• Asian Pacific Journal of Cancer Prevention
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• v.16 no.18
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• pp.8397-8403
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• 2016

Background: Breast cancer (BCa) is the most common malignancy in Mexican women. A set of histopathological markers has been established to guide BCa diagnosis, prognosis and treatment. Nevertheless, in only a few Mexican health services, such as that of the Secretariat of National Defense (SEDENA for its acronym in Spanish), are these markers commonly employed for assessing BCa. The aim of this study was to explore the association of Ki67, TP53, HER2/neu, estrogenic receptors (ERs) and progesterone receptors (PRs) with BCa risk factors. Materials and Methods: Clinical histories provided background patient information. Immunohistochemical (IHC) analysis was conducted on 48 tissue samples from women diagnosed with BCa and treated with radical mastectomy. The Chi square test or Fisher exact test together with the Pearson and Spearman correlation were applied. Results: On average, patients were $58{\pm}10.4$ years old. It was most common to find invasive ductal carcinoma (95.8%), histological grade 3 (45.8%), with a poor Nottingham Prognostic Index (NPI; 80.4%). ERs and PRs were associated with smoking and alcohol consumption, metastasis at diagnosis and Ki67 expression (p<0.05). PR+ was also related to urea and ER+ (p<0.05). Ki67 was associated with TP53 and elevated triglycerides (p<0.05), and HER2/neu with ER+, the number of pregnancies and tumor size (p<0.05). TP53 was also associated with a poor NPI (p<0.05) and CD34 with smoking (p<0.05). The triple negative status (ER-/PR-/HER2/neu-) was related to smoking, alcohol consumption, exposure to biomass, number of pregnancies, metastasis and a poor NPI (p<0.05). Moreover, the luminal B subty was associated with histological type (p=0.007), tumor size (p=0.03) and high cholesterol (p=0.02). Conclusions: Ki67, TP53, HER2/neu, ER and PR proved to be related to several clinical and pathological factors. Hence, it is crucial to determine this IHC profile in women at risk for BCa. Certain associations require further study to understand physiological/biochemical/molecular processes.

• Journal of the Korean Institute of Landscape Architecture
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• v.45 no.1
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• pp.94-104
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• 2017

With the recent increasing interest in preventive medicine, observation has been made regarding the positive relationship between a routinized place that includes activity and health improvement. This study evaluates the effective value of a designed landscape for seeing a healing environment and sees the difference of the effective value of classified physical settings regarding Evidence Based Design. Therefore, the study evaluates the perceived restorativeness scale of Cheonggyceheon's 1.5km section and five type settings in the same section regarding how much it works as a healthy urban park. The research methodology used to study sub-settings' and the research site's restoration effects was observation and questionnaires. A PRS (Perceived Restorativeness Scale) questionnaire survey was the research tool employed. The study drew two major results. Firstly, PRS 6.12 is the score of the whole research site, so the study identifies that Cheonggycheon has a mental fatigue restoration function. Secondly, the sub-setting named 'Near Sidewall' was the most attention restorative, according to the ANOVA results. In conclusion, this study suggests significant information support regarding the reasons for creating green areas in urban settings by identifying a particular designed healing sit.

• Journal of the Korea Concrete Institute
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• v.29 no.1
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• pp.3-10
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• 2017

In case of Korea highways, about 60% of highways are paved by concrete and more than 50% of them were repaired due to reduction in required performance such as damage in pave or joint and delamination of cover pavement. However, repairing old material in such structure generally costs a lot of money and induces difficulty in maintenance. Thus, enhanced material for ensuring economic efficiency should be developed. The present study designed concrete mixtures with 3 levels of replacement using OPC (0, 10, 20%) in calcium aluminate cement and to evaluate material performance for load pavement, experimental works for setting time, compressive strength and flexural strength were carried out on those materials. As a result, 20% replacement for OPC was determined as an optimized material in terms of required physical performance and its unit price. Moreover, to determine cost in load pavement economy analysis using a program (CA4PRS) was conducted with widely used paving materials. Result showed that application for 20% replacement for OPC was the most efficient in economical aspect, arising from 4.052 and 1.577 billion won for total construction and user cost, respectively.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.12 no.2
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• pp.87-91
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• 2016

