~ 6.8 was expected to be 2 to 30 days to reach the equilibrium, the Cfree of the PAHs at equilibrium could be corrected using performance reference compounds in 5 hours. Meanwhile, the total Cfree of PAHs were from 0.32 to 1.2 ng/L, which were higher than reported values in other oceans, but lower than in coastal water such as estuary, harbor, or shore. A bioavailability from the detected PAHs was highest at the sampling line near the dumping site of the Yellow Sea. Predicted residual concentrations in biota were relatively higher in offshore including the dumping site than in coastal regions.