Pierre Robin syndrome (PRS) is characterized by the triad of congenital mandibular hypoplasia, glossoptosis and cleft palate. Infant PRS patients are frequently suffering from upper airway obstruction, gastroesophageal reflux and growth retardation caused by above mentioned problems. We report a dental caries treatment of 3-year old girl with Pierre Robin syndrome with multiple caries. The cause of multiple caries was mainly presumed as patient's eating habit caused by her general condition. She had some feeding problems and had history of gastric tube. She was still using milk bottle and took more than an hour to finish a meal. The treatment was performed under general anesthesia considering patient's condition; mild autism, poor cooperation and respiratory problem due to micrognathia. Severely affected upper incisors were treated with pulp treatment and restored with zirconia crown for esthetic purpose. Lower incisors were treated with pulp treatment and restored with composite resin. Upper right first primary molar was restored with stainless steel crown and other primary molars were treated with composite resin. There were no postoperative complications. According to her parents, the patient's compliance to oral hygiene management was greatly improved after the treatment since she was very pleased with the esthetic result and highly motivated by her looks. The treatment without sedation or general anesthesia would be possible once the airway is improved as the mandible grows.

• Journal of Chest Surgery
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• v.57 no.2
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• pp.128-135
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• 2024

Background: This retrospective study aimed to determine the treatment patterns and the surgical and oncologic outcomes after completion lobectomy (CL) in patients with locoregionally recurrent stage I non-small cell lung cancer (NSCLC) who previously underwent sublobar resection. Methods: Data from 36 patients who initially underwent sublobar resection for clinical, pathological stage IA NSCLC and experienced locoregional recurrence between 2008 and 2016 were analyzed. Results: Thirty-six (3.6%) of 1,003 patients who underwent sublobar resection for NSCLC experienced locoregional recurrence. The patients' median age was 66.5 (range, 44-77) years at the initial operation, and 28 (77.8%) patients were men. Six (16.7%) patients underwent segmentectomy and 30 (83.3%) underwent wedge resection as the initial operation. The median follow-up from the initial operation was 56 (range, 9-150) months. Ten (27.8%) patients underwent CL, 22 (61.1%) underwent non-surgical treatments (chemotherapy, radiation, concurrent chemoradiation therapy), and 4 (11.1%) did not receive treatment or were lost to follow-up after recurrence. Patients who underwent CL experienced no significant complications or deaths. The median follow-up time after CL was 64.5 (range, 19-93) months. The 5-year overall survival (OS) and post-recurrence survival (PRS) were higher in the surgical group than in the non-surgical (p<0.001) and no-treatment groups (p<0.001). Conclusion: CL is a technically demanding but safe procedure for locoregionally recurrent stage I NSCLC after sublobar resection. Patients who underwent CL had better OS and PRS than patients who underwent non-surgical treatments or no treatments; however, a larger cohort study and long-term surveillance are necessary.

• International Journal of Naval Architecture and Ocean Engineering
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• v.10 no.5
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• pp.609-616
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• 2018

The cargo handling system, which is composed of a fuel gas supply unit and cargo tank pressure control unit, is the second largest power consumer in a Liquefied Natural Gas (LNG) carrier. Because of recent enhancements in ship efficiency, the surplus boil-off gas that remains after supplying fuel gas for ship propulsion must be reliquefied or burned to regulate the cargo tank pressure. A full or partial liquefaction process can be applied to return the surplus gas to the cargo tank. The purpose of this study is to review the current partial liquefaction process for LNG carriers and develop new processes for reducing power consumption using exergy analysis. The developed partial liquefaction process was also compared with the full liquefaction process applicable to a LNG carrier with a varying boil-off gas composition and varying liquefaction amounts. An exergy analysis showed that the Joule-Thomson valve is the key component needed for improvements to the system, and that the proposed system showed an 8% enhancement relative to the current prevailing system. A comparison of the study results with a partial/full liquefaction process showed that power consumption is strongly affected by the returned liquefied amount.

• Journal of Korean Library and Information Science Society
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• v.38 no.1
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• pp.3-28
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• 2007

It is thought that the various PRs of public library are the PR within the jurisdiction. outside the jurisdiction, by print media. by audio-video media. by fixture. by event. by media outlet. by campaign, through cyber space. and through associated organization. But the strategy of PR from this study is followed. First. the team for PR should be organized. Second. the librarian for PR should be distributed. Third, the budget for PR should be raised. Forth. the organizations of community should be made the full use of for PR. Fifth, the media outlet of the community should be made the best use of. Sixth. the news letter published by public library should be utilized. Seventh. the internet homepage of public library should be made good use of.

• The Journal of Internal Korean Medicine
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• v.26 no.4
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• pp.935-940
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• 2005

Objectives : This study it designed to evaluate the effects of an oriental medicine therapy, namely Binsosan-gamibang, on diabetic peripheral polyneuropathy. Methods : The clinical data was analyzed on a patient with diabetic peripheral polyneuropathy due to subyeolongsung(濕熱壅盛), gihyeoloeche(氣血瘀滯) whose main symptoms were pain and numbness in both legs. The patient was admitted at the internal medicine department of Dae-Gu Hanny University Dae-Gu Oriental Medicine Hospital on December 22, 2003, and was treated with herbal medicine(Binsosan-gamibang), acupuncture and physical therapy. Results : After treatment, improvement in pain and numbness in both legs was seen in the subsection of the pain rating score(PRS) and the visual analogue scale(VAS). Conclusions : This study suggests that Binsosan-gamibang is significantly effective in treatment of diabetic peripheral polyneuropathy.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2015.07a
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• pp.60-62
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• 2015

Dynamic Positioning System(DPS)은 동력, DP control 장치, DP 컴퓨터, 위치참조시스템(PRS), 센서, thruster 시스템 및 DP 운용자(DPO) 7가지로 구성되어 있다. DP 선박은 이들 구성요소들에 문제가 발생하면 그 기능을 상실할 수 있다. 본 연구에서는 2001~2010년까지 10년 동안 IMCA 보고된 DP 선박 관련사고 612건에 대한 분석을 바탕으로 DPS의 7가지 구성요소와 관련된 사고 원인을 파악하고 이들 중 가장 높은 비율을 차지하는 원인을 정성적, 정량적으로 상세 분석하여 요소별 관계와 주요 작용 요소를 확인하고자 한다. 이를 통해 DP 선박의 LOP사과 관련 분석에 있어 베이지안 네트워크의 활용성을 확인해 보았다. 10년 평균 가장 높은 비율을 차지한 DPS 사고원인 요인은 PRS이었으며 이를 전문가 브레인스토밍을 통해 작성된 flowchart를 바탕으로 베이지안 네트워크를 통해 상세 분석해 본 결과 PRS의 각 요소별 조건부 확률 확인할 수 있었다. DP 선박의 drive off를 발생시키는데 주요한 영향을 미치는 것은 DGPS, microwave radar 및 HPR 이었고 DGPS에 주요한 영향을 미치는 에러 요인은 signal blocked, electric components failure, relative mode error 및 signal weak or fail 이었다.

• Journal of the Korean Society for Precision Engineering
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• v.26 no.7
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• pp.127-133
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• 2009

We present a $3-{\underline{P}}RS$ compliant parallel manipulator actuated by PZTs. The motion ranges are $400-{\mu}m$ translation to the z-direction and 5.7-mrad rotation about any axis on the x-y plane. A mechanical amplifier whose advantage is approximately 5.5 is designed and integrated with flexure revolute and spherical joints in a monolithic way. We evaluated the performance of the system: kinematic and dynamic characteristics. In kinematic point of view, the flexures play the roles of conventional mechanism but any nonlinearity such as dead-zone and backlash, which make it possible to achieve the steady-state resolution less than $0.1{\mu}m$. The system shows resonance near 86 Hz with high magnitude and, therefore, poor transient response. But the settling is faster when the flexures are strained higher.